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picom@uji.es
Position:
Ramón y Cajal researcher
Bio:
2022 Postdoctoral Researcher (María Zambrano) at Neuropsychology and Functional Neuroimaging (NNF) group, Jaume I University
2018 - 2021 Postdoctoral Researcher at Life and Health Sciences Research Institute (ICVS), University of Minho, Portugal
2018 PhD in Medicine and Translational Research, University of Barcelona, Spain
2014 Master in Neuroscience, University of Barcelona, Spain
2013 Bachelor Degree in Psychology, University of Valencia, Spain
Research Interests:
Emotion regulation
fMRI analysis
Neuroimaging
Meta-analysis
OCD
Sex/gender
My research relies on the use of neuroimaging techniques as a window towards understanding typical and atypical behavior. One of my main lines or research is related to the neurobiology of emotion regulation, and on how we can use this knowledge to develop novel intervention techniques. I also have a particular interest in obsessive-compulsive disorder, and I am involved in a number of projects aimed at identifying multimodal neuroimaging biomarkers of treatment response, and at developing alternative interventions for those patients resistant to first-line treatments. Moreover, not only people with a psychiatric diagnosis suffer from mental health-related issues, which became even more obvious in the context of global crisis such as the COVID-19 pandemic. I believe projects focused at early stages of mental suffering are also of utmost importance, since early detection and prevention are critical to improve both the population’s quality of life and the socioeconomic costs associated with mental health problems.
Projects
Projects
As Principal Investigator
Assessing the consistency of neuroimaging sex/gender differences in impulsivity and emotional processing through meta-analysis and latent variable modeling analysis (UJI-2023-28). Funding entity: Jaume I University. 01/2024-12/2026.
Exploring sex/gender differences in stress and emotional processing using meta-analytical and neuroimaging techniques (CIAICO/2022/133). Funding entity: Generalitat Valenciana. 01/2023-12/2025.
Influence of sex and gender on the stress response: going beyond the binary framework for improving personalized healthcare (EXPL/PSI-GER/1030/2021). Funding entity: FCT - Fundação para a Ciência e a Tecnologia. 01/2022-12/2023.
Influence of individual differences in reward sensitivity on the modulation of cognitive-motivational interactions in patients with obsessive-compulsive disorder (CMI-OCD). Funding entity: 2CA - Centro Clínico Académico, Hospital de Braga. 04/2020-12/2021.
As part of the Research Team
The reinforcement sensitivity theory as a higher order model for structure-function organization in the human brain (Knowledge Generation Projects; PID2021-127340NB-C21). Funding entity: Spanish Ministry of Science and Innovation. PI: Alfonso Barrós-Loscertales (Jaume I University). 01/2022-12/2024.
A new hope for resistant Obsessive-Compulsive Disorder – innovative strategies for outcome prediction and treatment (FLAD Science Award Mental Health). Funding entity: Fundação Luso-Americana para o Desenvolvimento (FLAD). PI: Pedro Morgado (ICVS, School of Medicine, University of Minho). 06/2021-05/2024.
Neural basis of suicidality in Major Depression: from suicidal ideation to action (Id2Act). Funding entity: 2CA - Centro Clínico Académico, Hospital de Braga. PI: Rita Vieira (ICVS, School of Medicine, University of Minho). 07/2022-12/2023.
Towards robust biomarkers in mental health: Development of a magnetic resonance imaging-based atlas of mental disorders, and initial validation of an associated diagnostic aid tool (PI19/00394). Funding entity: Instituto de Salud Carlos III. PI: Joaquim Radua (Instituto de investigaciones biomedicas August Pi i Sunyer (IDIBAPS)). 01/2020-12/2022.
Promoting Mental Health During Pandemic - a digital platform for monitoring and intervention. Funding entity: FCT - Fundação para a Ciência e a Tecnologia. PI: Pedro Morgado (ICVS, School of Medicine, University of Minho). 05/2020-07/2020.
Neural correlates of impulsive behavior: from bench to bedside to bench (NeurImp4B). Funding entity: 2CA - Centro Clínico Académico, Hospital de Braga. PI: Madalena Esteves (ICVS, School of Medicine, University of Minho). 04/2019-12/2020.
Caracterització mitjançant neuroimatge de predictors i mecanismes de resposta a la teràpia cognitiu-conductual en el trastorn obsessiu-compulsiu (PERIS SLT006/17/249). Funding entity: Departament de Salut de la Generalitat de Catalunya. PI: Carles Soriano Mas. (Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)). 01/2018-12/2020.
