Journal Papers

1. Microfluidic nano-plasmonic imaging platform for purification- and label-free single extravesicular

vesicle characterization, npj Biosensing, 2:26, 2025.

2. Plasmonic nano-aperture label-free imaging of single small extracellular vesicles for cancer detection,

Communications Medicine, 4: 100, 2024.

3. Functional Plasmonic Microscope: Characterizing the Metabolic Activity of Single Cells via Sub-nm

Membrane Fluctuations, Analytical Chemistry, 96(15): 5771-5780 2024.

4. Single‐Exosome Counting and 3D, Subdiffraction Limit Localization Using Dynamic Plasmonic

Nanoaperture Label‐Free Imaging, Advanced Nanobiomed Research, 3(9): 2300039 2023.

5. Progressive and instantaneous nature of lithium nucleation discovered by dynamic and operando

imaging, Science Advances 9(21): eadg6813, 2023.

6. Exploring the synergy of radiative coupling and substrate undercut in arrayed gold nanodisks for

economical, ultra-sensitive label-free biosensing, IEEE Sensors Journal 21(21): 23971-23978, 2021.

7. Metamaterials based nanoporous metals: plasmonic properties and applications in enhanced

spectroscopy, ACS Nano 15(4): 6038-6060, 2021.

8. …, WC Shih, ** SERS-based Lateral Flow Assay for Quantitative Sensing of Protein Biomarkers,

IEEE JSTQE 27(5): 1-8, 2021.

9. N. Ohannesian, J. Li, I. Misbah, F. Zhao, and WC Shih, ** Directed concentrating of

micro/nanoparticles via near-infrared laser generated plasmonic microbubbles, ACS Omega 2020.

10. X. Yang et al., Imaging the electrochemical impedance of single cells via conductive polymer thin

film, ACS Sensors 5(50): 32481-32489, 2020.

11. N. Ohannesian, * Ibrahim Misbah, * Steven Lin, and WC Shih, ** Plasmonic Nano-Aperture Label-Free

Imaging, Nature Communications 11: 5805, 2020.

12. N. Ohannesian, …, WC Shih, ** Commercial and emerging technologies for cancer diagnosis and

prognosis based on circulating tumor exosomes, Journal of Physics Photonics 2, 032002, 2020.

13. H. Nguyen, * …, WC Shih, ** Magnetic active water filter membrane for induced heating for biofoulant

removal, ACS Applied Materials & Interfaces 12(9):10291-10298, 2020.

14. H. Nguyen, * Ibrahim Misbah, * and Wei-Chuan Shih, ** Smartphone nano-colorimetry for on-demand

multiplex lead and mercury detection and quantitation in drinking water, IEEE Sensor Journal

20(12):6685-6691, 2020.

15. C. H. Lee et al., Optically tunable Tin Oxide-Coated Hollow GoldSilver, ACS Omega, 5(37):

23769-23777, 2020.

16. Mid-infrared Laser Spectroscopy Detection and Quantification of Explosives in Soils Using

Multivariate Analysis and Artificial Intelligence, Applied Sciences 10(12), 4178, 2020.

17. S. Tsui et al., Single red blood cell analysis reveals elevated hemoglobin in poikilocytes, Journal of

Biomedical Optics 25(1): 015004, 2020.

18. Md Masud Parvez Arnob, * Camille Artur, * Ibrahim Misbah, * Mubeen Sayed, and Wei-Chuan Shih, **

10X-enhanced heterogeneous nanocatalysis on nanoporous gold disk array with high-density hot

spots, ACS Applied Materials & Interfaces 11(14): 13499-13506, 2019.

19. Ibrahim Misbah, * Fusheng Zhao, * and Wei-Chuan Shih, ** Symmetry breaking-induced plasmonic

mode splitting in coupled gold-silver nanodisk array for ultrahigh sensitivity RGB colorimetric

biosensing, ACS Applied Materials & Interfaces 11(2): 2273-2281, 2019.

20. Pasan C Bandara, Felipe Ibañez de Santi Ferrara, Hoang Nguyen, * Greggy M Santos, * Wei-Chuan

Shih and Debora F Rodrigues, Investigation of thermal properties of graphene-coated membranes by

laser irradiation to remove biofoulants, ACS Environmental Science & Technology 53(2): 901-911

2019.

21. Yu-Lung Sung, * Jacob Garan, * Zhenyu Hu, * Xiaonan Shan, and Wei-Chuan Shih, ** Modeling the

surface of fast-cured polymer droplet lenses for precision fabrication, Applied Optics 57(35): 10342-

10347, 2018.

22. Hoang Nguyen, * Yulung Sung, * Kelly O’Shaughnessy, * Xiaonan Shan, and Wei-Chuan Shih, **

Smartphone nanocolorimetry for on-demand lead detection and quantitation in drinking water,

Analytical Chemistry 90(19): 1151711522, 2018.

23. Christopher Ertsgaard, Nathan Wittenberg, Daniel Klemme, Avijit Barik, Wei-Chuan Shih, and Sang-

Hyun Oh, Integrated nanogap platform for sub-volt dielectrophoretic trapping and real-time Raman

imaging of biological nanoparticles, Nano Letters 18(9): 5946-5953, 2018.

24. Austin McDaniel, Lauren Perry, Qingzhong Liu, Wei-Chuan Shih, and Jorn Yu, Toward the

identification of marijuana varieties by headspace chemical forensics, Forensic Chemistry 11: 23-31,

2018.

25. Jingting Li, * Fusheng Zhao, * Yu Deng, Dong Liu, Chia-Hung Chen, and Wei-Chuan Shih, **

Photothermal generation of programmable microbubble array on nanoporous gold disks, Optics

Express 26(13): 16893-16902 2018.

26. Md Masud Parvez Arnob, * Hung Nguyen, Zhu Han, and Wei-Chuan Shih, ** Compressed sensing

hyperspectral imaging in the 0.9-2.5 m short-wave infrared wavelength range using digital micro-

mirror device and InGaAs linear array detector, Applied Optics 57(18): 5019-5024 2018.

27. Erkin Seker, Wei-Chuan Shih, ** and Keith J Stine, Nanoporous metal by alloy corrosion:

Bioanalytical and biomedical applications, MRS Bulletin 43(1): 49-56 2018.

28. Tiffany Franklin, Lauren Perry, Wei-Chuan Shih, and Jorn Yu, Detection of phytocannabinoids from

buccal swabs by headspace solid phase microextraction – gas chromatography/mass spectrometry,

Analytical Methods 10: 942-946 2018.

29. Shihhao Ran, Sebastian Berisha, Rupali Mankar, Wei-Chuan Shih, and David Mayerich, Mitigating

Fringing In Discrete Frequency Infrared Imaging Using Time-Delayed Integration, Biomedical Optics

Express 9(2): 832-843 2018.

30. Camille G Artur, * Tasha Womack, Fusheng Zhao, * Jason L Eriksen, David Mayerich, and Wei-Chuan

Shih, ** Plasmonic nanoparticle-based expansion microscopy with surface-enhanced Raman and dark-

field spectroscopic imaging, Biomedical Optics Express 9(2): 603-615 2018.

31. Md Masud Parvez Arnob * and Wei-Chuan Shih, ** 3D plasmonic nanoarchitecture as an emerging

biosensing platform, Nanomedicine 12(21): 2577-2580 2017.

32. Yu-Lung Sung, * Fernando Campa, * and Wei-Chuan Shih, ** Open-source, do-it-yourself multi-color

fluorescence smartphone microscopy, Biomedical Optics Express 8(11): 5075-5086 2017.

33. Yu-Lung Sung, * Jacob Garan, * Hoang Nguyen, * Zhenyu Hu, * and Wei-Chuan Shih, ** Automated batch

characterization of inkjet-printed elastomer lenses using a LEGO® platform, Applied Optics 56(26):

7346-7350 2017.

34. Fusheng Zhao, * Masud Arnob, * Oussama Zenasni, * Jingting Li, * and Wei-Chuan Shih, ** Far-field plasmonic

coupling in 2-dimensional polycrystalline plasmonic arrays enables wide tunability with low-cost

nanofabrication, Nanoscale Horizons 2(5): 267-276 2017.

35. Mehmet Tatli, Hye Jin Chun, Charles H Camp Jr., Jingting Li, * Marcus T Cicerone, Wei-Chuan Shih,

Jaan Laane, Timothy P Devarenne, Raman spectra and DFT calculations for botryococcene and

methylsqualene hydrocarbons from the B race of the green microalga Botryococcus braunii, Journal

of Molecular Structures 1147: 427-437 2017.

36. Fusheng Zhao, * Jianbo Zeng, * and Wei-Chuan Shih, ** Nanoporous gold nanocomposites as a versatile

platform for plasmonic engineering and sensing, Sensors 17(7): 1519 2017.

