Research
Our primary interest is to understand the molecular mechanisms of protein quality control in organelle homeostasis and metabolism. These studies will contribute to a number of scientific areas including the development of metabolic engineering in microorganisms, an understanding of clinical diseases of protein misfolding and the regulation of cell homeostasis during different metabolic conditions.
(1) Protein quality control.
(1) Protein quality control.
Molecular machineries of endoplasmic reticulum-associated degradation (ERAD).
Molecular machineries of endoplasmic reticulum-associated degradation (ERAD).
Quotations from Nakatsukasa et al., 2014 Curr. Opin. Cell Biol.
(2) Roles of protein degradation and post-translational modifications in regulation of metabolic pathways.
(2) Roles of protein degradation and post-translational modifications in regulation of metabolic pathways.
Quotations from Nakatsukasa et al., 2015 Crit. Rev. Biochem. Mol. Biol.