獲獎 & 著作 

獲獎

1. 國立陽明大學/陽明交通大學教師學術卓越獎勵(2011/8/01~2025/7/31) 

2. 一百一十二學年度 醫學系專題生吳婷貽獲國科會大專生計劃

3. 2022年1月獲得中華民國發明專利核准(申請案號：108125582;申請人：國立陽明大學、徐慧妤;發明人：楊定一、徐慧妤)，專利名稱為「一種落葵萃取物用於製備預防或治療神經系統疾病組合物的用途」 

4. 2020年2月經核定為本校永久免接受評估教師 

5. 一百一十學年度 博士生謝依衡發表論文於Free Radical Biology & Medicine獲陽明交通大學學生優良研究成果獎勵

6. 一百一十學年度 博士生謝依衡發表論文於Free Radical Biology & Medicine入圍陽明交通大學優良論文獎學金

7. 一百零八學年度 碩士生侯柏宇獲得「國際神經化學學會/美國神經化學學會2019聯合年會」(2019-ISN-ASN MEETING)所頒發之Travel Award (US$1500)以及科技部國際會議補助

8. 一百零八學年度 碩士生龔正傑參加「2018臺灣粒線體暨醫學研究研討會」獲頒論文競賽佳作獎

9. 一百零七學年度 碩士班畢業生陳芊慧榮獲生物醫學國際研討會暨第15屆前瞻生物醫學科學新知研討會壁報競賽特優論文獎

10. 一百零六學年度 碩士班畢業生謝依衡 獲「施再金文教基金會」獎學金

11. 一百零三學年度 碩士班畢業生張世欣發表論文(Molecular Neurobiology)獲頒2015「財團法人立夫文教基金會」學術獎第三名

12. 一百零二學年度 碩士班畢業生吳孟芳發表論文(Free Radical Research)獲頒2014「財團法人立夫文教基金會學術獎」第四名

13. 一百學年度 碩士班畢業生黃昭慈論文獲頒2011「財團法人立夫文教基金會學術獎」第六名佳作

14. 九十九學年度 碩士班畢業生洪郁欣論文獲頒2010「財團法人立夫文教基金會學術獎」第二名

15. 一百零四學年度 陽明大學分子醫學學程博士班畢業生吳佳霖獲頒三次「施再金文教基金會」獎學金(2009/05、2012/03、2013/03)

16. 九十八學年度 陽明大學腦科學研究所畢業生吳佳霖獲頒「生技教育基金」獎學金(2014/04)

17. 九十九學年度 陽明大學腦科學研究所畢業生唐青敏獲頒「施再金文教基金會」獎學金(2009/05)

18. 九十四學年度 慈濟大學論文獎(2006/06/30)

19. 九十三學年度 慈濟大學神經科學研究所畢業生朱自淳發表碩士論文(Ju et al., Free Radical Biology and Medicine, 38, 938, 2005)獲得「第二屆財團法人台北市林榮耀教授學術教育基金會論文獎」

20. 專題計畫「惡性腦膠質瘤細胞化療抗藥性機轉之探討:一氧化氮麩氨基硫與缺氧誘發因子所扮演之角色」獲國科會九十四年度吳大猷先生紀念獎(2006/03/02)

21. 九十三學年度 慈濟大學論文獎(2005/05/20)

22. Lowell B. Miller Memorial Research Grant supported by National Brain Tumor Foundation, USA (2001/07/01-2002/06/30)

23. Washington University School of Medicine-Pharmacia Biomedical Research Support Program (2001/01/01-2003/12/31)

期刊論文與專書章節 (另有88篇會議壁報論文未詳列)

期刊論文(*代表通訊作者，#代表共同第一作者)

1. Wu, M.S.†, Chao, A.C.†, Hsieh, Y.H., Lien, Y., Lin, Y.C.*, Yang, D.I* (2024) Protein kinase C-delta mediates cell cycle reentry and apoptosis induced by amyloid-beta peptide in post-mitotic cortical neurons. International Journal of Molecular Sciences 25(17): 9626. 【Full article PDF】

2. Hou, B.Y.†, Wu, M.S.†, Hsu, H.Y., Lin, Y.C.*, Yang, D.I* (2024) Polysaccharides from Basella alba protect post-mitotic neurons against cell cycle re-entry and apoptosis induced by the amyloid-beta peptide by blocking sonic hedgehog expression. International Journal of Molecular Sciences 25(13): 7316. 【Full article PDF】