37. Masud Arnob, * Fusheng Zhao, * Jingting Li, * and Wei-Chuan Shih, ** EBL-based fabrication and

different modeling approaches for nanoporous gold nanodisks, ACS Photonics 4(8): 1870-1878 2017.

38. Masud Arnob * and Wei-Chuan Shih, ** 3-dimensional plasmonic substrates based on chicken eggshell

bio-templates for SERS based bio-sensing, Micromachines 8(6): 196 2017.

39. Suyan Qiu, * Fusheng Zhao, * Oussama Zenasni, * Jingting Li, * and Wei-Chuan Shih, ** Catalytic

assembly of DNA nanostructures on nanoporous gold array as 3D architectures for label-free

telomerase activity sensing, Nanoscale Horizons 2(4): 217-224 2017.

40. Ngoc-Duy Dinh, Rongcong Luo, Maria Tankeh Asuncion Christine, Weikang Nicholas Lin, Wei-

Chuan Shih, James Cho-Hong Goh, and Chia-Hung Chen, Effective Light Directed Assembly of

Building Blocks with Microscale Control, Small 13(24): 1700684 2017.

41. Hoang Nguyen, * Md Masud Parvez Arnob, * Aaron T. Becker, John C. Wolfe, Matthew K. Hogan,

Philip J. Horner, and Wei-Chuan Shih, ** Fabrication of multipoint side-firing optical fiber by laser

micro-ablation, Optics Letters, 42(9): 1808-1811 2017.

42. Suyan Qiu, * Fusheng Zhao, * Oussama Zenasni, * Jingting Li, * and Wei-Chuan Shih, ** Nanoporous gold

disks functionalized with stabilized G-quadruplex moieties for sensing small molecules, ACS Applied

Materials & Interfaces 8(44): 29968-29976 2016.

43. Jingting Li, * Fusheng Zhao, * and Wei-Chuan Shih, ** Direct-write patterning of nanoporous gold

microstructures by in situ laser-assisted dealloying, Optics Express 24(20): 23610-23617 2016.

44. Jae Won Jeong, Md Masud Parvez Arnob, * Kwang-Min Baek, Seung-Yong Lee, Wei-Chuan Shih,

and Yeon Sik Jung, Three-dimensional cross-point plasmonic nano-architectures containing dense

and regular hot spots for surface-enhanced Raman spectroscopy analysis, Advanced Materials,

28(39): 8695-8704 2016.

45. Wei-Chuan Shih ** , Greggy Santos, * Fusheng Zhao, * Oussama Zenasni, * and Masud Arnob, *

Simultaneous chemical and refractive index sensing in 1-2.5 m wavelength range on nanoporous

gold disks, Nano Letters, 16 (7): 4641–4647 2016.

46. Greggy Santos, * Felipe Ibañez de Santi Ferrara, Fusheng Zhao, * Debora F. Rodrigues, and Wei-Chuan

Shih, ** Photothermal inactivation of heat-resistant bacteria on nanoporous gold disk arrays, Optical

Materials Express 6(4): 1217-1229 2016.

47. Jingting Li, * Yong Du, Ji Qi, * Ravikumar Sneha, Anthony Chang, Chandra Mohan, Wei-Chuan Shih, **

Raman spectroscopy as a diagnostic tool for monitoring acute nephritis, Journal of Biophotonics 9(3):

260-269 2015.

48. Yu-Lung Sung, * Jenn Jeang, * Chia-Hsiung Lee, * and Wei-Chuan Shih, ** Fabricating optical lenses by

inject printing and heat-assisted in situ curing of polydimethylsiloxane for smartphone microscopy,

Journal of Biomedical Optics 20(4): 047005 2015.

49. Wei-Chuan Shih, ** Kate L Bechtel, and Mihailo Rebec, Non-invasive glucose sensing by

transcutaneous Raman spectroscopy, Journal of Biomedical Optics 20(5): 051036 2015.

50. Ming Li, * Yong Du, Fusheng Zhao, * Jianbo Zeng, * Chandra Mohan, and Wei-Chuan Shih, ** Reagent-

and separation-free measurements of urine creatinine concentration by stamping surface-enhanced

Raman scattering (S-SERS), Biomedical Optics Express 6(3): 849-858 2015.

51. Greggy Santos, * Fusheng Zhao, * Jianbo Zeng, * Ming Li, * and Wei-Chuan Shih, ** Zepto-mole cancer

marker detection by surface-enhanced fluorescence on nanoporous gold disk substrates, Journal of

Biophotonics 8(10): 855-863 2015.

