journal club

092024/Nature/2024/Motone et al./Multi-pass, single-molecule nanopore reading of long protein strands

070524/Cell/2024/Eder et al./Systematic mapping of organism-scale gene-regulatory networks in aging using population asynchrony

040524/Nature/2024/Li et al./The HEAT repeat protein HPO-27 is a lysosome fission factor

122223/Science/2023/Snieckute et al./ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging

100524//Nature/2023/Nakatani et al./Emergence of replication timing during early mammalian development

102023/Science/2023/Cheng et al./Accurate proteome-wide missense variant effect prediction with AlphaMissense

101323/Nature/2023/Zhang et al./Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice

072123/Nucleic Acids Res/2023/Bitar et al./Redefining normal breast cell populations using long noncoding RNAs

071423/Cell/2023/Zhao et al./QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism

070723/Cell/2023/Müller et al./Mechanisms of readthorugh mitigation reveal principles of GCN1-mediated translational quality control

042423/Science/2023/Baughn et al./Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies

041423/Nature/2023/Seath et al./Tracking chromatin state changes using nanoscale photo-proximity labelling

033123/Science Advances/2023/Imanishi et al./RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8

032423/Cell/Oltion et al./An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes

020323/Cell/Liu et al./Resurrection of endogenous retroviruses during aging reinforces senescence

013022/Nat Genet/2023/Gyenis et al./Genome-wide RNA polymerase stalling shapes the transcriptome during aging

010623/Science Advances/Wang et al./Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response

111122/Nucleic Acids Res/Song et al./eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells

102122/Nature/Qian et al./Programmable RNA sensing for cell monitoring and manipulation

100722/Science Advances/Jiang et al./Progerin modulates the IGF-1R/Akt signaling involved in aging

081922/Science/2022/Kang et al./LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs

072222/Nat Biotechnol/2022/Chen et al./Engineering circular RNA for enhanced protein production

070822/Nat Comm/2022/Sturmlechner et al./Senescent cells limit p53 activity via multiple mechanisms to remain viable 

070122/Science Advances/Keren et al./Human organ rejuvenation by VEGF-A: Lessons from the skin

061022/Science/2022/Acosta-Rodríguez et al./Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

051322/Nature/2022/Iram et al./Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

042922/Science Advances/Anerillas et al./Early SRC activation skews cell fate from apoptosis to senescence

041522/Science/2022/Kozyrska et al./p53 directs leader cell behavior, migration, and clearance during epithelial repair

040122/Mol Cell/2022/Barutcu et al./Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns

030422/Elife/2021/Venz et al./End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies

021822/Cell Metab/2021/Liu et al./Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease

011422/Mol Cell/2022/Rossi et al./Circular RNA ZNF609/CKAP5 mRNA interaction regulates microtubule dynamics and tumorigenicity

121021/Nature/2021/Anishchenko et al./De novo protein design by deep network hallucination

111221/Science/2021/Sturmlechner et al./p21 produces a bioactive secretome that places stressed cells under immunosurveillance

102221/Cell/2021/Xu et al./ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance

101521/Nature commun/Kern et al./C. elegans feed yolk to their young in a form of primitive lactation

092421/Dev Cell/2021/Makeyeva et al./Cues from mRNA splicing prevent default Argonaute silencing in C. elegans

091021/Science/2021/Baek et al./Accurate prediction of protein structures and interactions using a three-track neural network

083021/Science/2021/Li et al./A noncoding RNA modulator potentiates phenylalanine metabolism in mice

072321/Science/2021/Poirier et al./An isoform of Dicer protects mammalian stem cells against multiple RNA viruses 

070921/Science/2021/Maxwell et al./Ubiquitination is essential for recovery of cellular activities after heat shock 

061121/Nature/2021/Schoonover et al./Representational drift in primary olfactory cortex

060421/Nature/2021/Simone et al./MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration

052821/Nat Commun/2021/Montes et al./The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype

052121/Cell Metab/2021/Shi et al./An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila

051421/Science/2021/Chen et al./Pervasive functional translation of noncanonical human open reading frames

050721/Neuron/2021/Lester et al./Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components

043021/Nat Cell Biol/2021/Liu et al./m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype

042321/Nat Commun/2021/Shiromoto et al./ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells

041621/Nat Commun/2021/Ziegler et al./Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging

040921/Cell Metab/2021/Wiley et al./Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis

040221/Nature/2021/Wu et al./Neuronal enhancers are hotspots for DNA single-strand break repair

032621/Cell Metab/2021/Wu et al./Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice

031921/Nature/2021/Yan et al./Systematic analysis of binding of transcription factors to noncoding variants

031221/Nature/2021/Dong et al./Chaperone-mediated autophagy sustains haematopoietic stem-cell function

030521/Science/2021/Palla et al./Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength

022621/Mol Cell/2021/Chaves et al./The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans

021921/Science/2021/Bauernfried et al./Human NLRP1 is a sensor for double-stranded RNA

020521/Sci Adv/2021/Wan et al./N6-methyldeoxyadenine and histone methylation mediate transgenerational survival advantages induced by hormetic heat stress

012921/Nat Commun/2021/Pérez-Jiménez et al./Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases

012221/Science/2021/Johmura et al./Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

011521/Nat Commun/2020/Foster et al./Sex chromosome evolution in parasitic nematodes of humans

010821/Cell/2021/Henninger et al./RNA-Mediated Feedback Control of Transcriptional Condensates

122820/Cell/2020/Mateju et al./Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules

121820/Nature/2020/Basu et al./Measuring DNA mechanics on the genome scale

112720/Sci Adv/2020/Gao et al./Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline

112020/Nature/2020/Gomes et al./Age-induced accumulation of methylmalonic acid promotes tumour progression

111320/Nature/2020/Sas-Chen et al./Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping

110620/Nat Commun/2020/Chamoli et al./Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction

103020/Nat Commun/2020/Heimbucher et al./PQM-1 controls hypoxic survival via regulation of lipid metabolism

102320/Nature/2020/Li et al./A unified mechanism for intron and exon definition and back-splicing

101620/Nucleic Acids Res/2020/Lopes et al./A C. elegans model for neurodegeneration in Cockayne syndrome

100820/Cell/2020/Zhao et al./Targeting mitochondria-located circRNA SCAR alleviates NASH via reducing mROS output

092520/Cell/2020/Houri-Zeevi et al./Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans

091820/Nature/2020/Kaletsky et al./C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance

091120/Nature/2020/Encode Project Consortium et al./Expanded encyclopaedias of DNA elements in the human and mouse genomes

090420/Nature/2020/Johnson et al./Functionally uncoupled transcription–translation in Bacillus subtilis

081420/Sci Adv/2020/Zhu et al./NuRD mediates mitochondrial stress–induced longevity via chromatin remodeling in response to acetyl-CoA level

072421/Sci Adv/2020/Higuchi-Sanabria et al./Lysosomal recycling of amino acids affects ER quality control

062620/Nature/2020/Shukla et al./poly(UG)-tailed RNAs in genome protection and epigenetic inheritance

061920/Nat Commun/2020/Volkova et al./Mutational signatures are jointly shaped by DNA damage and repair

061220/Nat Metab/2020/Brett et al./Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1

060520/Cell/2020/Contrepois et al./Molecular Choreography of Acute Exercise

052920/Cell Metab/2020/Aon et al./Untangling determinants of enhanced health and lifespan through a multi-omics approach in mice

052120/Nat Commun/2020_Burton et al./Cystein synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection

051520/Nature/2020/Yuan et al./Two conserved epigenetic regulators prevent healthy ageing

050820/Dev Cell/2020/Gerisch et al./HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence

022120/Mol Cell/2020/Tuck et al./Mammalian RNA Decay Pathways Are Highly Specialized and Widely Linked to Translation

021420/PNAS/2020/Li et al./Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging

020720/Science/2020/Frakes et al./Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans

013120/Nature/2019/De Rosa et al./The flight response impairs cytoprotective mechanisms by activating the insulin pathway

011720/Nature/2019/Marques et al./Internal state dynamics shape brainwide activity and foraging behaviour

011020/Nat Commun/2019/Waldherr et al./Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau

010320/Dev Cell/2019/Anderson et al./X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation

122719/Nat Commun/2019/Kumsta et al./The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

122019/Nature/2019/Bazopoulou et al./Developmental ROS individualizes organismal stress resistance and lifespan

121319/Nat Commun/2019/Fang et al./NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

112919/Cell/2019/Schinzel et al./The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER

112219/Mol Cell/2019/Chen et al./N6-methyladenosine modification controls circRNA immunity

110119/Cell/2019/Ganem et al./Disruption in A-to-I editing levels affects C. elegans development more than a complete lack of editing

102519/Nature/2019/Zullo et al./Regulation of lifespan by neural excitation and REST

101119/Nature/2019/Cook et al./Whole-animal connectomes of both Caenorhabditis elegans sexes

100419/Cell/2019/Gong et al./A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene

092719/Science/2019/Packer et al./A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution

092019/Cell/2019/Posner et al./Neuronal Small RNAs Control Behavior Transgenerationally

090619/Mol Cell/2019/Liang et al./The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

083019/Science/2019/Wang et al./Genetic behavioral screen identifies an orphan anti-opioid system

081619/Science/2019/Gamerdinger et al./The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum

080919/Nat Commun/2019/Herholz et al./KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants

080219/Cell Rep/2019/Lan et al./Translational Regulation of Non-autonomous Mitochondrial Stress Response PromotesLongevity

072619/Nature/Liakath-Ali et al./2018/ An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis

071919/Nature/Klompe et al./ 2019/ Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration

071219/Nucleic Acids Res/Philippe et al./An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assembly

070519/Nat Genet/Sher et al./Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis

062819/Cell Metab/Kai Mao et al./Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes

061919/Nat Commun/Chen et al./Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevityby regulating autophagy

061419/Nat Med/Yousef et al./Aged blood impairs hippocampal neural precursor activity and activates microglia via brainendothelial cell VCAM1

060719/eLife/2019/Lehrnach and Ruvkun/Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity

053119/Nat Commun/2019/Yang et al./Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker

052419/Nat Commun/2019/Wessels et al./Global identification of functional microRNAmRNA interactions in Drosophila

051619/Dev Cell/2019/Kiontke et al./The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28

051019/Nat Chem Biol/Chen et al./Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan

050219/Cell/ 2019 Zhou et al./ Motochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

042619/Nature/2019/ El-Brolosy et al./Genetic compensation triggered by mutant mRNA degradation

041919/Dev Cell/2019/Hill et al./Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2

041219/Science/2018/Wang et al./Comprehensive functional genomic resource and integrative model for the human brain.

032119/Science/2019/Toda H et al../A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila.

031519/Dev Cell/2019/Singh J & Aballay A/Microbial Colonization Activates an Immune Fight-and-Flight response via Neuroendocrine Signaling

030819/Cell/2019/Seth P et al./Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation