About MIME Lab

We develop computational models of bioprosthetic heart valves to study their structural mechanics, fluid-structure interaction, and long-term performance under physiological loading. Using patient-specific and idealized geometries, our work aims to improve the understanding of valve durability, hemodynamics, and disease progression, while supporting the design and evaluation of next-generation valvular therapies within a digital twin framework.

Our research in gastric biomechanics focuses on modeling the mechanical behavior and motility of the stomach, including wall deformation, peristalsis, and interactions with luminal contents. These models are used to investigate how physiological variability and disease states influence gastric function, with applications in orally administered drug delivery, device development, and mechanistic understanding of gastrointestinal physiology.

We apply computational fluid dynamics and multiphase modeling approaches to study orally inhaled drug products (OIDPs), including aerosol transport, deposition, and device-airway interactions. This work supports model-informed assessment of bioequivalence and performance, bridging fundamental transport physics with regulatory and translational considerations relevant to inhaler design and evaluation.

A core emphasis of the MIME Lab is the development and evaluation of credible computational models for decision-making in biomedical and regulatory contexts. We study verification, validation, uncertainty quantification, and context-of-use-driven model assessment to ensure that computational tools are scientifically sound, transparent, and fit for purpose. This work supports the responsible use of simulation in medical device evaluation, drug development, and emerging digital twin applications.