El modelo de incertidumbre-anticipación: uso de la neuroimagen funcional para predecir la trayectoria de los síntomas de ansiedad y caracterizar las alteraciones cerebrales relacionadas (PI16/00889). Funding entity: Instituto de Salud Carlos III. PI: Carles Soriano Mas. (Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)). 01/2017-12/2019.
Fernandes A, Ferreira S, Moreira P, Machado-Sousa M, Couto B, Raposo-Lima C, Costa P, Morgado P, Picó-Pérez M (2024). Stress, anxiety, and depression trajectories during the “first wave” of the COVID-19 pandemic: what drives resilient, adaptive and maladaptive responses in the Portuguese population? Frontiers in Public Health, 12. https://doi.org/10.3389/fpubh.2024.1333997
Picó-Pérez M, Abalos Marco E, Thurston LT, Ambrosi V, Genon S, Bryant KL, Martínez AB, Ciccia L, Kaiser Trujillo A (2024). Researchers’ sex/gender identity influences how sex/ gender question is investigated in neuroscience: an example from an OHBM meeting. Brain Structure and Function, 0123456789. https://doi.org/10.1007/s00429-023-02750-8
Si S, ..., Picó-Pérez M, ..., Kempton MJ (2024). Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study. Mol Psychiatry. doi: 10.1038/s41380-023-02343-1.
Bruin WB, ..., Picó-Pérez M, ..., van Wingen GA (2023). The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium. Mol. Psychiatry. https://doi.org/10.1038/s41380-023-02077-0
Picó-Pérez M*, Magalhães R*, Esteves M, Vieira R, Castanho TC, Amorim L, Sousa M, Coelho A, Moreira PS, Cunha RA, Sousa N (2023). Coffee consumption decreases the connectivity of the posterior Default Mode Network (DMN) at rest. Front. Behav. Neurosci., 17:1176382. https://doi.org/10.3389/fnbeh.2023.1176382. *Co-first Authorship.
D’Alva-Teixeira V, Picó-Pérez M, Morgado P (2023). Determinants of Poor Mental Health of Medical Students in Portugal - A Nationwide Study. Healthcare, 11, 1–11. https://doi.org/https://doi.org/10.3390/ healthcare11141991.
Vieira R, Raquel A, Ribeiro D, Picó-Pérez M†, Bessa JM† (2023). Structural and functional brain correlates of suicidal ideation and behaviors in depression: A scoping review of MRI studies. Prog. Neuropsychopharmacol. Biol. Psychiatry, 126, 110799. https://doi.org/10.1016/j.pnpbp.2023.110799. †Co-last Authorship.
Gomes M, Picó-Pérez M, Castro I, Moreira P, Ribeiro S, Mota NB, Morgado P (2023). Speech graph analysis in obsessive-compulsive disorder: The relevance of dream reports. J. Psychiatr. Res., 161, 358–363. https://doi.org/10.1016/j.jpsychires.2023.03.035.
Bertolín S, ..., Picó-Pérez M, ..., Soriano-Mas C (2023). Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder. J Am Acad Child Adolesc Psychiatry, 62(4), 403–414. doi: 10.1016/j.jaac.2022.07.865.
Vieira R, Reis J, Portugal-Nunes C, Coelho A, Magalhães R, Ferreira S, Moreira PS, Sousa N, Picó-Pérez M†, Bessa JM† (2023). Anticipatory cues in emotional processing shift the activation of a combined salience sensorimotor functional network in drug-naïve depressed patients. J. Affect. Disord, 320, 509–516. https://doi.org/10.1016/j.jad.2022.09.165. †Co-last Authorship.
de la Peña-Arteaga V, Morgado P, Couto B, Ferreira S, Castro I, Sousa N, Soriano-Mas C, Picó-Pérez M (2022). A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal. Eur. Psychiatry, 65(1), 1–8. https://doi.org/10.1192/j.eurpsy.2022.2322.
Caetano I, Ferreira S, Coelho A, Amorim L, Castanho TC, Portugal-Nunes C, Soares JM, Gonçalves N, Sousa R, Reis J, Lima C, Marques P, Moreira PS, Rodrigues AJ, Santos NC, Morgado P, Magalhães R, Picó-Pérez M, Cabral J, Sousa N (2022). Perceived stress modulates the activity between the amygdala and the cortex. Mol Psychiatry, 27(12), 4939-4947. doi: 10.1038/s41380-022-01780-8.
