Hereditary diffuse leukoencephalopathy with spheroids is an adult-onset rapidly progressive neurodegenerative disorders.
On imaging patients have patchy abnormalities in the cerebral white matter, with a frontal and parietal lobe predominance
Reference:
1. Rademakers, R., Baker, M., Nicholson, A. M., Rutherford, N. J., Finch, N., Soto-Ortolaza, A., Lash, J., Wider, C., Wojtas, A., DeJesus-Hernandez, M., Adamson, J., Kouri, N., and 26 others. Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nature Genet. 44: 200-205, 2012