Reason, why is there a change of name in the next page.

New Page of Anthon Torte Saviglio

ATTENTION: All information contained herein must not be cited, photocopied, printed, distributed or discussed publicly or privately without the consent of the author: Isidro A.T. Savillo. Thank you! THIS IS NOT FOR PROMOTIONAL PURPOSES BY or FOR ANY PARTY!

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Note: Old Google Sites are no longer accessible or viewable. Therefore your search results will be an error 404 supposedly, effective September, 2021 but in my pages, it started earlier. Follow directions for my new Google sites. Sorry for the inconvenience.

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Returning to the First Page Updated

You may proceed to my New Page No. 3.

Primary Articles to Read on COVID 19

So you want to get infected by and spread the coronavirus SARS COV2, then Do THIS. After reading, Below this article is a link titled: Things You Should Never Do During The Coronavirus Pandemic. Click on the Link and read.

What happens to your BRAIN?

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Updates are below this page. Please visit!

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In most recent paper of Dictyostelium's lonely cells, I would like to know if they were able to aggregate or their progenies in the place where they were found. In Phil Myxomycetes page of mine I had a Stemonitis sp. that never aggregated and produce fruiting bodies after a long time. Both seems not interested.

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Still with BASC, NAS, USA. One of the saved videos I randomly uploaded was America's Climate Choices. (BASC sent this to me and I saved it) Experts from various US universities, etc. made this video with all their primary ideas (about global warming) so as to accomplish the request of the US congress on this matter. Short for the droplets of sneeze and coughs, Nasty nature can reach up to the elbows. This has to be logistically planned for the future. Different from the pandemic.

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In the first page (in Zoonosis...etc.), I wrote about the bad consequences of traveling abroad... bringing in new pathogens as well developing new allergies. I only get vaccinated when I went to a country in Africa as well as proper dose of anti malarial drugs. How about if WHO will look into any country's pathogenic load (re- evaluate) and recommend vaccination, medicines etc. for travelers. And for travelers who claimed to be infectiously relevantly sick must be automatically quarantined. If these prophylaxis does not run out of supply then why not. At least one can go home not only with the goods but no disease to spread. Well this is different for zoonotic ones but i think the "intellectuals" are learning about "similar" emergency medicines that they have started with this new virus. It's time to look into the anti DNA and RNA viral drugs especially to see which of those life cycle station among pathogenic DNA as well as among RNA viruses they share and target it there. (e.g. HIV drugs target life cycle stations.) Or the use of common but specific for family/kind of conserved genes for vaccine development for future use.

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In 2001, I published an abstract titled Molecular Pathology Techniques in Clinical Virology

in Analytical Cellular Pathology 22(1-2): 84-85 eyeing third world countries to establish Molecular Pathology Laboratories for Clinical Virology. I know it's quite difficult especially if one follows the set up we had in our laboratories in the US. There is a flow chart where specimens were being passed/transferred from one lab. to the other in one spacious floor of a building. Therefore PCR has a room of it self free from contamination.

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Happy World Water Day 2020!

Memoir

This is a portion of my interview on the special Issue

of Green Interpreters Magazine (India) devoted to WATER.

In the ist page, I was looking for it. Here is my JHU Cap. TY Sib

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I just saw an updated (3/23/2020) list of antivirals and immunomodulators against this new virus that are being used in a TRIAL basis from John Hopkins ABX Guide. (JHU is just collecting this information so it may come from various sources unless JHU may also be doing it). At least this serve as a breather though its result is not yet completely confirmed. The most promising is the Drug for Ebola (remdesivir) also chloroquine is mentioned with an antibiotic. To quote Dr. A. Fauci, US top infectious disease expert "prove definitively from a scientific standpoint that they (these promising drugs) do work." Avoid self medication.

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Yelwa Yauri Beautiful Tears has 194 likes and it keeps on going..It seems that someone is answering the trivia posted in my other FB...I think it is too early. but your message will be kept. Of the three names you have one is correct. Are you? That will be great for Yelwa Yauri and the novel!

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Old and New, respectively- Impurities. Toxicities, other Microbes

The use of plasma from people who have recovered from the viral illness as cure* and the presence of anaerobic sulfur bacteria in bio gas (supposedly only for methane bacteria).

*There is one company who plan to generate specific antibodies.

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Wild life gives us a surprise. I have seen photos of wild life roaming around lockdown cities worldwide. No crowd present. What surprises me in the backyard is the presence of a nest of Pycnonotus goiavier in the same residential area where I did a lengthy research in them. A nest of Pycnonotus goaivier after six years plus? The nest is about 2 meters and a half high in a "shrub" (trimmed tree) thus it is easier to examine. The nest is adjacent to an elevated concrete flooring where household chores occur. Besides a number of Passer montanus, there are a few ones of Rhidipura javanica, Geopelia striata , a pair of Pycnonotus goiavier and of course, the pet dog.

P. goiavier nests after 6 years +? in the same residential area.

I observed that they are already in feeding stage of their brood... that's why the parents' visibility (as close as 3.5 meters away from me without flying) that led to nest discovery (this is explained in highlighted research above).

Using my "ordinary" camera I was able to get a picture of a parent P. goiavier in its "tamed state" (does not fly away) right after feeding the baby birds.

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3/27/2020

Boosting our Immune System? Supplements, Vitamins and other ways that can help our immune system.

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3/28/2020 (Opinion)

Gauging it through Antibodies versus PCR.

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From CDC Therapeutic Options. Ty for my sister an MD for bringing zinc (as an addendum drug) to my attention. Below are updates for these drugs or search online.

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I vouch for clinical trials spanning geographical regions for a particular disease in my former post (pls. see first page) How about for this new virus? I think there are and there is good assessment stated using the above post. A number of antiviral drugs (e.g. this) including HIV drugs are also being tested. Avoid self medication.

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April 3, 2020

The use of antibodies (please see my former post above) to gauge for this new virus is considered essential for herd immunity.

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4/3/2020

On Therapeutic antibodies a possible cure for coronavirus.

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April 3, 2020

On Vaccines, Megatrials of Potential Treatment, Repurposed drugs, Social distancing, etc.

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April 05, 2020

Seems viral drugs at work here.

Looking at the positive side but always remain obedient in keeping yourself away from being infected Like washing of hands with soap, by disinfecting - consult articles on these posted by CDC, WHO, inquire with your local communities etc. anything that comes your way or what you received and places which you think someone or you has/have respectively touched (read my previous post on "SARS COV 2 reconfiguration" in my first page), wear masks, observe social distancing and sneeze or cough away from people (get out of the room) and cover* your mouth (dispose used tissues/handkerchiefs properly) and avoid touching your face/ body if you think your hands are dirty.

*recent articles talked about spreading the virus while talking or breathing while exercising outdoors that's why mouth and nose covers (masks) properly placed are important with appropriate social distancing.

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April 07, 2020

Seems promising with HIV drugs Probably this has something to do with what I wrote about Anti Viral drugs targeting the common life cycle station among RNA viruses. (Please see post above).

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One of the keywords that I would like to look into as posted in my first page is cytokine release syndrome (includes cytokine storm). It is now resurfacing. No one drug (repurposed) may be suitable for this new virus but these drugs ought to be given at particular exact times. If there is a drug that stops viral sheds and prevent/favorably lessen cytokine storm, that will be very beneficial. Monoclonal antibody drugs are so expensive which I consider as a factor for third world clinical trials (mentioning "other geographical regions" in my first page). References 1, 2, and look for other related references online.

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For something new, Opinions-

Antibodies and the probe used in RT square PCR complement each other somehow. In my former post above I used the word versus per the content of the cited article. When it comes to RT square PCR, it may depend on the type of specimen that is being used to identify the presence of the virus . If it is niched in the chromosome then I think one had used the lymphocytes (remember the Ficoll Hypaque) or if it is the meningo- spinal fluid or in the phlegm etc. then probably the characteristic of their infection could be gauged here (e.g. Ig present, probe Pos like HIV; Ig present, probe - etc.) For scant reports on re-infection, probably due to its very fast and excellence in terms of reconfiguration then it may be possible. But I am sure the antibodies against them have a very good immunological memory against them.

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Repurposed vaccine and other new ones- I never thought that there were vaccines already intended for SARS 2003, etc. The latter has high genetic identity with this new virus and I hope that this repurposed vaccine can work. It is now undergoing clinical trials. Going back to my posted statement above-regarding making use of common but specific for family or kind of conserved structural genes etc.. could hopefully help make a vaccine not just for a single virus. This repurposed vaccine probably could be one. Ref 1

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When I was reading articles a long time ago in quality control in food microbiology, I remembered one of the design of a laboratory/ facility is the presence of viral filters in its "window". Too small the size is where viruses cannot enter. How about employing this in infectious disease facilities or putting it as a components of masks (some commercial masks have antiviral filters), etc. so as to further protect our health workers. In a recent chinese paper online, this virus has been reported up 13 feet in the air in hospital wards? with greater number in the floor.

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I will soon be wearing my Oxford Colleges velvet colored T shirt. I am just wondering where this proponent (a Prof. of Vaccinology) from Oxford for the vaccine that will be ready by September where in she has 80% confidence that it will work come from. As I viewed the Oxford colleges (in my shirt) there are 32, where do you think she belongs- I think at The University College. Kellogg is my sister's (another MD) favorite. From Bloomberg (See PH of JHU above on the cap), here is news about this.

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Update on Remdesivir (Please see above post about this).

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The use of Convalescent plasma (or the Immunoglobulins) as therapy.

As posted above this therapeutic procedure has been practiced ever since (years ago) and it shows some success. The FDA currently has given its guidelines. So I just hope that people who have recovered will be able to donate their plasma. There is an online form (applicable only in the US?) for those who would like to donate (but please verify this first). Here are some information on this as well as a success story. In one article about the use of plasma in Tanzania (plasma therapy is not new in Africa with the new diseases) they have a problem there of a blood purifier? so I hope the equipment for this will now be made available in countries who need it and must be ready for use. So I hope this will be made applicable to all countries.

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Something new, Opinions

Models in Science

As posted In my first page, I think I believe in what Dr. Wilson (Harvard University) said that theoretical models are much better than mathematical models (in theoretical biology). Regarding the model for this new disease, I would suggest that the most applicable therapeutic option will be included. You call this as a "stop gap" before drugs could be pinpointed as successful, so too with the vaccines. Let us say the most probable is the CPT (see above), then are there enough donors for CPT referring to those who recovered? Are the CP available in the country? Are the equipment and the competent technicians present, too? Is it successfully working well in this setting (replicating published success stories)? If they are then probably one can loosen the pin. A senator was able to question the model system in science and this is how they reacted.

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Memoir

Taken from this article- "Real time RT-PCR is a nuclear-derived method for detecting the presence of specific genetic material from any pathogen, including a virus. Originally, the method used radioactive isotope markers to detect targeted genetic materials,......" The use of "radioactive isotope markers" is included in my above- posted abstract "Molecular Techniques in Clinical Virology". Probably we ordered isotope for our use in your facility.

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False positive/negative results can exist in PCR as well as antibodies. In a recent paper from Mayo Clinic there is a concern about specimens used for covid19. They are all FN except for b. lavage specimen. This has been studied and mentioned in my first page as specimen examined.

Ref Asean Post- False negatives are complicating Covid 19 testing. April 13, 2020.

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Stomach strategy

Ref - 'Such a simple thing to do'

Why positioning covid 19 patients on their stomachs can save lives. 4/15/2020

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4/14/2020

Coronavirus weak points

Dr. Ian Wilson, Scripps Research Institute, San Diego, California, USA is a 2005 Molecule of the Year winner of ISMCBBPR (please see first page regarding ISMCBBPR) investigated the weak point of the new virus where upon an antibody known as CR3022 binds to it. This would be good candidate for vaccine production. Doing further work in this scientific endeavor.

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I have read additional model* regarding the future existence of this new virus and how our immune system particularly antibodies of similar kinds/ family could be involve in what we call cross reacting capacities (also see post above) besides the controlling evolution of the new virus because of the specific antibodies against them. At the end it is like the "Taming of the Shrew"**. When all of them are in this state I can now apply my theory of Molecular Synchronization. There are still more applications for this new theory of mine. Please see first page regarding this theory.

*by Harvard univ. epidemiologists

** In taming of the shrew, per summary/analysis the shrew was "tamed" but (in deeper scrutiny) she was not "tamed." Can we say if this is true for this new virus? Immunity questions are on the rise.

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Opinion

I think one of the general subjects that will be implemented or be included in a related ist year college subject is "Understanding yourself in a medical way". I think at UPD they had a subject that all ist year students will take in biology regardless of course enrolled in (remembering maam Edna A.). So it is possible to include it there. This will make it easier for them to understand the nature of diseases, the cause, the preventive measures... and as much as possible all relevant diseases including new ones will be discussed (differential diagnosis if possible) from mental health to pandemics. As disease explanations are already in the molecular and cellular level this will be used in lectures. The benefits will include shortening the period of asking MD's the why and what of the diseases and for them to understand the protocols in why and what they need to do this and that to make them safe etc. And be able to have a background of their prescriptions. Especially in quarantine set up it is difficult to come in contact with your MD. Learn the permissible skills (e.g. heart beat counts, etc.) for self diagnosis. Having particular knowledge, if there is a need of volunteers* (in case of emergencies), one may be able to participate. The Biology course at UP are having subjects with advanced medical knowledge (remembering my professors) but not all (in other courses) can avail it.

*Thanks to the CS UPDil volunteers, in some dept./research units PCR is just everyone's expertise.

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Something new, Opinions

On CPT (see above posts)

If one is looking for participants in clinical trials, choose the serious side of the coin. Please look around (in other establishments where you think they are). There I believe many are waiting. This may help the serious survive.