Varela Cunha G, Silva Moreira P, Machado-Sousa M, Castanho T, Picó-Pérez M, Ferreira S, Morgado P (2022). The Obsessive-Compulsive Inventory-Revised (OCI-R): Translation and Validation of the European Portuguese Version. Acta Med. Port. https://doi.org/10.20344/amp.16452.
Picó-Pérez M, Barbosa R, Couto B, Castro I, Magalhães R, Sousa N, Ferreira S, Morgado P (2022). Altered frontoparietal connectivity in patients with obsessive-compulsive disorder during an fMRI cognitive reappraisal task. Psychiatry Res. 114874. https://doi.org/10.1016/j.psychres.2022.114874.
Ivanov I, ..., Picó-Pérez M, ..., Fouche JP (2022). Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium. Journal of Affective Disorders, 318, 204-216. https://doi.org/10.1016/j.jad.2022.08.084.
Caetano I, Amorim L, Costa Castanho T, Coelho A, Ferreira S, Portugal-Nunes C, Soares JM, Gonçalves N, Sousa R, Reis J, Lima C, Marques P, Moreira PS, Rodrigues AJ, Correia Santos N, Morgado P, Esteves M, Magalhães R, Picó-Pérez M, Sousa N (2022). Association of amygdala size with stress perception: Findings of a transversal study across the lifespan. Eur. J. Neurosci. 1–12. https://doi.org/10.1111/ejn.15809.
De la Peña-Arteaga V, Fernández-Rodríguez M, Moreira PS, Abreu T, Portugal-Nunes C, Soriano-Mas C, Picó-Pérez M, Sousa N, Ferreira S, Morgado P (2022). An fMRI study of cognitive regulation of reward processing in generalized anxiety disorder (GAD). Psychiatry Research: Neuroimaging, 324:111493. https://doi.org/10.1016/j.pscychresns.2022.111493.
Raposo-Lima C, Moreira P, Magalhães R, Ferreira S, Sousa N, Picó-Pérez M†, Morgado P† (2022). Differential patterns of association between resting-state functional connectivity networks and stress in OCD patients. Prog Neuropsychopharmacol Biol Psychiatry, 118:110563. https://doi.org/10.1016/j.pnpbp.2022.110563. †Co-last Authorship.
Picó-Pérez M, Costumero V, Verdejo-Román J, Albein-Urios N, Martínez-González JM, Soriano-Mas C, Barrós-Loscertales A, Verdejo-Garcia A (2022). Brain networks alterations in cocaine use and gambling disorders during emotion regulation. Journal of Behavioral Addictions, 1–13. https://doi.org/10.1556/2006.2022.00018.
Reis JV, Vieira R, Portugal-Nunes C, Coelho A, Magalhães R, Moreira P, Ferreira S, Picó-Pérez M, Sousa N, Dias N, Bessa JM (2022). Suicidal Ideation Is Associated With Reduced Functional Connectivity and White Matter Integrity in Drug-Naïve Patients With Major Depression. Frontiers in Psychiatry, 13, 1–11. https://doi.org/10.3389/fpsyt.2022.838111
Costa AD, Fernandes A, Ferreira S, Couto B, Machado-Sousa M, Moreira P, Morgado P, Picó-Pérez M (2022). How Long Does Adaption Last for? An Update on the Psychological Impact of the Confinement in Portugal. International Journal of Environmental Research and Public Health, 19(4). https://doi.org/10.3390/ijerph19042243.
Weeland CJ, ..., Picó-Pérez M, ...; ENIGMA OCD Working Group, White T, Thompson PM, Stein DJ, van den Heuvel OA, Vriend C (2022). The thalamus and its subnuclei-a gateway to obsessive-compulsive disorder. Transl Psychiatry, 12(1):70. doi: 10.1038/s41398-022-01823-2.
Fortea L, Albajes-Eizagirre A, Yao YW, Soler E, Verdolini N, Hauson AO, Fortea A, Madero S, Solanes A, Wollman SC, Serra-Blasco M, Wise T, Lukito S, Picó-Pérez M, Carlisi C, Zhang J, Pan P, Farré-Colomés Á, Arnone D, Kempton MJ, Soriano-Mas C, Rubia K, Norman L, Fusar-Poli P, Mataix-Cols D, Valentí M, Via E, Cardoner N, Solmi M, Shin JI, Vieta E, Radua J (2022). Focusing on comorbidity – A novel meta-analytic approach and protocol to disentangle the specific neuroanatomy of co-occurring mental disorders. Frontiers in Psychiatry, 12. doi: 10.3389/fpsyt.2021.807839.
