A peroxisomal biogenesis disorder that is in the continuum of Zellwegger (the most severe phenotype), Neonatal adrenoleukodystrophy (intermediate phenotype), and Infantile Refsum disease (least severe phenotype)
On imaging patients with neonatal leukodystrophy have diminished myelination in the cerebral white matter and around the dentate nuclei. They may also show multiple small gyri, simulating polymicrogyria, of lesser severity than what is seen with Zellweger's.