Media:

https://reportermedical.ro/2022/11/02/descoperire-importanta-a-cercetatorilor-clujeni-in-lupta-cu-cancerul-ovarian/

Published articles:

M. Gal, L. Gaina, T. Lovasz, E. Gal, A-M. Craciun, M. Focsan, A. Turza, D. Rugina,A.M.V. Brânzanic, S. Pesek, R. Silaghi-Dumitrescu, C. Cristea, Sonochemical synthesis, optical properties and DFT studies on novel (N-arylamino)phenothiazinium dyes suitable for fluorescence cells imaging, Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 124768 (2024)  (IF = 4.3).

Bianca Stoean, Iulia Lupan, Castelia Cristea, Mihaela Silion, Luminita Silaghi-Dumitrescu, Radu Silaghi-Dumitrescu, Luiza Ioana Gaina, Outcomes of folic acid esterification upon the properties of hydrophilic phenothiazinium dyes: New photosensitizers for antimicrobial photodynamic therapy, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 451 (2024) 115500  (IF = 4.1).

Cristina Coman, Niculina Hădade, Szilárd Pesek, Radu Silaghi-Dumitrescu, Augustin C. Moț , Removal and degradation of sodium diclofenac via radical-based mechanisms using S. sclerotiorum laccase, Journal of Inorganic Biochemistry,  249 (2023) 112400  (IF = 3.8).

Silviu GROZA, Bianca STOEAN, Adriana GROZAV, Ana-Maria CRACIUN, Castelia CRISTEA, Luminita SILAGHI-DUMITRESCU, Dan PORUMB, SYNTHESIS AND OPTICAL PROPERTIES OF NOVEL STRONTIUM TETRANITROPHTHALOCYANINE, STUDIA UBB CHEMIA, LXVIII, 4 (2023) 7-26

M. Gal, C. Cristea, A. M. Craciun, A. Turza, L. Barbu-Tudoran, B. Balazs, T. Lovasz, L. Silaghi-Dumitrescu, L. Ioana Gaina,  New fluorescent electrospun polymer materials containing phenothiazinyl carboxylate metal salts for versatile latent fingerprint detection, Dyes and Pigments, 211 (2023) 111085 (IF = 5.122).

Alexandru Milentie Hada, Ana Maria Craciun, Adriana Vulpoi, Elena Larisa Borcan, Monica Focsan, Simion Astilean, Glutathione-capped gold nanoclusters as near-infrared-emitting efficient contrast agents for confocal fluorescence imaging of tissue-mimicking phantom, Microchimica Acta 189 (2022) 337  (IF = 6.408).

Monica Potara, Sorina Suarasan, Ana Maria Craciun, Monica Focsan, Alexandru Milentie Hada, Simion Astilean, Probing polyvinylpyrrolidone-passivated graphene oxide nanoflakes as contrast agents inside tissue-like phantoms via multimodal confocal microscopy, Talanta 247 (2022) 123581 (IF = 6.556).

Bianca Stoean, Luiza Gaina, Castelia Cristea, Radu Silaghi-Dumitrescu, Adrian Branzanic, Monica Focsan, Eva Fiser-Fodor, Bogdan Tigu, Cristian Moldovan, Andra Cecan, Patriciu Achimas-Cadariu, Simion Astilean, Luminita Silaghi-Dumitrescu, New methylene blue analogues with N-piperidinyl-carbinol units: Synthesis, optical properties and in vitro internalization in human ovarian cancer cells, Dyes and Pigments 205 (2022) 110460 (IF = 5.122).

Janka Leskovská, Natalia Miklášová, Paul Milan Kubelac , Patriciu Achimaş-Cadariu, Jindra Valentová, Mário Markuliak and Eva Fischer-Fodor Antiproliferative Ruthenium Complexes Containing Curcuminoid Ligands Tested In Vitro on Human Ovarian Tumor Cell Line A2780, towards Their Capability to Modulate the NF-κBTranscription Factor, FGF-2 Growth Factor, and MMP-9 Pathway, Molecules 27(14) (2022) 4565 (IF = 4.927).

