MOSCED (Modified Separation of Cohesive Energy Density) is a solubility parameter based method to predict infinite dilution activity coefficients and can be used to estimate accurate partition coefficient , solvation free energy, Henry's constant and parameterize excess Gibbs free energy model such as WILSON, NRTL, UNIQUAC to map out phase equilibria. In addition to making quantitative predictions, MOSCED can be used to understand the underlying molecular-level driving forces for intuitive solvent selection and formulation.