Publications

2026

Nah J, Sung E A, Zhai P, Maejima Y, Hu C, Ramos-Zepeda J, Ikeda S, Mizushima W and Sadoshima J (2026), "Cardiomyocyte-specific deficiency of C/EBPβ aggravates pressure overload-induced heart failure", Cardiovasc Res 122(4):527-538

Lee H J, Hwang S J, Jeong E H, Chang M H, Heo B Y, Kwon J, Noh Y and Nah J (2026), "Development of tri-cistronic CLDN18.2 CAR-T cells incorporating PD-1/CD28 switch and cyclophilin A for enhanced solid tumor immunotherapy", J Microbiol
64(1):e2510017

Jung D H, Park J U, Jo J H, Kim D K, Kim Y M, Kang M J, Hong S H, Cho H J, Nah J, Park J Y, Choi J H, Kim S and Jang S M (2026), "RepID promotes metastatic potential in osteosarcoma through regulation of the PRC1-GATA6 axis", Anim Cells Syst (Seoul) 30(1):47-58

Jeong M, Ryu S H, Cho Y S, Na D H, Baek J, Nah J, Kim K W and Jung Y K (2026), "Mitochondrial AK3 inhibits nuclear β-catenin localization and its activation through enhancing mitochondrial activity", Cell Death Dis 17(1):529

2023-2025

Kim Y M, Jo J H, Kim D K, Park J U, Jung D H, Cho H J, Seong H A, Nah J, Park J Y, Choi J H, Kim S, Kim K B and Jang S M (2025), "CRL4 mediates autoubiquitination of DDB1 upon deneddylation inhibition", Biochem Biophys Res Commun 786:152772

Kim H, Na J, Ryu H G, Lee E, Park H, Park H, Nam Y, Jeong G H, Pyo I H, Choi J H, Nah J, Jang S M, Song J H, Cho S J and Kim S (2025), "A novel peptide-based strategy to enhance GBA1 expression for treating Parkinson's disease", NPJ Parkinsons Dis 11(1):323

Baek S, Jo Y and Nah J (2025), "The Role of the Beclin1 Complex in Rab9-Dependent Alternative Autophagy", Int J Mol Sci 26(18):9151

Abdellatif M, Vasques-Nóvoa F, Trummer-Herbst V, Durand S, Koser F, Islam M, Nah J, Sung E A, Feng R, Aprahamian F, Prokesch A, Zardoya-Laguardia P, Sadoshima J, Diwan A, Linke W A, Ferreira J P, Kroemer G and Sedej S (2025), "Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction", Eur Heart J 46(19):1863-1866

Um J H, Shin D J, Choi S M, Nathan A B P, Kim Y Y, Lee D Y, Jeong D J, Kim D H, Kim K H, Kim Y H, Nah J, Jeong J H, Yoo E, Shin H K, Park H T, Jo J, Cho J H and Yun J (2024), "Selective induction of Rab9-dependent alternative mitophagy using a synthetic derivative of isoquinoline alleviates mitochondrial dysfunction and cognitive deficits in Alzheimer's disease models", Theranostics 14(1):56-74

Maejima Y, Nah J, Aryan Z, Zhai P, Sung E A, Liu T, Takayama K, Moghadami S, Sasano T, Li H and Sadoshima J (2024), "Mst1-mediated phosphorylation of FoxO1 and C/EBP-β stimulates cell-protective mechanisms in cardiomyocytes", Nat Commun 15(1):6279

Baek S, Chang J W, Yoo S M, Choo J, Jung S, Nah J and Jung Y K (2024), "TMEM9 activates Rab9-dependent alternative autophagy through interaction with Beclin1", Cell Mol Life Sci 81(1):322

Nah J (2023), "The Role of Alternative Mitophagy in Heart Disease", Int J Mol Sci 24(7): 6362

Nagarajan N, Oka S I, Nah J, Wu C, Zhai P, Mukai R, Xu X, Kashyap S, Huang C Y, Sung E A, Mizushima W, Titus A S, Takayama K, Mourad Y, Francisco J, Liu T, Chen T, Li H and Sadoshima J (2023), "Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia", J Clin Invest 133(3):

Maejima Y, Zablocki D, Nah J and Sadoshima J (2023), "The role of the Hippo pathway in autophagy in the heart", Cardiovasc Res 118(17):3320-3330

Jo J H, Park J U, Kim Y M, Ok S M, Kim D K, Jung D H, Kim H J, Seong H A, Cho H J, Nah J, Kim S, Fu H, Redon C E, Aladjem M I and Jang S M (2023), "RepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter", Cell Commun Signal 21(1):219

2020-2022

Nah J, Zablocki D and Sadoshima J (2022), "The role of autophagic cell death in cardiac disease", J Mol Cell Cardiol 173:16-24

Nah J, Sung E A, Zhai P, Zablocki D and Sadoshima J (2022), "Tfeb-Mediated Transcriptional Regulation of Autophagy Induces Autosis during Ischemia/Reperfusion in the Heart", Cells 11(2):258

Nah J, Shirakabe A, Mukai R, Zhai P, Sung E A, Ivessa A, Mizushima W, Nakada Y, Saito T, Hu C, Jung Y K and Sadoshima J (2022), "Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart", Cardiovasc Res 118(12):2638-2651

Motiño O, Lambertucci F, Anagnostopoulos G, Li S, Nah J, Castoldi F, Senovilla L, Montégut L, Chen H, Durand S, Bourgin M, Aprahamian F, Nirmalathasan N, Alvarez-Valadez K, Sauvat A, Carbonnier V, Djavaheri-Mergny M, Pietrocola F, Sadoshima J, Maiuri M C, Martins I and Kroemer G (2022), "ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis", Proc Natl Acad Sci U S A 119(41):e2207344119

Kim Y M, Kim H J, Kim D K, Jung D H, Cho H J, Kim S, Nah J and Jang S M (2022), "Differential dynamics of cullin deneddylation via COP9 signalosome subunit 5 interaction", Biochem Biophys Res Commun 637:341-347

Nah J, Zablocki D and Sadoshima J (2021), "The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death", Exp Mol Med 53(4):528-536

Klionsky D J, ..., Nah J, ..., et al.  (2021), "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)", Autophagy 17(1):1-382

Ikeda S, Nah J, Shirakabe A, Zhai P, Oka S I, Sciarretta S, Guan K L, Shimokawa H and Sadoshima J (2021), "YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases", J Clin Invest 131(5):e143173

Oka S I, Chin A, Park J Y, Ikeda S, Mizushima W, Ralda G, Zhai P, Tong M, Byun J, Tang F, Einaga Y, Huang C Y, Kashihara T, Zhao M, Nah J, Tian B, Hirabayashi Y, Yodoi J and Sadoshima J (2020), "Thioredoxin-1 maintains mitochondrial function via mechanistic target of rapamycin signalling in the heart", Cardiovasc Res 116(10):1742-1755

Nah J, Zhai P, Huang C Y, Fernández Á F, Mareedu S, Levine B and Sadoshima J (2020), "Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury", J Clin Invest 130(6):2978-2991

Nah J, Zablocki D and Sadoshima J (2020), "Autosis: A New Target to Prevent Cell Death", JACC Basic Transl Sci 5(8):857-869

Kaludercic N, Maiuri M C, Kaushik S, Fernández Á F, de Bruijn J, Castoldi F, Chen Y, Ito J, Mukai R, Murakawa T, Nah J, Pietrocola F, Saito T, Sebti S, Semenzato M, Tsansizi L, Sciarretta S and Madrigal-Matute J (2020), "Comprehensive autophagy evaluation in cardiac disease models", Cardiovasc Res 116(3):483-504

Jung S, Hyun J, Nah J, Han J, Kim S H, Park J, Oh Y, Gwon Y, Moon S, Jo D G and Jung Y K (2020), "SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions", Sci Signal 13(623):eaax8949

Fernández Á F, Liu Y, Ginet V, Shi M, Nah J, Zou Z, Zhou A, Posner B A, Xiao G, Tanguy M, Paradis V, Sadoshima J, Rautou P E, Puyal J, Hu M C and Levine B (2020), "Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia", JCI Insight 5(1):e133282

