Research Activities & Projects

Our Projects

Micro-Biomechanical Modeling and Simulation of Endothelial Cells Migration under the Flow Exposure

Thesis project of Mr. Dicky Setianto

The presence of a stent in an intravascular therapy, causing in the disturbances of the blood flow profile. It causes the changes of the wall shear stress (WSS) value and leads to the mechanotransduction effect in endothelial cells lining on the blood vessel wall such as change of orientation, migration and elongations. In this research, we would like to simulate the phenomenon of ECs migration under blood flow exposure using CFD simulation integrated by Cell Migration dynamic modelling based on agent based modeling . Also we will optimize the model to find the most representative one by using weighing factor for each forces, for further predictions and understanding about the ECs mechanism under the flow exposure.

ECs migration simulation

Droplet dispensing simulation

Droplet Dynamics in Microfluidic Liquid Dispenser

Thesis project of Mr. Petrus Diyos Widhi Prasetya

This project utilize the numerical simulation method (computational fluid dynamics - CFD) to to gain more insight on the optimal criteria of dispensing behavior on a commercial nanoliter liquid dispenser robot. We tries to understand the effect of various dispensing parameters to the generation process of droplet forming and estimate the droplet size, form, and volume from the simulation. The results are evaluated using the experimental measurement of the real dispensing system with image based measurement method.

Development of A Blood Flow Simulator Using Additive Manufacturing and Advanced Flow Sensor

final project of Ms. Fara Azzahra Dinata & Mr. Hadyan Fawwaz Anshori

Collaboration with Dr. Muhammad Salman Al Farisi, Hiroshima City University, Japan.

this final project will focus on developing a blood flow evaluation device (simulator) to represent the hemodynamic conditions within the vessels using a CT-scanned realistic blood vessel and also idealized blood vessel model with aneurysm or stenotic part which has been fabricated using 3D printer. For assessing the flow performance along the vessel model, we also develop a MEMS-based fluid flow rate will be tested for in situ measurements. Further information on the flow conditions on the measurement points can also be evaluated, compared, and used as a correction factor for the numerical simulation (CFD) of the same blood flow system.

Flow circuit with 3D printed blood vessel model

Numerical Simulation of Droplet Microfluidic Device

final project of Ms. Febricetta Z. Sarwono & Ms. Ariyani Saputro

This project research focuses on the numerical simulation of droplet formation in microfluidic devices using two-dimensional computational fluid dynamics (CFD) scheme. The numerical simulation results successfully provide a comprehensive understanding of the droplet formation scheme based on shear stress, pressure, and velocity values at the droplet formation point. Additionally, the simulation results exhibit comparative trends with the experimental results from previous research regarding channel height and flow rate variations, also assessing the performance of different design of microfluidic channels.

Simulation of droplet generation systems, with blue part represented oil and red part is water

Trials on stent-in-stent geometry construction

Analysis of Hemodynamics Behavior Towards Macrostructural Design Parameter of Double Stent

final project of Mr. M. Rafi Sudrajat

In clinical practice, the flow diverter stent insertion procedure can be modified, for example, the addition of a secondary stent after the first deployed stent can be used to reduce the stent porosity that hopefully can increase the success of the therapy. The analysis of the hemodynamics response to the macrostructural parameter of a double stent is carried out by using wall shear stress (WSS) and mass inflow rate (IR) as hemodynamics parameters, twist angle between the first and second deployed stent, and the stent's cell number as macrostructural parameters.

Fast Virtual Stenting Simulations and Post-Stenting CFD Simulation for Aneurysm & Stenosis (2020-now)

final project of Mr. B. Nainggolan , Mr. M. Hilliard, & Mr. M. Ihsan Maulana

The use of flow diverter (FD) stents is one of the treatment options where blood flow to the aneurysm is diverted back into the parent vessel without having to directly block the aneurysm, thus allowing the aneurysm to heal naturally. FDs are commonly imported which contributes to the economic burden of the healthcare system. Therefore, there is motivation to start producing FDs domestically. To be able to independently produce FDs, a method to evaluate the efficacy of FD designs before having clinical trials is needed. In this work, a fast virtual stenting algorithm which employ a spring expansion model is implemented along with a method to evaluate the performance of deployed FDs based on Computational Fluid Dynamics (CFD) simulations, both of which are fully based on open-source softwares.

Since the end of 2021, we expand the project which involves the devices-vessel contact conditions and the application for opening a stenosis plaque by balloon angioplasty.

Reference
Nainggolan B, Putra NK, Suprijanto, ICA conference 2021.

Illustration of flow diverter stent's deployment inside the realistic blood vessel model.

Illustration of balloon angioplasty deployment inside the ideal blood vessel model

Illustration of flow simulation around the S-AVS catheter's tip with variation of the notches shape .

Design Exploration on the Micro catheter Tip Geometrical Shape to Improve the Blood Sampling Performance during Segmental Adrenal Venous Sampling (S-AVS) Procedures (2020-2021)

Collaborations project with Biomedical Fluid Dynamics Laboratory, IFS Tohoku & Tohoku University Hospital., and Dept. of Aeronautics, FMAE ITB.

