New Targeted Optical Imaging NanoProbes for Near-Infrared (NIR) Real-Time (RT) Image-Guided Surgery of Ovarian Cancer
Frontier Complex Research Project
ESTIMATED RESULTS
Development of novel CA based on phenothiazines and other molecules which exhibit NIR fluorescence, good biocompatibility and specific targeting for FRα of ovarian cancer cells.
Development of nanoparticles/nanoclusters/quatum dots (gold, graphene, etc.) exhibiting intrinsic luminescence/plasmon-enhanced molecular fluorescence in NIR and their testing as potential new CA in solid tissue-like phantoms.
In vitro/in vivo/ex vivo testing and validation of novel fluorescent CA against ovarian cell lines/ovarian xenografts/peritoneal fragments with metastasis in ovarian cancer.
Acquisition and pre-clinical validation of a NIR fluorescence imaging systems (fluorescence surgical microscope).
Building of database of NIR images recorded on animal organ and peritoneal fragments treated by novel CA.