52. Orawan Khantamat, Chien-Hung Li, Fei Yu, Andrew C Jamison, Wei-Chuan Shih, Chengzhi Cai and

T Randall Lee, Gold nanoshell-decoraed silicone surfaces for the NIR photo thermal destruction of

the pathogenic bacterium E. faecalis, ACS Applied Materials & Interfaces 7(7): 3981-3993 2015.

53. Peter Liu, Ji Qi, * Wei-Chuan Shih, ** and Kirill Larin, Improvement of tissue analysis and

classification using Optical Coherence Tomography combined with Raman spectroscopy, Journal of

Innovative Optical Health Sciences 8(2): 1550006, 2015.

54. Fusheng Zhao, * Jianbo Zeng, * and Wei-Chuan Shih, ** In situ patterning of hierarchical nanoporous

gold structures by in-plane dealloying, Materials Science and Engineering B 194:34-40, 2015.

55. Ji Qi, * Pratik Motwani, * Jianbo Zeng, * John C. Wolfe, and Wei-Chuan Shih, ** Morphological,

plasmonic, and SERS characterization of DC-sputtered gold nanoislands, Biomedical Spectroscopy

and Imaging 4(1): 95-103, 2015.

56. Wei-Chuan Shih, ** Constrained regularization for non-invasive glucose sensing using Raman

spectroscopy, Journal of Innovative Optical Health Sciences 8(4): 1550022. 2015.

57. Jianbo Zeng, * Fusheng Zhao, * Ming Li, * Chien-Hung Li, T. Randall Lee, and Wei-Chuan Shih, **

Morphological control and plasmonic tuning of nanoporous gold nanoparticles by surface

modifications, Journal of Materials Chemistry C 3:247-252, 2015.

58. Ji Qi, * Kate L Bechtel, and Wei-Chuan Shih, ** Automated image curvature assessment and correction

for high-throughput Raman spectroscopy and microscopy, Biomedical Spectroscopy and Imaging

3(4): 359-368, 2014.

59. Md Masud Parvez Arnob, * Fusheng Zhao, * Jianbo Zeng, * and Wei-Chuan Shih, ** Laser rapid thermal

annealing enables tunable plasmonics in nanoporous gold nanoparticles, Nanoscale 6(21), 12470-

12475, 2014.

60. Narendran Sudheendran, Ji Qi, * Eric D. Young, Alexander J. Lazar, Dina C. Lev, Raphael E. Pollock,

Kirill V. Larin, Wei-Chuan Shih, ** High throughput Raman spectral imaging complements optical

coherence tomography for tumor boundary detection, Laser Physics Letters 11:105602, 2014 ( * :

Equal contribution).

61. Jianbo Zeng, * Ji Qi, * Fuquan Bai, Jorn Yu, and Wei-Chuan Shih, ** Analysis of ethyl and methyl

centralite vibrational spectra for mapping organic gunshot residue, Analyst 139(17), 4270-4278, 2014.

62. Jianbo Zeng, * Fusheng Zhao, * Chien-Hung Li, Yifei Li, Yan Yao, T. Randall Lee, and Wei-Chuan

Shih, ** Internal and external morphology-dependent plasmonic properties in nanoporous gold disks,

RSC Advances 4, 36682-36688, 2014.

63. Ming Li, * Fusheng Zhao, * Jianbo Zeng, * Ji Qi, * Jing Lu, * and Wei-Chuan Shih, ** Microfluidic surface-

enhanced Raman scattering (SERS) sensor with monolithically integrated nanoporous gold disk

(NPGD) arrays for rapid and label-free biomolecular detection, Journal of Biomedical Optics 19(11),

111611, 2014.

64. Ji Qi, * Jianbo Zeng, * Fusheng Zhao, * Steven Hsesheng Lin, Balakrishnan Raja, Ulrich Strych, Richard

C. Willson, and Wei-Chuan Shih, ** Label-free, in situ SERS monitoring of individual DNA

hybridization in microfluidics, Nanoscale 6(15), 8521-8526, 2014.

65. Jing Yang, Xuebin Tan, Wei-Chuan Shih, and Mark Cheng, A sandwich substrate for ultrasensitive

SERS spectroscopic detection of folic acid / methotrexate, Biomedical Microdevices 16(5): 673-679

2014.

66. Fusheng Zhao, * Jianbo Zeng, * Md Masud Parvez Arnob, * Po Sun, * Ji Qi, * Pratik Motwani, * Mufaddal

Gheewala, * Chien-Hung Li, Andrew Paterson, Uli Strych, Balakrishnan Raja, Richard C. Willson,

John C. Wolfe, T. Randall Lee, and Wei-Chuan Shih, ** Monolithic NPG nanoparticles with large

surface area, tunable plasmonics, and high-density internal hot-spots, Nanoscale 6, 8199-8207, 2014.

