patient-derived models, Metastasis, & Resistance

Patient-derived xenograft models

• What are the genes responsible for the succssful engraftment in breast cancer PDX models? (Breast Cancer Res Treat, 2015)

• PDX models for malignant phyllodes tumors reveals potential targeted therapeutic approaches. (Br J Cancer, 2023)

• CX3CR1-positive immune cells in pre-metastatic niche formation for TNBC liver metastasis. (Mol Cancer Res, 2023)

• Humanized PDX models (J Breast Cancer 2023)

Novel targets for resistance and recurrences

• PDX model identifies PPM1H and CDK signaling associated with drug resistance. (J Breast Cancer, 2020)

• JAK2 mediates paclitaxel resistance via microenvironment remodeling (J Mol Med, 2021)

• Polo-like kinase 1 regulates chromosomal instability and paclitaxel resistance in breast cancer cells (J Breast Cancer, 2022)

• AKR1C2 in TNBC may regulate the LAR subtype phenotype in TNBC (J Breast Cancer, 2023)