Andrei Pasca, Eva Fischer-Fodor, Nicoleta Monica Jiboc, Paul Milan Kubelac, Bhaskar Saha, Catalin Ioan Vlad. Patriciu Achimas Cadariu Meta-Analyses Reveal Serum Interleukin-6 As a Biomarker for Malignant Ovarian Neoplasia, 2022 Cytokine (IF = 3.488), editura Elsevier, ISSN 1043-4666, accepted oct 2022

MP Kubelac,C Vlad, B Pop, B Fetica, E Fischer-Fodor, O Soritau, O Balacescu, F Ignat, G Lazar, C Lisencu, A Rancea, A Irimie, P Achimas-Cadariu, Perioperative Dynamic Evaluation of Folate Receptor Alpha Expression in Ovarian Carcinoma, International Journal of Gynecological Cancer, 31 3 (2022) A207-A208, Meeting abstract 190,  (IF = 4.661).

Hada Alexandru-Milentie, Craciun Ana-Maria, Simion Astilean, Intrinsic photoluminescence of solid-state gold nanoclusters: towards fluorescence lifetime imaging of tissue-like phantoms under two-photon near-infrared excitation, Front. Chem. 9 (2021) 761711 (IF = 5.545).

Hada Alexandru-Milentie, Craciun Ana-Maria, Simion Astilean, Gold nanoclusters performing as contrast agents for non-invasive imaging of tissue-like phantoms via two-photon excited fluorescence lifetime imaging, Analyst 146 (2021) 7126-7130  (IF = 5.527). 

Raluca Borlan, Monica Focsan, Simion Astilean, Patriciu Achimas Cadariu, NIR Fluorescence Captures Clear Images of Cancerous Tumors During Surgery, Bio Photonics, Photonics Media- September/October (2021) 38-41.

Raluca Borlan, Monica Focsan, Dana Maniu, Simion Astilean, Review on next generation of dye loaded protein-based nanoparticles for real-time feedback during cancer surgery, Int. J. Nanomedicine 16 (2021) 2147 (IF = 7.033).

Raluca Borlan, Monica Focsan, Maria Perde-Schrepler, Olga Soritau, Andreea Campu, Luiza Gaina, Emoke Pall, Bogdan Pop, Oana Baldasici, Claudia Gherman, Daria Stoia, Dana Maniu and Simion Astilean Antibody-functionalized theranostic protein nanoparticles for the synergistic deep red fluorescence imaging and multimodal therapy of ovarian cancer, Biomater. Sci. 9 (2021) 6183-6202 (IF = 7.59).

Raluca Borlan, Daria Stoia, Luiza Gaina, Andreea Campu, Gabriel Marc, Maria Perde-Schrepler, Mihaela Silion, Dana Maniu , Monica Focsan, and Simion Astilean, Fluorescent Phthalocyanine-Encapsulated Bovine Serum Albumin Nanoparticles: Their Deployment as Therapeutic Agents in the NIR Region, Molecules 26(15) (2021) 4679 (IF = 4.927).

Melinda Gal, Castelia Cristea, Tamas Lovasz, Ana-Maria Craciun,, Alexandru Turza, Dan Porumb, Emese Gal, Gabriel Katona, Luminita Silaghi-Dumitrescu, Luiza Gaina, New fluorescent phenothiazine carboxylates for fluorescent nanomaterials, J. Mol. Struct. 1246 (2021) 131174 (IF = 3.841).

Bianca Stoean, Luiza Gaina, Emese Gal, Castelia Cristea, Tamas Lovasz, Luminita Silaghi-Dumitrescu, Examination of (phenothiazinyl) vinyl-pyridinium dye’s capacity of interaction with DNA, Studia UBB Chemia 66 (2) (2021) 59-66 (IF = 0.447).

Emese Gal, Balazs Brem, Luiza Ioana Gaina, Ana-Maria Craciun, Castelia Cristea, Luminita Silaghi-Dumitrescu, Optical properties of new 5-(phenothiazinyl) methylidenebarbituric acid derivatives, J.  Mol. Struct. 1247 (2021) 131334 (IF = 3.841).

