Broclear Tablet for Asthma, COPD & Bronchitis – Uses, Dosage & Side Effects

Key Composition & Ingredients

Active Ingredients:

• Acebrophylline (100mg): A xanthine derivative with bronchodilator and anti-inflammatory properties

• Acetylcysteine (600mg): A mucolytic agent that breaks down mucus and has antioxidant properties

Inactive Ingredients:

• Microcrystalline cellulose

• Lactose monohydrate

• Povidone

• Croscarmellose sodium

• Magnesium stearate

• Hypromellose

• Titanium dioxide

• Polyethylene glycol

• Other pharmaceutical excipients for tablet formulation

Uses of Broclear Tablet

Broclear Tablet is prescribed for the management of various respiratory conditions, including:

1. Chronic Obstructive Pulmonary Disease (COPD):
   
   

   • Helps reduce exacerbations

   • Improves airflow

   • Facilitates expectoration of viscous secretions

   • Aids in symptom management

2. Chronic Bronchitis:
   
   

   • Reduces frequency and severity of productive cough

   • Helps clear accumulated secretions

   • May reduce frequency of infections

3. Bronchial Asthma:
   
   

   • As adjunctive therapy in cases with mucus plugging

   • Helps in clearing airway secretions

   • May improve response to other asthma medications

4. Bronchiectasis:
   
   

   • Facilitates clearance of retained secretions

   • Helps manage chronic productive cough

   • May reduce frequency of respiratory infections

5. Acute Bronchitis:
   
   

   • Assists in recovery by promoting mucus clearance

   • Reduces coughing effort required to clear secretions

6. Other Respiratory Conditions:
   
   

   • Cystic fibrosis (as an adjunctive therapy)

   • Post-operative pulmonary complications

   • Atelectasis (lung collapse) due to mucus plugging

   • Pneumonia recovery phase

7. Preventive Use:
   
   

   • May be used to prevent exacerbations in chronic respiratory conditions

   • Seasonal use in patients prone to winter bronchitis

   • Perioperative use in patients with pulmonary risk factors

Benefits of Broclear Tablet

The combination of Acebrophylline and Acetylcysteine in Broclear Tablet offers multiple therapeutic benefits:

1. Dual Mechanism of Action:
   
   

   • Bronchodilation: Opens constricted airways

   • Mucolysis: Thins and breaks down thick mucus

   • Combined effect greater than either agent alone

2. Improved Respiratory Function:
   
   

   • Enhanced airflow through bronchial tubes

   • Increased forced expiratory volume (FEV1)

   • Improved vital capacity

   • Better oxygen exchange

3. Enhanced Mucus Clearance:
   
   

   • Reduced viscosity of bronchial secretions

   • Improved mucociliary clearance

   • Easier expectoration of phlegm

   • Prevention of mucus plugging

4. Anti-inflammatory Effects:
   
   

   • Reduces bronchial inflammation

   • Decreases airway hyperresponsiveness

   • May reduce structural changes in chronic conditions

5. Antioxidant Properties:
   
   

   • Acetylcysteine acts as a free radical scavenger

   • May protect lung tissue from oxidative damage

   • Potential to reduce inflammatory cascade

6. Reduced Exacerbation Frequency:
   
   

   • Fewer acute flare-ups of chronic conditions

   • Decreased need for emergency interventions

   • Reduced hospitalization rates in some patient groups

7. Quality of Life Improvements:
   
   

   • Reduced coughing effort

   • Decreased breathlessness

   • Improved exercise tolerance

   • Better sleep quality

   • Enhanced overall respiratory comfort

8. Convenient Combination:
   
   

   • Single tablet delivering dual therapeutic effects

   • Simplifies treatment regimen

   • May improve medication adherence

How Broclear Tablet Works (Mechanism of Action)

Broclear Tablet works through the complementary mechanisms of its two active components:

Acebrophylline (100mg):

1. Bronchodilation:
   
   

   • Inhibits phosphodiesterase enzymes, particularly PDE3 and PDE4

   • Increases intracellular cyclic adenosine monophosphate (cAMP)

   • Results in relaxation of bronchial smooth muscle

   • Reduces airway resistance and improves airflow

2. Anti-inflammatory Effects:
   
   

