＜Fiscal year of 2025＞

2025 08 30: K.N. had a research meeting with Prof. Jeffrey L. Brodsky from the University of Pittsburgh.

2025 08 27: K.N. participated in OsakaMito2025 (International Workshop on Metabolite Code and Cell Homeostasis)@Osaka University and gave a research presentation.

2025 08 14: A graduate (master’s degree) who started a research position at a cosmetics company visited our laboratory.

2025 08 14: The results of the 2025 Graduate School Entrance Examination were announced. One student from our laboratory (master’s Program) successfully passed.

2025 07 26: The 2026 graduate school entrance examination was held.

2025 07 25: The lab class for third-year undergraduate students were completed.

2025 06 20: Our manuscript entitled "Hydroxyurea modulates thiol–disulfide homeostasis in the yeast endoplasmic reticulum" has been published in Life Science Alliance. This project was led by Y.T., a graduate student in our lab. This is a joint research with labs at Kyoto Sangyo University and Nara Institute of Science and Technology. Congratulations to all involved! 

2025 06 06: K.N. gave a presentation at the 19th Research Grant Report Meeting of the Institute of Fermentation, Osaka.

2025 06 03: A review article entitled "Structural Basis for Metabolic Regulation and Defense Against Ectopic Metabolic Stress by Ubiquitin Ligases" was published in the Journal of the Crystallographic Society of Japan. This was co-authored by K.N. and Prof. Tsunehiro Mizushima (Hyogo University).

2025 05 29: Our paper was accepted for publication!! More details will be available shortly.

2025 04 15: The manuscript entitled "Snf1 and yeast GSK3-β activates Tda1 to suppress glucose starvation signaling" has been published in EMBO Reports. This is a joint research with labs at Nagoya University and Fukuoka Women's University. Congratulations to all involved!

2025 04 01: The member page has been updated.

＜Fiscal year of 2024＞

2025 03 28: K.N. visited Prof. Tsunehiro Mizushima's lab at the University of Hyogo and had a discussion.

2025 03 24: K.N. participated in the National Institute of Genetics research seminar "Diversity and Harmony of Cellular Apparatus in Single-Cell Organisms" and K.N. gave an oral presentation.

2025 03 21: The 2024 Graduation Ceremony was held. Congratulations to all graduates and those who completed their studies.

2025 03 06: The NCU Life Science Poster Presentation was held. Two members of our laboratory (Y.T., K.N.) gave poster presentations.

2025 03 14: We held an end-of year party @Sakurayama.

2025 02 14: A.K., H.S., and M.H. defended a master's degree. M.H. received an excellent presenter award. Congratulations!!

2025 02 10: Y.T. gave a doctoral dissertation interim presentation. He also gave a talk about a novel yeast gene replacement technique at the research assistant presentation.

2025 02 07: Two fourth-year undergraduate students from our laboratory (M.O., and Y.K.) defended a bachelor's degree. Congratulations!!

2025 01 10: We had a laboratory dinner party (Let's do our best at the end of the fiscal year!). 

2024 11 27: K.N., Y.T., and M.H. attended the 47th Annual Meeting of the Molecular Biology Society of Japan @ Fukuoka. Y.T. and M.H. gave poster presentations.

2024 11 19: K.N. gave a talk at Osaka Mito 2024 Fall at Osaka University (International Workshop on Mitochondrial Science).

2024 11 06: K.N. gave a talk at the symposium “Diversity of central metabolism” at the 97th Annual Meeting of the Japanese Biochemical Society in Yokohama.

2024 10 25: We had a laboratory dinner party (Let's keep up the good work in the second semester!).

2024 10 07: K.N. gave a talk at the 2024 Organelle Workshop @ Kurobe (Unazuki Onsen), Toyama prefecture.

2024 09 25: The 2024 Graduation Ceremony (Autumn Completion) was held. T.I. from our laboratory was awarded a doctoral degree. Congratulations!

2024 09 18: Y.T. and K.N. participated in the 3rd meeting of "Shin-Biology Regulated by Protein Life Time" @ Atami, Shizuoka prefecture.