Monica Potara, Timea Nagy-Simon, Monica Focsan, Emilia Licarete, Olga Soritau, Adriana Vulpoi, and Simion Astilean, Folate-targeted Pluronic-chitosan nanocapsules loaded with IR780 for near-infrared fluorescence imaging and photothermal-photodynamic therapy of ovarian cancer, Colloids Surf. B 203 (2021) 111755 (IF = 5.999).         

Bianca Stoean, Dumitrita Rugina, Monica Focsan, Ana-Maria Craciun, Madalina Nistor, Tamas Lovasz, Alexandru Turza, Dan Porumb, Gal Emese, Castelia Cristea, Luminita Silaghi-Dumitrescu, Simion Astilean, Luiza Gaina, Novel (Phenothiazinyl)Vinyl-Pyridinium Dyes and Their Potential Applications as Cellular Staining Agents, Int. J. Mol. Sci. 22(6) (2021) 2985 (IF = 6.2). 

Raluca Ghiman, Nistor Madalina, Monica Focsan, Adela Pintea, Simion Astilean, Dumitrita Rugina, Fluorescent polyelectrolyte system to track anthocyanins delivery inside melanoma cells, Nanomaterials 11 (2021) 782 (IF = 5.079). 

Alexandru-Milentie Hada, Ana-Maria Craciun, Monica Focsan, Raluca Borlan, Olga Soritau, Milica Todea, Simion Astilean, Folic acid functionalized gold nanoclusters for enabling targeted fluorescence imaging of human ovarian cancer cells, Talanta 225 (2021) 121960 (IF = 6.057).

Maria Lehene, Diana Plesa, Stefania Ionescu-Zinca, Stefania D. Iancu, Nicolae Leopold, Sergei V. Makarov, Adrian M. V. Brânzanic and Radu Silaghi-Dumitrescu, Adduct of Aquacobalamin with Hydrogen Peroxide, Inorg. Chem. 60, 17 (2021) 12681–12684 (IF = 5.436).

Ilia A. Dereven'kov, Sergei V. Makarov, Adrian M.V.Brânzanic, Radu Silaghi-Dumitrescu, Pavel A.Molodtsov, Elizaveta A.Pokrovskaya, Formation of hydroxyl radical in aqueous solutions containing selenite and glutathione, Polyhedron 198 (2021) 115072 (IF = 2.975).

Diana Díaz-García, Eva Fischer-Fodor, Cătălin Vlad, José M. Méndez Arriaga, Sanjiv Prashara Santiago, Gómez-Ruiza, Study of cancer cell cytotoxicity, internalization and modulation of growth factors induced by transferrin-conjugated formulations of metallodrug-functionalized mesoporous silica nanoparticles, Microporous and Mesoporous Materials, 323 (2021) 111238 (IF=5.878)

Raluca Borlan, Andra-Sorina Tatar, Olga Soritau, Dana Maniu, Gabriel Marc, Adrian Florea, Monica Focsan and Simion Astilean, Design of Fluorophore Loaded Human Serum Albumin Nanoparticles for Specific Targeting of NIH:OVCAR3 Ovarian Cancer Cells, Nanotechnology 31 (2020) 315102 (IF = 3.874).

Eva Molnar, Emese Gal, Luiza Gaina, Castelia Cristea, Eva Fischer-Fodor, Maria Perde-Schrepler, Patriciu Achimas-Cadariu, Monica Focsan, Luminita Silaghi-Dumitrescu, Novel Phenothiazine-Bridged Porphyrin-(Hetero)aryl dyads: Synthesis, Optical Properties, In Vitro Cytotoxicity and Staining of Human Ovarian Tumor Cell Lines, Int. J. Mol. Sci. 21(9) (2020) 3178 (IF = 5.923). 

Diana Diaz-Garci, Karla Montalan-Hernandez, Irene Mena-Palomo, Patriciu Achimas-Cadariu, Antonio Rodri­guez-Dieguez, Eduardo Lopez-Collazo, Sanjiv Prashar, Karina Ovejero Paredes, Marco Filice, Eva Fischer-Fodor, Santiago  Gomez-Ruiz, Role of Folic Acid in the Therapeutic  Action of Nanostructured Porous Silica Functionalized with Organotin(IV) Compounds against Different  Cancer Cell Lines, Pharmaceutics 15 (2020) 512 (IF = 6.321).

Eva Molnar, Emese Gál, Luiza Găină, Castelia Cristea, and Luminița Silaghi-Dumitrescu Ethyne Functionalized Meso-Phenothiazinyl-Phenyl-Porphyrins: Synthesis and Optical Properties of Free Base Versus Protonated Species, Molecules 25(19) (2020) 4546 (IF = 4.411).

Sorina Suarasan, Ana-Maria Craciun, Emilia Licarete, Monica Focsan, Klara Magyari, Simion Astilean, Intracellular Dynamic Disentangling of Doxorubicin Release from Luminescent Nanogold Carriers by Fluorescence Lifetime Imaging Microscopy (FLIM) under Two-Photon Excitation, ACS Appl. Mater. Interfaces 11(8) (2019) 7812-7822 (IF = 8.758). 

Dumitrița Rugină, Raluca Ghiman, Monica Focșan, Flaviu Tăbăran, Florina Copaciu, Maria Suciu, Adela Pintea, Simion Aștilean, Resveratrol-delivery vehicle with anti-VEGF activity carried to human retinal pigmented epithelial cells exposed to high-glucose induced conditions, Colloids Surf. B 181(1) (2019) 66-75 (IF = 4.389). 

R. Sisa, B. Brem, E. Gal, L. Gaina, D. Porumb, C. Cristea, L. Silaghi-Dumitrescu, Optical properties modulation of cyanine dyes în organic solvents and în the critical intracellular pH window, Studia UBB Chemia 64(2) (2019) 547-553 (IF = 0.494). 

Articles in evaluation:

1. Stephen de Doncker, Eva Fischer-Fodor, Catalin ioan Vlad, Patriciu Achimas Cadariu, Siyabonga Ngubane, Gregory Smith, Anticancer evaluation of unmodified paddlewheel dirhodium(II,II)-acetate/-formidinate complexes and their axially modified low-valent metallodendrimers: a comparative study, 2022 Jurnal of Inorganic Biochemistry (IF = 4.155), Elsevier ISSN 0162-0134 - in evaluation

Conferences:

1. Simion Astilean, Versatile plasmonic and Fluorescence-based nanoprobes for optical bioimaging and light-activated therapy, 14th International Conference on Physics of Advanced Materials (ICPAM-14), September 8 – 15, 2022, in Dubrovnik, Croatia - plenary lecture

2. Potara Monica, Suarasan Sorina, Craciun Ana-Maria, Hada Alexandru, Astilean Simion, Investigation of graphene oxide nanoflakes as optical imaging agents inside tissue-like phantoms via multimodal confocal microscopy, 14th International Conference on Physics of Advanced Materials, 8-15 sept 2022 Dubrovnik, Croatia - poster presentation

3. Simion Astilean, Plasmonic nanoplatforms: from sensing to cell imaging and multimodal light-activated therapy, International Symposium Biodynamics – A Transdisiplinary Approach, 19-21 May 2022, Bucharest, Romania- invited lecture

4. Melinda Gal, Castelia Cristea, Tamas Lovasz, Luminita Silaghi-Dumitrescu, Ana-Maria Craciun , Luiza Gaina*, Fluorescent electrospun nanofibers for latent fingerprint detection, 22nd Tetrahedron Symposium, 28  Juin - 1 July 2022, Lisabona, Portugalia - poster presentation

5. Eva Fischer-Fodor, Andrei Pasca, Dylan Giffard , Cristian Pop, Joaquin Barroso-Flores, Eugen Gurzau, Gregory S. Smith, Catalin Ioan Vlad, Bhaskar Saha, Eva Fischer-Fodor, Patriciu Achimas-Cadariu, Fine-tuning of multitarget anticancer metallodendrimers cellular incorporation, 8th International Symposium on Metallomics, 11-14 July 2022, Japan - oral presentation 

