生体機序論 - Publication

生体機序論

Publication

2011~Present

Shimizu T, Nomachi T, Matsumoto K, Hisamoto N.

A cytidine deaminase regulates axon regeneration by modulating the functions of the Caenorhabditis elegans HGF/plasminogen family protein SVH-1.

PLoS Genet. 20: e1011367 (2024).

Sakai Y, Shimizu T, Tsunekawa M, Hisamoto N, Matsumoto K.

Rhotekin regulates axon regeneration through the talin-Vinculin-Vinexin axis in Caenorhabditis elegans.

PLoS Genet. 19: e1011089 (2023).

Hanafusa H, Fujita K, Kamio M, Iida S, Tamura Y, Hisamoto N, Matsumoto K.

LRRK1 functions as a scaffold for PTP1B-mediated EGFR sorting into ILVs at the ER-endosome contact site.

J. Cell Sci. 136: jcs260566 (2023).

Fujita K, Kedashiro S, Yagi T, Hisamoto N, Matsumoto K, Hanafusa H.

The ULK complex-LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation.

J. Cell Sci. 135: jcs260395 (2022).

Sakai Y, Hanafusa H, Hisamoto N, Matsumoto K.

Histidine dephosphorylation of the Gβ protein GPB-1 promotes axon regeneration in C. elegans.

EMBO Rep. 23: e55076 (2022).

Hanafusa H, Kedashiro S, Gotoh M, Saitoh KH, Inaba H, Nishioka T, Kaibuchi K, Inagaki M, Hisamoto N, Matsumoto K.

LRRK1-mediated NDEL1 phosphorylation promotes cilia disassembly via dynein-2-driven retrograde intraflagellar transport.

J. Cell Sci. 135: jcs259999 (2022).

Shimizu T, Sugiura K, Sakai Y, Dar AR, Butcher RA, Matsumoto K, Hisamoto N.

Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans.

J. Neurosci. 42: 720-730 (2022).

Sakai Y, Tsunekawa M, Ohta K, Shimizu T, Pastuhov S 4th, Hanafusa H, Hisamoto N, Matsumoto K.

The Integrin Signaling Network Promotes Axon Regeneration via the Src-Ephexin-RhoA GTPase Signaling Axis.

J. Neurosci. 41: 4754-4767 (2021).

Kulkarni SS, Sabharwal V, Sheoran S, Basu A, Matsumoto K, Hisamoto N, Ghosh-Roy A, Koushika SP.

UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons.

Genetics 219: iyab139 (2021).

Hisamoto N, Sakai Y, Ohta K, Shimizu T, Li C, Hanafusa H, Matsumoto K.

CDK14 promotes axon regeneration by regulating the noncanonical Wnt signaling pathway in a kinase-independent manner.

J. Neurosci. 41: 2842-2853 (2021).

Sakai Y, Hasnafusa H, Shimizu T, Pastuhov SI, Hisamoto N, Matsumoto K.

BRCA1-BARD1 regulates axon regeneration in concert with the Gqα-DAG signaling network.

J. Neurosci. 41: 2842-2853 (2021).

Shimizu T, Pastuhov SI, Hasnafusa H, Sakai Y, Todoroki Y, Hisamoto N, Matsumoto K.

Caenorhabditis elegans F-Box protein promotes axon regeneration by inducing degradation of the Mad transcription factor

J. Neurosci. 41: 2373-2381 (2021).

Sakai Y, Hasnafusa H, Pastuhov SI, Shimizu T, Li C, Hisamoto N, Matsumoto K.

TDP2 negatively regulates axon regeneration by inducing SUMOylation of an Ets transcription factor

EMBO Rep. 20: e47517 (2019).

Shimizu T, Kato Y, Sakai Y, Hisamoto N, Matsumoto K.

N-Glycosylation of the discoidin domain receptor is required for axon regeneration in Caenorhabditis elegans.

Genetics 213: 491-500 (2019).

Hanafusa H, Yagi T, Ikeda H, Hisamoto N, Nishioka T, Kaibuchi K, Shirakabe K, Matsumoto K.

LRRK1 phosphorylation of Rab7 at S72 links trafficking of EGFR-containing endosomes to its effector RILP

J. Cell Sci.132: jcs228809 (2019).

Hisamoto N, Shimizu T, Asai K, Sakai Y, Pastuhov SI, Hanafusa H, Matsumoto K.

