Publications
ORIGINAL ARTICLES (PEER REVIEWED)
Zhao B, Peng Y, Itakura Y, Lizanda M, Haga Y, Satoh S, Navarro JC, Monroig Ó, Kabeya, N. A complete biosynthetic pathway of the long-chain polyunsaturated fatty acids in an amphidromous fish, ayu sweetfish Plecoglossus altivelis (Stomiati; Osmeriformes). Biochim. Biophys. Acta (BBA) - Mol. Cell Biol. Lipids 1869, 159498 (2024). https://doi.org/10.1016/j.bbalip.2024.159498
Ribes-Navarro, A., Kabeya, N., Castro, L.F.C., Gomes-dos-Santos, A., Fonseca, M.M., Alberts-Hubatsch, H., Hontoria, F., Navarro, J.C., Monroig, Ó. Examination of gammarid transcriptomes reveals a widespread occurrence of key metabolic genes from epibiont bdelloid rotifers in freshwater species, Open Biol. 13, 230196 (2023). https://doi.org/10.1098/rsob.230196
Matsushita, Y., Kabeya, N., Kawamura, W., Haga, Y., Satoh, S. & Yoshizaki, G. Capability of DHA biosynthesis in a marine teleost, Pacific saury Cololabis saira: functional characterization of two paralogous Fads2 desaturases and Elovl5 elongase. Fish. Sci. 89, 687–698 (2023). https://doi.org/10.1007/s12562-023-01710-9
Kabeya, N., Kimura, K., Matsushita, Y., Suzuki, S., Nagakura, Y., Kinami, R., Noda, H., Takagi, K., Okamoto, K., Miwa, M., Haga, Y., Satoh, S. & Yoshizaki, G. Determination of dietary essential fatty acids in a deep-sea fish, the splendid alfonsino Beryx splendens: functional characterization of enzymes involved in long-chain polyunsaturated fatty acid biosynthesis. Fish Physiol. Biochem. 49, 425–439 (2023). https://doi.org/10.1007/s10695-023-01192-7
Tansutaphanit, S., Haga, Y., Kabeya, N., Matsushita, Y., Kondo, H., Hirono, I. & Satoh, S. Impact of purine nucleotide on fatty acid metabolism and expression of lipid metabolism-related gene in the liver cell of rainbow trout Oncorhynchus mykiss. Comp. Biochem. Physiol. B 266, 110845 (2023). https://doi.org/10.1016/j.cbpb.2023.110845
Boyen, J., Ribes‐Navarro, A., Kabeya, N., Monroig, Ó., Rigaux, A., Fink, P., Hablützel, P., Navarro, J.C. & Troch, M.D. Functional characterization reveals a diverse array of metazoan fatty acid biosynthesis genes. Mol. Ecol. 32, 970–982 (2023). https://doi.org/10.1111/mec.16808
Ramos-Llorens, M., Ribes-Navarro, A., Navarro, J.C., Hontoria, F., Kabeya, N. & Monroig, Ó. Can Artemia franciscana produce essential fatty acids? Unveiling the capacity of brine shrimp to biosynthesise long-chain polyunsaturated fatty acids. Aquaculture 563, 738869 (2023). https://doi.org/10.1016/j.aquaculture.2022.738869
Yoldas, G.Y., Ueda, S., Takino, T., Seong, T., Kabeya, N., Satoh, S., Haga, Y. Effects of an enzyme complex-treated rice protein concentrate on growth performance and feed utilization of rainbow trout Oncorhynchus mykiss Juveniles. Aquac. J. 2, 316–325 (2022). https://doi.org/10.3390/aquacj2040019
Seong, T., Matsuyoshi, J., Haga, Y., Kabeya, N., Kitagima, R., Miyahara, J., Koshiishi, T. & Satoh, S. Utilization of microalgae Schizochytrium sp. in non-fish meal, non-fish oil diet for yellowtail (Seriola quinqueradiata). Aquaculture Res. 53, 2042– 2052 (2022). https://doi.org/10.1111/are.15732
Seong, T., Uno, Y., Kitagima, R.E., Kabeya, N., Haga, Y. & Satoh, S. Microalgae as main ingredient for fish feed: Non‐fish meal and non‐fish oil diet development for red sea bream, Pagrus major, by blending of microalgae Nannochloropsis, Chlorella and Schizochytrium. Aquaculture Res. 52, 6025–6036 (2021). https://doi.org/10.1111/are.15463