6. Milan Paul Kubelac Vlad Catalin, Andrei Pasca, Maximilian Muntean, Vlad Gata, Dragos Morariu, Alex Oradan, Olga Soritau, Eva Fischer-Fodor, Ovidiu Balacescu, Bogdan Pop, Bogdan Fetica, Patriciu Achimas-Cadariu, Indocyanine Green in Near-Infrared Light for Intra-Operative Imaging of Residual Ovarian Cancer after Neoadjuvant Chemotherapy. Initial Experience, ESGO 2022 European Congress on Gynecological Oncology - poster presentation 

7. Raluca Borlan, Monica Focsan, Maria Perde-Schrepler, Luiza Gaina, Dana Maniu, Simion Astilean, Fluorescent nanoparticles decorated with ovarian cancer-specific ligands as theranostic nanoagents for the deep red interventional imaging and multimodal therapy of cancer, International school of nanomedicine, Workshop: advanced nano- and micro-structured materials for medical applications, July 20-25, 2022, Erice, Italy - poster presentation

8. Mădălina-Maria Tudor, Raluca Borlan, Mădălina Nistor, Dumitrița Rugină, Simion Aștilean, Monica Focșan, NIR-797 loaded poly (lactic-co-glicolic acid) nanoparticles for in vitro fluorescence imaging, 17th National Conference of Biophysics, September 23-25, 2022, Tg. Mureș, România - poster presentation. Best poster presentation prize

9. Castelia Cristea, Luiza Găină, Bianca Stoean, Melinda Gal, Emese Gal, Luminita Silaghi-Dumitrescu, Monica Focsan, Eva Fischer-Fodor, Fluorescence imaging of ovarian cancer cells using novel methylene blue analogues,  22nd Tetrahedron Symposium, Lisabona, Portugalia, 28 iunie-1 iulie 2022- poster presentation

10. Bianca Stoean, Melinda Gal, Monica Focsan, Dumitrita Rugina, Castelia Cristea, Luminita Silaghi-Dumitrescu, Luiza Gaina, Phenothiazinyl-vinyl-pyridinium dyes with potential applications as selective cellular staining agents, New trends and strategies in the chemistry of advanced materials with relevance in biological systems, technique and environmental protection, October 20-21, 2022, Timișoara - poster presentation

11. Melinda Gal, Bianca Stoean, Castelia Cristea, Monica Focsan, Luminita Silaghi-Dumitrescu, Design, synthesis and evaluation of novel phenothiazinium dyes for tumoral cells visualization. New trends and strategies in the chemistry of advanced materials with relevance in biological systems, technique and environmental protection, October 20-21, 2022, Timișoara - poster presentation

12. B. Stoean, L. Gaina, C. Cristea, R. S.-Dumitrescu, A. M.V., Branzanic, M. Focsan, E. F.-Fodor, L. Silaghi-Dumitrescu, New methylene blue analogues with n-piperidinyl-carbinol units: synthesis, optical properties and in vitro internalization in human ovarian cancer cells, A XXXVI-a CONFERINŢĂ NAŢIONALĂ DE CHIMIE –CNChim-2022 04-07.10.2022, Călimăneşti – Căciulata - poster presentation

13. Sorina Suarasan, Monica Potara, Ana Maria Craciun, Alexandru Hada, Simion Astilean, PVP modified graphene oxide nanoflakes as contrast agents inside tissue-mimicking phantoms via two-photon-excited fluorescence lifetime imaging and confocal Raman microscopy, 13th International Conference on Physics of Advanced Materials (ICPAM-13), September 24-30, 2021, Sant Feliu de Guixols, Spain - poster presentation

14. Milan Paul Kubelac, Perioperative Dynamic Evaluation of Folate Receptor Alpha Expression in Ovarian Carcinoma, ESGO 2021 European Congress on Gynecological Oncology - poster presentation

15. Alexandru-Milentie Hada, Ana-Maria Craciun, Monica Focsan, Olga Soritau, Simion Astilean, Intrinsic photoluminescent protein-stabilized gold nanoclusters: towards fluorescence imaging applications, 13th International Conference on Physics of Advanced Materials (ICPAM-13), 24-30 September 2021, Sant Feliu de Guixols, Spain - poster presentation