The C. elegans Tensin promotes axon regeneration by linking the Met-like SVH-2 and integrin signaling pathways.

J. Neurosci. 39: 5662-5672 (2019).

Hisamoto N, Tsuge A, Pastuhov SI, Shimizu T, Hanafusa H, Matsumoto K.

Phosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration.

Nature Commun. 9: 3099 (2018).

Shimizu T, Pastuhov SI, Hanafusa H, Matsumoto K, Hisamoto N.

The C. elegans BRCA2-ALP/Enigma complex regulates axon regeneration via a Rho GTPase-ROCK-MLC phosphorylation pathway.

Cell Rep. 24: 1880-1889 (2018).

Hisamoto N, Matsumoto K.

Signal transduction cascades in axon regeneration: insights from C. elegans.

Curr. Opin. Genet. Dev. 44: 55-60 (2017).

Choudhary B, Kamak M, Ratnakaran N, Kumar J, Awasthi A, Li C, Nguyen K, Matsumoto K, Hisamoto N, Kaushika SP.

UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes.

PLoS Genet. 13: e1007100 (2017).

Alam T, Maruyama H, Li C, Pastuhov SI, Nix P, Bastiani M, Hisamoto N, Matsumoto K.

Axotomy-induced HIF–serotonin signalling axis promotes axon regeneration in C.elegans.

Nature Commun. 7: 10388 (2016).

Hisamoto N, Nagamori Y, Shimizu T, Pastuhov S, Matsumoto K.

The C. elegans discoidin domain receptor DDR-2 modulates the Met-like RTK–JNK signaling pathway in axon regeneration.

PLoS Genet. 12: e1006475 (2016).

Pastuhov S, Fujiki K, Tsuge A, Asai K, Ishikawa S, Hirose K, Matsumoto K, Hisamoto N.

The core molecular machinery used for engulfment of apoptotic cells regulates the JNK pathway mediating axon regeneration in Caenorhabditis elegans.

J. Neurosci. 36: 9710-9721 (2016).

Sai K, Morioka S, Takaesu G, Muthusamy N, Ghashghaei HT, Hanafusa H, Matsumoto K, Ninomiya-Tsuji J.

TAK1 determines susceptibility to endoplasmic reticulum stress and hypothalamic leptin resistance.

J. Cell Sci. 129: 1855-1865 (2016).

Pastuhov SI, Matsumoto K, Hisamoto N.

Endocannabinoid signaling regulates regenerative axon navigation in C. elegans via the GPCRs NPR-19 and NPR-32.

Gene Cells 21: 696-705 (2016).

Fukuzono T, Pastuhov SI, Fukushima O, Li C, Hattori A, Iemura S, Natsume T, Shibuya H, Hanafusa H, Matsumoto K, Hisamoto N.

The chaperone complex BAG2–HSC70 regulates localization of C. elegans Leucine-rich repeat kinase LRK-1 in the Golgi.

Gene Cells 21: 311-324 (2016).

Hanafusa H, Kedashiro S, Tezuka M, Funatsu M, Usami S, Toyoshima F, Matsumoto K.

PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.

Nature Cell Biol. 17: 1024-1035 (2015).

Li C, Hisamoto N, Matsumoto K.

Axon regeneration is regulated by Ets–C/EBP transcription complexes generated by activation of the cAMP/Ca2+ signaling pathways.

PLoS Genet. 11: e1005603 (2015).

Kedashiro S, Pastuhov S, Nishioka T, Watanabe W, Kaibuchi K, Matsumoto K, Hanafusa H.

Phosphorylation of CLIP-170 by LRRK1 regulates EGFR trafficking by promoting recruitment of p150Glued to MT plus-ends.

J. Cell. Sci. 128: 385-396 (2015).

Hanafusa H, Matsumoto K.

LRRK1 regulates spindle orientation downstream of PLK1 by phosphorylating CDK5RAP2.

Cell Cycle 14: 3349-3350 (2015).

Hisamoto N, Li C, Yoshida M, Matsumoto K.

The C. elegans HGF/plasminogen-like protein SVH-1 has protease-dependent and -independent functions.

Cell Reports 9: 1628-1634 (2014).

