Program

Oct 11, Friday

2:00-3:00 pm Registration (Jennings Hall 001 Atrium)

3:00-3:10 pm Opening Remarks (Jennings Hall 001)

Shan-Lu Liu, Co-Director, Viruses and Emerging Pathogens Program, Infectious Diseases Institute, OSU

Michael Oglesbee, Director, Infectious Diseases Institute, OSU

Viral entry and assembly (Jennings Hall 001)

Session chairs:Pranav Danthiand Mark Peeples

3:10-3:35 pm Rebecca Dutch“Mechanisms of Pneumovirus Infection”

3:35-4:00 pm Tuli Mukhopadhyay“Making and Breaking Alphavirus Particles: My Version of Legos”

4:00-4:25 pm Billy Tsai“How non-enveloped viruses hijack host membrane transport and disassembly machineries to cause infection”

4:25-4:50 pm Kristin Parent“Entry mechanisms of Giant Viruses”

4:50-5:15 pm Coffee break

Viral replication and pathogenesis (Jennings Hall 001)

Session chairs:Seema Lakdawalaand Katherine Spindler

5:15-5:40 pm John Patton"Boundless Flexibility of the Rotavirus Genome"

5:40-6:05 pm Anastasia Vlasova“Avian Deltacoronavirus in US migratory birds: implications for swine health”

6:05-6:30 pm Zongdi Feng“New insights into hepatitis E virus biology and pathogenesis”

6:30-7:30 pm Keynote Address

Terence Dermody“The Amazing Assembly Mechanism of a Viral Nanomachine”

Keynote sponsored by the open access journal Viruses (https://www.mdpi.com/journal/viruses)

Walk to Thompson Library for Dinner and Reception

7:30-9:30 pm Banquet Dinner (Thompson Library)

All registrants are invited to attend. ID and wrist bands (to be provided) will be required for bar service.

Oct 12, Saturday

Persistent viral infection (Jennings Hall 001)

Session chairs: Akira Onoand Li Wu

8:00-8:25 am Kathleen Collins“The role of HIV-1 Vpr in macrophage infection”

8:25-8:50 am Jonathan Karn"The shocking case for an HIV cure"

8:50-9:15 am Michael ImperialeThe Transition from Persistent BKPyV Infection to Lytic Replication”

9:15-9:40 am Paul Spearman“Mechanism of HIV Particle Capture and Transmission by Macrophages and Microglia”

9:40-9:55 am Flash Talks - 1 minute, 1 slide in rapid succession

Ashley Zani(Yount Lab, Ohio State U)

Julie Button(Mukhopadyay Lab, Indiana U)

Carmen Mirabelli(Wobus Lab, U Michigan)

Deniece Brown (Pager Lab, SUNY Albany)

Behdokht Jan Fada(Gu Lab, Wayne State U)

Jin Dai (Patton Lab, Indiana U)

Autumn LaPointe (Sokoloski Lab, U Louisville)

Al Awal Mohammed Jimah (Excoffon Lab, Wright State U)

Yu Zhang(Williams Lab, U Pittsburgh)

Praveen Manivannan(Malathi Lab, U Toledo)

Rajni Shukla(Liyanage Lab, Ohio State U)

9:55-10:20 am Coffee Break

10:20-11:40 am Short Talks - 8 minutes, 2 minutes for questions

Session chairs: Christopher Robinsonand Melissa Kane

Maria Virgilio(Collins Lab, U Michigan) Single-cell RNA sequencing analysis of HSPCs harboring latent and active HIV infections

Emily Bowman(Funderburg Lab, Ohio State U) Lipidome abnormalities may contribute to altered macrophage phenotype and vascular inflammation in people with HIV

Tamanash Bhattacharya (Hardy Lab, Indiana U) Viral RNAs are targeted during endosymbiont-mediated multi-stage inhibition of arboviruses mediated by a cellular RNA methyltransferase

Enakshi Roy (Reid Lab, U Nebraska) Chikungunya virus impairs function of BMMSCs derived osteogenic cells

Jennifer Jones(Lakdawala Lab, U Pittsburgh) The puzzle of packaging: Predicting influenza virus genomic assembly order from evolutionary history

Mahesh Chemudupati (Yount Lab, Ohio State U) Short chain fatty acid butyrate inhibits the type I interferon antiviral response

Anna Bruchez (Lacy-Hulbert Lab, Benaroya) Transposon-mediated activation screening in human cells identifies the class II transactivator as a restriction factor for Ebola

Jian Wu(Bisaro/Ding Labs, Ohio State U) An RNA element in PSTVd determines intercellular movement from epidermal to mesophyll cells

11:40-11:55 am Flash Talks - 1 minute, 1 slide in rapid succession

Pavithra Aravamudhan (Dermody Lab, U Pittsburgh)

Tiffany King(Peeples Lab, Nationwide Children’s)

Rachel Netzband (Pager Lab, SUNY Albany)

