Characterization of the function of vascular pathways in nervous system development and plasticity
Characterization of key signaling pathways regulating the blood-brain barrier
Neuronal pathways governing angiogenesis
Identifying novel roles for neuronal pathways influencing angiogenesis
The nervous and the vascular system share the same molecular vocabulary. We have contributed to show that classical neuronal cues also modulate the vascularization of the central nervous system (CNS). These molecules with a dual role in both systems are named angioneurins.
Neuronal and vascular patterning in the Zebrafish
Instructive roles of the vasculature on the neuronal organization in the embryonic and adult zebrafish
We are interested in elucidating the molecular pathways involved in the crosstalk between vascular and nervous systems and how this crosstalk signaling is integrated among the different cellular players (neurons, endothelial cells, glial cells) during the development and homeostasis of zebrafish trunk and brain.
Endothelial heterogeneity in the CNS
Study of endothelial cell heterogeneity in the CNS
Using up-to-date transcriptomic approaches, we investigate the characteristics of different subtypes of endothelial cells in the brain and how the neurovascular interface modulates their molecular signature in different physiological and pathological scenarios.
Homeostatic regulation of dendritic spines
Molecular mechanisms regulating homeostatic changes at dendritic arbors and dendritic spines
Structural plasticity is a fundamental process accompanying both Hebbian and homeostatic synaptic plasticity and it is necessary for proper circuit wiring and maintenance.
Synaptic and extracellular nucleotide signaling in the CNS
Vessels with EC tip cells