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Research Overview
Autophagy is a cellular mechanism that removes unnecessary proteins and organelles from within the cell. Recent studies have revealed that autophagy activity plays an important protective role across a wide range of disease states. Our laboratory focuses on elucidating the roles of autophagy and mitophagy—a form of selective autophagy directed at mitochondria—in the context of various cardio-cerebrovascular diseases.
Basic research on alternative autophagy
Building on the Rab9–Ulk1 axis, we are investigating the molecular mechanisms of alternative autophagy across the entire process—from initiation to membrane fusion—with a particular focus on alternative mitophagy. We are also establishing in vivo disease models to validate these mechanisms in the context of cardio-cerebrovascular disease.
Discovery of novel regulators of autophagy and selective autophagy through cell-based screening assays
Using a cDNA library comprising over 5,000 genes together with diverse compound libraries, we are identifying novel regulators of autophagy and conducting preliminary studies to define their roles in cardio-cerebrovascular disease and their potential as therapeutic targets.
Development of a novel class of autophagy activators targeting Rubicon
We are pursuing pioneering research on Rubicon, a well-established negative regulator of autophagy. By uncovering new regulatory mechanisms involving Rubicon, we aim to develop sustainable, non-toxic autophagy activators applicable across a range of disease contexts.
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