2024 09 13: K.N. joined the Advisory Board of FEBS Letters.

2024 09 08: Y.T. and K.N. participated in the 57th Yeast Genetics Forum @ Kagawa. Y.T. gave a talk and K.N. gave a poster presentation.

2024 09 06: K.N. Participated in Bioforum 2024 held at Kyoto Sangyo University (seminar by Dr. Tom Rapoport, Dr. Ramanujan Hegde, Dr. Alexander Mankin, and Dr. Nora Vázquez-Laslop).

2024 09 05: Three undergraduate students joined the lab (T.I., Y.N., and K.B.). Member's page has been updated. Welcome!  

2024 08 23: T.I. defended a doctor's degree. Congratulations!!

2024 08 22: The short report entitled "Structural basis for the recognition of citrate synthase by the SCFUcc1 ubiquitin ligase complex" has been published in SPring-8/SACLA Research Frontiers 2023.

2024 08 15: M.O. passed the entrance examination for master course. Congratulations!! 

2024 08 08: Our lab members attended the BCC12 (Beyond the Chromatin Club 12)@Nagoya City University. M.H., Y.T., and K.N. presented their ongoing research projects.

2024 08 07: K.N. visited Assoc. Prof. Ryo Ushioda's lab at Kyoto Sangyo University.

2024 08 07: K.N. visited Prof. Toshiya Endo's lab at Kyoto Sangyo University.

2024 08 06: K.N. attended the Yeast meeting 2024@Kirin Brewery Kobe.

2024 07 26: Eight rotation students finished their time in the lab. They analyzed the half-life and the ubiquitination status of mislocalized mitochondrial citrate synthase in wild-type and mutant cells.

2024 07 05: Lab dinner!!

2024 06 06: Dr. Koji Okamoto from Osaka University visited our lab. Thank you very much!

2024 05 09: K.N. gave a talk at the 2nd meeting of "Shin-Biology Regulated by Protein Life Time" @ The Institute of Medical Science, The University of Tokyo.

2024 04 19: Dr. Koshi Imami from RIKEN gave a talk at the 30th NCU life science seminar. Thank you very much! 

2024 04 09: The preprint entitled "ER-associated degradation by Doa10 restrains mitophagy in yeast" has been posted to bioRxiv.

2024 04 01: The member page has been updated.

2024 04 01: K.N. has been awarded a Grant-in-Aid for Transformative Research Areas (A) (Publicly Offered Research).

＜Fiscal year of 2023＞

2024 03 22: The 2023 graduation ceremony was held. T.K., a member of our laboratory, received the doctoral degree as a representative of the graduating class.

2024 03 21: K.N. visited the Dr. Kimata's lab at NAIST.

2024 03 14: K.N., Y.T., C.K., M.K., M.O., and Y.K. attended the NCU life science seminar-IBS joint meeting at Tsumagoi Resort Sai no Sato in Kakegawa, Shizuoka.

2024 03 07: K.N. attended the 93rd yeast meeting at Kwansei Gakuin University in Nishinomiya.

2024 03 06: T.K., A.K., and N.M.'s last day in the lab. We'll miss you!!

2024 03 02: K.N. attended the 70th birthday party of Professor Toshiya Endo in Tokyo.

2024 02 15: A.K. defended a master's degree and received the best presenter award. Congratulations!!

2024 02 14: T.K. defended a doctor's degree. Congratulations!!

2024 02 14: Y.T. gave a talk about a novel yeast gene replacement technique at the research assistant presentation.

2024 02 09: Three fourth-year undergraduate students from our laboratory (C.K., M.K., and N.M.) defended a bachelor's degree. Congratulations!!

2024 02 01: The manuscript entitled "Role of the San1 ubiquitin ligase in the heat stress-induced degradation of non-native Nup1 in the nuclear pore complex" was accepted for publication in Genetics. This project was led by T.I., a graduate student in our lab. This is a joint research with labs at Nagoya University and Fukuoka Women's University. Congratulations to all involved! 