Ridwanudin, A., Kasuya, H., Haga, Y., Kabeya, N. & Satoh, S. Interactive effect of dietary fish oil and pyrimidine nucleotides supplementation on the fatty acid composition of juvenile rainbow trout Oncorhynchus mykiss: Enhancement of ARA and DHA contents in the fillet of fish fed supplemented diet. Aquaculture Res. 52, 4934–4945 (2021). https://doi.org/10.1111/are.15327
Twining, C., Bernhardt, J., Derry, A., Hudson, C., Ishikawa, A., Kabeya, N., Kainz, M., Kitano, J., Kowarik, C., Ladd, S.N., Leal, M., Scharnweber, K., Shipley, J. & Matthews, B. The evolutionary ecology of fatty-acid variation: Implications for consumer adaptation and diversification. Ecol. Lett. 24, 1709–1731 (2021). https://doi.org/10.1111/ele.13771
De la Cruz-Alvarado, F.J., Álvarez-González, C.A., Llera-Herrera, R., Monroig, Ó., Kabeya, N., Rodríguez-Morales, S., Concha-Frias, B., Guerrero-Zárate, R., Jiménez-Martínez, L.D. & Peña-Marín, E.S. Expression of long-chain polyunsaturated fatty acids biosynthesis genes during the early life-cycle stages of the tropical gar Atractosteus tropicus. Comp. Biochem. Physiol. B 256, 110628 (2021). https://doi.org/10.1016/j.cbpb.2021.110628
Kabeya, N., Ogino, M., Ushio, H., Haga, Y., Satoh, S., Navarro, J.C. & Monroing, Ó. A complete enzymatic capacity for biosynthesis of docosahexaenoic acid (DHA, 22:6n–3) exists in the marine Harpacticoida copepod Tigriopus californicus. Open Biol. 11, 200402 (2021). https://doi.org/10.1098/rsob.200402
Nakamura, K., Gonzales-Plasus, M.M., Ushigusa-Ito, T., Masuda, R., Kabeya, N., Kondo, H., Hirono, I., Satoh, S. & Haga, Y. Taurine synthesis via the cysteic acid pathway: effect of dietary cysteic acid on growth, body taurine content, and gene expression of taurine-synthesizing enzymes, growth hormone, and insulin-like growth factor 1 in Japanese flounder Paralichthys olivaceus. Fish. Sci. 87, 353–363 (2021). https://doi.org/10.1007/s12562-021-01500-1
Ribes-Navarro, A., Navarro, J.C., Hontoria, F., Kabeya, N., Standal, I.B., Evjemo, J.O. & Monroig, Ó. Biosynthesis of long-chain polyunsaturated fatty acids in marine gammarids: Molecular cloning and functional characterisation of three fatty acyl elongases. Mar. Drugs 19, 226 (2021). https://doi.org/10.3390/md19040226
Matsushita, Y., Miyoshi, K., Kabeya, N., Sanada, S., Yazawa R., Haga, Y., Satoh, S., Yamamoto, Y., Strüssmann, C.A., Luckenbach, J.A., Yoshizaki, G. Flatfishes colonized freshwater environments by acquisition of various DHA biosynthetic pathways. Commun. Biol. 3, 516 (2021). https://doi.org/10.1038/s42003-020-01242-3
Kabeya, N., Gür, İ., Oboh, A., Evjemo, J.O., Malzahn, A., Hontoria, F., Navarro, J.C. & Monroig, Ó. Unique fatty acid desaturase capacities uncovered in Hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading. Phil. Trans. R. Soc. B 375, 20190654 (2020). https://doi.org/10.1098/rstb.2019.0654
Galindo, A., Garrido, D., Monroig, Ó., Pérez, J.A., Betancor, M.B., Acosta N.G., Kabeya, N., Marrero, M.A., Bolaños, A. & Rodríguez, C. Polyunsaturated fatty acid metabolism in three fish species with different trophic level. Aquaculture 530, 735761 (2020).