Picó-Pérez M, Vieira R, Fernández-Rodríguez M, Pereira De Barros MA, Radua J, Morgado P (2022). Multimodal meta-analysis of structural grey matter, neurocognitive and social cognitive fMRI findings in schizophrenia patients. Psychological Medicine, 1-11. doi: 10.1017/S0033291721005523.
Picó-Pérez M*, Fullana MA*, Albajes-Eizagirre, Vega D, Marco-Pallarés J, Vilar A, Chamorro J, Felmingham KL, Harrison BJ, Radua J†, Soriano-Mas C† (2022). Neural predictors of cognitive-behavior therapy outcome in anxiety-related disorders: a meta-analysis of task-based fMRI studies. Psychological Medicine, 1-9, doi: 10.1017/S0033291721005444. *Co-first Authorship. †Co-last Authorship.
Domingos C, Picó-Pérez M, Magalhães R, Moreira M, Sousa N, Pêgo JM, Santos NC (2021). Free-Living Physical Activity Measured With a Wearable Device Is Associated With Larger Hippocampus Volume and Greater Functional Connectivity in Healthy Older Adults: An Observational, Cross-Sectional Study in Northern Portugal. Frontiers in Aging Neuroscience, 13:729060. doi: 10.3389/fnagi.2021.729060
Picó-Pérez M, Ferreira S, Couto B, Raposo-Lima C, Machado-Sousa M, Morgado P. Sociodemographic and lifestyle predictors of mental health adaptability during COVID-19 compulsory confinement: A longitudinal study in the Portuguese population. J Affect Disord. 2021 Dec 1;295:797-803. doi: 10.1016/j.jad.2021.08.150. Epub 2021 Sep 3. PMID: 34517254; PMCID: PMC8413096.
Caetano I, Amorim L, Soares JM, Ferreira S, Coelho A, Reis J, Santos NC, Moreira PS, Marques P, Magalhães R, Esteves M, Picó-Pérez M, Sousa N. Amygdala size varies with stress perception. Neurobiol Stress. 2021 May 1;14:100334. doi: 10.1016/j.ynstr.2021.100334. PMID: 34013000; PMCID: PMC8114169.
Magalhães R*, Picó-Pérez M*, Esteves M*, Vieira R, Castanho TC, Amorim L, Sousa M, Coelho A, Fernandes HM, Cabral J, Moreira PS, Sousa N. Habitual coffee drinkers display a distinct pattern of brain functional connectivity. Mol Psychiatry. 2021 Apr 20. doi: 10.1038/s41380-021-01075-4. *Co-first Authorship.
Silva Moreira P, Ferreira S, Couto B, Machado-Sousa M, Fernández M, Raposo-Lima C, Sousa N, Picó-Pérez M, Morgado P. Protective Elements of Mental Health Status during the COVID-19 Outbreak in the Portuguese Population. Int J Environ Res Public Health. 2021 Feb 16;18(4):1910. doi: 10.3390/ijerph18041910. PMID: 33669453; PMCID: PMC7920474.
Ferreira S, Sousa MM, Moreira PS, Sousa N, Picó-Pérez M, Morgado P. A Wake-up Call for Burnout in Portuguese Physicians During the COVID-19 Outbreak: National Survey Study. JMIR Public Health Surveill. 2021 Jun 9;7(6):e24312. doi: 10.2196/24312. PMID: 33630744; PMCID: PMC8191732.
Ferreira S, Couto B, Sousa M, Vieira R, Sousa N, Picó-Pérez M, Morgado P. Stress Influences the Effect of Obsessive-Compulsive Symptoms on Emotion Regulation. Front Psychiatry. 2021 Jan 20;11:594541. doi: 10.3389/fpsyt.2020.594541. PMID: 33551866; PMCID: PMC7854917.
Dos Santos CF, Picó-Pérez M, Morgado P. COVID-19 and Mental Health-What Do We Know So Far? Front Psychiatry. 2020 Oct 26;11:565698. doi: 10.3389/fpsyt.2020.565698. PMID: 33192687; PMCID: PMC7649114.