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4/17/2020

Update 2 on Remdesivir.

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Posted above is about the CPT and plasma is rich in antibodies against the new virus. But one outstanding component are the neutralizing antibodies (see post above). So next keywords to deal with: therapeutic proteins, neutralizing antibodies, mono clonal and polyclonal antibodies versus recombinant antibodies, hybridomas secreting specific neutralizing monoclonal antibodies, therapeutic proteins as duplicate drugs replicating antibodies in large scale production and given into shots either singly or mixed in cocktails, therapeutic proteins immunogenicity, anti drug antibodies, cytokine storm. Use the keywords as guidelines to full understanding of the methodologies in the production and application of therapeutic proteins (antibodies in this case) and its effect to the cellular level after reading this article from Bloomberg (April 20,2020).

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Milestone in Vaccinology/Public Health

The late Dr. Maurice Hilleman,* an American microbiologist helped the US from the 1957 influenza outbreak (Asian flu) (Ref online- How the 1957 flu pandemic was stopped early in its path). I remembered he was featured with other scientists mostly theoretical biologists in my snippets at bing.com. Please see mementoes from bing.com in subpages section in first page.

* Recent ref: The man who beat the 1957 flu pandemic. Scientific American, April 19, 2020.

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Something new, some questions..

Specificity/(Sensitivity) in Polycistronicity.

I think being a SARS virus, it follows that it may possesses the biggest polycistronic genome among RNAv. When it comes to antibodies ?. In nature probably there may be wobbles of similarity [among strains] which I think may be helpful. But I haven't seen a "naked" lit on DNA probes used (Was I late?) (whether it is the subgenomic mRNA 2,3,4 or 5 or a non structural protein gene, etc.). I have seen probes for vaccine development (by a biopharmaceutical company)... ?. I know everyone is busy for the right cure and publications on this will soon churn out and that is understandable. Pandemic a long time ago is symptom based (not really a complete medical term) without molecular test or are there signs of beginning?

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20th of April, 2020

Update of Vaccine and Plasma Therapy in UK for this new disease.

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Something new, Opinions

Anecdotal/Compassionate Drug trials and Clinical trials

For this pandemic emergency, with this NEW virus the former* is important but the latter

whether + or - are cascaded (methodology) in publication with no doubts if replicated.

*publications are also possible but labeled as such

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Something new, Opinions

A daily routine of announcements that this "clinical" trial is about to start in various media outlets is sometimes not so interesting to re read or re learn it. Molecular biology is a highly "imaginative" science. You cannot see the result unless for instance in one aspect you see it in a gel after PCR. So if this is all talking without the beginning then it's all eyes rolling then what is the result of this imagination. If one could have started and announce that we are in this status and it is 99% successful that would be the reality of molecular biology as expected.

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On Dichotomous roles of immune cells-

I came up with this statement upon knowing as far as I remember of cell transformation, I think there is the CD4 as an example. Please see subpage in first page on: Discoveries. With the inflammatory aftermath of the immune cell(s) it seems that it has a dual role but probably not intended. It tries or gets rid of the foreign body. And as a consequence make the cells targeted (with the virus) unfavorable to sustain life. So there is such a subtle type of a Dichotomous role. Good and Bad. This can be observed during infectious takeover of this new disease. A detailed explanation (warning may be too specific) of this can be read in Science mag April 17, 2020. Ref.- "How does coronavirus kill? Clinicians trace a ferocious rampage through the body from brain to toes". But the recoveries are also increasing and wish for more.

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Something new, Opinions

Pondering Re- infections-

Viruses can be dormant and undergo infectious transformation (please see my theory of Molecular Synchronization and the Varicella- Herpes zoster conversion in the first page). "This SarsCov 2 is not a retrovirus, it's a coronavirus" (as stated by Dr. Baltimore's recent interview at Caltech; the discoverer of RT and Nobel Laureate) therefore its ability to be integrated in the cells chromosomal system is nil (unless there is a special mechanism but no pub in hand as far as I am concerned). So where is this new virus hiding? Patients become negative and later become Pos again. One reason could be the viruses are in the b. lavage after they were done in their upper respiratory tract sojourn making those swab samples from throat negative. And later they just could re enter the cells through the Ace2 receptors and start multiplying. But Ace2 also has anti inflammatory capacities /immunomodulatory role (considered by one as "counter- intuitive"). Are they capable of keeping the virus from replicating in such detectable numbers because of this? I think more studies will be centered in this new virus and the Ace2 receptor of the cells because as of now this is where the virus is clearly associated. There is also an accessory enzyme known as Tmprrs2 that is worth looking into.

[Ace2 of Vascular and Immunological Importance]

Ref 1- About Ace2

Ref 2- About Viral Cellular Entry; Ace2 and Tmprrs2

Ref 3- More on Ace2

Ref 4- More on Ace2

* In references there may be other topics discussed.

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How's the stop gap? (Please see above post: Something new, Opinions: Models in Science) Loosening may be difficult without it.

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Something new, Opinions

Resurgence 101-

In case this will happen, what's next? With or without resurgence- I think lessons learned the public has to be wary of "going" out. This has to be done in a minimum. Let the suavity of life be at its lowest and just consider life's basic needs. Buy in batches. Go to essential places where you can practise physical distancing and avoid those you can't. Avoid grouping, chattering and handshaking or anybody's touch. As usual do the basic instructions (as given above- April 05 2020 post; in "seems viral drugs at work here"). Just imagine you are entering a CDC lab of Ebola virus as a researcher and you need to be extra careful. The attire one uses and all safety precautions. That's how you treat yourself. Do a self quarantine yourself and practise it. Everyone is a suspect. In case you feel you are in the "resurgence" category- is there a hot local number to call? Talk to your MD, go to the hospital. They say they are ready so be it ready. Let us see how "spaciously" and protocol based (step by step) ready. How's the stop gap status in your area (pls. see post above)?

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I am happy for the people who supported the Earth Day 2020. And I remembered my Stare and the Drown scenario that I wrote (It's still can be accessed online) respective to the unexpected dangers (just like the pandemic) of climate change. With the over exploitation of the Earth, (Who permits it?) I think one has to be multi specialized to know what to do in case "it's in the environment." Finding one with that specialty when you are in an enclosure (e.g quarantine, flood, war) is difficult to do but if you have other specializations you can dismantle the problem yourself. I believe in liberal education. Harvard does. If you specialize in just one it is just sitting in a nest all the time hatching the eggs even when there are no more eggs to hatch because that is your specialty and that is the only movement that you know in such a disastrous situation.

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Viral similarity and differences

I have read in news, pub. different percentages of similarity between SARS 2003 and this latest, genetically wise. Let us assume there is a 6% difference. Scientist are now asking what's in it?

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Knowing the effect of cytokine storm and all the other inflammatory reaches of covid 19 to other cells of the body is a molecular and a cellular enrichment in the analysis of this disease after the viral's stronghold.

Ref - I like the paper's content - like having an HIV similarity with zero lymphocytes and other things you will learn incorporated together with Colchicine as a candidate drug for inflammation.

The other Ref. if you missed it is Ref 4. above in "Something new, Opinions; Pondering Re-infections."

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Being repeatedly posted above and in the first page as the Cytokine release syndrome- one of my keywords of importance, Here is an online definition (of cytokine storm).

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Something new, Opinions

Falsities (DNA and Antibody Assays)

Is there such a thing as anecdotal/ compassionate trial testing?

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04/26/2020

Massive blood plasma Donation

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Something new, Opinions

Viral titers/particles

Just like in the health profession, exposure to patients in this pandemic situation, one must be careful of introducing numerous viral titers / particles inside the body burdening the immune system whereby it could not spare one from getting sick. Strictly wear the proper protective attire and strictly observe the precautionary measures especially if you have to deal with different patients carrying the same virus.

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Another promising drug considered to have a role in molecular enzymatic control is Famotidine*, a component of Pepcid (heartburn med.).

*Reference

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April 27, 2020

A case of re- infection* (Pos to Neg (recovery) to Pos). This has been boggling my mind eversince. Please see posts above. Was there a comparison of test kits used? I am not aware of the probes but I take it in consideration that it is specific as well of course as sensitive. I am happy to know that in the accredited Phil. Genome Center Testing Site in UPD scientific technical staff now includes a Molecular biologist and a Molecular Pathologist.

*Reference also there are similar news items but different areas on re-infections- see online.

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Memoir

Our molecular pathology lab. had a DNA synthesizer room, a DNA sequencer room, a Scintillation counter/Radioactive room, a dark room for autoradiography etc ., a room for gel electrophoresis, southern blot, cloning, dot blot etc, a PCR room with division for reagent preparation, etc .Before I left I had to check my lab gown, shoes and arm covers with G.C. The health science campus is so huge. I had to dry newly synthesized probes in the county hospital, developed films at the exclusively cancer hospital, processed new specimens in a research building across our mol. pathology lab. It's worth the walk but it's worth the knowledge and experience.

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Loosening the lockdown is not excitement read Resurgence 101 post above. Ty

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"Leave the wild life in the wild." A statement from an interesting article.

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Thanks to the new breed of heroes, the Blood Plasma Donors!

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Public at large

Now being wiser not to get infected, You also have to thank yourselves!

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Something new, Opinions

Even you have numerous staff in your testing center if the diagnostic assay is not doing well, it is a sham. Some of them may be able to elute the band or the hybridized probe and analyze it if there is a problem as visualized. Do the work of a molecular biologist! Consult with your Molecular Pathologist! But with those patients who recovered and were able to donate the appropriate antibodies I can see some connections so it seems that the PCR diagnostic assay is working well.

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Old as we know but it has a greater advantage when a pandemic revisits. Let it be a routine. But considering that we have the advanced technology if we could further improve in it the better. Think of what's the best!

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Before I left Los Angeles, Clinical Laboratory Technologist (MedTech) becomes a Clinical Laboratory Scientist. Are you one?

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Opinion

A sign of wetland thriving.... This happens only in this pandemic situation but a pair of P goiavier are regular bathers in a shallow of water supposedly intended for dogs (drinking)... I think they do this frequently because there are not so many people around.. still with pandemic influence.

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Light Laughter-

A cult figure in Berlin... a hero on a microphone talking and answering all sorts of questions (asked by whoever) about this new virus over the radio.. Before I share to you, I would like to cite a quote [from this link] regarding the late S. Hawking by a journalist when he talked "Many people may not understand everything he says. But it is comforting to listen to someone explaining what is going on." Remembering Berlin.... is where one of the Molecule of the Year winner of ISMCBBPR comes from and the flecthen herbarium. I took the bus or the train but this cult figure uses the bike.

Reference/Link

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Something new, Opinions

On Stop Gaps

There are a lot of recoveries but mortalities are also increasing. What happened to the supposed choice of stop gap? Is there a need of additional stop gap known - medicines (mostly still in clinical trials)?

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Something new, Opinions

Coronavirus is a common term but how about instead of mid March, the causative agent SARS CoV 2 was announced one minute before New year 2020, do you think this may be of great help? Our DNA sequencers are getting more advanced. I am just wondering?

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Update 3 in Remdesivir. This could be a "stop gap" med but if its effect is clearly felt this could be elevated as a cure. Congratulations! Hope third world countries will have free access to this as a form of compassion.

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April 29, 2020

Update in the Oxford vaccine.

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Something new, Opinions*

Modified Laminar flow principle/UV/sterilizer

Can the viruses in the air or in an area be able to be funneled (sucked in) and killed (in a catchment) in a conventional way? UV treatment for PPE during removing/wearing from time to time? Floors be sterilized (by a friendly but efficient virucide) from time to time?

*Pls see post above on Something new, Opinions: Viral titers/particles

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Weeds common name i.d./ in constant meditation/serenity/peaceful moments, being used to it

By the way. remember we are still in the pandemic situation, therefore getting outside to the streets and identifying the common names of weed is not appropriate. A UK inspired biodiversity evaluation project in their surrounding vicinity has made me establish the ISTE. There are some people (in Europe) who are interested in naming urban weeds by "chalking" (maybe illegal) which seems fit for my org., if these are accurate and they need to have equivalent scientific names (probably to be posted online). Otherwise, being in a lockdown, The Bali (Indonesia) people considered it as an extension of Nyepi....if only we have their surroundings...

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May 1, 2020

UC San Diego investigators have initiated clinical trial using hypertension drug Ramipril for this new disease. Ramipril was mentioned in the above post- Something new, Opinions; Pondering Re- infections- Reference 2, in an Oxford CEBM paper.

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Something new, Opinions

Sars Cov 2- HIV ?

There are new claims such as the fast infectious entry of this new virus to the cells with or without Ace 2? is due to the presence of the HIV envelope gene within the Sars CoV 2 Spike gene (see keywords below for reference). This is maybe responsible (while others such as furin etc.) for the "membrane fusion" capability of Sars CoV 2 (Sars 2003 and other coronaviruses do not have this capability?) to penetrate the T cells, kill it but it could not reproduce (Ref1 ;Ref 2), therefore both of them die in the process. The HIV env gene could not be recognized by Blast for if searched it brings forth names of other organisms. That is why others say they are just fragments naturally (Ref 3) occurring not synthetically inserted. I was also surprised that in an answer and question forum in an article online someone said that this virus is a coronavirus followed by a separate statement that it is a retrovirus. Seems no RT as far as I read the papers. Labeling it as an airborne HIV (Thailand news) makes it more complicated as well as reports of having mutated spike genes (Thailand news). Overall this happens when a complete genome is available for thorough sequencing. "What's in it" question comes in (Please see above post). To find more articles on this search online use keywords: Sars CoV 2 and HIV (more specific keywords: third sequence; Covid -19; research gate; discussion; HIV isolate; envelope glycoprotein (env) gene)

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References 1 and 2 about the "ReInfection" phenomenon.