Garrido, D., Monroig, Ó., Galindo, A., Betancor, M.B., Pérez, J.A., Kabeya, N., Marrero, M. & Rodríguez, C. Lipid metabolism in Tinca tinca and its n-3 LC-PUFA biosynthesis capacity. Aquaculture 523, 735147 (2020). https://doi.org/10.1016/j.aquaculture.2020.735761
Garrido, D., Kabeya, N., Betancor, M.B., Pérez, J.A., Acosta, N.G., Tocher, D.R., Rodríguez, C. & Monroig, Ó. Functional diversification of teleost Fads2 fatty acyl desaturases occurs independently of the trophic level. Sci. Rep., 9, 11199 (2019). https://doi.org/10.1038/s41598-019-47709-0
Garrido, D., Kabeya, N., Hontoria, F., Navarro, J.C., Reis, D.B., Martín, M.V., Rodríguez, C., Almansa, E. & Monroig, Ó. Methyl-end desaturases with ∆12 and ω3 regioselectivities enable the de novo PUFA biosynthesis in the cephalopod Octopus vulgaris. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864, 1134–1144 (2019). https://doi.org/10.1016/j.bbalip.2019.04.012
Ishikawa, A., Kabeya, N., Ikeya, K., Kakioka, R., Cech, J.N., Osada, N., Leal, M.C., Inoue, J., Kume, M., Toyoda, A., Tezuka, A., Nagano, A.J., Yamasaki, Y.Y., Suzuki, Y., Kokita, T., Takahashi, H., Lucek, K., Marques, D., Takehana, Y., Naruse, K., Mori, S., Monroig, Ó., Ladd, N., Schubert, C.J., Matthews, B., Peichel, C.L., Seehausen, O., Yoshizaki, G. & Kitano, J. A key metabolic gene for recurrent freshwater colonization and radiation in fishes. Science 364, 886–889 (2019). https://doi.org/10.1126/science.aau5656
Semmelmann, S., Kabeya, N., Malcicka, M., Bruckmann, A., Broschwitz, B., Straub, K., Merkl, R., Monroig, Ó., Sterner, R., Ruther, J. & Ellers, J. Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia. J. Exp. Biol. 222, jeb201038 (2019). https://doi.org/10.1242/jeb.201038
Yazawa, R., Takeuchi, T., Machida, Y., Amezawa, K., Kabeya, N., Tani, R., Kawamura, W. & Yoshizaki, G. Production of triploid eastern little tuna, Euthynnus affinis (Cantor, 1849). Aquaculture Res. 50, 1422–1430 (2019). https://doi.org/10.1111/are.14017
Vasconcelos, A.C.N., Streit Jr, D.P., Octavera, A., Miwa, M., Kabeya, N. & Yoshizaki, G. The germ cell marker dead end reveals alternatively spliced transcripts with dissimilar expression. Sci. Rep. 9, 2407 (2019). https://doi.org/10.1038/s41598-019-39101-9
Vasconcelos, A.C.N., Streit Jr, D.P., Octavera, A., Miwa, M., Kabeya, N., Garcia, R.R.F., Rotili, D.A. & Yoshizaki, G. Isolation and characterization of germ cell marker in teleost fish Colossoma macropomum. Gene 683, 54–60 (2019). https://doi.org/10.1016/j.gene.2018.10.027
Lopes-Marques, M., Kabeya, N., Qian, Y., Ruivo, R., Santos, M., Venkatesh, B., Tocher, D.R., Castro, L.F.C. & Monroig, Ó. Retention of fatty acyl desaturase 1 (fads1) in Elopomorpha and Cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates. BMC Evol. Biol. 18, 157 (2018). https://doi.org/10.1186/s12862-018-1271-5
Ferraz, R.B., Kabeya, N., Lopes-Marques, M., Machado, A.M., Ribeiro, R.A., Salaro, A.L., Ozório, R., Castro, L.F.C. & Monroig, Ó. A complete enzymatic capacity for long-chain polyunsaturated fatty acid biosynthesis is present in the Amazonian teleost tambaqui, Colossoma macropomum. Comp. Biochem. Physiol. B 227, 90–97 (2018). https://doi.org/10.1016/j.cbpb.2018.09.003
Machado, A.M., Tørresen, O.K., Kabeya, N., Couto, A., Petersen, B., Felício, M., Campos, P., Fonseca, E., Fonseca, M., Bandarra, N., Lopes-Marques, M., Ferraz, R., Ruivo, R., Jentoft, S., Monroig, Ó., da Fonseca, R. & Castro, L.F.C. “Out of the can”: A draft genome assembly, liver transcriptome and nutrigenomics of the European sardine, Sardina pilchardus. Genes 9, 485 (2018). https://doi.org/10.3390/genes9100485
Kabeya, N., Fonseca, M.F., Ferrier, D.E.K., Navarro, J.C., Bay, L.K., Francis, D., Tocher, D.R., Castro, L.F.C. & Monroig, Ó. Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals. Sci. Adv. 4, eaar6849 (2018). https://doi.org/10.1126/sciadv.aar6849
Kabeya, N., Yevzelman, S., Oboh, A., Tocher, D.R. & Monroig, Ó. Essential fatty acid metabolism and requirements of the cleaner fish, ballan wrasse Labrus bergylta: Defining pathways of long-chain polyunsaturated fatty acid biosynthesis. Aquaculture 488, 199–206 (2018). https://doi.org/10.1016/j.aquaculture.2018.01.039
Takeuchi, Y., Yatabe, T., Yoshikawa, H., Ino, Y., Kabeya, N., Yazawa, R. & Yoshizaki, G. Production of functionally sterile triploid Nibe croaker Nibea mitsukurii induced by cold-shock treatment with special emphasis on triploid aptitude as surrogate broodstock. Aquaculture 494, 45–56 (2018). https://doi.org/10.1016/j.aquaculture.2016.05.030
Before 2017
Kabeya, N., Chiba, M., Haga, Y., Satoh, S. & Yoshizaki, G. Cloning and functional characterization of fads2 desaturase and elovl5 elongase from Japanese flounder Paralichthys olivaceus. Comp. Biochem. Physiol. B 214, 36–46 (2017).
Oboh, A., Kabeya, N., Carmona-Antoñanzas, G., Castro, L.F.C., Dick, J.R., Tocher, D.R. & Monroig, Ó. Two alternative pathways for docosahexaenoic acid (DHA, 22:6n–3) biosynthesis are widespread among teleost fish. Sci. Rep. 7, 3889 (2017).
Kabeya, N., Sanz-Jorquera, A., Carboni, S., Davie, A., Oboh, A. & Monroig, Ó. Biosynthesis of polyunsaturated fatty acids in sea urchins: molecular and functional characterisation of three fatty acyl desaturases from Paracentrotus lividus (Lamark 1816). PLOS ONE 12, e0169374 (2017).
Yazawa, R., Takeuchi, Y., Satoh, K., Machida, Y., Amezawa, K., Kabeya, N. & Yoshizaki G. Spawning induction and seed production of Eastern little tuna, Euthynnus affinis (Cantor, 1849), in the post- and pre-spawning seasons by hormonal treatment in a semi-closed recirculation system with elevated temperature. Aquaculture Res. 48, 3472–3481 (2017).
Yoshikawa, H., Takeuchi, Y., Ino, Y., Wang, J., Iwata, G., Kabeya, N., Yazawa, R. & Yoshizaki, G. Efficient production of donor-derived gametes from triploid recipients following intra-peritoneal germ cell transplantation into a marine teleost, Nibe croaker (Nibea mitsukurii). Aquaculture 478, 35–47 (2017).
Kabeya, N., Takeuchi, Y., Yazawa, R., Haga, Y., Satoh, S. & Yoshizaki, G. Transgenic modification of the n–3 HUFA biosynthetic pathway in nibe croaker larvae: improved DPA (docosapentaenoic acid; 22:5n–3) production. Aquaculture Nutr. 22, 472–478 (2016).
Yazawa, R., Takeuchi, Y., Satoh, K., Machida, Y., Amezawa, K., Kabeya, N., Shimada, Y. & Yoshizaki, G. Eastern little tuna, Euthynnus affinis (Cantor, 1849) mature and reproduce within 1 year of rearing in land-based tanks. Aquaculture Res. 47, 3800–3810 (2016).
Kabeya, N., Yamamoto, Y., Cummins, S.F., Elizur, A., Yazawa, R., Takeuchi, Y., Haga, Y., Satoh, S. & Yoshizaki, G. Polyunsaturated fatty acid metabolism in a marine teleost, nibe croaker Nibea mitsukurii: functional characterization of Fads2 desaturase and Elovl5 and Elovl4 elongases. Comp. Biochem. Physiol. B 188, 37–45 (2015).