2023 12 19: The manuscript entitled "Degradation of citrate synthase lacking the mitochondrial targeting sequence is inhibited in cells defective in Hsp70/Hsp40 chaperones under heat stress conditions" was accepted for publication in FEMS Yeast Research. Two graduate students (M.H. and T.K.) contributed to this project. Congratulations to all involved! 

2023 12 06: Two graduate students (A.K. and T.K.) gave poster presentations at the 46th Annual Meeting of the Molecular Biology Society of Japan at Kobe Port Island. 

2023 09 08: Two undergraduate students joined the lab (Y.K. and M.O.). Member's page has been updated. Welcome! 

2023 08 30: Y.T. gave a poster presentation at the 56th Yeast Genetics Society of Japan at Niigata University.

2023 08 10: C.K. and M.K. passed the entrance examination for master course. Congratulations!!

2023 07 28: Eight rotation students finished their time in the lab. They purified recombinant proteins from bacteria and reconstituted the ubiquitination reaction in a test tube.

2023 04 15: Our manuscript entitled "Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress" has been published in Science Advances. Four graduate students, T.K., A.K., Y.T.,  and M.H. in our lab joined this project. T.K. (co-first author) made an extremely important contribution to this project. This is a joint research with laboratories at Hyogo University, Nagoya University, Kyoto University, Fukuoka Women's University, and Kyusyu University. Congratulations to all involved!!

2023 04 03: The member page has been updated.

2023 04 03: K.N. has been awarded a Grant-in-Aid for Scientific Research(B), a research grant from the Institute for Fermentation, Osaka, and a research grant from the Hori Sciences and Arts Foundation.

＜Fiscal year 2022＞ 

2023 03 24: Congrats to undergraduate researcher M.H. for being awarded Zuiyosho!

2023 03 23: Dr. Hayashi Yamamoto from Nippon Medical School gave a talk at the 27th NCU life science seminar. Thank you very much!

2023 03 13: Three graduate students (T.I., T.K., and Y.T.) gave poster presentations at NCU life science seminar-IBS joint meeting.

2023 03 10: Dr. Yuki Nakamura visited the lab. Thank you very much!

2023 02 17: Y.T. defended a master's degree and received the best presenter award. Congratulations!!

2023 02 14: Two doctor course students (T.I. and T.K.) gave a doctoral dissertation interim presentation.

2023 02 10: Three fourth-year undergraduate students from our laboratory (A.K., H.S., and H.M.) defended a bachelor's degree. Congratulations!!

2023 01 23: Our preprint entitled "Hydroxyurea inhibits ERAD-L independently of S-phase arrest in budding yeast" has been posted to bioRxiv. 

2023 01 20: The manuscript entitled "Metabolomics analysis of an AAA-ATPase Cdc48-deficient yeast strain" was accepted for publication in Heliyon. Congratulations to all involved!

2022 11 11: T.K. and T.I. gave poster presentations at the 95th annual meeting of the Japanese Biochemical Society.

2022 10 20: K.N. attended the Society for Biotechnology Japan, 74th Annual Meeting 2022. K.N. presented a talk at the symposium "Puzzle of Glycolysis Revealed by the Latest Metabolism Research-Celebrating the 100th Anniversary of Otto Meyerhof’s Nobel Prize-".

2022 09 08: Three undergraduate students joined the lab (C.K., M.K., and N.M.). Welcome!

2022 08 09: The manuscript entitled "Triacylglycerol lipase Tgl4 is a stable protein and its dephosphorylation is regulated in a cell cycle-dependent manner in Saccharomyces cerevisiae" was accepted for publication in Biochemical and Biophysical Research Communications. This is a joint research with labs at the Nagoya University and Fukuoka Women's University. Congratulations to all involved!

2022 07 30: K.N. presented a talk to the ER stress meeting in Kyoto.

2022 07 29: Eight rotation students finished their time in the lab. They purified recombinant proteins from bacteria and reconstituted the ubiquitination reaction in a test tube. COOL!!

2022 07 07: Two high school students visited the lab, welcome!!

2022 06 30: T.K. gave a poster presentation at Japan Society for Cell Biology meeting in Tokyo.