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05/02/2020

Clinical trials for Ivermectin.

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05/03/2020

Update 4 Remdesivir (Stanford)

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05/04/2020

Update 5 Remdesivir (WHO)

*C.T. for Singapore and Japan plans to dispense? this sooner.

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Something new, Opinions

A pub that I need to analyze soon but I still prefer stop gap drugs that could control viral sheds as more important than inflammatory ones.... In case a single potential drug is needed. Just like in HIV... the titer has been reduced and I just don't know if there is a drug that targets DNA intermediaries but having a small titer do you think this could create a DAMP? In HIV, it is as safe as having unprotected sex therefore it is not infectious (Please see my first page regarding HIV pub on this). Prominently important, HIV is "vacinneless" until now.

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Currently two stop gaps for this new disease

CPT and Remdesivir

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Something new, Opinions

ReInfection and Reactivation are two important terminologies in viral life cycle. The gaining of a positive cue after a negative test could not be a reactivation of a coronavirus. Unless there is such a thing as a generalization that all viruses has some sort of a "latency" period especially for those humans whose immune system are strong enough. Just like in HIV there is a latency period (but pos) and it is asymptomatic just like in this virus there are asymptomatic bearers too (but pos, then neg, then back to pos for some). Can we consider this also as their "own" latency period? ReInfection is considered as "ReInfection" per se or is it due to a sturdy remnant that was able to undergo cDNA in the PCR process? Where are the RNAses? I really don't like to dwell on this for the reason that I haven't seen the DNA probes sequences much more the viral genome.

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Something new, Opinions

But once the inflammation has peaked in this new viral disease thus a failure of initial inflammatory med or other drugs beforehand, then specific ones will be given to combat the inflammatory reactions. Like anti coagulants for the hypothesis that this virus produces superoxides causing endothelial dysfunction releasing vwf* that would cause blood clots. This is just one of those inflammatory obs (hypothetical connections from a video) but I believe there are still others (acting in different organs or emanating from it) which I think need to have their own prescribed meds. *Keyword of importance: ADAMTS-13 is of zinc and calcium dependency...

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Something new, Opinions

Disinfecting booth* (with antimicrobial coating/nano needles) tried at an airport. Maybe needs a follow up evaluation study (scientific) and is promising!! Has applicability especially to the health sector.

*See above post: Something new, Opinions- Modified Laminar flow principle; UV etc.

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Something new, Opinions

Leveling off process*, on Molecular Synchronization theory (Pls see first page)

At this stage the viruses will be able to reduce mortality, lessen serious infectivity so mostly asymptomatic. What are the reasons- the virus has met its fighters in an overall aspect of the immune system if it transfers it becomes weaker and may be asymptomatic or symptomatic but mild. Another reason maybe the cross reacting antibodies from it's clade or from other coronavirus in the respiratory system (polycistronic see my above post) whereby they had experienced being "bludgeoned" but if they survive and transfer, they are not as strong as before. They'll encounter their second bouts. Human to human transmission is much tolerable than direct zoonotic ones. They later become silent or dormant or being effaced out especially if vaccine is present. Regarding mutation that still need to be seen to what extent. Probably in some instances it has a better animal? host. Take care of your immune system (See Discoveries sub page)!

* In this pandemic, one may rely to the immune system but importantly especially that this is a new virus donot allow oneself for the viral particleS to enter the body so observe the necessary mechanisms/ precautions to protect oneself (Review posts above).

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Update- mRNA vaccine by Moderna (2nd Phase of C.T.)

-Previously this was mentioned in my above post on "repurposed vaccines" ...so is this a modification of the previous or really different one? Other Biotech companies are also developing their mRNA vaccines (as mentioned in the highlighted article above)

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Another new for my statement in the Biological Evolution of Immune cells- see Discoveries in sub page in the ist page for the new type of DC: the inf cDC2* discovered by scientists from Ghent university VIB team. Congratulations! By the way, one of the Molecule of the Year winners of ISMCBBPR was bestowed a 2017 F. Chair Laureate at the Univ. of Ghent! Congratulations, too.

*Ref 1, 2.

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Contrasting Terms

Ease or no lockdown and the deadly virus.

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Urban nightbird

After browsing the internet for nocturnal/night birds of the Philippines, I was able to find out that nocturnal aves that usually voices in nearby trees during the predawn time. But I was surprise I haven't heard it for consecutive days. It is the Philippine nightjar (Caprimulgus manillensis). Please click audio in the link page.

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Update 6 Remdesivir* (owned by Gilead) Thanks Gilead!

*a stop gap drug (Pls see above posts) soon be available to 127 countries.

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Universal healing for the Vaccine Makers....cheer each other.

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May 17, 2020

Update 2 on Hydroxychloroquine and azithromycin

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May 18, 2020

Update 2 mRNA Moderna vaccine (participants developed antibodies against the virus) Thumbs Up!

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Something new, Opinions

Skipping the traditional lines (in vaccine making)

Either partially doing animal trial or concurrently doing it with clinical trials or no animal trials at all, I think this is reasonable for such a haste in saving lives of the people infected with this new virus. Probably in particular circumstance one that is resilient in animals can be physiologically beneficial to humans. Introducing (remembering that Ph.D. researcher injecting himself a package of genes so as to improve an aspect of his cosmetic phenotype - Pls. see first page ) weakened virus having the protein of interest or constitutive (if not this will take time) protein machineries such as mRNA , I think this may not be so harmful because the goal here is to appropriately produce neutralizing antibodies. Eventually it has a protective purpose. Therefore it may be like a "stop gap" (term which I think is appropriate for "vaccineless" diseases) when favorably producing antibodies and humans have the benefit and if it deletes all the viruses in particular long term span then it could be a cure (a vaccine). In the first page, there was an article regarding the combo use of antibiotics for bacteria that are highly resistant to broad spectrum specific ones. Another alternative is to use bacteriophages (please see first page) And of course one is familiar of the various anti HIV drugs. If there are "vaccines" that could not spell a cure, why not use them as "stop gap". They may act in particular proteins of the virus and stop (to such an extent) viral sheds and subsequent stations of its pathogenic life cycle It may also hinder its mutability considering the various structures it may have attacked. Being a member of DELS, NAS, USA with one of its unit: ILAR, I am also particular of the use of animals in research. There is a protocol to use 3Rs in dealing with animal testing being practiced particularly in UK.

Ref 1, 2

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What are bi specific antibodies?

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Something new, Opinions

What we need is an innovative molecular and cellular vaccinology. Probably we have to say goodbye but not completely to the methods of conventional vaccine and introduce something workable especially in dealing with new pathogens (viruses, bacteria and micro fungi) claiming new emerging diseases. Let the incoming pandemic be met with innovative methods so as to "contain" it and stop mortality. How about a "vaccine or a "new technique" directed or suitable for "controlling" or "eliminating" its clade? Identification and pooling of neutralizing and other potential antibodies and appropriate super active immune cells for specific, fast and efficient actions. I think there is nothing new in vaccinology except for the mRNA vaccines and hope there will be newer ones. Oncology is kicking off. See below.

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On Live Therapeutics/ June 1, 2020.

Last time I posted/talked about antibodies against cancer (please see first page). Here is something which could aid (cold) tumor attack by using a bacterium. Did this bacterium triggers an antibody production or something else?

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Update on the Oxford vaccine (Astrazeneca) and a Related Topic on Moderna, Pfizer as the other candidates vying for the vaccine to be ready by Fall/ and the rest by end of 2020. How molecular are they?

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Antibody Shot for Lyme Disease (as stated no vaccine exists)

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New Zealand's way of conserving their bird species is to transfer to islands that are "predator free". This has provoked my memory when our names were (understandably with the paper on Pycnonotus goiavier - pl. see above) cited (please see subpages in the first page) during the transfer of Porphyrio hochstetteri to an island.

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Something new, Opinions

The virus is still lurking so be cautious whatever type of situation you are in. Please see my above post in Resurgence 101 just to be reminded. Having a lockdown for a long time may be mentally straining. Have a happy outlook and never be miserable. Think that being "cocooned" is a privilege. List down all your healthy hobbies that you can do that makes you happy. If you have other ailments what are the best ways to treat yourself at home. Put them down in paper too. Pray. But subconsciously protect yourself from viral exposure once you are out of your "cocoon". Always remember the precautionary measures like hand washing etc. Please refer to my post in Resurgence 101 above. Thanks.

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New article in my Taxonomic Explorations Page- this questions whether P. goiavier has a human adaptation gene or a part of its "acting" folly. Theory of human familiarity (applicable to lower forms)]. Please see below.

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June 9, 2020

"Retraining" Immune System so as to prevent attack of healthy cells. Link.

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June 9, 2020

On Nanoparticles

Aiding the checkpoint inhibitors.

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Quote embedded in a photo: newly seen

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I think, Dr. Steven A. R. Murphy, the President of ISCSPM, what I have written here is a good suggestion to make Personalized Med more patient friendly. PM is still very important!

On Personalized Medicine*

Two major concerns here. The first is this must not be purely a human genome perspective but as talked about in the article (see link below) the environment has to be considered. To make it easier I did mention two types of environments: Exogeneous and Endogeneous environments. (The article talking about these environments is in the Google Scholar as a Citation). In addition the science of Epigenetics has to be included. It may modify human genome direct gene expression or will have its own way. The second concern is the "strip -naked" decoding of the human genome. This is really difficult to take but probably, familial (bad and good) genes will be the major focus. After which thorough laboratory tests of non familial traits would be undertaken. That's the time that the gene(s) will be rooted after laboratory based differential diagnosis of lethal or semi lethal or future occurrence of lethal diseases. But if the epigene or its protein has more relevance than the human genome gene then a set of laboratory test for this will be undertaken. In some circumstances, the epigenes are the ones that need to be the target for cure rather than the human genome gene. I think the human genome code has to be secretly vaulted and be revealed only to the person who owns it... in the first place that is why it is called personalized medicine. [or a person who would like his or her genome to be decoded will be given a thorough guide of the genes that a human genome may consist (a complete map) and once his or her own genomic map is available (as the only copy) then he or she has to make the choices to what couple of genes he or she wants to work on. This would involve quite a lengthy genetic lecture and analysis.] I think the person's genomic component (not all maybe expressed) is not to be judged right away but by his or her present phenotypes. Here is the Link (under Life and Style).

*I vouched for personalized medicine (Re: ISCSPM)

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This is an interesting article to read probably an updated gist of the advances of HIV research focusing on treatment.

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Novel writing and screenwriting as one package: This is writing a novel intended for the movies...

Currently: Amidst Old Los Angeles

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Having pet dogs as our constant company in this lockdown sometimes the dog gets bored due to the all- the -time- presence. Here are the 5 ways not to feed them. These are usual ingredients/food in the ref.

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June 14, 2020

Goal:

Combo approach for HIV cure- antibodies and vaccines

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Update on the Covid 19 vaccines/June 15, 2020

In my post above, I also mentioned that these "vaccines" can be used as "stop gaps" and I think they will be successful too in not making a severe disease out of the viral infection (pls see Discoveries sub page in main or first page). In here (pls. see Link below) scientists from various prestigious research schools talked about the "first vaccines" of this disease/or this virus. Dr. Dennis Burton is one of them, also the winner of the Molecule of the Year of ISMCBBPR together with Dr. Ian Wilson both from Scripps Research Institute, La Jolla, California (please see above). Also as to my post above I am hoping that there will be vaccines' molecular and cellular modifications and "other tests" that will take the place of vaccines for those pathogens that are difficult to contain by true vaccine categories. As far as I analyze (opinion), it will just be like the pandemic Influenza virus that killed so many in the past but later they (I hope they are of the same strain or high percentage of genetic similarity as of our current i.v.) molecularly synchronized (my theory- pls. see first page) with the immune system, still infectious but no widespread deaths and are no longer in epidemic or pandemic proportions because people infected could self cure [somehow tamed by the immune system] themselves (or could be hastened by available "stop gaps" or "vaccines"). It's like having a plateau effect for both. [Quite similar to my post above on "Leveling Off Process"] Here is the Link.

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According to this source, these are foods that are rich in zinc. The latter has been mentioned in my above posts in relation to the immune system's "health".

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Keywords: Cross reacting antibodies (see post above on "Coronavirus weak points") against a clade, broadly neutralizing antibodies

As cited in my above posts* I vouch for broadly neutralizing antibodies against a clade (e.g. imminently important, the coronaviruses) and I am happy that they (June 15, 2020) are currently working on it.

*Could be read in the ff above posts:

-In the first page (in Zoonosis...etc.)..........

-Leveling off process.....

-What we need is an innovative molecular and cellular vaccinology.....

**Above post related to neutralizing antibodies, monoclonal antibodies:

-Posted above is about the CPT and plasma is rich in antibodies against the new virus. But one outstanding component are the neutralizing antibodies.....

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A quandary for Covid 19 antibodies especially for immunity certificates.

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Primate research: (Interesting technique)

New adjuvant extends immunity against HIV

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Newly discovered snippet A B

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Lockdown entertainment- Ten highest flying birds of the world.

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"Anne: Life goes on. We change"- a quote from the movie "Endless Love" (taken from Rotten Tomatoes Quotes from the Movie Endless Love) Just to give one a glimpse- It's a story about admiration (Anne has for David), love (as defined differently for Jade) and fiery obsessive passion (for Jade by David). Nice emotional breakdown (piece by piece analysis) for a writer. Applying this quote for months of being in a lockdown is mentally healthy... Of course: Life goes on.... you can loosen that quote in your mind but subconsciously you can't loosen the thought that there are a lot of "dont's " that one needs to do because of this "virus." Just be quick to say "I don't have to do this." Make it a habit...

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June 27, 2020

Update in Covid 19 vaccines. Who leads?

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Curiosity

Being a Research Associate in the Planetary Biodiversity Inventory: Global Biodiversity of Eumycetozoans*- What is my major role?

Answer: (taken from the Philippine Myxomycetes Page as an Update)- What is the major job of a Research Associate in this PBI: Global Biodiversity Eumycetozoan Project**? There are a small number of research associates around the world. Our most important task is to support the proposal PBI: Global Biodiversity of Eumycetozoans for funding to the USA National Science Foundation. Therefore our statements of support and our signatures are important for without it there is no existing PBI GBE project. Aren't you glad that you had such workshop training in Thailand or any designated nook in the world? Aren't you happy that studies in myxomycetes/eumycetozoans are progressively going on in your country because of this?

* Slime moulds

**The Global PI is Dr. Steven L. Stephenson, Univ. of Arkansas. Thanks a lot.

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Pertaining to the above post (their ongoing projects)

- I observed I started my last two statements with "Aren't you" and automatically what comes to my mind is a line from the movie Out of Africa: Aren't you glad I brought my china and limoge? (or was it crystals... I am not sure but it sounds like this). Nevertheless as to the above post... Cheers for University of Santo Tomas! and remembering Dr. E. S. then.

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An addition to urban birds mentioned above is the sunbird (hummingbird?) (am not really sure) Hummingbirds hover while they feed not the sunbirds. But sunbirds are song birds. This wakes me up in the early morning with its shrill songs. An early waker bird. I think it is a sunbird. Or is it a hummingbird? These are birds that were subjected to convergent evolution. Why not study them? According to one source online flowerpeckers (is this a sunbird?) are found in the Phil except Panay island. By the way, their small size and swift flying processes may belong to a domesticity scale of 7 or more? Their domesticity skills are far out. Such birds I had observed making nest in a plant planted in the sidewalk near the bus stop in Los Angeles, California and in Bauhinia sp at the CSUDH campus.

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6/29/2020

Update in the Oxford Vaccine... Leading?

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Theory of Human Familiarity {for lower forms of animals}.

In this observation, P. goiavier offspring reacts to "responsive domestication" but only in very limited condition compared to home grown fowls. Therefore this is an addition to their (adult) domesticity skills in reproduction (published paper; see post above)..

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The University of Oxford

~Previously I promised (see post above) to wear the Oxford U tshirt and in here I pointed to the dept. where the Jenner Institute is located, the place where the Oxford vaccine has been studied/originated, This is one way of learning academic/ research life in the East(for UofO)/East Coast (for JHU) where my MD sib likes, visits, studies and learns. My research/academic/scientific experience are in schools in the West. Well Caltech is second (to Oxford) in Times Higher Education survey of the best schools worldwide for 2020. Congratulations!

University of Oxford is known as the Collegiate Research University in Oxford, England (from Wikipedia).

As pointed, That is the Department where the Jenner Institute is located. (Search Online)

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Top 5 most promising candidates for Covid 19 vaccines (Cornell Alliance for Science)

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June 30, 2020 (Yale U News) (Murine Research)

Stress and the Immune System. Other keywords: psychological stress, stressful environments

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It's the typical rainy season months of June and July but I haven't heard the anurans calling each other for reproduction purposes. If I recall these were the months where they sounded in chorus.

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July 5, 2020

Three methods of Covid19 transmission.

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July 7, 2020

Asthma is absent from the list of comorbidities of people with serious COVID 19 illnesses (per this study). Are asthmatics and others with related respiratory illnesses protected? (there is the molecular explanation as well as the effect of therapeutic treatments but still needs to be dug deeper)

. *Please see related articles online e.g. the planned clinical trials (on corticosteroids)

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Canadian English Bing.com site displays this when searched for Isidro A T Savillo quotes:

This is a conversational or script line from the novel "Amidst Old Los Angeles" my second novel. As the author, then this could be my quote, too. hmmm or probably this could be a quote from the novel. But thanks for bringing up my second novel through this snippet.

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7/8/2020

Pancreatic cancer cells halted by cholesterol blockage (using organoid and mouse models)

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7/9/2020

Ready for human clinical trial: Cancer Vaccine. Cancer vaccines are limited to Preventive,Therapeutic and Personalized and are very few: Link 101. In my post in the main page I talked about antibodies against cancer and there was one finding of a possible "natural antibody".

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July 11, 2020

MIT Technology Review: On Covid19 airborne transmission

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July 14, 2020

Update from the World Health Organization. Is there such thing as "normal'?

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7/14/2020

More on SarsCov2 airborne transmission

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Opinion from Harvard School of Public Health (May 26, 2020) On Airborne Transmission

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Knowledge 101 (7/14/2020 - could be updated)

Coronavirus Vaccine Tracker.. Quite a long list of vaccines being worked- upon for this virus.

If you are or would like to be a molecular biologist, this will be your job. As what I mentioned in the first page (working in molecular research)- You usually work as a team and each one is precise with the methodology assigned to him or her.

This is an expanded list (of types) of vaccines and the phases of trials (pre clinical, phase I, II, III and Approval). Here is the Link.

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July 15, 2020 Hebrew university

Depleting the virus' nutrition may get rid of the virus in a certain way.

Keyword: anti-cholesterol. Here is the Link.

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On spillovers:The Viruses

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I talked about a conserved gene* (pls. see post above which starts with ."In the first page...(in zoonosis)" for a vaccine so it would cover a clade or even more of it. Here is a new discovery (Universal Vaccine)

*please see discoveries sub page in main page

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On Pinterest

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If you plan of putting me in your reference or elsewhere... Be careful.

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In my post above, I mentioned about the "Leveling Off Process" and this is due to the "overall aspect of the immune system" which can include the T cells and Antibodies at work as stated in this coronavirus vaccine updates. Important keywords here: Tests/Clinical Trials for the elderly still has to be undertaken; how effective?; dose increase? Here is the Link.

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"Roll up the sleeves for science."

As long as there is a gistful antigen of the virus those vaccines will work in stopping the virus, in boosting the white blood cells and the like, in helping synchronize the viral level of potency where the immune system could pick on them. I was about to say stop gap vaccine but I would rather use Stop Vaccines for I can see a wider range of their activities. The eagerness to become volunteers is in this Link. Great and Thanks!

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Something new, Opinions

I read a paper saying that herd immunity is present (from a foreign source). Are you exposing a final statement about it? How about saying progressive herd immunity (where I discussed this likely to happen with the flu pandemic in the above post), if there is? If herd immunity is like the "leveling off process (molecular synchronization)" that I wrote in my posts above then what are your indices? What are written in your comments seem like what I have written in my posts above? (e.g. cross reactions etc. ) Where does this "herd immunity" exist that you are claiming? Just randomly cluttered? Is this within a family, a neighborhood, a place of work, a local community, a small town, a city, a metropolis, the whole state, the whole region, the whole country? (- to be called a herd) or predisposed in particular races? What is your ratio with those infected to mortality? Or your ratio of Covid 19 deaths to the population? How do you gauge the Covid 19 existence for the positives? How many people are asymtptomatic? Did they progress further to serious manifestations of the disease or it (being positive) just disappears? How many are symptomatic but not serious? How many are serious and lead to hospital admission and so on and so forth? How many of these people got well (but remain positive or negative)? How many people exhibit recurrence (re infection, repetition of symptoms)? Though the latter statement is a major index for "leveling off process" usually they donot become serious. This is common sense unless comorbidities and old age may come into play. The immune mechanism for this virus has not yet been finalized so avoid making final statements.

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Caltech's Newly Funded Research Approaches

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Surprise to be second in trending people today in the Philippines. (Aug. 5, 2020). Second to Jerry Yan of Meteor Garden Fame. He has a new movie exposing his "body". In tabloids now.

August 6. 2020. I am now second to Elon Musk in Trending People Today in the Philippines. He is my MODEL!

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MGCQ module with ACTHUNG! and may add more ACTHUNG*

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Waking up to see 1400 viewers this week and 177 viewers today is a surprise. Thanks a lot for your visit at my people.pill.com bio.

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Keywords: Why famous?

Other queries about me are in the first "paragraph" of the first page. But this question that has remained for a long time (Thanks for constantly asking) has not been given importance. Here is the question. This has something I think to do with my achievements in all honesty. It's reflecting back.. Just when I reflect back when I toured alone the world over at the age of 18. Reflect at your honest achievements and Be happy! And share with your fans! Hello Fans!!!

Screenshot of common queries:

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To All People , especially From the City of Angels (Los Angeles), CALIFORNIA, USA

Discover the whimsicalities of my second novel Amidst Old Los Angeles Search Online and type AMIDST OLD LOS ANGELES... Read some script lines and see the choices for the beautiful people at The BLOC. Discover the fantastic THE BLOC of LA/DTLA (Los Angeles/Downtown Los Angeles) I know your heart will feel the grip but that's normal while falling in love with LA/DTLA.

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Waking up in a constantly rainy morning, I have 1662 viewers for the week with 253 viewers for today an increase from what was posted above. Tracking the quantity of my viewers in the days of pandemic. This finally came up to 1700+ viewers for the week with the last day (for the week) with more than a 100 viewers.

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Most likely the same content as my posts above only that it is written as an article. Here is the Link.

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Current HIV news.

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In my post above, I was challenging the "classical way" of making vaccines. But at that time innovations in vaccines are already on going only that it was not fully exposed. This article will show us the molecular and cellular strategies of vaccine production. I know these advanced sciences in biology- molecular biology, cell biology will pave way for a more efficient weapon against these types of pathogens. Here is the link.

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The aerosols (what are the sources?) and the virus in it.. Face Shields + Masks... What are the advantages? Please read.

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About Covid 19 immunity

An analysis of CDC statements and others.... Here is the Link...

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Update of CDC on Comorbidities (partnering with Covid 19) (if released three days ago- then dates back to Aug. 14, 2020)

The analysis of the certain medical conditions with COVID 19 are classified as having the:

a) strongest and most consistent evidence- defined as consistent evidence from multiple small studies or a strong association from a large study b) mixed evidence- defined as multiple studies that reached different conclusions about risk associated with a condition c) limited evidence-defined as consistent evidence from a small number of studies, categorization for a condition's association with severe illness from Covid 19, the condition was added to the list (if not already on the previous underlying medical conditions list [originally released March 2020]). By the way the references of these outcomes (a-c) were based on publications.

Here are the Links: (They may be subject to an update in the future)

Updated CDC Statement in the Classification of Comorbidities (with Covid 19)

(I do have posts above regarding asthma etc, CDC includes it now under Mixed Evidence)

Scientific Evidences (list of Supporting Publications

STAY SAFE. Follow the Precautionary Measures against COVID 19 and always be with your PPE and Be alert..

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Current interpretation of mutated coronavirus by an infectious disease expert.

Comments: With the mutated counterpart as acceptable, I think i don't have that much question on the probe used as well as the genetic sequence of the virus itself. I am very concerned about specificity and sensitivity. (See my above posts)

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The nerve residing/hiding Herpes virus likely to have a cure. This is usually known to reveal itself once stress overtakes.

Comment: I am very interested on the gene therapy techniques used here.

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Germany comes into view as one of the first COVID 19 vaccine producers

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Re infection? (search online)

There is an ongoing saga regarding re- infection of Covid 19. Some scientists do not agree because the presence of antibodies is enough to stop the virus from re- infecting the person and the person's new acquisition of symptoms is the reactivation state of the previous virus to cause a re infection. But once the immune system lowers its capacity to prevent that reactivation with that previous virus in vivo then the body I think is open for re infection from the outside. Another issue here if you add a lot of viral titers from the outside will you not get re infected? Therefore if this is your perspective about viruses, I wrote a statement in my post above about the generalization of a latency period(s) for the viruses as in this Covid 19 virus (pos-neg-pos then probably neg then what pos again?) just like HIV's own but pos. This will be added to my discoveries sub page. It's like saying that viruses will remain a flora of the human body.

This is not a molecular cocktail but a cocktail of ?? thoughts:

In HIV, dormancy means the patient is positive but no serious symptoms leading to AIDS. In Coronavirus for Covid 19, dormancy means no virus present in rt pcr and no symptoms. But I think this is an anti thesis to the fact that scientists' assertion the virus is in the body only that it cannot be detected (you mean it was "adulterated" but it could re assemble then the virus is alive and kicking). If one can find its hiding place (e.g. in HIV it's the lymphocytes) and use it as a specimen then probably you can apply your rationale that reactivation is occurring and re infection source is the previous virus for people who become "positive again". If you compare both HIV and Covid 19 virus, they ended up with dormancy referring to no symptoms but as expected in the scientist's rationale that the Covid 19 virus ought to be present therefore it has to be pos. Otherwise if scientific enough (it degrades into a single A or G that no PCR machine could ever detect it and later it swirls and twirls until it re connects all the bases to be a PCR readable virus again) both will be included as new phases of the latency period but bit awkward. Please if you release a statement see to it that you can support it fully.

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Updates of medicines used/ intended to be used as stop gaps mentioned above, I haven't encountered much info about it. Please search online. Thanks.

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Cheers and Congratulations to Malaysia (Selangor)!!

In their most recent study (2020) on the Biomonitoring Tool for Air Pollution Assessment using lichens published in a Scopus indexed Journal IJAST, Pyxine cocoes was identified as the most tolerant lichen. For information on Pyxine cocoes please browse Page 1 and the subpages. Thanks. Here is the Link.

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Pandemic Entertainment

PCR is in everyone's mind because of this current pandemic. But don't you know that the discovery of the PCR was rejected for publication and was one of the 8 rejected papers that won the Nobel Prize award. Dr. Kary Mullis, Nobel Laureate for the PCR just had his first death anniversary. RIP

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The Pros and Cons of Omega 3 Fatty Acids. In fishes, they are mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Read Healthline's Evidence Based 13 benefits (Good for mental health?) and 8 little known side effects (Side effects are not so good). It seems that there is a difficulty of zeroing into something that one could say Yes! My attention was taken by its anti- asthmatic role in a Conversation article. The fatty acids interact with and stimulate a protein known as the free fatty acid receptor 4 that opens up and relaxes the lungs and airways knowing that the lungs are rich with these receptors. But I think, these receptors also has a role in glucose regulation and may not be good for diabetics (unless managed well).

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On Covid 19 transmissions

When transmission was scarce and only limited, the idea of protection was solely personal. One must have PPE, exhibit social distancing and washing of hands, etc. This refers to individual guidelines to prevent infection and transmission. But once the spread is community based what are the guidelines? This time the individual is in the actual intersecting point of the infectious virus. CDC has a community mitigation framework and this is the only one that I saw that is quite well organized. At least the individual must know what to do in cases of community transmission (and infection) and the community itself will engage in some specific responsibilities or guidelines of their own. This comprise the residential community, business and government establishments like transportation sector and all other transactions (not viral free) that an individual will undertake targeting his/her protection in the midst of the community transmission or (possibility of) mass infection in a community. Here is the link (Unless there is an updated link or additional link of substance from other sources). Community spreads call for people to continuously be more vigilant.

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Pandemic Entertainment

Saved Stories in my About Section of my 3 FB Pages (will soon be deleted due to new FB Pages)

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Abrupt CDC guidelines questioned : On Asymptomatics; "no need of COVID 19 test". Here is the Link.

AMA's reaction on CDC guideline*.

*Thanks for highlighting in yellow only in my page I think.

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Something New/ Opinion

By the way as (if you are) a theoretical scientist, please support your statement. If you release a statement and you cannot support it readily but it has an urgent connotation then do not release it especially if it affects a major life or death situation.

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I mentioned in my above post about being vigilant involving community spreads.. Here is one example that occurred in their very own situation.

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Pandemic Entertainment

Virtual Argentine Dance Competition- Dancing while reminding of how to be protected against Covid !9. Search video online.

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Vigilant (or keeping careful watch for possible danger or difficulties- from Oxford Languages) is the word

Infectious but Milder (Mutated Strain in Indonesia)

Something new/Opinion

The word "milder" has a lot of meanings for it would lead to an x, y or a z. ( pos*, neg** or an in between***, respectively) We will just have to wait what the molecular epidemiologists say (these are epidemiologists who know how to incorporate molecular data into their findings even with a statistical depth).

*toward herd immunity

**toward phases/kinds/ranges of morbidity [which may subsequently lead to mortality]

***similar as prevailing situation- recoveries + death

This link above (in the word strain) calls for people to be Vigilant against Covid 19. No one knows the actual effect of the mutated strain of this coronavirus at present to humans.

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WHO and the late stage trials of promising vaccines. Here are the links: 1, 2

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**Team members where are they now*? Of course, I miss you. Thanks.

Team Member for the "Molecular Analysis of Symbiosis" (archive as a document by Geocities- Thanks... more archives needed for this please..) which I founded/established while in the U.S.A., Vera Besse, an Austrian is very active in Environment, Climate Change and Lifestyle Solidarity Programs as a Director and also in Akaryon as Project manager. Probably there are still more achievements. Congratulations for this ongoing endeavor of yours together with your colleagues!

Also to Matthew D. Pagel. He was the Membership Chair and most importantly the Web Manager for ISMCBBPR (online), the society that I founded. He has been working in research at UC Davis most importantly in Biotelemetry studies (animal movement, e.g. fishes) under two PIs. He also co authored papers together with others [from Harvard Univ and Arizona Univ., UC Davis, etc.], a publication reviewer and was a fellow in the Exobiology program at UC San Diego. Congratulations to you and to your colleagues!

*Online Information

**Team Memberships are voluntary positions.

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Dr. Fred Wilt, an advisor of ISMCBBPR is currently an MCB Professor Emeritus at UC Berkeley. Here is the complimentary copy of the book he sent--A Token (Thanks again):

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Still Risky

Though the stop gaps and remedies mentioned in this article that were also mentioned in my posts above are showing pooled signs of positivity there is still a need to be vigilant against this virus. Here is the link.

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Memoir... (Hotspot!)

It's quite impossible for me to hit (careers) with one stone... and I can see how some of the listee [in our directory] (until now) hold on to their careers (i.e. imdb, etc) in films. [How I missed those two "Pitchng" events where an Invitation was sent to me.] Congratulations!

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Wetlands at a Loss. There are a number of environmental factors that contributed to the burning of the world's largest tropical wetland. Here is the Link. Help Save the Wetlands and its natural components.

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New rules are coming out modifying the previous ways people consider to be better off but the epidemiological data do not support it. More deaths are sprouting. Still I would say to all people "Don't let down your guard." Stay vigilant forever as of now.

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By the way I would like to thank the International Symbiosis Society (this is the only time I searched for ISS and I am so happy that it is very much active until now. Congratulations !!) for featuring my "Molecular Analysis of Symbiosis " Web Page (please see above post) in their news letter. I still have the copy and of course, in their part it is an archive.

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Thanks for mentioning ISMCBBPR in your article. ISMCBBPR is a hub (international society) only for Geniuses in molecular/cell biology/biotechnology as volunteers. ISMCBBPR "Molecule of the Year" winners are listed in Wikipedia's VTE template for Molecule of the Year/ISMCBBPR. Please see first page. Thanks.

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Curiosity? Memoir (U.S.A.)

I passed a graduate course in Clinical Microbiology which paved the way to participate in research in Molecular Pathology and Clinical Microbiology Laboratories. Previous to that I had been doing research in Molecular and Cell Biology (NSF, MBRS funded). Thanks a lot .

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Memoir (U.S.A.)

Dr. Ted Esslinger [a lichenologist, who introduced me to Dr. Harrie Sipman, also a lichenologist ] and Dr. Marinus Otte [who paved the way for my establishment of the Society of Wetland Scientists Asia Chapter and I, became its first President; currently Editor, Wetlands] are currently both members of the Faculty of North Dakota State University. Met Marinus personally during the 2009 Wetland Conference in Madison and so too with Dr. Jae Geun Kim of South Korea together with his student. Jae was in the academic committee during the Asia and China Chapters Wetland conference last 2018 in Jilin, China. Thanks a lot.

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Memoir with Dr. Donald Pfister Harvard University Herbarium (U.S.A.)

I believe I had the best lichen-tree related research proposal with the help of Dr. Pfister. Thanks a lot.

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Gratitude

It's time to say a big thank you to all the important scientists who have been a part of my important life. I am retiring soon, there is a pandemic and I will devote myself to fictitious literary writing. I told myself that 50 and above I will concentrate in writing. But I still feel 50 until now.

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Procrastination and a bit of intro-- and Thank You-

For important reasons (health, etc.), I was not able to attend to the expectations like applying for Fulbright*... Thanks for all those who would like to bestow their letters of recommendations from the U.S.A., All funded China wetland conventions wherein I was not able to appear** in the embassy and my travel agent just did her part. Thanks to C.A., the Colorado dinner meeting in an international wetland convention that I was about to be a part of the four member team (including Beth, the former Pres. of the SWS Org.) of the International chapter... what else? More will come as I remember them. Oh by the way Thanks to the former executive director of PAEF, Dr. Esmeralda Cunanan for the realization of a Fulbright visitor from the U.S.A. (Please see first page) I received an email (not a scam!) from the Dept. of State (USA) inviting me to do a "peace corps" type of job. But I think my late father is more qualified to that job than I do. Thanking the Dept. of State and the CIES for the visiting Fulbright professor. I acclaim the scientific advancements and literary awesomeness of the U.S.A. and I believe in world citizenship!

*Being a US traveler for some time, it may not be appropriate

I was with Society of Wetland Scientists org as President of the S.W.S., Org Asia Chapter during the reigns of the profound Society of Wetland Scientists Presidents from 2005 to 2010 . One of them surprised me to run for the SWS Org Pres. I was so unprepared (a third world country office? could not hold a 3000+ wetland scientists worldwide in a smooth technological way if voted ) and I was not able to answer the precious phone call. I am sorry but I sincerely thank all of you! In my first page I do have statements of gratitude/plaudits for SWS Org. The International Federation of Cell Biology invitation in Korea convention where I think the South Korean organizers needed my passport, etc. for a sponsored trip but I was not able to do it (see Page 1). **Probably I am used to get visas without appearing in embassies just like what happened to (1 Asian [non ASEAN] and 2 Non- Asian) advanced countries for scientific reasons. Well they know me and my achievements. But all my thanks. South Korea is active in wetlands nowadays and I am happy!

^A wetland scientist from South Asia which was my choice (given the authority) for a free sponsored trip in an advanced country to attend a convention declined it for health reasons. To procrastinate is reasonable.

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A Permanent place to be Remembered (Hopefully)

Thanks too,

My name is immortalized at the BGBM (Botanical Garden and Botanical Museum) Herbarium in Berlin Germany... my copyrighted novel at the Library of Congress, D.C., USA. It is always there and of course Google internet information as well as Bing.com and others (online search engines) that I haven't known yet. And all the hard copies about me (publications, newsletter, photos, discoveries, etc.) in libraries, online, archives etc. Life is a tapestry.

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Memories...

I am thinking sitting in a well polished bench and I look backwards to those wonderful and beautiful moments.... no ugly ones that intercept. Life is beautiful.

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Status of Fall Classes in the US

Keywords: Moving in thing, face to face versus online, Yale tests students twice a week, Harvard every three days, spike in positives among students; resort to online classes; thesis strategy at UC Berkeley (this is a nice A Day in a Life Article of Justin). Well as a conclusion the Coronavirus is still difficult to tame/contain Be vigilant.

Here are the links: First Link, Second Link (Justin's A day in a Life) (Thanks for sending this update to me),

Memoir (U.S.A.)

Justin uses key card to enter his lab. I had a personal key card too which I used to enter the huge LAC USC County Hospital and the Hoffman Research (for Pathology) Building in the Univ. of Southern California Health Science Campus. What a memory to remember. Thanks a lot for being a part of the Molecular Pathology Lab. and Researches!

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Memoir (U.S.A.)

Justin's research (above) is on retinal degeneration. Oh that's what my Graduate PI Dr. Laura J. Robles (thanks for labeling me once a "US Scientist"), the profound scientist behind MBRS and NSF funds for research at CSUDH (Foundation), was working on on Retina. I was able to detect the Serum Retinol Binding like protein of O. bimaculoides (pls. see first page). She had awesome RA's and they were so friendly... where do you think they are? Efren is now a physician at the University of Miami Hospital (Dr. Efren Manjarrez, Jr.) the Senior RA, Drs. (Physicians) Nnenaya, Felicia, Joaquin F. (Dr. Forbes, hi!), and Hee Young. Tony, Steve, Debbie etc... that Cuban guy (who offered me a ride in his car at the bus stop and (I think) also an RA), Mr. Camacho, Dr. Roberts, etc. I still have to say hi to Dr. Ann Warford, a mentor etc. for the clinical science. List will go on as remembered (sometimes I just can't remember names). Thanks for your company.. Yael now at UCLA and Jacqui from Alabama... Laura you're such as a cosmopolitan scientist in molecular and cell biology and being featured in ASCB. Very Sorry was not able to go to Florida convention for my srbp discovery and also the Indiana University prospect for higher studies {Pls. see above on "Procrastination" [a part of]}! Laura cared for her Research students! Three thumbs up! But a Great Thank You and all.

Curiosity?

*By the way , I know you are curious, why I am calling Laura as Laura--- because in the U.S.A. we call our Project Investigators/Mentors/Bosses who are PhD's , Profs, and the like using their first names... that's why Project Investigators (as one example as to my experience) and Research Assistants have a very good relationship when it comes to research. We feel comfortable with each other and we are productive.

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Sept. 17, 2020

WHO warns Europe as cases spike (on Covid 19)

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Memoir (U.S.A.)

Roving Eyes of a writer. It was 12 midnight (exactly). I was at Ritz Carlton, French Quarter at Louisiana. I liked to see what's out there. I drew open the curtains in the huge bay window (see photo). I needed new ideas to spark my writings. Not what I saw but the "adaptation" of it or something that will lead me into a new scene or activity. Fictitious writers are full of imaginations and it needs a stimulus.

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Photo

I and Dr. Harrie J. Sipman (please see first page link: BGBM)

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Pandemic Entertainment

Can a shiba act like a human being and be indifferent? I am thinking like a human being. Here is the Link.

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This date: 9/22/2020

I am happy that 5 renowned scientists from the Philippines are also the people's choice by these people who searched for me. Four are UP alumni (the late L.O. Belardo, the late E. Quisumbing (Hi Agnes Q,! the economist), M. Lagmay and M. Fudolig (Wow Smart!) and of course the late E. Gomez* (of MSI, UPD) My brain becomes relaxed feels like a breather when I see scientists among the 23 names searched by people who searched for me. Thanks.

*(Memoir UPD)

I met the late Dr. E. Gomez in the junction of Marine Microbio. lab and the old Marine Bio Lab.(now the MSI at a different location) besides the street.

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NASEM (National Academies of Science, Engineering and Medicine) sent two announcements to me:

1. Emerging science in indoor chemistry

2. NASEM Earth and Life Studies: Explore resources on new climate change topic and on Wildland Fires (Call for Registration or was it past the date? failed to open my email as soon).

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Going back to Oxford University's List of Experimental and Translational Therapeutics, they are all interesting but what stimulates me is I can find this molecular topic (as a publication) in an invertebrate like the echinoderm (even discussed this in class) but very much visible in humans too because it's here. I haven't read the human counterpart but I will if I have the time. It's "Dedifferentiation and with an additional topic on induced pluripotency". How about approaches on ex vivo gene therapy? These are coffee table reads for me. I find it a pleasure. Still so many topics to explore like ImmTACS.