Yazawa, R., Takeuchi, Y., Amezawa, K., Sato, K., Iwata, G., Kabeya, N. & Yoshizaki, G. GnRHa-induced spawning of the Eastern little tuna (Euthynnus affinis) in a 70-m3 land-based tank. Aquaculture 442, 58–68 (2015).
Kabeya, N., Takeuchi, Y., Yamamoto, Y., Yazawa, R., Haga, Y., Satoh, S. & Yoshizaki, G. Modification of the n–3 HUFA biosynthetic pathway by transgenesis in a marine teleost, nibe croaker. J. Biotechnol. 172, 46–54 (2014).
Yamamoto, Y.*, Kabeya, N.*, Takeuchi, Y., Higuchi, K., Yatabe, T., Tsunemoto, K., Yazawa, R., Kawamura, T. & Yoshizaki, G. Establishment of a stable transgenic strain in a pelagic egg spawning marine teleost, nibe croaker Nibea mitsukurii. Aquaculture 313, 42–49 (2011). (*These authors contributed equally to this work)
Yazawa, R., Takeuchi, Y., Iwata, G., Kabeya, N., Komoda, A. & Yoshizaki, G. Rearing of Pacific bluefin tuna Thunnus orientalis in a 70 m3 land-based tank system. Aquaculture Sci. 59, 473–481 (2011). [in Japanese with English abstract]
Kabeya, N., Okutsu, T., Yazawa, R., Higuchi, K., Nagasawa, K., Mimori, R., Chuda, H., Hamasaki, M., Takeuchi, Y. & Yoshizaki, G. Identification of bluefin tuna germ cells and larvae by PCR detection of vasa sequence polymorphisms. Fish Genet. Breed. Sci. 39: 115–126 (2010). [in Japanese with English abstract]
Yamamoto, Y., Kabeya, N., Takeuchi, Y., Alimuddin, Haga, Y., Satoh, S., Takeuchi, T. & Yoshizaki, G. Cloning and nutritional regulation of polyunsaturated fatty acid desaturase and elongase of the marine teleost nibe croaker, Nibea mitsukurii. Fish. Sci. 76, 463–472 (2010).
Yazawa, R., Takeuchi, Y., Higuchi, K., Yatabe, T., Kabeya, N. & Yoshizaki, G. Chub mackerel gonads support colonization, survival, and proliferation of intraperitoneally transplanted xenogenic germ cells. Biol. Reprod. 82, 896–904 (2010).
OTHERS (REVIEWS, BOOK CHAPTERS)
Monroig, Ó., Shu-Chien, A.C., Kabeya, N., Tocher, D.R. & Castro, L.F.C. Desaturases and elongases involved in long-chain polyunsaturated fatty acid biosynthesis in aquatic animals: From genes to functions. Prog. Lipid Res. 86, 101157 (2022). https://doi.org/10.1016/j.plipres.2022.101157
Monroig, Ó. & Kabeya, N. Desaturases and elongases involved in polyunsaturated fatty acid biosynthesis in aquatic invertebrates: A comprehensive review. Fish. Sci. 84, 911–928 (2018).
Kabeya, N., Yoshizaki G., Tocher, D.R. & Monroig, Ó. Diversification of Fads2 in finfish species: Implications for aquaculture. In: Cruz-Suárez, L.E., Ricque-Marie, D., Tapia-Salazar, M., Nieto-López, M.G., Villarreal-Cavazos, D. A., Gamboa-Delgado, J., López Acuña, L.M. y Galaviz-Espinoza, M. (Eds), Investigación y Desarrollo en Nutrición Acuícola Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Nuevo León, México, pp. 338–362. ISBN 978-607-27-0822-8 (2017).
吉崎悟朗, 矢澤良輔, 壁谷尚樹, 片山直人 (2017) 「第12章 遺伝子・細胞操作と水産育種における応用」水産遺伝育種学, 中嶋正道, 荒井克俊, 岡本信明, 谷口順彦 編, 東北大学出版会, 宮城, pp.215–227. ISBN 978-4-86163-270-9.