2016-2019

Saito T, Nah J, Oka S I, Mukai R, Monden Y, Maejima Y, Ikeda Y, Sciarretta S, Liu T, Li H, Baljinnyam E, Fraidenraich D, Fritzky L, Zhai P, Ichinose S, Isobe M, Hsu C P, Kundu M and Sadoshima J (2019), "An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia", J Clin Invest 129(2):802-819

Chen G, Xie W, Nah J, Sauvat A, Liu P, Pietrocola F, Sica V, Carmona-Gutierrez D, Zimmermann A, Pendl T, Tadic J, Bergmann M, Hofer S J, Domuz L, Lachkar S, Markaki M, Tavernarakis N, Sadoshima J, Madeo F, Kepp O and Kroemer G (2019), "3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB", EMBO Mol Med 11(11):e10469

Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel C B, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer S J, Bauer M A, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot D P, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber T R, Sadoshima J, Ventura N, Sigrist S J, Kroemer G and Madeo F (2019), "The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species", Nat Commun 10(1):651

Nah J, Yoo S M, Jung S, Jeong E I, Park M, Kaang B K and Jung Y K (2017), "Phosphorylated CAV1 activates autophagy through an interaction with BECN1 under oxidative stress", Cell Death Dis 8(5):e2822

Nah J, Miyamoto S and Sadoshima J (2017), "Mitophagy as a Protective Mechanism against Myocardial Stress", Compr Physiol 7(4):1407-1424

Kim Y D, Jeong E I, Nah J, Yoo S M, Lee W J, Kim Y, Moon S, Hong S H and Jung Y K (2017), "Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy", J Neurochem 142(5):734-746

Nah J, Fernández Á F, Kitsis R N, Levine B and Sadoshima J (2016), "Does Autophagy Mediate Cardiac Myocyte Death During Stress?", Circ Res 119(8):893-5

Kim Y, Choi H, Lee W, Park H, Kam T I, Hong S H, Nah J, Jung S, Shin B, Lee H, Choi T Y, Choo H, Kim K K, Choi S Y, Kayed R and Jung Y K (2016), "Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model", Neurobiol Dis 87:19-28

Jung S, Nah J, Han J, Choi S G, Kim H, Park J, Pyo H K and Jung Y K (2016), "Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia", J Neurochem 137(5):770-81

2010-2015

Park S, Choi S G, Yoo S M, Nah J, Jeong E, Kim H and Jung Y K (2015), "Pyruvate stimulates mitophagy via PINK1 stabilization", Cell Signal 27(9):1824-30

Nah J, Yuan J and Jung Y K (2015), "Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach", Mol Cells 38(5):381-9

Kim Y, Park H, Nah J, Moon S, Lee W, Hong S H, Kam T I and Jung Y K (2015), "Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition", Biochem Biophys Res Commun 462(2):112-8

Choi T Y, Jung S, Nah J, Ko H Y, Jo S H, Chung G, Park K, Jung Y K and Choi S Y (2015), "Low levels of methyl β-cyclodextrin disrupt GluA1-dependent synaptic potentiation but not synaptic depression", J Neurochem 132(3):276-85

Han J, Jung S, Jang J, Kam T I, Choi H, Kim B J, Nah J, Jo D G, Nakagawa T, Nishimura M and Jung Y K (2014), "OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin", Cell Mol Life Sci 71(13):2561-76

Pyo J O, Yoo S M, Ahn H H, Nah J, Hong S H, Kam T I, Jung S and Jung Y K (2013), "Overexpression of Atg5 in mice activates autophagy and extends lifespan", Nat Commun 4:2300

Nah J, Pyo J O, Jung S, Yoo S M, Kam T I, Chang J, Han J, Soo A A S, Onodera T and Jung Y K (2013), "BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid β 42", Autophagy 9(12):2009-21

Pyo J O, Nah J and Jung Y K (2012), "Molecules and their functions in autophagy", Exp Mol Med 44(2):73-80

2008

Pyo J O, Nah J, Kim H J, Lee H J, Heo J, Lee H and Jung Y K (2008), "Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death", Autophagy 4(3):315-21

Pyo J O, Nah J, Kim H J, Chang J W, Song Y W, Yang D K, Jo D G, Kim H R, Chae H J, Chae S W, Hwang S Y, Kim S J, Kim H J, Cho C, Oh C G, Park W J and Jung Y K (2008), "Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice", J Biol Chem 283(45):30707-14