Deletion of the terminal part of the short arm of chromosome 6, including 6p25, leads to dysmorphic features, hearing impairment, ocular dysgenesis (corneal opacities, iris coloboma, and hypoplasia of the eye with adherent iris strands to the peripheral cornea [Rieger anomaly])..
On imaging patients may have static multifocal white matter hyperintensities, diffusely enlargerd perivascular spaces, ventriculomegaly, atrophy, a thin/short corpus callosum, and a small cerebellar vermis. The findings are similar to congenital CMV infections but it lacks parietal predominance of white matter lesions and anterior temporal abnormalities that are seen in CMV.
References:
1. Cerebral white matter abnormalities in 6p25 deletion syndrome. M.S. van der Knaap, M. Kriek, W.C.G. Overweg-Plandsoen, K.B. Hansson, K. Madan, J.S. Starreveld, P. Schotman-Schram, F. Barkhof and S.A.M.J. Lesnik Oberstein. American Journal of Neuroradiology March 2006, 27 (3) 586-588;