Alpha-Mannosidosis (MANSA) is caused by a mutation in the MAN2B1 gene on chromosome 19p13, and this type of Mannosidosis may have brain MRI changes
On imaging half of patients studied showed occipital white matter signal abnormalities including increased T2 signal in the periventricular white matter, and cysts. Some patients have a broad peak on MRS between 3.5 and 3.9 ppm reflecting mannose complexes in grey matter, white matter, and centrum semiovale.
References: