We are actively looking for highly motivated students to:
a) Explore role of HSPs in modulating neurodegenerative diseases, particularly Tauopathy and ALS.
b) Understand inflammatory response through chaperone-dependent cytoskeleton regulation.
Contact us at: vimlesh@iiserb.ac.in or neurogenetics.iiserb@gmail.com for
further information.
Recently published work:
https://doi.org/10.7554/eLife.104691.1
Summary: In axons, Pfdn5 physically associates with microtubules and stabilizes them. Loss of Pfdn5 facilitates dislodging of microtubule-associated Tau, resulting in Tau-aggregate formation and stepping up the early onset of Tauopathies. Pfdn5 suppresses Tau-aggregation in a manner that involves microtubule stability and does not appear to regulate Tau solubility directly. Notably, neuronal overexpression of Pfdn5 suppresses the microtubule disruption even in aged flies, thereby inhibiting the progression of Tauopathy.
Lab News:
20th-22nd August, 2025: Zeeshan (currently working at UCSD, USA) visited the lab. It was great to catch-up (some science) with him after about 8 years!
28th July 2025: Biteshwari and Shruti join the group as graduate students. Welcome to the lab!
20th June 2025: Anjali defends her PhD work. Congratulations, Dr. Anjali Bisht!
01 Jan 2025: Priyabarta joins the group as a graduate student. Welcome to the Neuorogenetics lab!
23 Dec 2023: Anjali's paper demonstrating a novel role of Prefoldins in Tauopathy, got published in eLife (RP) (https://doi.org/10.7554/eLife.104691.1). Congratulations Anjali!
Anjali received the prestigious Trainee Professional Development Award at the Society for Neuroscience annual meeting 2024 in Chicago.
Srikanth received the best poster award at the Organelle Biology and Membrane Trafficking Meeting 2024, IISER Pune.
