2025년
Kim H, Na J, Ryu HG, Lee E, Park H, Park H, Nam Y, Jeong GH, Pyo IH, Choi JH, Nah J, Jang SM, Song JH, Cho SJ, Kim S. A novel peptide-based strategy to enhance GBA1 expression for treating Parkinson's disease. NPJ Parkinsons Dis. 2025 Nov 19;11(1):323.
Kim YM, Jo JH, Kim DK, Park JU, Jung DH, Cho HJ, Seong HA, Nah J, Park JY, Choi JH, Kim S, Kim KB, Jang SM. CRL4 mediates autoubiquitination of DDB1 upon deneddylation inhibition. Biochem Biophys Res Commun. 2025 Oct 8;786:152772.
Baek S*, Jo Y*, Nah J. The Role of the Beclin1 Complex in Rab9-Dependent Alternative Autophagy. Int J Mol Sci. 2025 Sep 19;26(18):9151. (*co-first authors)
Abdellatif M, Vasques-Nóvoa F, Trummer-Herbst V, Durand S, Koser F, Islam M, Nah J, Sung EA, Feng R, Aprahamian F, Prokesch A, Zardoya-Laguardia P, Sadoshima J, Diwan A, Linke WA, Ferreira JP, Kroemer G, Sedej S. Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction. Eur Heart J. 2025 May 14;46(19):1863-1866. (IF:38.1)
2024년
Baek S, Chang JW, Yoo SM, Choo J, Jung S, Nah J*, Jung YK*. TMEM9 activates Rab9-dependent alternative autophagy through interaction with Beclin1. Cell Mol Life Sci. 2024 Jul 30;81(1):322. (*co-corresponding)
Maejima Y, Nah J, Aryan Z, Zhai P, Sung EA, Liu T, Takayama K, Moghadami S, Sasano T, Li H, Sadoshima J. Mst1-mediated phosphorylation of FoxO1 and C/EBP-β stimulates cell-protective mechanisms in cardiomyocytes. Nat Commun. 2024 Jul 25;15(1):6279.
Um JH, Shin DJ, Choi SM, Nathan ABP, Kim YY, Lee DY, Jeong DJ, Kim DH, Kim KH, Kim YH, Nah J, Jeong JH, Yoo E, Shin HK, Park HT, Jo J, Cho JH, Yun J. Selective induction of Rab9-dependent alternative mitophagy using a synthetic derivative of isoquinoline alleviates mitochondrial dysfunction and cognitive deficits in Alzheimer's disease models. Theranostics. 2024 Jan 1;14(1):56-74.
2023년
Jo JH, Park JU, Kim YM, Ok SM, Kim DK, Jung DH, Kim HJ, Seong HA, Cho HJ, Nah J, Kim S, Fu H, Redon CE, Aladjem MI, Jang SM. RepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter. Cell Commun Signal. 2023 Aug 23;21(1):219.
Nah J. The Role of Alternative Mitophagy in Heart Disease. Int J Mol Sci. 2023 Mar 28;24(7):6362.
Nagarajan N, Oka SI, Nah J, Wu C, Zhai P, Mukai R, Xu X, Kashyap S, Huang CY, Sung EA, Mizushima W, Titus AS, Takayama K, Mourad Y, Francisco J, Liu T, Chen T, Li H, Sadoshima J. Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia. J Clin Invest. 2023 Feb 1;133(3):e162326.
Maejima Y, Zablocki D, Nah J, Sadoshima J. The role of the Hippo pathway in autophagy in the heart. Cardiovasc Res. 2023 Jan 18;118(17):3320-3330.
2022년
Kim YM, Kim HJ, Kim DK, Jung DH, Cho HJ, Kim S, Nah J, Jang SM. Differential dynamics of cullin deneddylation via COP9 signalosome subunit 5 interaction. Biochem Biophys Res Commun. 2022 Dec 31;637:341-347.
Motiño O, Lambertucci F, Anagnostopoulos G, Li S, Nah J, Castoldi F, Senovilla L, Montégut L, Chen H, Durand S, Bourgin M, Aprahamian F, Nirmalathasan N, Alvarez-Valadez K, Sauvat A, Carbonnier V, Djavaheri-Mergny M, Pietrocola F, Sadoshima J, Maiuri MC, Martins I, Kroemer G. ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis. Proc Natl Acad Sci USA. 2022 Oct 11;119(41):e2207344119.
Nah J, Zablocki D, Sadoshima J. The role of autophagic cell death in cardiac disease. J Mol Cell Cardiol. 2022 Sep 6;173:16-24.
Nah J, Sung E, Zhai P, Sadoshima J. Tfeb-mediated transcriptional regulation of autophagy induces autosis during ischemia/reperfusion in the heart. Cells. 2022 Jan 13;11(2):258.
Nah J, Shirakabe A, Zhai P, Mizushima W, Nakada Y, Saito T, Sung E, Hu C, Sadoshima J. Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart. Cardiovasc Res. 2022 Jan 9:cvac003.
2021년
Nah J, Zablocki D, Sadoshima J. The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death. Exp Mol Med. 2021 Apr;53(4):528-536.
Klionsky DJ, …, Nah J, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382.
Ikeda S*, Nah J*, Shirakabe A, Zhai P, Oka SI, Sciarretta S, Guan KL, Shimokawa H, Sadoshima J. YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases. J Clin Invest. 2021 Mar 1;131(5):e143173.
2020년
Nah J, Zablocki D, Sadoshima J. Autosis: A New Target to Prevent Cell Death. JACC Basic Transl Sci. 2020 Aug 24;5(8):857-869.
Oka SI, Chin A, Park JY, Ikeda S, Mizushima W, Ralda G, Zhai P, Tong M, Byun J, Tang F, Einaga Y, Huang CY, Kashihara T, Zhao M, Nah J, Tian B, Hirabayashi Y, Yodoi J, Sadoshima J. Thioredoxin-1 maintains mitochondrial function via mTOR signaling in the heart. Cardiovasc Res. 2020 Aug 1;116(10):1742-1755.
Nah J, Zhai P, Huang CY, Fernández ÁF, Mareedu S, Levine B, Sadoshima J. Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury. J Clin Invest. 2020 Jun 1;130(6):2978-2991.
Jung S, Hyun J, Nah J, Han J, Kim SH, Park J, Oh Y, Gwon Y, Moon S, Jo DG, Jung YK. SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions. Sci Signal. 2020 Mar 17;13(623): eaax8949.
Kaludercic N, Maiuri MC, Kaushik S, Fernández ÁF, de Bruijn J, Castoldi F, Chen Y, Ito J, Mukai R, Murakawa T, Nah J, Pietrocola F, Saito T, Sebti S, Semenzato M, Tsansizi L, Sciarretta S, Madrigal-Matute J. Comprehensive autophagy evaluation in cardiac diseases models. Cardiovasc Res. 2020 Mar 1;116(3):483-504.
Fernández ÁF, Liu Y, Ginet V, Shi M, Nah J, Zou Z, Zhou A, Posner BA, Xiao G, Tanguy M, Paradis V, Sadoshima J, Rautou PE, Puyal J, Hu MC, Levine B. Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia. JCI Insight. 2020 Jan 16;5(1):e133282.
2020년 이전
1. Chen G, Xie W, Nah J, Sauvat A, Liu P, Pietrocola F, Sica V, Carmona-Gutierrez D, Zimmermann A, Pendl T, Tadic J, Bergmann M, Hofer SJ, Domuz L, Lachkar S, Markaki M, Tavernarakis N, Sadoshima J, Madeo F, Kepp O, Kroemer G. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019 Nov 7;11(11):e10469.
2. Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019 Feb 19;10(1):651.
3. Saito T, Nah J, Oka SI, Mukai R, Monden Y, Maejima Y, Ikeda Y, Sciarretta S, Liu T, Li H, Baljinnyam E, Fraidenraich D, Fritzky L, Zhai P, Ichinose S, Isobe M, Hsu CP, Kundu M, Sadoshima J. An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia. J Clin Invest. 2019 Feb 1;129(2):802-819.
4. Nah J, Miyamoto S, Sadoshima J. Mitophagy as a Protective Mechanism against Myocardial Stress. Compr Physiol. 2017 Sep 12;7(4):1407-1424.
5. Kim YD, Jeong EI, Nah J, Yoo SM, Lee WJ, Kim Y, Moon S, Hong SH, Jung YK. Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy. J Neurochem. 2017 Sep;142(5):734-746.
6. Nah J*, Yoo SM*, Jung, S, Jeong EI, Park M, Kaang BK, Jung YK. Phosphorylated CAV1 activates autophagy through an interaction with BECN1 under oxidative stress. Cell Death Dis. 2017 May 25;8(5):e2822.
7. Nah J, Fernández ÁF, Kitsis RN, Levine B, Sadoshima J. Does Autophagy Mediate Cardiac Myocyte Death During Stress? Circ Res. 2016 Sep 30;119(8):893-5.
8. Jung S, Nah J, Han J, Choi SG, Kim H, Park J, Pyo HK, Jung YK. Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia. J Neurochem. 2016 Jun;137(5):770-81.
9. Kim Y, Choi H, Lee W, Park H, Kam TI, Hong SH, Nah J, Jung S, Shin B, Lee H, Choi TY, Choo H, Kim KK, Choi SY, Kayed R, Jung YK. Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model. Neurobiol Dis. 2016 Mar;87:19-28.
10. Park S, Choi SG, Yoo SM, Nah J, Jeong E, Kim H, Jung YK. Pyruvate stimulates mitophagy via PINK1 stabilization. Cell Signal. 2015 Sep;27(9):1824-30.
11. Kim Y, Park H, Nah J, Moon S, Lee W, Hong SH, Kam TI, Jung YK. Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition. Biochem Biophys Res Commun. 2015 Jun 26;462(2):112-8.
12. Nah J, Yuan J, Jung YK. Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach. Mol Cells. 2015 May 31;38(5):381-389.
13. Choi TY, Jung S, Nah J, Ko HY, Jo SH, Chung G, Park K, Jung YK, Choi SY. Low levels of methyl β-cyclodextrin disrupt GluA1-dependent synaptic potentiation but not synaptic depression. J Neurochem. 2015 Feb;132(3):276-85.
14. Han J, Jung S, Jang J, Kam TI, Choi H, Kim BJ, Nah J, Jo DG, Nakagawa T, Nishimura M, Jung YK. OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin. Cell Mol Life Sci. 2014 Jul;71(13):2561-76.
15. Nah J, Pyo JO, Jung S, Yoo SM, Kam TI, Chang JW, Han J, A.An SS, Onodera T, Jung YK. BECN1/Beclin1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid beta 42. Autophagy. 2013 Dec;9(12):2009-21.
16. Pyo JO, Yoo SM, Ahn HH, Nah J, Hong SH, Kam TI, Jung S, Jung YK. Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nat Commun. 2013;4:2300.
17. Pyo JO, Nah J, Jung YK. Molecules and their functions in autophagy. Exp Mol Med. 2012 Feb 29;44(2):73-80.
18. Pyo JO, Nah J, Kim HJ, Chang JW, Song YW, Yang DK, Jo DG, Kim HR, Chae HJ, Chae SW, Hwang SY, Kim SJ, Kim HJ, Cho C, Oh CG, Park WJ, Jung YK. Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice. J Biol Chem. 2008 Nov 7;283(45):30707-14.
19. Pyo JO*, Nah J*, Kim HJ, Lee HJ, Heo J, Lee H, Jung YK. Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death. Autophagy. 2008 Apr;4(3):315-21.