3. Chao, Y.M., Wu, H.Y., Yeh, S.H., Yang, D.I, Her, L.S., Wu, Y.L.* (2024) Glucosamine enhancement of learning and memory functions by promoting fibroblast growth factor 21 production. International Journal of Molecular Sciences 25(8): 4211. 【Full article PDF】

4. Hua KF†, Chao AC†, Lin TY, Chen WT, Lee YC, Hsu WH, Lee SL, Wang HM, Yang DI, Ju TC* (2022) Ginsenoside compound K reduces the progression of Huntington’s disease via the inhibition of oxidative stress and overactivation of the ATM/AMPK pathway. Journal of Ginseng Research 46(4): 572-584.【Full article PDF】

5. Chen KP#, Hua KF#, Tsai FT, Lin TY, Cheng CY, Yang DI, Hsu HT, Ju TC* (2022) A selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington’s disease. Journal of Neuroinflammation 19(1): 56.【Full article PDF】

6. Chen SD#, Yang JL#, Hsieh YH, Lin, TK, Lin YC, Chao AC*, Yang DI* (2021) Potential roles of sestrin2 in Alzheimer’s disease: antioxidation, autophagy promotion, and beyond. Biomedicines 9(10): 1308.【Full article PDF】

7. Hsieh YH, Chao AC, Lin YC, Chen SD, Yang DI* (2021) The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons. Free Radical Biology and Medicine 169: 36-61.【Full article PDF】

8. Bhore N, Wang BJ, Wu PF, Lee YL, Chen YW, Hsu WM, Lee H, Huang YS, Yang DI, Liao YF* (2021) Dual-specificity phosphatase 15 (DUSP15) modulates Notch signaling by enhancing the stability of Notch protein. Molecular Neurobiology 58(5): 2204-2214.【Full article PDF】

9. Chen SD#, Yang JL#, Lin YC, Chao AC, Yang DI* (2020) Emerging roles of inhibitor of differentiation-1 in Alzheimer’s disease: cell cycle reentry and beyond. Cells 9(7): 1746.【Full article PDF】

10. Chao AC#, Chen CH#, Wu MS, Hou BY, Yang DI* (2020) Role of Id1/HIF-1 and CDK5/HIF-1 in cell cycle reentry induced by amyloid beta-peptide in post-mitotic cortical neurons. Biochimica et Biophysica Acta - Molecular Cell Research 1867(4): 118628.【Full article PDF】

11. Chen SD#, Yang JL#, Lin TK, Yang DI* (2019) Emerging roles of sestrins in neurodegenerative diseases: counteracting oxidative stress and beyond. Journal of Clinical Medicine 8: 1001.【Full article PDF】

12. Chao AC#, Chen CH#, Chang SH, Huang, CT, Hwang WC, Yang DI* (2019) Id1 and sonic hedgehog mediate cell cycle re-entry and apoptosis induced by amyloid beta-peptide in post-mitotic cortical neurons. Molecular Neurobiology 56(1): 465-489.【Full article PDF】

13. Chen SD#, Yang JL#, Hwang WC, Yang DI* (2018) Emerging roles of sonic hedgehog in adult neurological diseases: neurogenesis and beyond. International Journal of Molecular Sciences 19(8): E2423. ("†" denotes equal contribution as co-first author.)【Full article PDF】

14. Chen SD, Wu CL, Hwang WC, Yang DI* (2017) More insight into BDNF against neurodegeneration: anti-apoptosis, anti-oxidation, and suppression of autophagy. International Journal of Molecular Sciences 18(3): E545.【Full article PDF】

15. Wu CL#, Chen CH#, Hwang CS, Chen SD, Hwang WC, Yang DI* (2017) Roles of p62 in BDNF-dependent autophagy suppression and neuroprotection against mitochondrial dysfunction in rat cortical neurons. Journal of Neurochemistry 140(6): 845-861.【Full article PDF】

16. Wu CL, Chen SD, Yin JH, Hwang CS, Yang DI* (2016) Nuclear factor-kappaB-dependent sestrin2 induction mediates the antioxidant effects of BDNF against mitochondrial inhibition in rat cortical neurons. Molecular Neurobiology 53(6): 4126-4142.【Full article PDF】

17. Hung, YH#, Chang SH#, Huang CT, Yin JH, Hwang CS, Yang LY, Yang DI* (2016) Inhibitor of differentiation-1 and hypoxia-inducible factor-1 mediate sonic hedgehog induction by amyloid beta-peptide in rat cortical neurons. Molecular Neurobiology 53(2): 793-809.【Full article PDF】

18. Chao AC, Lee TC, Juo SHH, Yang DI* (2016) Hyperglycemia increases the production of amyloid beta-peptide leading to decreased endothelial tight junction. CNS Neuroscience & Therapeutics 22(4): 291-297.【Full article PDF】