Sumit Bandyopadhyay(Gu Lab, Wayne State U)

Matt Beucler(Miller Lab, U Cincinnati)

Busha Hika(Wang Lab, South Dakota State U)

Irene Owusu (Wobus Lab, U Michigan)

Elizabeth Regedanz(Bisaro Lab, Ohio State U)

Jiayi Sun(Brooke Lab, U Illinois UC)

Anna Glanz (Chattopadhyay Lab, U Toledo)

Marissa Louis (Pager Lab, SUNY Albany)

Walk to Biomedical Research Tower for Lunch and Poster Sessions

Lunch and Poster Sessions (Biomedical Research Tower)

12:00-12:50 pm Lunch

12:50-1:50 pm Poster Session Group 1

1:50-2:50 pm Poster Session Group 2

Walk to Jennings Hall for Scientific Sessions

Virus-host interaction: genetic and epigenetic modifications (Jennings Hall 001)

Session chairs: Jesse Kwiekand Namal Liyanage

3:00-3:25 pm Shou-Jiang Gao“Metabolic reprogramming and metabolic sensors in KSHV-induced oncogenesis"

3:25-3:50 pm Karin Musier-Forsyth“Unexpected Roles of tRNAs and Aminoacyl-tRNA Synthetases in Retroviral Replication”

3:50-4:15 pm Haitao Guo“HBV cccDNA minichromosome formation and epigenetics”

4:15-4:40 pm Kristine Yoder"Investigating retroviral intasome search dynamics using single molecule technology: Can integration be targeted?"

4:40-5:10 pm Coffee Break

5:10-6:10 pm Short Talks - 8 minutes, 2 minutes for questions

Session chairs:Haidong Guand Sanggu Kim

Krithika Karthigeyan(Kwiek Lab, Ohio State U) Metabolic flux through the lipogenic host enzyme fatty acid synthase (FASN) generates de novo fatty acyl groups for myristoylation of HIV-1 Gag

Nina Beri(Payton Lab, Washington U) hRSV Non-Structural protein 1 (NS1) associates with host chromatin at regulatory regions of immune response genes

Arvind Kumar (Kapoor Lab, Nationwide Children’s) First evidence of endemic flavi-like segmented virus infection in North America

Asha Philip(Patton Lab, Indiana U) Generation of Recombinant Rotaviruses Expressing Norovirus and Astrovirus Capsid Proteins

Shuliang Chen(Wu Lab, Ohio State U) Role of m6A modification of HIV-1 RNA in viral immune evasion

Brigitte Martin (Brook Lab, U Illinois) The functional consequences of cellular co-infection and viral heterogeneity during influenza virus infection

Dinner on your own

Oct 13, Sunday

Antiviral immunity and signaling (Jennings Hall 001)

Session chairs: David Bisaroand Saurabh Chattopadhyay

8:00-8:25 am Carolyn Coyne“Antiviral signaling at the maternal-fetal interface”.

8:25-8:50 am Jianrong Li“N6-methyladenosine is a molecular marker for discrimination of self and nonself RNAs by innate immunity”

8:50-9:15 am Peter Nagy“Exploitation of host factors and cellular pathways by tombusviruses for the biogenesis of the viral replication compartment”

9:15-9:40 am Robert Silverman“The antiviral OAS-RNase L pathway is triggered by self double-stranded RNA”

9:40-10:10 am Coffee Break

10:10 -11:40 am Short Talks- 8 minutes, 2 minutes for questions

Session chairs: Kevin Sokoloskiand Haitao Wen

Kai Rogers(Maury Lab, U Iowa) Acute Plasmodium infection promotes resistance to Ebola virus via type 1 immunity

Zachary Koenig (Hartman Lab, U Pittsburgh) Type III Interferons Control Rift Valley Fever Virus Infection at Epithelial Cell Barriers

Gayatri Subramanian(Chattopadhyay Lab, U Toledo) Interferon-inducible protein TDRD7 inhibits the autophagy-initiating kinase, AMPK to inhibit virus replication

Andrew McNamara(Danthi Lab, Indiana U) Multi-step blockade of NF-kappaB signaling by reovirus

Tomoyuki Murakami (Ono Lab, U Michigan) Virion-incorporated PSGL-1 and CD43 inhibit HIV-1 entry via a novel mechanism that prevents virus attachment to target T cells

Xianyi Xiong(Cattaneo Lab, Mayo) Characterizing the role of the measles virus V protein C-terminal domain in negative selection in human lymphocytes

Karnail Singh(Spearman Lab, Cincinnati Children’s) A bivalent Ebola virus-like particle vaccine enhances breadth of immune responses against pathogenic ebolaviruses in rhesus macaques

Laurie Silva(Silva Lab, U Pittsburgh) Chikungunya virus requires COPI regulatory factor GBF1 at multiple steps in the replication cycle

11:40 - 12:00 pm Closing Remarks