Collaborators: Prof. Makoto Ohta, Dr. Hitomi Anzai, Dr. Tomo Kinoshita, MD., Dr. Pramudita Satria Palar.

Final project of Ms. J. Muliany

Segmental adrenal venous sampling (S-AVS) is believed to be a gold standard on the diagnosis of aldosterone producing adenoma (APA) that cause hypertension. In this project, an exploration of the split-tip microcatheter design is performed as an effort to explain its effects in the (S-AVS) procedure. Exploration of the microcatheter’s design variables, namely the amount and depth of the notches, was carried out in silico through computational fluid dynamics (CFD) simulations and metamodel construction of the system response.

Reference

Kinoshita, T. et al. (2019)Med. & Bio. Eng. & Comp..

Study on Different Boundary Conditions Effects in Biofluidic Computational Simulation (2019 - 2021)

final project of Mr. P.C.A.Santosa

Intravascular bloodflow simulations always try to resemble blood flow in real condition. However many studies on this field have applied simplification of the fluid characteristics e.g. non-Newtonian fluid, no pulsatile flow, and rigid wall assumptions. In this project, we try to do an evaluation of the boundary conditions in the stenotic Internal Carotid Artery (ICA) simulations to observe how the different boundary conditions setting may effect the simulation results. We also try to compare the results of simulations with Newtonian, pulsatile and fluid-structure interactions (FSI) flow conditions to the simulation which include the aforementioned simplified boundary conditions.

Illustration of flow conditions inside a stenotic plaque relatives to the change of velocity pattern of the blood flow.

Modeling and Simulations of Suspended-Load Backpack Design to Reduce Musculoskeletal Load during Dynamics Activities (2019-2021)

Collaborations project with Ergonomics Lab, Product Design, Faculty of Art and Design, ITB .

Collaborators: Dr. Andar Bagus Sriwarno, Mr. Harmein Khagi

final project of Ms. M. Kurnia, Mr. D.F.E.Faiz & Mr. M. Fadhil

We are developing a novel suspended-load backpack design which believed to be effective in reducing the mechanical loads on the user's musculoskeletal systems. In this research we evaluate the backpack performance using image based motion and gait analysis also electromyography biosignal analysis to do the improvement of the backpack design. This including its spring-mass configurations and other dynamical properties of the backpack system to optimized its performance.

References:

Putra, NK, et al. (2020) IOS science, 2020.

Illustration of motion analysis and biofeedback measurement on the evaluation of suspended-load backpack design.

CFD results of the flow pattern and behaviour inside the flow chamber.

CFD based Endothelial Cells Distributions' Prediction on In Vitro Experiments (2018 - now)

Collaborations project with Biomedical Fluid Dynamics Laboratory, IFS Tohoku.

Collaborators: Prof. Makoto Ohta, Dr. Hitomi Anzai, Mr. Zi Wang

Numerical simulations know as a powerful tools to predict the flow behavior on the fluid systems. In this research, we try to use CFD as a prediction tools to observed the flow behaviour on the small cellular flow chamber experiment. On the experiment, Endothelial Cells (ECs) have been cultured and exposed to the flow. post-flow exposure. This research found that CFD founds that WSS effects and flow pattern on the chamber have a significant influence to the distributions of ECs and the endothelialization process.

References:

Putra, NK, et al. (2018) The 40th EMBC 2021 .

Wang Z, et al. (in press) Frontiers in Physiol.

Design Exploration and Optimization of Intravascular Stent Geometry with Vessel Wall Deformation (2015 - 2018)

Ph.D. Project at Graduate School of Engineering, Tohoku University. Performed at Biomedical Flow Dynamics Laboratory, Institute of Fluid Science, Tohoku University.

Supervisors: Prof. Makoto Ohta, Dr. Hitomi Anzai

Collaborators: Dr. Koji Shimoyama, Dr. Pramudita Satria Palar

The stent geometrical design (e.g., inter-strut gap, length, and strut cross-section) is responsible for stent–vessel contact problems and changes in the blood flow. These changes are crucial for causing some intravascular abnormalities such as vessel wall injury and restenosis. Therefore, structural optimization of stent design is necessary to find the optimal stent geometry design. In this study, we performed a multiobjective stent optimization for minimization of average stress and low wall shear stress ratio while considering the wall deformation in 3D flow simulations of triangular and rectangular struts. Surrogate-based optimization with Kriging method and expected hypervolume improvement (EHVI) are performed to construct the surrogate model map and find the best configuration of inter-strut gap and side length .

the obtained non-dominated solutions the objective domain (left) and comparison of its flow pattern around the rectangular strut respected to the non-dominated points a and b (right).

References:

Putra, NK, et al. (2019) Medical & Biological Engineering & Computing 57:15-26.
Putra, NK, et al. (2017), 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), p. 1344-1347.
Putra, NK, et al. (2017), World Congress of Structural and Multidisciplinary Optimisation (WCSMO), p. 1097-2109.

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