19. Chen SD, Lin TK, Yang DI, Lee SY, Shaw FZ, Liou CW, Chuang YC* (2016) Peroxisome proliferator-activated receptor-gamma dependent pathway reduces the phosphorylation of dynamin-related protein 1 and ameliorates hippocampal injury induced by global ischemia in rats.  Journal of Biomedical Science 23(1): 44.【Full article PDF】

20. Chang SH, Hwang CS, Yin JH, Chen SD, Yang DI* (2015) Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons. Biochimica et Biophysica Acta - Molecular Cell Research 1853(10): 2306-2325.【Full article PDF】

21. Chuang YC, Yang JL, Yang DI, Lin TK, Liou CW, Chen SD* (2015) Roles of sestrin2 and ribosomal protein S6 in transient global ischemia-induced hippocampal neuronal injury. International Journal of Molecular Sciences 16(11): 26406-26416.【Full article PDF】

22. Chen SD, Lin TK, Yang DI, Lee SY, Shaw FZ, Liou CW, Chuang YC* (2015) The roles of PTEN-induced putative kinase 1 and dynamin-related protein 1 in transient global ischemia-induced hippocampal neuronal injury. Biochemical and Biophysical Research Communications 460(2): 397-403.【Full article PDF】

23. Wu MF, Yin JH, Hwang CS, Tang CM, Yang DI* (2014) NAD attenuates oxidative DNA damages induced by amyloid beta-peptide in primary rat cortical neurons. Free Radical Research 48(7): 794-805.【Full article PDF】

24. Chen YS#, Chen SD#,*, Wu CL, Huang SS, Yang DI* (2014) Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary rat cortical cultures. Experimental Neurology 253: 63-71.【Full article PDF】

25. Huang SS, Cheng H, Tang CM, Nien MY, Huang YS, Lee IH, Yin JH, Kuo TBJ, Yang CCH, Tsai SK*, Yang DI* (2013) Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. Experimental Neurology 247: 680-688.【Full article PDF】

26. Huang SS, Su HH, Kuo TB, Chen CY, Lan YY, Liu BY, Yang DI, Tsai SC, Yang CC* (2012) Suppressing cardiac vagal modulation and changing sleep patterns in rats after chronic ischemic stroke injury. Autonomic Neuroscience - Basic & Clinical 169(2): 116-123.【Full article PDF】

27. Chen SD#, Wu CL#, Lin TK, Chuang YC, Yang DI* (2012) Renin inhibitor aliskiren exerts neuroprotection against amyloid beta-peptide toxicity in rat cortical neurons. Neurochemistry International 61(3): 369-377.【Full article PDF】

28. Chen SD, Yin JH, Hwang CS, Tang CM, Yang DI* (2012) Anti-apoptotic and anti-oxidative mechanisms of minocycline against sphingomyelinase/ceramide neurotoxicity: implication in Alzheimer’s disease and cerebral ischemia. Free Radical Research 46(8): 940-950.【Full article PDF】

29. Wu CL, Yin JH, Hwang CS, Chen SD, Yang DY, Yang DI* (2012) c-Jun-dependent sulfiredoxin induction mediates BDNF protection against mitochondrial inhibition in rat cortical neurons. Neurobiology of Disease 46(2): 450-462.【Full article PDF】

30. Hung YW, Yang DI, Huang PY, Lee TS, Kuo TBJ, Yiu CH, Lin YY* (2012) The duration of convulsive sustained seizures determines the pattern of hippocampal neurogenesis and development of spontaneous epilepsy in rats. Epilepsy Research 98(2-3): 206-215.【Full article PDF】

31. Chen SD*, Yang DI, Lin TK, Shaw FZ, Liou CW, Chuang YC* (2011) Roles of oxidative stress, apoptosis, PGC-1alpha and mitochondrial biogenesis in cerebral ischemia. International Journal of Molecular Sciences 12(10): 7199-7215.【Full article PDF】

32. Tang CM, Hwang CS, Chen SD, Yang DI* (2011) Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: roles of Bcl-2 and thioredoxin. Free Radical Biology and Medicine 50(6): 710-721.【Full article PDF】

33. Chen SD, Lin TK, Lin JW, Yang DI, Lee SY, Shaw FZ, Liou CW, Chuang YC* (2010) Activation of calcium/calmodulin-dependent protein kinase IV and peroxisome proliferator-activated receptor γ coactivator-1α signaling pathway protects neuronal injury and promotes mitochondrial biogenesis in the hippocampal CA1 subfield after transient global ischemia. Journal of Neuroscience Research 88(14): 3144-3154.【Full article PDF】

