Welcome to the
International Multiomics Initiative:
Precision Nutrition and Health
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Nutriome → Microbiome → Metabolome → Epigenome → Transcriptome → Translatome → Health
Advancing basic science for better health and future longevity
Mission
Mission
Our mission is to promote health and prevent disease by advancing precision nutrition. This is achieved through global cooperation among leading scientific institutions worldwide, including strategic partnerships that enable academic exchange, shared infrastructure, knowledge transfer, and collaborative grants across basic research, translational projects, and organizational initiatives. PROJECTS:
Alone we can do so little; together we can do so much (Helen Keller)
I. Multiomics-guided mechanistic understanding of gut microbiome-mediated epigenome reprogramming in response to functional food–based dietary intervention
I. Multiomics-guided mechanistic understanding of gut microbiome-mediated epigenome reprogramming in response to functional food–based dietary intervention
NUMIEP is a research initiative focused on understanding how diet, the gut microbiome, and the epigenome interact to support long-term health. Using iodine- and selenium-biofortified lettuce as a model, the project investigates how dietary components shape microbial communities and how microbiome-derived metabolites influence epigenetic and functional changes in colonic epithelial cells. By combining microbial fermentation assays, in vivo mouse models, human organoids, and multi-omics profiling including metabolomics, RNA-seq, ATAC-seq, single-cell multiomics, and DNA methylation, NUMIEP aims to map the cascade from nutriome to microbiome to metabolites to epigenome to transcriptome to epithelial phenotype. The ultimate goal is to uncover how targeted dietary interventions modulate microbiome–epigenome interactions to enable personalized nutrition and microbiome-guided strategies for healthy longevity.
II. International Research Network in Translational Systems Biology and Nutriomics for the Development of Precision Nutrition in Health Promotion and the Prevention of Non-Communicable Diseases
II. International Research Network in Translational Systems Biology and Nutriomics for the Development of Precision Nutrition in Health Promotion and the Prevention of Non-Communicable Diseases
MSB-TBSN is an international strategic partnership focused on advancing Translational Systems Biology (TSB) and nutriomics as key drivers of precision nutrition. The initiative addresses the need for improved integration of multiomic data by linking the diet–microbiome–epigenome axis within a coordinated translational framework. By establishing a connected research network and a shared digital platform, and by leveraging advanced approaches such as multiomics and artificial intelligence, MSB-TBSN aims to translate complex biological insights into practical nutrition strategies that support health promotion and the prevention of non-communicable diseases. The initiative also strengthens international collaboration and training (see Strategic Partners), contributing to a systems-level understanding of diet–host interactions and their relevance to healthy longevity.
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