Journal Club
20240716TBA
20240709Mol Cell. 2024 Jan 18;84(2):386-400.e11. doi: 10.1016/j.molcel.2023.11.016. Epub 2023 Dec 15.Ubiquiton-An inducible, linkage-specific polyubiquitylation tool
20240702EMBO J. 2023 Apr 3;42(7):e112309. doi: 10.15252/embj.2022112309. Epub 2023 Jan 27.MitoStores: chaperone-controlled protein granules store mitochondrial precursors in the cytosol
20240625Nat Commun. 2023 Dec 15;14(1):8363. doi: 10.1038/s41467-023-44096-z.Orphan quality control by an SCF ubiquitin ligase directed to pervasive C-degrons
20240618EMBO Rep. 2024 Apr;25(4):2071-2096. doi: 10.1038/s44319-024-00113-w. Epub 2024 Apr 2.The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria
20240611J Cell Biol. 2024 May 6;223(5):e202308074. doi: 10.1083/jcb.202308074. Epub 2024 Mar 5.The derlin Dfm1 couples retrotranslocation of a folded protein domain to its proteasomal degradation
20240604J Cell Biol. 2024 May 6;223(5):e202306051. doi: 10.1083/jcb.202306051. Epub 2024 Mar 26.OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization
20240528Mol Cell. 2024 Apr 4;84(7):1290-1303.e7. doi: 10.1016/j.molcel.2024.01.029. Epub 2024 Feb 23.Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation
20240521Cell Rep. 2023 Nov 28;42(11):113359. doi: 10.1016/j.celrep.2023.113359. Epub 2023 Nov 2.The ubiquitin conjugase Rad6 mediates ribosome pausing during oxidative stress
20240514Cell Rep. 2024 Apr 23;43(4):114018. doi: 10.1016/j.celrep.2024.114018. Epub 2024 Mar 28.Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress
20240507bioRxiv 2024 Mar 12. doi.org/10.1101/2024.03.11.584465The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi
20231220Cell Rep. 2023 Sep 26;42(9):113100. doi: 10.1016/j.celrep.2023.113100. Epub 2023 Sep 6.Mechanism and evolutionary origins of alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10
20231213Nat Cell Biol. 2023 Sep;25(9):1290-1302. doi: 10.1038/s41556-023-01207-8. Epub 2023 Aug 17.Lipid saturation controls nuclear envelope function
20231129Cell. 2023 Jan 5;186(1):63-79.e21. doi: 10.1016/j.cell.2022.12.007.Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan
20231122Cell. 2023 Aug 3;186(16):3443-3459.e24. doi: 10.1016/j.cell.2023.06.016. Epub 2023 Jul 21.Mechanism of orphan subunit recognition during assembly quality control
20231117Elife. 2022 Jul 29:11:e80497. doi: 10.7554/eLife.80497.Manganese is a physiologically relevant TORC1 activator in yeast and mammals
20231108EMBO J. 2023 Feb 1;42(3):e111802. doi: 10.15252/embj.2022111802. Epub 2022 Dec 27.Cytosolic stress granules relieve the ubiquitin-proteasome system in the nuclear compartment
20231101Cell Rep. 2023 Oct 3;42(10):113186. doi: 10.1016/j.celrep.2023.113186. Online ahead of print.Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae
20231027Nat Metab. 2023 Aug 28. doi: 10.1038/s42255-023-00872-1.Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth
20231018Mol Cell. 2023 Aug 17;83(16):2976-2990.e9. doi: 10.1016/j.molcel.2023.07.021.E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response
20231011Elife. 2023 May 2;12:e84330. doi: 10.7554/eLife.84330.Mitochondrial protein import clogging as a mechanism of disease
20230601Sci Adv. 2023 Jan 13;9(2):eadd8579. doi: 10.1126/sciadv.add8579. Epub 2023 Jan 13.The ERAD system is restricted by elevated ceramides
20230525Science. 2023 Apr 28;380(6643):376-381. doi: 10.1126/science.add7631. Epub 2023 Apr 27.Engineering longevity-design of a synthetic gene oscillator to slow cellular aging
20230518EMBO J. 2023 May 2;42(9):e113333. doi: 10.15252/embj.2022113333. Epub 2023 Mar 23.The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast
20230511Nat Cell Biol. 2022 Jul;24(7):1077-1087. doi: 10.1038/s41556-022-00938-4. Epub 2022 Jun 23.Actin remodelling controls proteasome homeostasis upon stress
20230427EMBO J. 2021 Aug 16;40(16):e107913. doi: 10.15252/embj.2021107913. Epub 2021 Jun 30.Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol
20230420J Cell Biol. 2022 Jun 6;221(6):e202201036. doi: 10.1083/jcb.202201036. Epub 2022 May 19.Regulated targeting of the monotopic hairpin membrane protein Erg1 requires the GET pathway
20230413Nat Cell Biol. 2021 Oct;23(10):1085-1094. doi: 10.1038/s41556-021-00760-4. Epub 2021 Oct 6.Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly
20230111Nat Commun. 2022 Jun 28;13(1):3720. doi: 10.1038/s41467-022-31213-7.A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery
20221221Nat Commun. 2022 Sep 16;13(1):5435. doi: 10.1038/s41467-022-33087-1.Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function
20221207Mol Cell. 2022 Sep 1;82(17):3209-3225.e7. doi: 10.1016/j.molcel.2022.07.004. Epub 2022 Aug 4.PEX5 translocation into and out of peroxisomes drives matrix protein import
20221130Nat Commun. 2022 Oct 25;13(1):6331. doi: 10.1038/s41467-022-34133-8.Termination of the unfolded protein response is guided by ER stress-induced HAC1 mRNA nuclear retention
20221122EMBO J. 2022 Dec 17;41(2):e106837. doi: 10.15252/embj.2020106837. Epub 2021 Dec 7.Molecular species selectivity of lipid transport creates a mitochondrial sink for di-unsaturated phospholipids
20221116Nat Struct Mol Biol. 2022 Aug;29(8):791-800. doi: 10.1038/s41594-022-00808-5. Epub 2022 Aug 4.Yeast PI31 inhibits the proteasome by a direct multisite mechanism
20221108Nat Commun. 2020 Oct 7;11(1):5052. doi: 10.1038/s41467-020-18805-x.Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling serine for one-carbon metabolism
20221102Mol Cell. 2022 Sep 1;82(17):3239-3254.e11. doi: 10.1016/j.molcel.2022.08.003. Epub 2022 Aug 25.A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing
20221027Cell Rep. 2022 Aug 16;40(7):111195. doi: 10.1016/j.celrep.2022.111195.Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses
20221019Mol Cell. 2022 Sep 15;82(18):3453-3467.e14. doi: 10.1016/j.molcel.2022.07.006. Epub 2022 Aug 11.TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation
20221012Elife. 2022 Jul 25;11:e77706. doi: 10.7554/eLife.77706.A network of cytosolic (co)chaperones promotes the biogenesis of mitochondrial signal-anchored outer membrane proteins
20220928Cell Rep. 2022 Jan 11;38(2):110206. doi: 10.1016/j.celrep.2021.110206.NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans
20220803Nat Commun. 2022 Jun 2;13(1):3084. doi: 10.1038/s41467-022-30748-z.Mistargeting of aggregation prone mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes
20220727Cell Rep. 2022 Jun 7;39(10):110918. doi: 10.1016/j.celrep.2022.110918.Assembly checkpoint of the proteasome regulatory particle is activated by coordinated actions of proteasomal ATPase chaperones
20220720Nat. Commun. 2022 Apr 14;13(1):2005. doi: 10.1038/s41467-022-29704-8.Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae
20220713Cell Rep. 2022 Apr 19;39(3):110702. doi: 10.1016/j.celrep.2022.110702.Dimerization-dependent membrane tethering by Atg23 is essential for yeast autophagy
20220706Cell Rep. 2022 May 24;39(8):110860. doi: 10.1016/j.celrep.2022.110860.Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes
20220615Elife. 2022 Apr 19;11:e67659. doi: 10.7554/eLife.67659.High and stable ATP levels prevent aberrant intracellular protein aggregation in yeast