Hattori A, Mizuno T, Akamatsu M, Hisamoto N, Matsumoto K.

The C.elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex.

PLoS Genet. 9: e1003315 (2013).

Inoue A, Sawatari E, Hisamoto N, Kitazono T, Teramoto T, Fujiwara M, Matsumoto K, Ishihara K.

Forgetting in C. elegans is accelerated by neuronal communication via the TIR-1/JNK-1 pathway.

Cell Reports 3: 808-819 (2013).

Li C, Hisamoto N, Nix P, Kanao S, Mizuno T, Bastaini M, Matsumoto K.

The growth factor SVH-1 regulates axon regeneration in C.elegans via the JNK MAPK cascade.

Nature Neurosci. 15: 551-557 (2012).

Pastuhov SI, Fujiki K, Nix P, Kanao S, Bastiani M, Matsumoto K, Hisamoto N.

Endocannabinoid-Goalpha signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqalpha-PKC-JNK signalling .

Nature Commun. 3:1136 (2012).

Ishikawa K, Nara A, Matsumoto K, Hanafusa H.

EGFR-dependent phosphorylation of Leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR.

Mol. Biol. Cell 23: 1294-1306 (2012).

Hanafusa H, Ishikawa K, Kedashiro S, Saigo K, Iemura S, Natsume T, Komada M, Shibuya H, Nara A, Matsumoto K.

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor.

Nature Commun. 2: 158 (2011).

Nix P, Hisamoto N, Matsumoto K, Bastiani M.

Axon regeneration requires coodinate activation of p38 and JNK MAPK pathways.

Proc. Natl. Acad. Sci. USA. 108: 10738-10743 (2011).

Arimoto M, Koushika SP, Choudhary BC, Li C, Matsumoto K, Hisamoto N.

The C. elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein.

J. Neurosci. 31: 2216-2224 (2011).

Yuan Y, Cao P, Smith MA, Kramp K, Huang Y, Hisamoto N, Matsumoto K, Hatzoglou M, Jin H, Feng Z.

Disregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans.

PLoS One 6: e22354 (2011).

Hayakawa T, Kato K, Hayakawa R, Hisamoto N, Matsumoto K, Takeda K, Ichijo H.

Regulation of anoxic death in Caenorhabditis elegans by the ASK-p38 pathway ortholog NSY-1–SEK-1–PMK-1.

Genetics 187: 785-792 (2011).

~2010

Shivers, R. P., Pagano, D. J., Kooistra1, T., Richardson, C. E., Reddy, K. C., Whitney, J. K., Matsumoto, K., Hisamoto, N., Kim, D. H.

The CREB/ATF family transcription factor ATF-7 regulates PMK-1 p38 MAPK mediated innate immunity in C. elegans.

PLoS Genet. 6: e1000892 (2010).

Fujiki, K., Mizuno, T., Hisamoto, N., Matsumoto, K.

The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the JNK signaling pathway mediating the stress response.

Mol. Cell. Biol. 30: 995-1003 (2010).

Okuyama, T., Inoue, H., Ookuma, S., Satoh, T., Kano, K., Honjoh, S., Hisamoto, N., Matsumoto, K., Nishida, E.

The ERK MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in C. elegans.

J. Biol. Chem. 285, 30274-30281 (2010).

Hanafusa, H., Matsumoto, K., Nishida, E.

Regulation of the ERK activity duration by Sprouty contributes to dorsoventral patterning

Nature Cell Biol. 11: 106-109 (2009).

Saha, S., Guillily, M., Ferree, A., Lanceta, J., Chan, D., Ghosh, J., Hsu, C., Segal, L., Raghavan, K., Matsumoto, K., Hisamoto, N., Kuwahara, T., Iwatsubo, T., Moore, L., Goldstein, L., Cookson, M., Wolozin, B.

LRRK2 modulates vulnerability to mitochondrial dysfunction in C. elegans.

J. Neurosci. 29: 9210-9218 (2009).

Hiatt, S. M., Duren, H. M., Shyu, Y. J., Ellis, R. E., Hisamoto, N., Matsumoto, K., Kariya, K., Kerppola, T. M., Hu, C-D.

C. elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation.

Mol. Biol. Cell 20: 3888-3895 (2009).

Kim, J. Schouest, K. R., Kurasawa, Y., Furuta, T., Hisamoto, N., Matsumoto, K., Schumacher, J. M.

The Germinal Center Kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline.

PLoS One 4: e7450 (2009).

Hisamoto, N., Moriguchi, T., Urushiyama, S., Mitani, S., Shibuya, H., Matsumoto, K.

C. elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.

EMBO Rep. 9: 70-75 (2008).

Mizuno, T., Fujiki, K., Sasakawa, A., Hisamoto, N., Matsumoto, K.

Role of the C. elegans Shc adaptor 1 protein in the JNK signaling pathway.

Mol. Cell. Biol. 28: 7041-7049 (2008).

Ishibashi, H., Matsumura, N., Hanafusa, H., Matsumoto, K., De Robertis, E.M., Kuroda, H.

Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos.

Mech. Dev. 125: 58-66 (2008).

Sakaguchi-Nakashima, A., Meir, J., Jin, Y., Matsumoto, K., Hisamoto, N.

LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins.

Curr. Biol. 17: 592-598 (2007).

Inoue, H., Hisamoto, N., An, J. H., Oliveira, R. P., Nishida, E., Blackwell, T. K., Matsumoto, K.

The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.

Genes Dev. 19: 2278-2283 (2005).

Sakamoto, R., Byrd, D. T., Brown, H. M., Hisamoto, N., Matsumoto, K., Jin, Y.

The C. elegans UNC-14 RUN domain protein binds to the Kinesin-1/UNC-16 complex and regulates synaptic vesicle localization.

Mol. Biol. Cell 16: 483-496 (2005).

An, J. H., Vranas, K., Lucke, M., Inoue, H., Hisamoto, N., Matsumoto, K., Blackwell, T. K.

Regulation of the C. elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3.

Proc. Natl. Acad. Sci. USA 102: 16275-16280 (2005).

Moriguchi, T., Urushiyama, S., Hisamoto, N., Iemura, S., Uchida, S., Natsume, T., Matsumoto, K., and Shibuya, H.

WNK1 regulates phosphorylation of cation-chloride-coupled kinases, SPAK and OSR1.

J. Biol. Chem. 280: 42685-42693 (2005).

Yasunaga, T., Kusakabe, M., Yamanaka, H., Hanafusa, H., Masuyama, N., Nishida, E.

Xenopus ILK (integrin-linked kinase) is required for morphogenetic movements during gastrulation.

Genes Cell 10: 369-379 (2005).

Nishiwaki, K., Kubota, Y., Chigira, Y., Roy, S.K., Suzuki, M., Schvarzstein, N., Jigami, Y., Hisamoto, N., Matsumoto, K.

An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans.

Nature Cell Biol. 6: 31-37 (2004)

Mizuno, T., Hisamoto, N., Terada, T., Kondo, T., Adachi, M., Nishida, E., Kim, D. H., Ausubel, F. M., Matsumoto, K.

The C. elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response.

EMBO J. 23: 2226-2234 (2004).

Hanafusa, H., Torii, S., Yasunaga, T., Matsumoto, K., Nishida, E.

Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty.

J. Biol. Chem., 279: 22992-22995 (2004).

Kim, D. H., Liberati, N. T., Mizuno, T., Inoue, H., Hisamoto, N., Matsumoto, K., Ausubel, F. M.

Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK.

Proc. Natl. Acad. Sci. USA 101: 10990 - 10994 (2004).

Kim, D.H., Feinbaum, R., Alloing, G., Emerson, F.E., Garsin, D.A., Inoue, H., Tanaka-Hino, M., Hisamoto, N., Matsumoto, K., Tan, M-W., Ausubel, F.M.

A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.

Science 297: 623-626 (2002).

Hanafusa, H., Torii, S., Yasunaga, T., Nishida E.

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

Nature Cell Biol. 4: 850-858 (2002).

Tanaka-Hino, M., Sagasti, A., Hisamoto, N., Kawasaki, M., Nakano, S., Ninomiya-Tsuji, J., Bargamnn, C. I., Matsumoto, K.

SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans.

EMBO Rep. 3: 56-62 (2002).

Yamanaka, H., Moriguchi, T., Kusakabe, M., Hanafusa, H., Takada, R., Takada, S., Nishida, E.

JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates.

EMBO Rep. 3: 69-75 (2002).

Sagasti, A., Hisamoto, N., Hyodo, J., Tanaka-Hino, M., Matsumoto, K., Bargmann, C. I.

The CaMKII UNC-43 activates the MAPKKK NSY-1 to excute a lateral signaling decision required for asymmetric olfactory neuron fates.

Cell 105: 221-232 (2001).

Byrd, D. T., Kawasaki, M., Walcoff, M., Hisamoto, N., Matsumoto, K., Jin, Y.

UNC-16, a JNK signaling scaffold protein, regulates vesicle transport in C. elegans.

Neuron 32: 787-800 (2001).

Suzuki, N., Buechner, M., Nishiwaki, K., Hall, D. H., Nakanishi, H., Takai, Y., Hisamoto, N., Matsumoto, K.

A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans.

EMBO Rep. 2: 530-535 (2001).

Ono, K., Ohtomo, T., Sato, S., Sugamata, Y., Suzuki, M., Hisamoto, N., Ninomiya-Tsuji, J., Tsuchiya, M., Matsumoto, K.

An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.

J. Biol. Chem., 276: 24396-24400 (2001).

Kusakabe, M., Masuyama, N., Hanafusa, H., Nishida, E.

Xenopus FRS2 is involved in early embryogenesis in cooperation with the Src family kinase Laloo.

EMBO Rep. 3: 727-735 (2001).

Nishiwaki, K., Hisamoto, N., Matsumoto, K.

A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans.

Science 288: 2205-2208 (2000).

Hanafusa, H., Masuyama, N., Kusakabe, M., Shibuya, H., Nishida, E.

The TGF-beta family member derrière is involved in regulation of the establishment of left-right asymmetry.

EMBO Rep., 1: 32-39 (2000).

Kuroyanagi, H., Kimura, T., Wada, K., Hisamoto, N., Matsumoto, K., Hagiwara, M.

SPK-1, a C. elegans protein kinase homologue, is essential for embryogenesis and required for germline development.

Mech. Dev., 99: 51-64 (2000).

Meneghini, M.D., Ishitani, T., Carter, C., Hisamoto, N., Ninomiya-Tsuji, J., Thorpe, J., Matsumoto, K., Bowerman, B.

MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans.

Nature 399: 793-797 (1999).

Kawasaki M., Hisamoto N., Iino Y., Yamamoto M., Ninomiya-Tsuji, J., Matsumoto, K.

A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons.

EMBO J., 18: 3604-3615 (1999).

Nakashima, S., Wang, S., Hisamoto, N., Sakai, H., Andoh, M., Matsumoto, K., Nozawa, Y.

Molecular cloning and expression of a stress-responsive mitogen-activated protein kinase-related kinase.

J. Biol. Chem., 274: 9976-9983 (1999).

Hanafusa, H., Ninomiya-Tsuji, J., Masuyama, N., Nishita, M., Fujisawa, J., Shibuya, H., Matsumoto, K., Nishida, E.

Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression.

J. Biol. Chem., 274: 27161-27167 (1999).

Masuyama, N., Hanafusa, H., Kusakabe, M., Shibuya, H., Nishida, E.

Identification of two Smad4 proteins in Xenopus. Their common and distinct properties.

J. Biol. Chem., 274: 12163-12170 (1999).

Review

Chang, C., Hisamoto, N.
Engulfment genes promote neuronal regeneration in Caenorhabditis elegans: Two divergent but complementary views.
Bioessays. 42: e1900185 (2020)

Shimizu, T., Hisamoto, N.
Factors regulating axon regeneration via JNK MAP kinase in C. elegans.
J Biochem. 167: 433-439 (2020)

Hisamoto, N., Matsumoto, K.
Signal transduction cascades in axon regeneration: insights from C. elegans.
Curr. Opin. Genet. Dev. 44: 54-60 (2017).

Pastuhov, S.I., Hisamoto, N., Matsumoto, K.
MAP kinase cascades regulating axon regeneration in C. elegans.
Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 91: 63-75 (2015).

Sakaguchi, A., Matsumoto, K., Hisamoto, N.
Roles of MAP kinase cascades in Caenorhabditis elegans.
J. Biochem. 136: 7-11 (2004).

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