2022 05 19: Congrats to undergraduate researcher M.H. for being awarded Zuihosho!

2022 04 15: The manuscript entitled "Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae" was accepted for publication in Nature Communications. This is a joint research with labs at the Nagoya University. Congratulations to all involved!

2022 04 01: The member page has been updated. 

＜Fiscal year 2021＞ 

2022 03 14: Dr. Yuki Nakamura and Dr. Kazue Kanehara (Academia Sinica) visited the lab. Thank you very much!

2022 03 11: Dr. Yuki Sugiura from Keio University gave a talk at the 21st NCU life science seminar. Thank you very much!

2022 02 24: Our manuscript entitled "Dot6/Tod6 degradation fine-tunes the repression of ribosome biogenesis under nutrient-limited conditions" was accepted for publication in iScience. This project was led by former grad students K.K., E.K., and Y.S. This is a joint research with labs at the Nagoya University and the Fukuoka Women's University. Congratulations to all involved!

2022 02 10: Three fourth-year undergraduate students from our laboratory (Y.I., A.K., and R.M.) defended a bachelor's degree. Congratulations!!

2021 12 30: Our manuscript entitled "A positive genetic selection for transmembrane domain mutations in HRD1 underscores the importance of Hrd1 complex integrity during ERAD" was accepted for publication in Current Genetics. Two graduate students, Y.T. and T.K. joined this project. This is an international joint research with the Brodsky Lab at the University of Pittsburgh and the Kamura Lab at the Nagoya University. Congratulations to all involved!

2021 11 03: K.N. presented a talk to the Science Partnership Event at the Nagoya City Science Museum .

2021 10 22: The manuscript entitled "SWIM8 is a myogenic protein that partly prevents C2C12 differentiation" was accepted for publication in Scientific Reports. This is a joint research with labs at the Nagoya University, the Fukuoka Women's University, and the Waseda University. Congratulations to all involved!

2021 10 04: Three undergraduate students joined the lab (A.K., H.S., and M.H.). Welcome!

2021 08 25: X.Y. defended a master's degree. Congratulations!!

2021 08 13: A.K. and R.M. passed the entrance examination for master course. Congratulations!!

2021 07 23: Nine rotation students finished their time in the lab. They purified recombinant proteins from bacteria and reconstituted the ubiquitination reaction in a test tube. COOL!!

2021 07 13: Congrats to undergraduate researcher A.K. for being awarded Zuihosho!

2021 06 29: K.N. organized the symposium "Life of proteins and beyond: the interface with metabolism" at the 73rd Annual Meeting of the Japan Society for Cell Biology.  K.N. also chaired the workshop "Life of proteins".

2021 04 01: Y.T. (first year of the master course) joined the lab.

＜Fiscal year 2020＞ 

2021 02 24: K.N. gave an invited talk at the meeting of Young Research Group on Cutting-edge Circulatory Metabolism (2nd) (@ Kowa Company, Ltd.).

2021 02 24: T.K. passed the entrance examination for doctoral course. Congratulations!!

2021 02 08: T.K. and K.K. defended a master's degree and received the best presentation awards. Congratulations!!

2021 01 21: Our review entitled "Potential Physiological Relevance of ERAD to the Biosynthesis of GPI-Anchored Proteins in Yeast" was published in Int. J. Mol. Sci.

2020 10 01: Three undergraduate students joined the lab (Y.I., A.K., and R.M.). Welcome!

2020 08 12: Y.T. passed the entrance examination for master course. Congratulations!!

2020 07 31: Six rotation students finished their time in the lab. They purified recombinant proteins from bacteria and performed in vitro ubiquitination assay.

2020 06 18: Our lab moved to the TANABE-DORI campus.

2020 06 09: The 72nd Annual Meeting of the Japanese Society for Cell Biology (@Kyoto Miyako Messe) was held on the Web. K.N. organized the symposium "Life of proteins and beyond: the interface with nutrition and metabolism". Two graduate students from our lab (K.K., T.K.) gave poster presentations.

2020 04 01: T.I. (first year of the doctoral course) joined the lab.