Phage Display

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Phage Display: Engineering Antibodies for Health

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The Big Picture: Discovering New Medicines

Phage display is a powerful, Nobel Prize-winning technology that we use as a tool for discovery. Imagine having a massive library of billions of different keys (antibodies) and needing to find the one specific key that can unlock a solution to a disease. Phage display allows us to do exactly that. We use it to find unique human antibodies that can be developed into new medicines for treating cancer, autoimmune disorders, and infectious diseases.

Our Approach: The "Ya-Mo 1" Human Antibody Library

Our lab has developed a unique and powerful resource: the "Ya-Mo 1" human antibody library. This library was constructed using blood samples from 170 healthy donors in the Nakhon Ratchasima province, making it a rich and diverse source of human antibodies.

The process works by genetically engineering bacteriophages (viruses that infect bacteria) to "display" a specific antibody protein on their outer coat. By creating a vast library of these phages, each displaying a different antibody, we can screen them against a disease target (like a cancer cell protein). Phages that carry an antibody that binds to the target stick to it, allowing us to isolate, identify, and produce that specific antibody.

Applications & Goals

Our primary goal is to create a robust platform for discovering and producing antibody-based drugs, making them more accessible and affordable in Thailand and beyond.

Therapeutic Drug Discovery: Identifying novel antibodies to treat cancer, autoimmune diseases (like lupus or rheumatoid arthritis), and drug-resistant bacterial infections.
Diagnostic Tools: Developing antibodies that can be used in diagnostic kits to detect disease markers or contaminants in food and the environment.
Affordable Biologics: Engineering animal cell lines to efficiently produce these antibody drugs, aiming to lower the cost of these life-saving treatments.

Key Innovations

"Ya-Mo 1" Library: Our proprietary, locally-sourced human antibody library provides a unique advantage in discovering antibodies suited for our population.
End-to-End Platform: We are developing a complete workflow, from initial antibody discovery to the technology for its large-scale production.