Writing Committee for the Attention-Deficit/Hyperactivity Disorder; Autism Spectrum Disorder; Bipolar Disorder; Major Depressive Disorder; Obsessive- Compulsive Disorder; and Schizophrenia ENIGMA Working Groups, Patel Y, ... Picó-Pérez M,... Paus T. Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders. JAMA Psychiatry. 2021 Jan 1;78(1):47-63. doi: 10.1001/jamapsychiatry.2020.2694. Erratum in: JAMA Psychiatry. 2021 Jan 1;78(1):112. PMID: 32857118; PMCID: PMC7450410.
Picó-Pérez M, Moreira PS, de Melo Ferreira V, Radua J, Mataix-Cols D, Sousa N, Soriano-Mas C, Morgado P. Modality-specific overlaps in brain structure and function in obsessive-compulsive disorder: Multimodal meta-analysis of case- control MRI studies. Neurosci Biobehav Rev. 2020 May;112:83-94. doi: 10.1016/j.neubiorev.2020.01.033. Epub 2020 Jan 30. PMID: 32006553.
Steward T, Picó-Pérez M, Mestre-Bach G, Martínez-Zalacaín I, Suñol M, Jiménez-Murcia S, Fernández-Formoso JA, Vilarrasa N, García-Ruiz-de-Gordejuela A, Veciana de Las Heras M, Custal N, Virgili N, Lopez-Urdiales R, Menchón JM, Granero R, Soriano-Mas C, Fernandez-Aranda F. A multimodal MRI study of the neural mechanisms of emotion regulation impairment in women with obesity. Transl Psychiatry. 2019 Aug 20;9(1):194. doi: 10.1038/s41398-019-0533-3. PMID: 31431608; PMCID: PMC6702163.
Picó-Pérez M, Alemany-Navarro M, Dunsmoor JE, Radua J, Albajes-Eizagirre A, Vervliet B, Cardoner N, Benet O, Harrison BJ, Soriano-Mas C, Fullana MA. Common and distinct neural correlates of fear extinction and cognitive reappraisal: A meta-analysis of fMRI studies. Neurosci Biobehav Rev. 2019 Sep;104:102-115. doi: 10.1016/j.neubiorev.2019.06.029. Epub 2019 Jul 3. PMID: 31278951.
Suñol M, Martínez-Zalacaín I, Picó-Pérez M, López-Solà C, Real E, Fullana MÀ, Pujol J, Cardoner N, Menchón JM, Alonso P, Soriano-Mas C. Differential patterns of brain activation between hoarding disorder and obsessive-compulsive disorder during executive performance. Psychol Med. 2020 Mar;50(4):666-673. doi: 10.1017/S0033291719000515. Epub 2019 Mar 25. PMID: 30907337.
Picó‐Pérez M, Ipser J, Taylor P, Alonso P, López‐Solà C, Real E, Segalàs C, Roos A, Menchón JM, Stein DJ, Soriano‐Mas C (2018). Intrinsic functional and structural connectivity of emotion regulation networks in obsessive‐compulsive disorder. Depress Anxiety, 1–11. doi: 10.1002/da.22845
Picó-Pérez M, Alonso P, Contreras-Rodríguez O, Martínez-Zalacaín I, López-Solà C, Jiménez-Murcia S, Verdejo-García A, Menchón JM, Soriano-Mas C (2017). Dispositional use of emotion regulation strategies and resting-state cortico-limbic functional connectivity. Brain Imaging Behav, 12(4):1022-1031. doi: 10.1007/s11682-017-9762-3. PubMed PMID: 28866781.
Picó-Pérez M, Radua J, Steward T, Menchón JM, Soriano-Mas C (2017). Emotion regulation in mood and anxiety disorders: A meta-analysis of fMRI cognitive reappraisal studies. Prog Neuropsychopharmacol Biol Psychiatry, 79(Pt B): 96-104. doi: 10.1016/j.pnpbp.2017.06.001. Epub 2017 Jun 1. Review.
Steward T.*, Picó-Pérez M.*, Mata F., Martínez-Zalacaín I., Cano M., Contreras-Rodríguez O., Fernández-Aranda F., Yucel M., Soriano-Mas C., Verdejo-García A. (2016). Emotion Regulation and Excess Weight: Impaired Affective Processing Characterized by Dysfunctional Insula Activation and Connectivity. PLoS One 11(3):e0152150. *Co-first Authorship.
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