Mitochondrial DNA and derived peptides in Health and Disease

22nd October 2018, Coimbra, Portugal

CNC - Center for Neuroscience and Cell, University of Coimbra, Portugal

8:30 - 9:00 - Registration

9 - 9:10 - Paulo Oliveira - Welcome

Mitochondrial DNA and disease

9:10 - 9:40 - Afshan Malik (King's College, London, UK) - Potential Mechanisms of Mitochondrial DNA mediated Acquired Mitochondrial Disease

9:40 - 10:20 - Manuela Grazina (CNC, Coimbra, PT)- Mitochondrial DNA: When the Circle Goes Bad

10:20 - 11:00 - Filipe Pereira (CIIMAR, University of Porto, PT) - Mitochondrial DNA mutations in Health and Disease

11:00 - 11:20 - Coffee Break

11:20 - 11:50 - Ana Coelho (CNC, Coimbra, PT) - Horizontal Mitochondrial Transfer to mtDNA-devoid Cancer Cells and the Role of Dihydroorotate Dehydrogenase in Tumor Initiation

11:50 - 12:05 - Short talk: Cláudio F. Costa (CNC, Coimbra, PT) - Mitochondrial remodeling after forcing OXPHOS in human skin fibroblasts

12:05 - 12:20 - Short talk: Safa Khan (King's College London, UK)

12:15 - 12:30 - General Discussion

12:30 - 14:00 Lunch

Mitochondria-derived peptides

14:00 - 14:50 - David Lee (USC, CA, USA) - The New Old Alphabets of Mitochondrial Communication

14:50 - 15.30 - Joseph Reynolds (USC, CA, USA) - Mitochondrial-Encoded Peptide Regulator of Physical Performance with Age

15:30 - 15:50 - Coffee Break

15:50 - 16:30 - Valdemar Maximo (Ipatimup, Porto, PT) - Mitochondrial DNA alterarions in cancer: emphasis in oncocytomas

16:30 - 17:20 - David Lee (USC, CA, USA) - Integration of the Co-evolved Mitonuclear Genomes

17:20 - Closing remarks