34. Chen SD, Lin TK, Yang DI, Lee SY, Shaw FZ, Liou CW, Chuang YC* (2010) Protective effects of peroxisome proliferator-activated receptors coactivator-1 against neuronal cell death in the hippocampal CA1 subfield after transient global ischemia. Journal of Neuroscience Research 88(3): 605-613.【Full article PDF】

35. Wu CL, Chen SD, Yin JH, Hwang CS, Yang DI* (2010) Erythropoietin and sonic hedgehog mediate the neuroprotective effects of brain-derived neurotrophic factor against mitochondrial inhibition. Neurobiology of Disease 40(1): 146-154.【Full article PDF】

36. Wu CL, Hwang CS, Chen SD, Yin JH, Yang DI* (2010) Neuroprotective mechanisms of brain-derived neurotrophic factor against 3-nitropropionic acid toxicity: Therapeutic implications for Huntington’s disease. Annals of the New York Academy of Sciences 1201: 8-12.【Full article PDF】

37. Wu CL, Chen SD, Hwang CS, Yang DI* (2009) Sonic hedgehog mediates BDNF-induced neuroprotection against mitochondrial inhibitor 3-nitropropionic acid. Biochemical and Biophysical Research Communications 385(1): 112-117.【Full article PDF】

38. Wu CL, Hwang CS, Yang DI* (2009) Protective effects of brain-derived neurotrophic factor against neurotoxicity of 3-nitropropionic acid in rat cortical neurons. Neurotoxicology 30(4): 718-726.【Full article PDF】

39. Huang CY, Yang HI, Chen SD, Shaw FZ, Yang DI* (2008) Protective effects of lipopolysaccharide preconditioning against nitric oxide neurotoxicity. Journal of Neuroscience Research 86(6): 1277-1289.【Full article PDF】

40. Yang JJ, Yin JH, Yang DI* (2007) Nitric oxide donors attenuate clongenic potential in rat C6 glioma cells treated with alkylating chemotherapeutic agents. Neuroscience Letters 418(1): 106-110.【Full article PDF】

41. Hu CJ, Chen SD, Yang DI, Lin TN, Chen CM, Huang THM, Hsu CY* (2006) Promoter region methylation and reduced expression of thrombospondin-1 after oxygen-glucose deprivation in murine cerebral endothelial cells. Journal of Cerebral Blood Flow and Metabolism 26(12): 1519-1526.【Full article PDF】

42. Chen SD, Wu HY, Yang DI, Lee SY, Shaw FZ, Lin TK, Liou CW, Chuang YC* (2006) Effects of rosiglitazone on global ischemia-induced hippocampal injury and expression of mitochondrial uncoupling protein 2. Biochemical and Biophysical Research Communications 351(1): 198-203.【Full article PDF】

43. Si ML, Long C, Yang DI, Chen MF, Lee TJF* (2005) Statins prevent beta-amyloid inhibition of sympathetic alpha7-nAChR-mediated nitrergic neurogenic dilation in porcine basilar arteries. Journal of Cerebral Blood Flow and Metabolism 25(12): 1573-1585.【Full article PDF】

44. Chen SD, Hu CJ, Yang DI, Nassief A, Chen H, Yin KJ, Xu J, Hsu CY* (2005) Pravastatin attenuates ceramide-induced cytotoxicity in mouse cerebral endothelial cells by HIF-1 activation and increased VEGF expression. Annals of the New York Academy of Sciences 1042: 357-364.【Full article PDF】

45. Yang DI, Chen SD, Yin JH, Hsu CY* (2005) S-Nitrosoglutathione and hypoxia-inducible factor-1 confer chemoresistance against carbamoylating cytotoxicity of BCNU in rat C6 glioma cells. Annals of the New York Academy of Sciences 1042: 229-234.【Full article PDF】

46. Yang DI, Chen SW, Ezekiel UR, Xu J, Wu YJ, Hsu CY* (2005) Antisense RNA to inducible nitric oxide synthase reduces cytokine-mediated brain endothelial cell death. Annals of the New York Academy of Sciences 1042: 439-447.【Full article PDF】

47. Ju TC, Chen SD, Liu CC, Yang DI* (2005) Protective effects of S-nitrosoglutathione against amyloid beta-peptide neurotoxicity. Free Radical Biology and Medicine 38(7): 938-949.【Full article PDF】

48. Yang YT, Ju TC, Yang DI* (2005) Induction of hypoxia inducible factor-1 attenuates metabolic insults induced by 3-nitropropionic acid in rat C6 glioma cells. Journal of Neurochemistry 93(3): 513-525.【Full article PDF】

49. Yang DI#, Yeh CH#, Chen SW, Xu J, Hsu CY* (2004) Neutral sphingomyelinase activation in endothelial and glial cell death induced by amyloid beta-peptide. Neurobiology of Disease 17(1): 99-107.【Full article PDF】

50. Ju TC, Yang YT, Yang DI* (2004) Protective effects of S-nitrosoglutathione against neurotoxicity of 3-nitropropionic acid in murine neurons. Neuroscience Letters 362(3): 226-231.【Full article PDF】

51. Yang DI, Yin JH, Ju TC, Chen LS, Hsu CY* (2004) Nitric oxide and BCNU chemoresistance in C6 glioma cells: role of S-nitrosoglutathione. Free Radical Biology and Medicine 36(10): 1317-1328.【Full article PDF】

52. Yang DI, Chen SD, Yang YT, Ju TC, Xu JM, Hsu CY* (2004) Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: putative roles of hypoxia- inducible factor-1. British Journal of Pharmacology 141(6): 988-996.【Full article PDF】

53. Lee JT, Xu J, Lee JM, Ku G, Han XL, Yang DI, Chen SW, Hsu CY* (2004) Amyloid β-peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway. Journal of Cell Biology 164(1): 123-134.【Full article PDF】

54. Chen SD, Lee JM, Yang DI, Nassief A, Hsu CY* (2002) Combination therapy for ischemic stroke: potential of neuroprotectants plus thrombolytics. American Journal of Cardiovascular Drugs 2(5): 303-313.【Full article PDF】

55. Yang DI, Yin JH, Mishra S, Mishra R, Hsu CY* (2002) NO-mediated chemoresistance in C6 glioma cells. Annals of the New York Academy of Sciences 962: 8-17.【Full article PDF】

56. Chen H#, Hu CJ#, He YY, Yang DI, Xu J, Hsu CY* (2001) Reduction and restoration of mitochondrial DNA contents after focal ischemia-reperfusion. Stroke 32(10): 2382-2387.【Full article PDF】

57. Yin JH#, Yang DI#, Chou H, Thompson EM, Xu J, Hsu CY* (2001) Inducible nitric oxide synthase neutralizes carbamoylating potential of 1,3-bis(2-chloroethyl) -1-nitrosourea in C6 glioma cells. Journal of Pharmacology and Experimental Therapeutics 297(1): 308-315.【Full article PDF】

58. Yin JH, Yang DI, Ku G, Hsu CY* (2000) iNOS expression inhibits hypoxia-inducible factor-1 activity. Biochemical and Biophysical Research Communications 279(1): 30-34.【Full article PDF】

59. Yang DI, Louis CF* (2000) Molecular cloning of ovine connexin44 and temporal expression of gap junction proteins in a lens cell culture. Investigative Ophthalmology & Visual Science 41(9): 2658-2664.【Full article PDF】

60. Yang DI, Louis CF* (1996) Molecular cloning of sheep connexin49 and its identity with MP70. Current Eye Research 15(3): 307-314.【Full article PDF】

61. Mickelson JR, Knudson CM, Kennedy CF, Yang DI, Litterer LA, Rempel WE, Campbell KP, Louis CF* (1992) Structural and functional correlates of a mutation in the malignant hyperthermia-susceptible pig ryanodine receptor. FEBS Letters 301(1): 49-52.【Full article PDF】

62. Yang DI, Feng TY, Chen CC, Lai YK* (1992) Physical maps of Nicotiana chloroplast DNA constructed by an efficient procedure. Theoretical and Applied Genetics 83: 515-527.【Full article PDF】

專書章節(*代表通訊作者)

1.  Yang DI, Lee JT, Yin KJ, Yeh CH, Xu J, Hsu CY* (2004) Molecular mechanism of amyloid peptide-induced cerebral endothelial cell apoptosis. Pharmacology of Cerebral Ischemia, p. 41-50, Medpharm Scientific Publishers, Stuttgart 【Full article PDF】

2.  Yang DI, Lin TN, Yin KJ, Hu CJ, Chen SD, Xu J, Hsu CY* (2006) Cerebral endothelial cell reaction to ischemic insult. In Acute ischemic injury and repair in the nervous system. In Handbook of Neurochemistry, 3rd Edition, Volume 23, Chapter 10, p. 165-183, edited by Pak Chan. Kluwer Academic/Plenum Publishers, New York, NY, USA【Full article PDF】