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Re: Taxonomic Classification of Fishes. There are 2 camps (I have no idea if there are still others) fighting over a taxonomic category in the fish ladder. One still uses their own while the other prefer their own, but one has more influence to the WORMS but the latter is also saying that there will be revision in the taxonomic classification of (higher?) fishes. (quoted in 2017). So where is it? How is it going? So if this could not be patched up.. Well there is molecular and cell biology that could further find the right answer. If phylogeny is the eye of the needle then explore molecular phylogeny for better insight.

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This is not something new/Opinion

BE VIGILANT** TO SCIENCE!

It's an opinionated* world. (On Covid 19)

Tall tales versus Science

CDC is posting "Opinions" and others are posting their own "Opinions" about it (CDC). So if Covid 19 is treated this way, then there are so many tales (about it) mixed with adaptations and fiction probably from dreams and individual's own experience that others may share their own, too so no valid conclusion but a paper mache of all sorts. Let's go Disney but Disney is not morbid or Let's go horror like those street numbers that horror movies are named after. WHO, a few hours ago (it usually does) warns about fake news/items like editors paid to write opinions and say sorry again. The world is a stage where people are acting what? Fake to their own disadvantage? And to rest of the world? Here are the current Links 1, 2, 3, 4

*Opinions may be scientific (as asserted) or may lead to a scientific statement or a tall tale or a sham. Which is which? Where are we now?

**Protect the Science behind Covid 19.

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Covid 19: A conversation on the mutated coronavirus. Here is the link.

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Are they really Asymptomatic for Covid 19? Here is the recent study.

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On predispositions- I read about developmental predisposition (e.g. apomixis) but how about reproductive predisposition- when it comes to the "reproductive arena" animals tend to be at their fiercest catapulting the domesticated behavior they earned or are subjected to as a part of the/their environmental mainstay. Of course, we also have the usual genetic predisposition.

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Whiling the while (of public health concern)/Opinion

In "cosmopolitan glitters" a lot of testing are occurring absolutely there are registries of pos how about in "the bush" areas? Where are the testing centers/lab? and where are the massive swabbings? Be careful of self announced "freedom" it may lead to a quixotic quirk.

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--Memoir (UP Mnl)/(An add on to Procrastination)

A kind invitation to talk (email communication) (Thanks) with this scientist about Clinical Molecular Virology in Pathology did not push through because of the traffic experience. When I arrived from the U.S.A., there was this very disgusting traffic. During my time, I can approximate the minutes I would be arriving at UP Diliman but now it is a turtle's pace. That's why when I leave for abroad I stay in hotels then approximately four hours before the flight I hired a transport to Airport Terminal No. ? my fav. PAL or any Int'l Airport designation. Going places in Manila before and after an international flight is not my cup of tea.

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Sept. 29, 2020. I do have a hodge podge of personalities that people search with me. Scientists, Heroes, Religious, Actors, Actress, Politicians, Pioneers (Mexican Am and a Fil Am), Businessmen, carreers with the Social media, Artists, Sports, Writers... hope I didn't miss anyone... Great!

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Sept. 30, 2020

Adviser of the ISMCBBPR (please see first page), Dr. Wayne Grody and very much supportive of this organization is an invited speaker in this very important EWC Virtual Conference in Pathology and Laboratory Management. Congratulations! (See ZoomInfo)

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Another adviser of ISMCBBPR is Dr. Sonia Wallman, whose programs as Executive Director, with the Northeast Biomanufacturing Center and Collaborative/Northeast Biomanufacturing Institute has created the New Hampshire's Biotechnology Education Training Center, as one way of bringing molecular and cell biology as well as biotechnology knowledge and expertise to students and employees of various colleges and universities in the East Coast. Congratulations! (See ZoomInfo)

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Pandemic Entertainment

Searching for Amidst Old Los Angeles in mobile phones produces 6 posts online.. Thanks fans. This is for all races.

* 7 posts about Amidst Old Los Angeles in New York (IP) /Lap Top when searched Thanks.

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Memoir

Looking back at the publications, I thoroughly analyzed (see above coffee table reads). Oncology is not simply oncology but Molecular and Cellular Oncology.

a) Which of the publications I would like to re- read? It's the paper of Quach et al. (2019). A strategy to protect off the shelf cell therapy products using virus specific T cells engineered to eliminate alloreactive T cells. Journal of Translational Medicine.

I would like to return to Fig. 1. Retroviral constructs using CHAR sequence, and its molecular components.. and how to induce CHAR... how the HLA Class I and CHAR complex was formed?

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b) Guess the paper source for the statement below:

and the statement I made:

"A major breakthrough in ACT came to being when T cells whether autologous or allogenic can be engineered specifically against cancer cells. Two types of antitumoral receptors could be introduced in T cells. These include the TAA specific T cell receptors that are HLA restricted and the chimeric antigen receptors (CARs) directed against tumor specific proteins that are expressed on the surface of the cancer cells."

A paper of Russell, Wilky, Bueren or Howe? Make the right guess.

One of the best papers I read and analyzed was by Dan Li et al. 2019. A review article on Genetically Engineered T cells for Immunotherapy. You'll fall in "love" with this (not with the authors but its content).

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October 3, 2020

Herd immunity or vaccine or both in the latter part of 2021*...PPE must be continued, washing of hands and social distancing until the time we can see/feel/be subjected to the same "normal" we are used to (includes public health data of course). But still the vaccine has to be looked into... so this raises two questions of the aftermath*: a) Where is the virus? b) What "residual" diseases [or the same Covid 19 reactivation- the fickle positive- negative- positive- ... (see above post on this) virus] are there to fight for [for those who were previously positive/are positive but survived]? Here is the Link.

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Oct. 5, 2020

CDC updated what it withdrew.

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Oct. 10, 2020

When I was looking for 2020 papers in wetlands online, I saw this link. It was officially uploaded by CHED Administration**. Thank You. This is a book and there is a chapter* where I am cited (please see subpage section in my main page). That's why this link came out in my search. I hope that there will be researches of the mountains in the Philippines (most of the Phil. references are authored by ADB location- wise in this book). Like what the ICIMOD is all about. I am happy for all countries comprising the Himalayas especially Nepal. My heart is with you!

*I made a comment in the link in my subpage that this is one of the Best Assessment Papers.

** phlconnect.ched.gov.ph>uploads

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About the Black Hole- The Nobel Prize Winners (from UCLA, Oxford, Max Planck and the UC Berkeley) for Physics in 2020

This is an interesting find among the scientists who were given this award. But I think, the mathematician from Oxford is very much visible as a theoretical physicist (similar caliber with the most famous ones) and defies Quantum mechanics. His discovery of the formation of black hole has a firm prediction for the general theory of relativity. His reasons (of defiance) are so clear to read in an early moning over a cup of coffee. I also like "his about to be born theory" in "brain consciousness" that he compares it to look like "a bit of Harvey's blood circulation". Black Hole too is also a "monstrous eater" of the stars.

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Wetland Biodiversity

A Rare species of aquatic murine frequent the streams in search for food. As described, it's too furry.

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Something not new, fantastic Ideas

The "Ifs" On Albinism

This link answers the question "if all" but how about "if most". I think I can see how superior they are when it comes to governance that others who may not be like them will succumb to their rulings. And may be through the eyes of the world be the fashion statement or they may interbreed with most of their traits dominant and be considered as the most respective "race" in earth and their hybrids be "slave" to what they lack in terms of "survival" phenotypes. Both are fantasies but the "most thing" is more a probability. This is not limited to albinism other traits will do. Anyone in the movies?

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Something not new, Opinions

The CRISPR award and the others

Only two were chosen leaving out the others. I think the pioneering scientist meaning who discovered it first will be given the award- the one who made a basic stand in it while those who applied the idea will be subservient to the pioneer.

How about advanced patenting the basic find so the applied scientists would no longer hunger for it. Sometimes it is unfair especially if a "chorus" of people are working on it but some miss the honor. I think this discovery, co discovery thing has to be re written. Science has to be honest.

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I was informed by my online analytics that this paper is their next choice after visiting my new page. It is about Herbs and Covid 19.

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Update: Plant Identified 10/21/2020

In the U.S.A., they have the Spring Plant Scatters. In fact you can buy the seeds to make a mound of spring flowers (e.g. Composites) while in the Philippines, we also have the Rainy Season Plant Scatters. Here is one.

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Defiers and what to do about them

They thought there is normalcy in the air but the truth is they are spreading the pandemic. Covid 19 spread is easier to obtain and realize compared to HIV. So not to follow the preventative measures will still allow the pandemic to exist and cause unstoppable deaths worldwide. Stop defying the rules wear the PPE, observe social distancing and other measures. Vaccines may not be a promising cure in the near time. Here is the link from a conversation with Dr. Fauci.

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Handouts for Covid 19 (In response to the above post)

Just like HIV, there will be handouts for Covid 19. There will be illustrations of people who are asymptomatic but positive (later to find out) and not wearing PPE as well as practicing preventative measures and their capability of passing the infection to other people especially to those who are not also following the rules on preventative measures like social distancing, etc. Of course the goal here is to contain the pandemic worldwide. But without proper monitoring and penalty, the pandemic will still continue.

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In response to the above post/A Common Sense Discussion /Opinion

Common sense about Handouts for HIV and Covid 19 .. Discussing common sense statement is a little bit ... but well it is a great reminder of You and the Covid 19 pandemic.

- When it comes to HIV, a high percentage of infectious activity/spread is attributed to sexual urge and sexual performances while some are due to blood/milk/bodily fluid contamination not necessarily sexual in nature (but it could be). While in Covid 19- non sexual activities which include performances (like talking, sneezing, breathing heavily and exhaling, anything that involves whisking and throwing out of the fluids such as aerosols of the respiratory system, the mouth, the sinus, lungs, nose or even eyes (tears)? or the vapored gas or aerial gushing of lungs or outpouring a mouthful of air to the outside (just like what the kids are doing) or touching the viral laden fluids (dry or not) in any surface/matter/place/thing or manipulating any part of the human body (organs, tissues, cells, molecules) that is contributory for human Covid 19 spread but currently this part is unknown) and exposures (being a recipient of what is written in "performances" above) towers infectious rate (for Covid 19) while for sexual activities, this could be attributed for those who cannot sleep separately, appears innocent or are innocent about Covid 19 spread when on ..... or believe that in the "same bubble we are safe" (because we're together in our "siamese twin" type of activities) but when one goes out of the bubble's way (not necessarily sexual), he/she may have a chance of getting infected . So can we say, both non sexual and sexual activities are the culprit for the Covid 19 continuous pandemic foray? Of course as of now the most that the people could do is not to practice them for HIV but for Covid, it is not so good to say so. There is a need to breath, to talk, to exhale ... and not to spit? or sneeze (can you?), therefore the solution to this is the wearing of PPE, social distancing , washing of hands, using accurate sanitizers, avoiding face to face interactions, wearing of face masks and shields etc. To all: Be vigilant. a) Protect yourself and the people you are associating with, during your "performances"{usually measured in meters in social distancing, indoor and outdoor risks, air-conditioned and natural ventilation risks, etc.} And the b) people around you/or the listeners (for short time face to face interactions) must see to it that they will not become recipients (of fluids/moisture/aerosols) of your "performances" and the "performances" of others in the surrounding and c) you must not be a recipient, too of fluids from the "performances" of the audience. Fluids (with the virus) may come in some forms.. aerosols, liquid, semi dried may be in the air, floor or anywhere. Stop the exposures (see "exposures" above) (See the underlined the solution to this above...) ((d) avoid wrong "performances" such as not using sanitizers while handling infectious items such as grocery carts etc./ falls under "own personal performance, own personal exposure"). If properly done, No one will be contaminated (Contamination include - Infected if neg., re infected if pos then neg., if pos an addition of viral titers still pos., asymptomatic or not.. what else? this virus mode of infection and reinfection? was discussed in former post above). By doing all of these you are protecting each other in a mutualistic way. Or you can quarantine yourself but the place you are in is essentially full of what you need {except of course to be contaminated by Covid 19} (A Reality show?) But still wherever you are PPE. etc. are needed and most importantly be practiced. Stay safe. So clear?

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New update from CRISPR

I cannot remember if I was given an article about a review of CRISPR. I think I do have a copy (I "tied a knot in my finger" about it in the first page). Most likely new findings in this are proliferating from various schools or are these findings of the past, only modified? But this new enzyme they have is terrific. Here is the link. Remembering my UPD friend CRISP_ _ _ B. For short, we call her Cris.

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Cold season and Covid 19

The US has made some forecasts (see online) and precautionary measures about the viral' s status this coming winter. The first winter with Covid 19. How about in tropical countries with lowering temperatures, rains instead of snow, will prevail? What's your forecast? Think Tanks in Public Health What can you say?

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First timers for CRISPR

According to a 2015 paper, CRISPR is the prokaryotic equivalent of the adaptive immunity in vertebrates. Continue reading the linked publication.

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Covid 19 as endemic. As to the content of this article, I already discussed this in my above post that there will come a time when Molecular synchronization between the immune system and the Covid 19 virus will occur. And this would be characterized just like our current flu virus(es) (Its source may be a variety of a clade of the flu pandemic a long time ago). But as of now no Molecular synchronization could be felt thus this is too early for a claim of herd immunity. Therefore with or without the vaccine the virus remains to stay in human bodies for generations (see my comment in the above post about it as a flora of the human body- a new discovery again) then we are still under a dangerous zone embodying both asymptomatic and symptomatic diseases. So the personal preventative measures will continue that include wearing of masks, social distancing... until the molecular synchronization exist. In this paper it is postulated that vaccines can aid in the molecular synchronizations for the Covid 19 virus.

Having been out of the Covid so neg. (read post above in the neg- pos- neg- pos.. etc. test results) There are still the remaining/aftermath diseases* that could provide evidences that one had COVID 19 once.

*may be similar to "residual diseases", I mentioned in my above post.

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Pandemic Entertainment (Psychologically yours, Are you in this library now?)

I just read the paper in the use of "and/both" for a decision making especially if one is in the most difficult stage. It's just like choosing a career.. you need to consider both if that only one choice does not give you an edge. Is that it? Well one is a true career- imagine how you sweat it out to earn that degree (you will really have to keep on kicking on this if it is available) and the other "career" could be a hobby. Well you may search online about this "and/both" paper in psychology if you want to know more about it. While In this paper that I would like to share, it adds "spirituality" as one of the gauges for wisdom (where wisdom is also intertwined to mental health). There is no extensive discussion of each of the factors but you may pick one and apply it to yourself or apply it to your life and try to cogitate on it for a while. (You may need to search online for each of the factors if you want.) Are you practicing it? Does it help and make your situation a smoothie? I miss the smoothies that I usually drink but as of now, having limitations to go to restaurants, I can survive without it. (Smoothies are a combination of fruits in a drink with finely crushed ice). The mind will not focus on something but it will radiate into a number of things that makes your life a happier one being a social being (or sometimes a quasi- hermit) and I think this link will serve as your guide. Here is the link. I hope this could help you to a T.

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Sharing the Information: UCLA Vice Chancellor Offices

Bit Surprise why Vice Chancellor Office tags along UCLA under institution. I think this has something to do with the Oct. 22, 2020 announcement from the offices of the UCLA Vice Chancellors regarding the Covid 19 important update. Here is the link.

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Pandemic Entertainment

Some tips: Halloween 2020 during the pandemic:

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Personalized medicine at work . (Pls. see article posted above on Personalized Medicine: Dr. Steven A. R. Murphy)

Instead of symptoms, genetic analyses used as a basis. Here is the link.

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Memoir. Procrastination addendum (See way above posts in this topic)

I was not able to meet Dr. S. A. R. Murphy. Sorry.

See private personal FB post below.

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Pandemic Entertainment

Dog training is difficult but there are some who like to make their dogs their "babies." Do you have mixed feelings on this? Here is the link.

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Nov. 14, 2020

Update on vaccines

Reminder

-The article linked here (directly above) reminds everyone not to let down our guard against the virus. Meaning there is still an ongoing need to be extra cautious so as not to introduce the Covid 19 inside the body. In fact I mentioned this common statement "Don't let down your guard" in one of my above posts. This include social distancing, washing of hands etc. the usual precautionary measures. Read above my posts; some tackle the common sense of protection if correctly performed. Why? Because this virus brings surprising diseases besides pneumonia. Blood Clotting is one. (Please see above posts for other developing diseases brought about by Covid 19; usually linked publications). So donot boast that you don't have pneumonia (could be silent/walking) that you are fine but once the virus is inside your body this may lead to other diseases and might be lethal.

Nov. 16, 2020

Update on Vaccines #2

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Something new, Opinion

I think there is a need of publications that will support the recent statements regarding the Covid 19 virus mainstays in surfaces to be considered as nil/ minor when it comes to infectious set up. The first SARS virus (in HK) was considered to be potentially dangerous even by touch (e.g. fomites). Were they able to make favorable experiments in such a way that it will provide ambience for the "dead" viral particles to reconfigure to life after some time once they landed in these surfaces? Did they use the influenza and other viruses that are known to be infectious from contaminated surfaces as models? There must be lab cultures that will be undertaken in surfaces peopled frequently and if there are viable viruses of these types/strains, then disinfection will still continue. It is quite unique (or wrong?) if this phase of viral niches be considered as non communal for this virus in its infectious capability or pattern. Talking is not a scientific experiment.

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Vaccine updates 1 (11/25/2020) and 2 (11/26/2020)

Which is more important the DNA or the mRNA? We could say it is the DNA but the mRNA has I think a role in emergency need* of proteins. Let us site the matured Human RBC- It does not have the DNA because all the protein products as they say were produced for use through out its life time or can we say that mRNA were left behind* of the DNA, too. By looking at this perspective, One could see the relevance of the mRNA vaccines.

*the mRNA stability has to be looked into (especially for therapeutic purposes)

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Something new, Opinion Keywords: Your Disease +Stress* (other stresses besides Covid 19) + Covid 19 worries* (which leads to stress)

When one gets sick, focus on the type of sickness you have. Be happy in other words be positive. As long as you have the proper medicine, then have faith on it and avoid stress . And do not think about Covid 19 while you are sick (Avoid the "Covid Fever**" because this brings a lot of stress). If you have Covid 19, focus on the symptoms, the major disease that may develop and the appropriate medicines for these and to take medicines that could enhance your immune system and also medicines that will not aggravate the other diseases in its presence. Learn from MDs, from your own background about Health Sciences, Human Physiology .. that you have taken in school or search in the internet. Just be sure that what you obtain online are credible. Usually facts are supported by references. The latest the references are the better. What you learned from the internet, consult it with knowledgeable people. Learn from it so you can help cure yourself.

* the latter two are considered unnecessary

**making one self very worrisome especially even without Covid 19

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Reviews or even textbooks needed for:

Genetically Engineered Biomolecules (these will be numerous) and Competent Genetically Engineered Microbes/Cells/Organisms for Expressions of these Genetically Engineered Biomolecules. From plasmids to be competent to receive DNA during subcloning procedures, to making competent immune cells (a lot of methods here) and the new modifications in the mRNA used for the mRNA vaccines. Of course, this is simply addition and deletion of DNA etc. fragments, molecular re arrangement for some and other mechanisms with their functions as a modification for effective expression. Also making competent microbes/cells/organisms to receive these gen. engr. biomolecules for expressions such as the classical E. coli HB101. These textbooks/reviews could help bring about the realization of concepts of the unexplored biomolecules such as the use of mRNA for therapeutic purposes that I mentioned in my above post (mRNA vaccines leads the way). In this paper (11/25/2020) the concept of mRNA as a therapeutic molecule was observed in experimental mice in a 1990 publication. This article also discusses the problems and solutions in the making of the mRNA vaccines: Here is the link.

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11/25/2020

A Solution to the Raw materials needed for the voluminous manufacture of the mRNA vaccines. Here is the link.

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11/28/2020

Vaccine update

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Dec. 1, 2020

Vaccine update

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Congratulations to the 40th Anniversary of the Society of Wetland Scientists!! I congratulate all the members of the Executive Board Past and Present especially the Past and Present Presidents of the Society of Wetland Scientists and all the other Past and Current Officers. I also congratulate all the Members of SWS Org. and the enthusiasts and supporters of the SWS Org.

I am very thankful for recognizing me in the Wetland Science and Practice Journal, July 2020, a special issue for the Momentous celebration of the 40th Anniversary of the Society of Wetland Scientists Org. USA . Thanks to the current President of SWS Org., Dr. Loretta Battaglia.

Recognitions:

As the First Chair/ Regional President of the Society of Wetland Scientists Asia Chapter

As the 2011 Recipient of the Society of Wetland Scientists President's Service Award

THANK YOU SO MUCH AGAIN!

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Dec. 8, 2020 Pfizer (USA)- BioNTech (Germany) Covid 19 vaccine

First Covid 19 vaccination in UK. Here is the link.

How the Pfizer- BioNTech Covid 19 vaccine works? Here is the link.

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Comments on the Roll out for the above mentioned vaccine. Links 1, 2.

One individual who had undergone clinical trial spelled out the side effects of the vaccine and according to this person those taking it will hopefully be oriented about its effect. We will see,

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Feedback (Precautions) In the Use of the above mentioned vaccine. Link 1.

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Pfizer Vaccine for the US (Dec. 13, 2020)

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CRISPR gene therapy (News- Dec. 09, 2020) (Re: Blood Diseases)

Here is the link.

I am just concerned about the effect of patents to prices of these molecular meds. Please do not make it too expensive so people from low income families can take advantage of it. I know the MDs are wiling to use this but it would be difficult for them to consider this for cure if the price is not right. I remembered Dr. Grody's concern about BRCA gene being patented. But it was not. I think human genes cannot be patented as probe for screening purposes.

*if there is deletion then insertion of an exogeneous gene, this belongs to "cosmetic" genetics category. How long can it stay? I would suggests to make this procedure not too expensive because of the observational status.

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Dec. 15, 2020 (Status of First Patients with CRISPR Gene editing treatment)

Additional Update for CRISPR gene editing treatment. Here is the link.

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CRISPR -Cas9 in Maize

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Update for CRISPR systems Dec 16, 2020. Here is the link.

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Anaphylactic Reaction against the Pfizer vaccine (12/16/2020)

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Dec. 17, 2020

Status of the Oxford Vaccine

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The woman behind the mRNA vaccines....

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CRISPR and Simian HIV (Dec. 17, 2020)

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Remembering Sudan, the last male Northern white Rhino. Using molecular and cellular techniques I am positive that this will beget a male progeny. Let us give a lot of support, morally and technically scientific to the scientists who are working on this.

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CDC endorses Moderna's Covid 19 Vaccine (Dec. 19, 2020)

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The Whys of 2020 An emotional pandemic entertainment (From Google)

Here is the Link.

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Updates on Roll Out of Vaccines in Europe. Here is the Link.

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ABC News Dec. 27, 2020 Videos

Listen to the first and second videos (consecutively) for more information. Great for other vaccines from other Pharmaceutical companies will soon roll-out for use. We hope for the very best!!

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How long it takes for the coronavirus vaccine to work? from Huffpost 12/15/2020 and Why is there a need for continuous PPE usage?

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On herd immunity (I was about to write nerd immunity. It could be because my title in this short opinionated article* is Trust your Immunity. You are co- evolving with it. The immune cells (read above post in the "evolution" of immune cells as one) and the "foreign bodies" could be living or non living are being worked out for the betterment of you in a special type of a relationship- commensal ? the most that I could think or one is benefited and the other none at all, etc.. This is response to the statement that the "vaccine could boost the immunity." The vaccine is just one of those "armaments" but shooting it right (right med/treatment) during its first appearance, it's the immune system who'll do the rest (for a lifetime). It may not be a 100% but there is a tendency to lessen the effects of the disease somehow compared to its first encounter.

*still has to be written and may include the strains/variants/etiology

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How do you know that the pandemic is over? (11/30/2020) One of the criteria is "There needs to be fewer deaths and fewer infections"*. This is the main gauge in third world countries therefore testing must be continuously done.

Here is the LINK.

*I had previous discussion on this, etc. in my above posts.

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Pandemic Entertainment (on Possessive Aggression by a Pet Dog). Transferred to FB Page

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CoVid 19 variants and the current vaccines. Here is the link.

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People are wondering where the photo in my Peoplepillcom page was taken. It was from our photo when we attended an Int'l SWS Wetland Conference in Madison, Wisconsin, U.S.A. We were in the Monona Terrace Convention Center, Madison, Wisconsin. At our back is a Lake. I have no idea who trimmed our photo and make my face, my banner photo. Here is the original photo: (from left is my co- delegate from Taiwan , in the middle is my co- delegate from Japan and of course me on your right side).

In the middle is Dr. Keita Furukawa from Japan. The rest can be identified in the Taiwan photo below.

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Picture Below:

I am at the Canal Street, New Orleans, Louisiana. At my back across the street are the Shops at the Canal Place. If one walks to the right, one could reach the Ritz Carlton French Quarter where our conference (World Delta Dialogues) was held and also we lodged in this hotel throughout the conference. Before the hotel there is an intersecting road that proceeds toward a small pier and a board walk to view the vast Mississippi River. Exhilarating days!

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Picture Below (in Taiwan): This is the Taipei BoardWalk... with the Two Presidents of the Society of Wetland Scientists, Org.: Dr. Christopher Craft (2nd from the left) and Dr. Patrick Megonigal, (next to me), Past Presidents of the Society of Wetland Scientists, Org., U.S.A. and Dr. Wei Ta Fang, the Regional President for SWS Asia Chapter, my successor and I, in the extreme right (in your side) fresh from Las Vegas, USA. We were attending the first SWS Asia Chapter Wetland Conference.

Precious memories...

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Society of Wetland Scientists (SWS) Awardees for 2011 were treated to a special Awards Dinner at Bellevue restaurant located at Smetanovo nábř. 18 Praha 1, 110 00, Czech Republic by Dr. Stephen Faulkner, Chairman, (SWS) Awards Committee and Dr. Glenn Guntenspergen, President, SWS 2010-2011.

I am in front in blue shirt with stripes (on your right side) and Dr. Glenn Guntenspergen, the President of the Society of Wetland Scientists Org. USA is in opposite row (on your left side) and third (wearing a dark shirt) from the front.

Precious memories... Congratulations and Thanks again!

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Scientific Question-

Which of the countries of the world, Do I have the greatest number of publication citation in Google Scholar?

The answer is NEPAL.

"My greatest appreciation to all of you. Thank you very much."

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Spoken Citation in the Audio Article of Complex Systems Biology [Click View All] in Google Scholar. At exactly 8:34 minutes, my article contribution titled- Drawing the Line Between Theoretical and Basic Biology which is cited in Google Scholar is mentioned together with my name as the author in this video article. Here is the link: Video Article in Complex Systems Biology Thanks a lot for your efforts in making this audio article!

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Literary Question-

Which of my literary works has the greatest number of fans/likers/supporters?

The answer is YELWA- YAURI BEAUTIFUL TEARS

Most likely the likers come from Africa specifically in Nigeria; Yelwa- Yauri, Nigeria

1/13/2021- there are 600+ likers

"My greatest appreciation to all of you. Thank you very much."

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As promised I am Updating my First U.S.A. visit in 1977. The linked photo has been posted to its original home/place in the Old/First Page (Pls. see Return to the First page Link topmost and click, then use the ff. Keywords to find the correct place: 18 years, Michigan. etc.) Thanks.

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Update on Covid 19 mutant strains. Here is the link.

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New videos about the RNA - as it's never been seen. Here is the link.

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Controlling the Natural killer cells. Here is the link.

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Memoir: Going back to my CALTECH visit and talking to a renowned Professor about the fate of nerve cells... this finding has quite brought an excitement to me where glial cells that have limited functions mostly supportive have been seen to develop into neurons. (Paper title: Enteric Glia as a source of neural progenitors in adult zebrafish*).

*2020

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San Diego Scientists closely eyeing whether the current vaccines are effective for the several emerging Covid 19 variants. One of then is Dr. Dennis Burton, an antibody expert, (please see earlier posts about him) the Molecule of the Year winner of the ISMCBBPR. Here is the link.*

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1/24/2021

CDC suggests: UK Covid 19 variant as more deadly: Here is the Link

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Genome Sequencing-

I mentioned about this in my above post because of the delay in the announcement of the new Covid 19 virus Sars Cov2 that sequencing could have been done as pre- new year 2020 as what I can recall. Now in discovering new strains or variants of this Covid 19 CoV, Genome sequencing must be undertaken. It has to be fast, accurate and sensitive. This would help if these new strains come from other countries or an emerging mutant is taking place in the country itself*. Sometimes, announcing of the absence of strains in ones vicinity needs genome sequencing results as a back up. But how about in countries who do not have the capacity or sequencing is not their forte. Then one would jump into the pathogenesis of the disease.. and furthermore, focusing in the final effects in the human body taking in consideration its functional and structural changes (in the human cells). In this respect pathogenesis and the disease manifestations must be different from the original Sars Cov 2 of Covid 19. Do you think this is an easy task? Another is to make probes but single mutations may have some problems of cross reactivity so why not do a dot blot (if ever there is a supposedly probe) at least there will be chances in a spread out of samples. That may lead to a particular conclusion. I hope that these new strains could clearly be molecularly and cellularly analyzed so their antibody specific patterns will be deciphered and proper pathogenesis etc. will be marked. And to know if these mutated genes could bring devastating results (by its own expression) by gene banks comparative analyses.

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The wonders of Sardinella tawilis. In one of my written statements now in peoplepill.com, I stated that there are "loop holes" in DNA barcoding and I vouch for the morphological inclusion in identification**. The recent paper of Chan et al. 2019***, titled: DNA Barcoding cannot discriminate between S. tawilis and S. hualiensis (Clupeiformes: Clupeidae), means that they are of the same species. Considering their biological and evolutionary characteristics, Willette (2014) stated* that they are sister species. They are geographically and reproductively isolated hindering natural inbreeding and there are morphological differences that have to be looked into. Also of importance is the physiological evolution of osmoregulatory mechanism. It is nice to know that the "morphological" component whether structural or biological is given attention (I read before about this Taiwanese species which is related to S. tawilis and I think this is the group of Carpenter* as authors).

*cited in the paper of Chan et al, 2019.

**See Discoveries Sub Page in ist page

***I like the molecular techniques that they used here

@Morphology as defined. Waisbren's 1988, included the definition of Morphology respective to Evolutionary synthesis as demonstrated by the Contributions of the Oxford Group.

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Scientific Question-

Which of the countries around the world has the greatest number of publications regarding Pyxine cocoes* as a bioindicator/biomonitor for atmospheric pollution and following extensive researches about it (e.g. pollution tolerance, chlorophyll characteristics, etc.) in Google Scholar?

The Answer is INDIA

"My greatest appreciation to all of you. Thank you very much."

*Regarding Pyxine cocoes, please see first page. Scroll up and click "Returning to the First Page" link.

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As of now, there is a trend of lichen transplantation even not using a widely existing in terms of polluted areas covered (as habitat), pollution tolerant ones. So I think the gauge there will just include- the pollutants examined, the physiological and morphological damage that may exist which is to be expected. So how would your findings be written? Is it worth it? (e.g. In Zone 10, it has a growth niche, in Zone1 it has none and it is transplanted in Zone 1, then...??) In my first page, I talked about the Lichen transplantation mania. Please proceed to Page 1.

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Happy World Wetlands Day 2021 !!

- From:

I.A.T. Savillo

Former, Regional President of the Society of Wetland Scientists Asia Chapter/First in Asia

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Scientific Question-

Which of the continents of the world where I established or organized chapters of an international organization resulting to have in hand underwriters or petitioners* as well as members in almost all of its countries?

The answers are:

Asia- Society of Wetland Scientists Asia Chapter *

South America- Society of Wetland Scientists South American Chapter

*finding petitioners from a country member belonging to the continent to satisfy the number of petitioners/underwriters needed as a requirement of putting up chapters by the Society of Wetland Scientists Org. U.S.A.

"My greatest appreciation to all of you. Thank you very much."

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Remembering Dr.Brij Gopal-

-He was a pioneering member (from India) of the Society of Wetland Scientists Asia Chapter (when the chapter was established for I think he was already a member of SWS as a whole [?].)

-I invited him to attend the 2006 SWS Int'l Meeting in Cairns, Australia through the AUSAID funding but failed due an urgent personal reason.

-I think I saw him attending my presentation either in Washington D.C. or Madison, Wisconsin.

My heartfelt condolences to his family and friends.

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Scientific Question-

What International organization did I founded, organized, lead and uplifted wherein the Advisory Board consists of renowned U.S. Scientists and the Voters** for the Molecule of the Year are Presidents of Organizations in Molecular and Cell Biology and Biotechnology and related fields representing their countries, a continent and the international arena?

The Answer is ISMCBBPR*- International Society for Molecular and Cell Biology and Biotechnology Protocols and Researches.

**The Molecule of the Year winners have encyclopedic inclusion in featured articles starting 2009 to 2012 with these Voters. Thanks a lot.

"My greatest appreciation to all of you. Thank you very much."

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Why Am I doing these? Due to the worrisome Pandemic... I would like to extend my appreciation to those who have been a part of my achievements. At least this will generate smiles of remembrances and happiness.

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Greetings to all my Colleagues, Co- RA's in neighboring labs, Mentors and Everyone I worked with and met at the University Southern California School of Medicine Pathology/Clinical Laboratories and the LAC+ USC Medical Center!

"My greatest appreciation to all of you. Thank you very much."

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Vaccines and Mutants- Feb 8 and 9, 2021 articles

Here are the Links: 1, 2, 3

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Everyday--

We are Co- Evolving with the Virus, molecularly and cellularly... and "we are peeking through the hole" trying to know- What are the Improvements of the Immune System in the long run? Let's be Optimistic. But always possess and wear properly, the PPE and practice all the precautions - Goal is to lower viral titer of infection or no (new) viral introduction at all... besides others mentioned in my above posts. Take the necessary supplements (e.g. Zinc in Vits). Ask your M.D. Avoid stress and Enjoy Life!

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TRACKERS

I think I have this link posted above regarding the status of vaccines being developed. But it would be nice if I do create a link of it here again considering that this new page is continuously updated with news articles/data and it will be difficult to scroll back to find it. Here is the Link from NYT. Thanks to NYT. But what bothers me is a-

Tracker for the Effects of these approved vaccines currently being used to humans who received it. Some people in some countries are skeptical of having themselves vaccinated. So hopefully there will be a Tracker which is similar to the link above but this time it has something to do with its effects to the patients (as well as to the virus; variants or not) who were vaccinated. There will be specific items which will be included to describe its effect in detail.

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WHO (educational video) on Vaccines. Here is the link.

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Scientific Question-

Which of my International Scientific Positions has benefited the world, including the Philippines in the taxonomic classification and wholesome knowledge in Eumycetozoans?

The Answer is Research Associate* of the Planetary Biodiversity Inventory: Global Biodiversity of Eumycetozoans.

The country's researches in Eumycetozoans are being undertaken by the excellent biodiversity researchers of the University of Santo Tomas.

"My greatest appreciation to all of you. Thank you very much."

*Please scroll up to read about the PBI: Global Biodiversity of Eumycetozoans

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Scientific Question-

Which of the country in the world did I had my first external advisory for an undergraduate thesis*?

The answer is CANADA at Bishop’s University, Sherbrooke, Quebec, Canada. I also have to thank the Central Philippine University Biology Laboratory, Iloilo City, Philippines for the use of laboratory facilities.

*Please visit the first page regarding this.

"My greatest appreciation to all of you. Thank you very much."

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Continuation with the Procrastination matters (see above)-

I have to thank the significant people involved from the University of San Agustin*, Iloilo City, Philippines for bringing the Ford Foundation Program Application in my residence c/o a kind person which I received later when I arrived at home but I was not able to push through with it because I was inundated with a lot of activities- in international level during that time. But thanks for that surprise!

*USA HS alma mater

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Also to Thank all the Organizers and the Persons In-charge that came from various schools and institutions in Iloilo (UPV, SEAFDEC, CPU, WVSU) and of course the Participants to the Days with the Fulbright Senior Specialist*, a part of the program of the International Society for Molecular and Cell Biology Protocols and Researches, Inc., Iloilo City, Philippines Part 1 August 27- Sept. 09, 2006; Part II December 2006

*Please see first page for information dissemination in a SEAFDEC Journal and the links.

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My Novel/Book (Yelwa- Yauri Beautiful Tears) dedicated* to the People of Africa especially to the people of Yelwa, Yauri in Nigeria has garnered almost 700 likers (2/23/2021) in such a short span of time** mostly from the African continent. Sometimes I am thinking of hurling the book to relevant institutions/persons abroad for us to work on it (e.g. movie) before it will be publicly disseminated. But there are barriers because of the current pandemic.

*elevating it for the whole African continent

To the Likers- Thank you very much for the continuing support.

**see post above

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Vaccines? Variants? Lessons Learned

Why is there a need to continuously prepare? Here is the Link.

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Some Reading Materials (mostly written on Feb 2021)

Not Hopeful but Grateful during the Pandemic. Here is the Link (not dated)

Science policies by the US President. Here is the Link.

People with extremist views, are they good in doing complex mental tasks? Here is the Link

WHO: Insurance* for People with serious side effects for the COVAX. Here is the Link.

*I hope this could be realized readily especially for third world countries.

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Feb. 23, 2021

The California SARS COV2 Variant*... Dangerous? Here is the Link.

*A "California variant" was mentioned in a linked article in a post above about the San Diego Scientists studying whether the current vaccines are effective againsts the new strains of SARS COV 2

Feb 25, 2021

About the New York Variant. Here is the Link.

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March 13, 2021

A Philippine variant has been detected in Japan. There are plans of having a universal vaccine (see above post) but this fast production of variants, would direct the minds of how to deal with this. First, what part (including the mechanisms associated with it) of the virus has the greatest frequency of mutations? (Part of the mutation has been cited in the Philippine variant article). And from there, probably means of controlling it like producing quite a "specific but how broad" type of antibodies. And a much faster of vaccine production. I think the mRNA vaccine producers have found the expertise of assembling or manufacturing it in a quick but scientific and highly functioning manner. On Viral Mutations... unless you have found a more updated article. Here is the link..

*If these mutations have products that are independent of antibodies or as a result of these antibodies, then other products such as drugs (e.g. used in HIV) and other molecular elements may be used. Vaccine plus these other molecular products may be the next target.

Literatures needed to augment the above information:

*Viral Genome of SARS COV2 strain for COVID 19

*Viral probes used what ever nucleic acid forms

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March 4, 2021 Evolving Views of the Scientists Regarding COVID 19

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Cultural Adaptations/Changes Outside of Humans

When one deals with culture then we are after a population of similar species and there are particular adaptations and changes in their very own "culture". I talked about this when I saved a P. goiavier birdling for a night (please see post above -Theory of Human Familiarity) and I was able to observe particular behavior where in I could say that it was taught by its parents to behave that way considering that its ancestry (?) (a couple of pairs) had been studied (in an ambient/friendly manner) by me (Please see post above: Wildlife gives us a surprise) in the same place where the birdling was found. Now here are two articles, where these "cultural observations" have been studied by scientists. One is a Bird and the other is a Whale.

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For Genetics and Fish Breeding Class

Use of GMO (Genetically Modified Organism)

GMO is also known as genetically engineered organism. Therefore there is gene insertion (for instance using recombinant DNA techniques) let us say in a cell (e.g. zygote) and this is incorporated and copied in every cells' chromosomes leading to the organism with superior phenotype(s). In case, the superior phenotype produced is by hormonal then crossing over after a series of generations then it is no other than breeding, probably a superior procedure in breeding. If you observed the latter has no gene insertion so it is not a transgenic animal. Then the crossing over fits the (laws of) Mendelian Inheritance and considering that the gene(s) (e.g. in a chromosome like in the YY-> there was an attempt to i.d. this but I have no present idea about it) for that superior phenotype has not been identified, then having it as a candidate for a GMO is not possible. It remains phenotypic so Mendelian (e.g. smooth seeds X wrinkled seeds produce a percentage of wrinkled seeds etc.; follows the Mendelian laws but no phenotypic gene was identified).But let us say the gene for that superior phenotype has been discovered, isolated and purified and it is available for gene insertion to produce a transgenic animal, then it is now appropriately called a GMO. So say goodbye to Mendelian Genetics (Phenotypic). You are now entering the world of Molecular Genetics (rooting out for the Gene(s).

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Welcome to my New Page. The reason why I built a new one is written in this published page.

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