16. C. Cristea, L. Găină, M Gal, A Matei, E Gal, T Lovasz L Silaghi-Dumitrescu, Novel NIR phenazathionium dyes, 21st Tetrahedron Symposium 21-24 juin 2021, Gothenburg, Sweden - poster presentation

17. Patriciu  Achimas-Cadariu, Chirurgia  cancerului  ovarian.  Progresele  ultimilor  ani, Congresul National de Oncologie: "Provocarile Anului 2020 in  Oncologie", 15-17 octombrie 2020 - plenary presentation

18. Paul Kubelac, Catalin Vlad, Patriciu Achimas-Cadariu, Ioana Berindan-Neagoe, Alexandru Irimie, The clinical features of ovarian cancer patients with BRCA mutations, Congresul National de Oncologie: "Provocarile Anului 2020 in  Oncologie", 15-17 octombrie 2020 - oral presentation

19.  Eva Fischer-Fodor, Maria Perde-Schrepler, Eva Molnar, Emese Gal, Luiza Gaina, Castelia Cristea, Monica Focsan, Luminita Silaghi-Dumitrescu, Patriciu Achimas-Cadariu, Novel targeted phenothiazine-bridged porphyrin compounds for image-guided surgery of ovarian cancer, Congresul National de Oncologie: "Provocarile Anului 2020 in Oncologie", 15-17 octombrie 2020 - poster presentation

20. Alexandru-Milentie Hada, Ana-Maria Craciun, Monica Focsan, Olga Soritau, Simion Astilean, Investigation of protein-stabilized gold nanoclusters with applicability in cellular imaging, Conferinta nationala a studentilor doctoranzi, Iasi, 21-22 Octombrie, 2020 - oral presentation

21. Raluca Borlan, Andra-Sorina Tatar, Olga Soritau, Dana Maniu, Monica Focsan,and Simion Astilean, Design of protein-based nanoparticles loaded with fluorescent dyes for biomedical imaging of ovarian cancer cells, Conferinta nationala a studentilor doctoranzi, Iasi, 21-22 Octombrie, 2020 - oral presentation

22. Raluca Borlan, Andra-Sorina Tatar, Dana Maniu, Olga Sorițau, Eva Fischer-Fodor, Monica Focșan, Patriciu Achimaș-Cadariu, Simion Aștilean, Indocyanine Green–Loaded Protein Nanoparticles for Near Infrared Imaging and Targeting of Ovarian Cancer Cells, European Conference on Spectroscopy of Biological Molecules, Dublin, August 19-22, 2019 - poster presentation

23. Raluca Borlan, Andra-Sorina Tatar, Olga Sorita, Dana Maniu, Monica Focsan, Simion Astilean, Sinteza și caracterizarea spectroscopică a unor nanoparticule proteice încărcate cu verde de indocianină pentru aplicații biomedicale, Conferinta nationala a studentilor doctoranzi, Bucuresti, Septembrie 26-28, 2019 - oral presentation

24. Andra-Sorina Tatar, Monica Potara, Timea Nagy-Simon, Sorina Suarasan, Raluca Ghiman, Olga Soritau, Eva Fischer-Fodor, Monica Focsan, Patriciu Achimas-Cadariu, Simion Astilean, Near-Infrared Fluorophores-loaded Nanoparticles:Encapsulation, Stabilisation and Targeting for Ovarian Cancer Cells, European Conference on Spectroscopy of Biological Molecules, Dublin, August 19-22, 2019 - poster presentation

25. Eva Fischer-Fodor, Catalin Vlad, Patriciu Achimas-Cadariu, Dylan Giffard, Gregory Smith, Cristian Pop, Eugen Gurzau, Alma Maniu, Ioana Berindan Neagoe, The in nitro antitumor mechanisms of mono-and nuclear [2+1] tricarbonylrhenium(I) complexes, 7th International Symposium on Metallomics, 30 iunie- 3 iulie 2019, Varsovia, Polonia, ISBN: 978-83-950720-0-0 - oral presentation