67. Ji Qi * and Wei-Chuan Shih, ** Performance of line-scan Raman microscopy for high-throughput

chemical imaging of cell population, Applied Optics 53(13), 2881-2885, 2014.

68. Ming Li, * Jing Lu, * Ji Qi, * Fusheng Zhao, * Jianbo Zeng, * Jorn Chi-Chung Yu, and Wei-Chuan Shih, **

Stamping surface-enhanced Raman spectroscopy for label-free, multiplexed, molecular sensing and

imaging, Journal of Biomedical Optics 19(5): 050501, 2014.

69. Greggy M. Santos, * Fusheng Zhao, * Jianbo Zeng, * and Wei-Chuan Shih, ** Characterization of

nanoporous gold disks for photothermal light harvesting and light-gated molecular release, Nanoscale

6(11), 5718-5724, 2014.

70. Ji Qi, * Pratik Motwani, * Mufaddal Gheewala, * Christopher Brennan, John C. Wolfe, and Wei-Chuan

Shih, ** Surface-enhanced Raman spectroscopy using monolithic nanoporous gold disk substrates,

Nanoscale 5: 4105-4109, 2013. (Journal cover)

71. Ji Qi, * Jingting Li, * and Wei-Chuan Shih, ** High-speed hyperspectral Raman imaging for label-free

compositional microanalysis, Biomedical Optics Express 4(11): 2376-2383, 2013.

72. Ji Qi * and Wei-Chuan Shih, ** Parallel Raman microspectroscopy using programmable multi-point

illumination, Optics Letters 37(8): 1289-1291, 2012.

73. Szu-Te Lin, * Jack C. Wolfe, John A. Dani, and Wei-Chuan Shih, ** Flexible optitrode for localized

light delivery and electrical recording, Optics Letters 37(11): 1-3, 2012.

74. Albert B. Andrews, Wei-Chuan Shih, Oliver C. Mullins, and N. Koyo, Molecular size determination

of coal-derived asphaltene by fluorescence correlation spectroscopy, Applied Spectroscopy 65(12):

1348-1356, 2011.

Published before own group

75. Wei-Chuan Shih, Kate L Bechtel and Michael S Feld, ** Intrinsic Raman spectroscopy for quantitative

biological spectroscopy Part I: Theory and simulations, Optics Express 16(17): 12726-12736, 2008.

76. Kate L Bechtel, Wei-Chuan Shih and Michael S. Feld, ** Intrinsic Raman spectroscopy for quantitative

biological spectroscopy Part II: Experimental applications, Optics Express 16(17): 12737-12745,

2008.

77. Wei-Chuan Shih ** and Albert B. Andrews, Infrared contrast of crude oil covered water surfaces,

Optics Letters 33(24): 3019-3021, 2008.

78. Wei-Chuan Shih ** and Albert B. Andrews, Thermal infrared contrast of native and crude oil covered

water surfaces, Optics Express 16(4): 10535-10542, 2008.

79. Wei-Chuan Shih ** , Kate L Bechtel and Michael S Feld, Constrained regularization: A new method for

multivariate calibration, Analytical Chemistry 79(1): 234-239, 2007.

80. Obrad R. Šćepanović, Kate L. Bechtel, Abi S. Haka, Wei-Chuan Shih, Taewoon Koo, Andrew J.

Berger, Michael S. Feld, ** Determination of uncertainty in parameters extracted from single

spectroscopic measurements, Journal of Biomedical Optics 12(6), 064012, 2007.

81. Wei-Chuan Shih ** , Sang-Gook Kim and George Barbastathis, High resolution electrostatic analog

tunable grating with a single-mask fabrication process, IEEE/ASME Journal of

Microelectromechanical Systems 15(4), pp. 763-769, 2006.

82. Annika Enejder, Tom Scecina, Jeankun Oh, Martin Hunter, Wei-Chuan Shih, Slobadan Sasic, Gary

Horowitz and Michael S. Feld * , Raman spectroscopy for non-invasive glucose measurements,

Journal of Biomedical Optics 10(3), 031114, 2005.

83. Wei-Chuan Shih ** , Chee Wei Wong, Yungbae Jeon, Sang-Gook Kim and George Barbastathis,

MEMS tunable gratings with analog actuation, Information Sciences 149(1-3), 31-40, 2003.