20220608Cell Rep. 2021 Apr 6;35(1):108936. doi: 10.1016/j.celrep.2021.108936.The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress
20220601Mol Cell. 2022 Feb 3;82(3):585-597.e11. doi: 10.1016/j.molcel.2022.01.004.Co-adaptor driven assembly of a CUL3 E3 ligase complex
20220525Cell Rep. 2020 Jun 2;31(9):107680. doi: 10.1016/j.celrep.2020.107680.Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions
20220518Nat. Commun. 2020 Sep 25;11(1):4866. doi: 10.1038/s41467-020-18704-1.Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
20220511Mol Cell. 2021 Dec 16;81(24):5066-5081.e10. doi: 10.1016/j.molcel.2021.10.024. Epub 2021 Nov 18.Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation
20220427Cell Rep. 2022 Feb 22;38(8):110354. doi: 10.1016/j.celrep.2022.110354.K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
20220420Sci. Adv. 2022 Jan 14;8(2):eabk2141. doi: 10.1126/sciadv.abk2141. Epub 2022 Jan 12.Peroxisome function relies on organelle-associated mRNA translation
20220413Cell Rep. 2022 Mar 15;38(11):110535. doi: 10.1016/j.celrep.2022.110535.A trio of ubiquitin ligases sequentially drives ubiquitylation and autophagic degradation of dysfunctional yeast proteasomes
20220111J Cell Biol. 2020 Jul 6;219(7):e201910063. doi: 10.1083/jcb.201910063.TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes
20211220Cell Rep. 2021 Oct 19;37(3):109840. doi: 10.1016/j.celrep.2021.109840.Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates
20211213Mol Cell. 2021 Sep 16;81(18):3786-3802.e13. doi: 10.1016/j.molcel.2021.08.021.Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress
20211206Mol Cell. 2020 Sep 3;79(5):768-781.e7. doi: 10.1016/j.molcel.2020.07.009. Epub 2020 Jul 31.Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex
20211129Cell Rep. 2021 Sep 21;36(12):109717. doi: 10.1016/j.celrep.2021.109717.Substrate ubiquitination retains misfolded membrane proteins in the endoplasmic reticulum for degradation
20211122Cell Rep. 2020 Mar 17;30(11):3691-3698.e5. doi: 10.1016/j.celrep.2020.02.084.Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex
20211115Mol Cell. 2021 Jun 3;81(11):2417-2427.e5. doi: 10.1016/j.molcel.2021.03.030. Epub 2021 Apr 9.Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis
20211108Cell Rep. 2021 Aug 3;36(5):109468. doi: 10.1016/j.celrep.2021.109468.The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation
20211101Nat Commun. 2020 Feb 6;11(1):756. doi: 10.1038/s41467-020-14528-1.Regulation of lipid saturation without sensing membrane fluidity
20211025J Cell Biol. 2020 Aug 3;219(8):e201904141. doi: 10.1083/jcb.201904141.Conserved metabolite regulation of stress granule assembly via AdoMet
20211018Sci Rep. 2020 Nov 12;10(1):19704. doi: 10.1038/s41598-020-76898-2.Functional impacts of the ubiquitin-proteasome system on DNA damage recognition in global genome nucleotide excision repair
20211011Mol Cell. 2020 Jan 2;77(1):108-119.e9. doi: 10.1016/j.molcel.2019.10.003. Epub 2019 Oct 31.Quality Control of Protein Complex Assembly by a Transmembrane Recognition Factor
20210721Elife. 2020 Jun 26;9:e56945. doi: 10.7554/eLife.56945.Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation
20210714Cell Rep. 2019 May 7;27(6):1657-1665.e4. doi: 10.1016/j.celrep.2019.04.036.CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1
20210707Mol Cell. 2020 Jan 2;77(1):180-188.e9. doi: 10.1016/j.molcel.2019.09.026. Epub 2019 Oct 17.An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates
20210623Mol Cell. 2020 Jul 16;79(2):320-331.e9. doi: 10.1016/j.molcel.2020.06.023. Epub 2020 Jul 8.RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins
20210616Cell Rep. 2020 Aug 25;32(8):108059. doi: 10.1016/j.celrep.2020.108059.Mitochondrial Regulation of the 26S Proteasome
20210609Cell Rep. 2020 Jul 14;32(2):107902. doi: 10.1016/j.celrep.2020.107902.Mitochondria-Associated Degradation Pathway (MAD) Function beyond the Outer Membrane
20210602Cell Rep. 2020 Jul 14;32(2):107898. doi: 10.1016/j.celrep.2020.107898.The Cdc48 Complex Alleviates the Cytotoxicity of Misfolded Proteins by Regulating Ubiquitin Homeostasis
20210526Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21319-21327. doi: 10.1073/pnas.1922891117. Epub 2020 Aug 18.Cdc48 cofactor Shp1 regulates signal-induced SCF Met30 disassembly
20210519Elife. 2021 Mar 18;10:e61230. doi: 10.7554/eLife.61230.A nuclear-based quality control pathway for non-imported mitochondrial proteins
20210512Nat Commun. 2020 Apr 24;11(1):2019. doi: 10.1038/s41467-020-16003-3.A masked initiation region in retinoblastoma protein regulates its proteasomal degradation
20210428Cell Rep. 2018 Jun 5;23(10):2852-2863. doi: 10.1016/j.celrep.2018.05.013.Ubiquitin-Dependent Degradation of Mitochondrial Proteins Regulates Energy Metabolism
20210421Science. 2017 Aug 4;357(6350):472-475. doi: 10.1126/science.aan0178.UBE2O is a quality control factor for orphans of multiprotein complexes
20240709Mol Cell. 2024 Jan 18;84(2):386-400.e11. doi: 10.1016/j.molcel.2023.11.016. Epub 2023 Dec 15.Ubiquiton-An inducible, linkage-specific polyubiquitylation tool
20240702EMBO J. 2023 Apr 3;42(7):e112309. doi: 10.15252/embj.2022112309. Epub 2023 Jan 27.MitoStores: chaperone-controlled protein granules store mitochondrial precursors in the cytosol
20240625Nat Commun. 2023 Dec 15;14(1):8363. doi: 10.1038/s41467-023-44096-z.Orphan quality control by an SCF ubiquitin ligase directed to pervasive C-degrons
20240618EMBO Rep. 2024 Apr;25(4):2071-2096. doi: 10.1038/s44319-024-00113-w. Epub 2024 Apr 2.The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria
20240611J Cell Biol. 2024 May 6;223(5):e202308074. doi: 10.1083/jcb.202308074. Epub 2024 Mar 5.The derlin Dfm1 couples retrotranslocation of a folded protein domain to its proteasomal degradation
20240604J Cell Biol. 2024 May 6;223(5):e202306051. doi: 10.1083/jcb.202306051. Epub 2024 Mar 26.OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization
20240528Mol Cell. 2024 Apr 4;84(7):1290-1303.e7. doi: 10.1016/j.molcel.2024.01.029. Epub 2024 Feb 23.Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation
20240521Cell Rep. 2023 Nov 28;42(11):113359. doi: 10.1016/j.celrep.2023.113359. Epub 2023 Nov 2.The ubiquitin conjugase Rad6 mediates ribosome pausing during oxidative stress
20240514Cell Rep. 2024 Apr 23;43(4):114018. doi: 10.1016/j.celrep.2024.114018. Epub 2024 Mar 28.Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress
20240507bioRxiv 2024 Mar 12. doi.org/10.1101/2024.03.11.584465The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi
20231220Cell Rep. 2023 Sep 26;42(9):113100. doi: 10.1016/j.celrep.2023.113100. Epub 2023 Sep 6.Mechanism and evolutionary origins of alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10
20231213Nat Cell Biol. 2023 Sep;25(9):1290-1302. doi: 10.1038/s41556-023-01207-8. Epub 2023 Aug 17.Lipid saturation controls nuclear envelope function
20231129Cell. 2023 Jan 5;186(1):63-79.e21. doi: 10.1016/j.cell.2022.12.007.Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan
20231122Cell. 2023 Aug 3;186(16):3443-3459.e24. doi: 10.1016/j.cell.2023.06.016. Epub 2023 Jul 21.Mechanism of orphan subunit recognition during assembly quality control
20231117Elife. 2022 Jul 29:11:e80497. doi: 10.7554/eLife.80497.Manganese is a physiologically relevant TORC1 activator in yeast and mammals
20231108EMBO J. 2023 Feb 1;42(3):e111802. doi: 10.15252/embj.2022111802. Epub 2022 Dec 27.Cytosolic stress granules relieve the ubiquitin-proteasome system in the nuclear compartment
20231101Cell Rep. 2023 Oct 3;42(10):113186. doi: 10.1016/j.celrep.2023.113186. Online ahead of print.Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae
20231027Nat Metab. 2023 Aug 28. doi: 10.1038/s42255-023-00872-1.Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth
20231018Mol Cell. 2023 Aug 17;83(16):2976-2990.e9. doi: 10.1016/j.molcel.2023.07.021.E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response
20231011Elife. 2023 May 2;12:e84330. doi: 10.7554/eLife.84330.Mitochondrial protein import clogging as a mechanism of disease
20230601Sci Adv. 2023 Jan 13;9(2):eadd8579. doi: 10.1126/sciadv.add8579. Epub 2023 Jan 13.The ERAD system is restricted by elevated ceramides
20230525Science. 2023 Apr 28;380(6643):376-381. doi: 10.1126/science.add7631. Epub 2023 Apr 27.Engineering longevity-design of a synthetic gene oscillator to slow cellular aging
20230518EMBO J. 2023 May 2;42(9):e113333. doi: 10.15252/embj.2022113333. Epub 2023 Mar 23.The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast
20230511Nat Cell Biol. 2022 Jul;24(7):1077-1087. doi: 10.1038/s41556-022-00938-4. Epub 2022 Jun 23.Actin remodelling controls proteasome homeostasis upon stress
20230427EMBO J. 2021 Aug 16;40(16):e107913. doi: 10.15252/embj.2021107913. Epub 2021 Jun 30.Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol
20230420J Cell Biol. 2022 Jun 6;221(6):e202201036. doi: 10.1083/jcb.202201036. Epub 2022 May 19.Regulated targeting of the monotopic hairpin membrane protein Erg1 requires the GET pathway
20230413Nat Cell Biol. 2021 Oct;23(10):1085-1094. doi: 10.1038/s41556-021-00760-4. Epub 2021 Oct 6.Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly
20230111Nat Commun. 2022 Jun 28;13(1):3720. doi: 10.1038/s41467-022-31213-7.A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery
20221221Nat Commun. 2022 Sep 16;13(1):5435. doi: 10.1038/s41467-022-33087-1.Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function
20221207Mol Cell. 2022 Sep 1;82(17):3209-3225.e7. doi: 10.1016/j.molcel.2022.07.004. Epub 2022 Aug 4.PEX5 translocation into and out of peroxisomes drives matrix protein import
20221130Nat Commun. 2022 Oct 25;13(1):6331. doi: 10.1038/s41467-022-34133-8.Termination of the unfolded protein response is guided by ER stress-induced HAC1 mRNA nuclear retention
20221122EMBO J. 2022 Dec 17;41(2):e106837. doi: 10.15252/embj.2020106837. Epub 2021 Dec 7.Molecular species selectivity of lipid transport creates a mitochondrial sink for di-unsaturated phospholipids
20221116Nat Struct Mol Biol. 2022 Aug;29(8):791-800. doi: 10.1038/s41594-022-00808-5. Epub 2022 Aug 4.Yeast PI31 inhibits the proteasome by a direct multisite mechanism
20221108Nat Commun. 2020 Oct 7;11(1):5052. doi: 10.1038/s41467-020-18805-x.Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling serine for one-carbon metabolism
20221102Mol Cell. 2022 Sep 1;82(17):3239-3254.e11. doi: 10.1016/j.molcel.2022.08.003. Epub 2022 Aug 25.A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing
20221027Cell Rep. 2022 Aug 16;40(7):111195. doi: 10.1016/j.celrep.2022.111195.Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses
20221019Mol Cell. 2022 Sep 15;82(18):3453-3467.e14. doi: 10.1016/j.molcel.2022.07.006. Epub 2022 Aug 11.TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation
20221012Elife. 2022 Jul 25;11:e77706. doi: 10.7554/eLife.77706.A network of cytosolic (co)chaperones promotes the biogenesis of mitochondrial signal-anchored outer membrane proteins
20220928Cell Rep. 2022 Jan 11;38(2):110206. doi: 10.1016/j.celrep.2021.110206.NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans
20220803Nat Commun. 2022 Jun 2;13(1):3084. doi: 10.1038/s41467-022-30748-z.Mistargeting of aggregation prone mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes
20220727Cell Rep. 2022 Jun 7;39(10):110918. doi: 10.1016/j.celrep.2022.110918.Assembly checkpoint of the proteasome regulatory particle is activated by coordinated actions of proteasomal ATPase chaperones
20220720Nat. Commun. 2022 Apr 14;13(1):2005. doi: 10.1038/s41467-022-29704-8.Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae
20220713Cell Rep. 2022 Apr 19;39(3):110702. doi: 10.1016/j.celrep.2022.110702.Dimerization-dependent membrane tethering by Atg23 is essential for yeast autophagy
20220706Cell Rep. 2022 May 24;39(8):110860. doi: 10.1016/j.celrep.2022.110860.Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes
20220615Elife. 2022 Apr 19;11:e67659. doi: 10.7554/eLife.67659.High and stable ATP levels prevent aberrant intracellular protein aggregation in yeast
20220608Cell Rep. 2021 Apr 6;35(1):108936. doi: 10.1016/j.celrep.2021.108936.The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress
20220601Mol Cell. 2022 Feb 3;82(3):585-597.e11. doi: 10.1016/j.molcel.2022.01.004.Co-adaptor driven assembly of a CUL3 E3 ligase complex
20220525Cell Rep. 2020 Jun 2;31(9):107680. doi: 10.1016/j.celrep.2020.107680.Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions
20220518Nat. Commun. 2020 Sep 25;11(1):4866. doi: 10.1038/s41467-020-18704-1.Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
20220511Mol Cell. 2021 Dec 16;81(24):5066-5081.e10. doi: 10.1016/j.molcel.2021.10.024. Epub 2021 Nov 18.Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation
20220427Cell Rep. 2022 Feb 22;38(8):110354. doi: 10.1016/j.celrep.2022.110354.K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
20220420Sci. Adv. 2022 Jan 14;8(2):eabk2141. doi: 10.1126/sciadv.abk2141. Epub 2022 Jan 12.Peroxisome function relies on organelle-associated mRNA translation
20220413Cell Rep. 2022 Mar 15;38(11):110535. doi: 10.1016/j.celrep.2022.110535.A trio of ubiquitin ligases sequentially drives ubiquitylation and autophagic degradation of dysfunctional yeast proteasomes
20220111J Cell Biol. 2020 Jul 6;219(7):e201910063. doi: 10.1083/jcb.201910063.TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes
20211220Cell Rep. 2021 Oct 19;37(3):109840. doi: 10.1016/j.celrep.2021.109840.Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates
20211213Mol Cell. 2021 Sep 16;81(18):3786-3802.e13. doi: 10.1016/j.molcel.2021.08.021.Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress
20211206Mol Cell. 2020 Sep 3;79(5):768-781.e7. doi: 10.1016/j.molcel.2020.07.009. Epub 2020 Jul 31.Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex
20211129Cell Rep. 2021 Sep 21;36(12):109717. doi: 10.1016/j.celrep.2021.109717.Substrate ubiquitination retains misfolded membrane proteins in the endoplasmic reticulum for degradation
20211122Cell Rep. 2020 Mar 17;30(11):3691-3698.e5. doi: 10.1016/j.celrep.2020.02.084.Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex
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