   • Reduces the release of inflammatory mediators

   • Decreases neutrophil and eosinophil activity in lung tissue

   • Inhibits certain pro-inflammatory cytokines

   • Diminishes bronchial hyperresponsiveness

3. Mucoregulatory Activity:
   
   

   • Enhances mucociliary clearance

   • Stimulates production of surfactant by type II pneumocytes

   • Improves the rheological properties of mucus

   • Facilitates expectoration

4. Pulmonary Microcirculation:
   
   

   • May improve blood flow in pulmonary capillaries

   • Enhances oxygen delivery to respiratory tissues

   • Reduces pulmonary congestion

Acetylcysteine (600mg):

1. Mucolytic Action:
   
   

   • Contains a free thiol (-SH) group that breaks disulfide bonds (S-S) in mucus glycoproteins

   • Reduces the viscosity and elasticity of mucus

   • Transforms thick, sticky secretions into thinner, more fluid material

   • Facilitates removal through normal ciliary action and coughing

2. Antioxidant Properties:
   
   

   • Acts as a direct scavenger of free radicals, particularly reactive oxygen species

   • Replenishes glutathione, a major antioxidant in lung tissue

   • Protects cells from oxidative damage

   • Interrupts inflammatory cascades triggered by oxidative stress

3. Anti-inflammatory Effects:
   
   

   • Reduces neutrophil chemotaxis and activation

   • Decreases pro-inflammatory cytokine production

   • Inhibits nuclear factor-kappa B (NF-κB) activation

   • May decrease mucin production in airways

4. Biofilm Disruption:
   
   

   • Can disrupt bacterial biofilms in the respiratory tract

   • May enhance antibiotic penetration in respiratory infections

   • Potentially reduces bacterial colonization

Synergistic Effects:

The combination of these two agents provides synergistic benefits:

• While Acebrophylline opens the airways, Acetylcysteine makes the mucus easier to clear

• The bronchodilator effect enhances the distribution of the mucolytic agent

• The mucolytic action improves the effectiveness of bronchodilation by clearing obstructing secretions

• Combined anti-inflammatory and antioxidant effects may protect lung tissue more effectively than either agent alone

Dosage of Broclear Tablet

Standard Dosage

The typical recommended dosage for adults is:

1. For Chronic Respiratory Conditions:
   
   

   • One tablet once or twice daily, depending on severity of symptoms

   • Common regimen is one tablet in the morning and one in the evening

2. For Acute Exacerbations:
   
   

   • One tablet twice daily until symptoms improve

   • May be adjusted to one tablet three times daily in severe cases (physician discretion)

   • Usually reduced to maintenance dose after acute symptoms resolve

3. For Maintenance Therapy:
   
   

   • One tablet daily, typically in the morning

   • Duration depends on the underlying condition and clinical response

   • May be used for extended periods in chronic conditions

4. For Elderly Patients:
   
   

   • Usually start with one tablet daily

   • Dose may be adjusted based on tolerance and response

Special Populations:

Pediatric Use:

• Not recommended for children under 12 years

• For adolescents (12-18 years): Dosage should be determined by a physician

Renal Impairment:

• Mild to moderate: No specific dose adjustment necessary but monitor closely

• Severe: Use with caution, consider dose reduction or increased interval

Hepatic Impairment:

• Mild to moderate: No specific dose adjustment necessary

• Severe: Consider dose reduction and monitor liver function

Missed Dose

If a dose is missed:

• Take it as soon as remembered if it's within a few hours of the scheduled time

• If it's almost time for the next dose, skip the missed dose

• Do not double the dose to make up for a missed dose

• Return to the regular dosing schedule

Overdose

Symptoms of overdose may include:

• Nausea, vomiting, epigastric pain

• Tachycardia, palpitations, or heart rhythm disturbances

• Headache, dizziness, insomnia

• Tremors or seizures (in severe cases)

• Hypotension or hypertension

If overdose is suspected, seek medical attention immediately.

How to Use Broclear Tablet

Directions for Use

1. Take Broclear Tablet exactly as prescribed by your healthcare provider

2. Swallow the tablet whole with a full glass of water (approximately 240 ml)

3. The tablet can be taken with or without food, though taking with food may reduce stomach upset

4. If stomach irritation occurs, take with meals or immediately after eating

5. Take at approximately the same time(s) each day to maintain consistent blood levels

6. Do not crush, chew, or break the tablet as this may affect the release of the medication

7. Stay well-hydrated while taking this medication to help thin mucus further

8. If prescribed as "when needed," use at the first signs of mucus accumulation

9. For best results in chronic conditions, take regularly even if symptoms improve

10. Maintain airway clearance techniques (if recommended) such as controlled coughing or chest physiotherapy

Side Effects of Broclear Tablet

Common Side Effects (Usually Mild)

Gastrointestinal Effects:

• Nausea or upset stomach

• Heartburn or indigestion

• Mild abdominal discomfort

• Diarrhea

Nervous System Effects:

• Mild headache

• Dizziness

• Slight tremors

Other Common Effects:

• Unpleasant taste in mouth (especially from Acetylcysteine)

• Facial flushing

• Palpitations

• Rash or itching

• Slight increase in heart rate

These side effects often resolve as your body adjusts to the medication.

Less Common Side Effects

• Insomnia or sleep disturbances

• Anxiety or nervousness

• Muscle cramps

• Tinnitus (ringing in the ears)

• Dry mouth

• Increased sweating

• Changes in blood pressure

• Bronchospasm (paradoxical reaction, more common in asthmatic patients)

Rare but Serious Side Effects

• Severe allergic reactions (anaphylaxis)

• Severe skin reactions (Stevens-Johnson syndrome, very rare)

• Significant cardiac rhythm disturbances

• Seizures

• Gastrointestinal bleeding

• Severe liver function abnormalities

• Significant changes in blood counts

Managing Side Effects

• For gastrointestinal issues: Take with food or milk

• For headache: OTC pain relievers may help (consult doctor first)

• For taste issues: Drinking juice after taking medication may help

• For dizziness: Change positions slowly, avoid driving if affected

• Report any persistent or severe side effects to your healthcare provider immediately

Safety Advice for Broclear Tablet

Alcohol

• Moderate Caution: Alcohol may increase the risk of stomach irritation

• May enhance dizziness or drowsiness side effects

• May reduce the effectiveness of the medication

• Best to limit or avoid alcohol while taking this medication

Pregnancy

• Category C: Potential risks to the fetus; benefits may outweigh risks in certain situations

• Not enough well-controlled studies in pregnant women

• Use only if clearly needed and after discussion with an obstetrician

• Alternative medications may be considered for respiratory symptoms during pregnancy

Breastfeeding

• Both active ingredients may pass into breast milk

• Limited data on safety during lactation

• Potential for side effects in nursing infants

• Discuss risks and benefits with healthcare provider

• Consider temporary interruption of breastfeeding or alternative medications

Driving and Operating Machinery

• May cause dizziness, headache, or tremors in some patients

• Avoid driving or operating hazardous machinery until you know how the medication affects you

• Take particular caution during the first few days of treatment

Kidney Function

• Acetylcysteine is generally safe in patients with kidney impairment

• Dose adjustment usually not required for mild to moderate kidney impairment

• In severe kidney disease, monitor renal function and consider dose reduction

• Report any changes in urination patterns or fluid retention

Liver Function

• Both components are metabolized in the liver

• Use with caution in patients with pre-existing liver disease

• Regular liver function tests may be recommended during long-term therapy

• Discontinue if signs of liver injury develop (jaundice, dark urine, right upper abdominal pain)

Use in Children

• Safety and efficacy not fully established for children under 12 years

• Should only be used in pediatric patients when clearly needed

• Dosage must be determined by a pediatric specialist

• Monitor children closely for side effects

Use in Older Patients

• Generally well-tolerated but may be more sensitive to side effects

• Start with lower doses and titrate carefully

• Monitor for dehydration, especially with increased expectoration

• Greater risk of drug interactions due to polypharmacy common in elderly

Allergies

• Contraindicated in patients with known hypersensitivity to either component

• Those with asthma or bronchospasm may be at higher risk of hypersensitivity reactions

• Acetylcysteine has a distinctive odor that some may find unpleasant, but this is not an allergic reaction

Warnings & Precautions for Broclear Tablet

1. Asthma and Bronchospasm:
   
   

   • Use with caution in patients with asthma

   • Bronchospasm can occur, especially in those with hyperreactive airways

   • Initial doses should be monitored in asthmatic patients

   • Have bronchodilator rescue medication available

2. Peptic Ulcer Disease:
   
   

   • Use with caution in patients with active or history of peptic ulcers

   • May exacerbate gastrointestinal irritation

   • Consider protective co-medication in high-risk patients

3. Cardiac Conditions:
   
   

   • Use with caution in patients with cardiac arrhythmias, coronary artery disease, or hypertension

   • Xanthine derivatives can cause tachycardia and palpitations

   • Monitor cardiac function in high-risk patients

4. Increased Secretions:
   
   

   • Initially, patients may experience increased volume of secretions

   • Ensure adequate clearance ability, especially in debilitated patients

   • May require temporary assistance with airway clearance

5. Dehydration Risk:
   
   

   • Maintain adequate hydration while taking this medication

   • Particularly important in elderly patients or during acute illness

   • Adequate fluid intake enhances the mucolytic effect

6. Elderly Patients:
   
   

   • May be more sensitive to side effects

   • Monitor for adverse reactions more closely

   • Consider starting with lower doses

7. Renal or Hepatic Impairment:
   
   

   • Use with caution in severe disease

   • May require dose adjustment or increased monitoring

   • Discontinue if evidence of worsening function

8. Drug Interactions:
   
   

   • Multiple potential interactions (see Interactions section)

   • Review all current medications before starting

   • Inform all healthcare providers about this medication

9. Paradoxical Bronchospasm:
   
   

   • If bronchospasm occurs after administration, discontinue and seek medical attention

   • More common in patients with hyperreactive airways

   • Have rescue medication available, especially when starting therapy

10. Long-term Use:
    
    

    • Periodic assessment of continued need for therapy

    • Monitor for side effects with extended use

    • Regular follow-up with healthcare provider recommended

Interactions with Broclear Tablet

Drug-Drug Interactions

1. Acebrophylline Interactions:
   
   Other Xanthines:
   
   

   • Theophylline, aminophylline, caffeine

   • Increased risk of xanthine-related side effects

   • Avoid concurrent use when possible

2. Beta-Blockers:
   
   

   • May counteract the bronchodilating effects of Acebrophylline

   • Cardioselective beta-blockers have less interaction

   • Monitor for reduced efficacy

3. Certain Antibiotics:
   
   

   • Erythromycin, ciprofloxacin, clarithromycin

   • May increase Acebrophylline levels

   • Monitor for increased side effects

4. Cimetidine:
   
   

   • Decreases clearance of xanthines

   • May increase drug levels and side effects

   • Consider alternative H2 antagonists if needed

5. Acetylcysteine Interactions:
   
   Antibiotics:
   
   

   • May reduce absorption of some antibiotics (especially penicillins, tetracyclines)

   • Administer antibiotics at least 2 hours before or after Broclear

   • Monitor for reduced antibiotic efficacy

6. Nitroglycerin:
   
   

   • Acetylcysteine may enhance vasodilatory effects

   • Monitor for increased hypotensive response

   • Dose adjustments may be necessary

7. Activated Charcoal:
   
   

   • Reduces effectiveness of Acetylcysteine

   • Avoid concurrent administration

   • Separate doses by at least 2 hours

8. Carbamazepine:
   
   

   • Acetylcysteine may reduce carbamazepine levels

   • Monitor for decreased seizure control

   • May require carbamazepine dose adjustment

9. Other Significant Interactions:
   
   Corticosteroids:
   
   

   • Concurrent use generally beneficial in respiratory conditions

   • May enhance efficacy without significant interaction

10. Blood Pressure Medications:
    
    

    • Monitor blood pressure when starting Broclear

    • Adjust antihypertensive medications if needed

11. Insulin/Antidiabetic Drugs:
    
    

    • Xanthines may affect glucose metabolism

    • Monitor blood glucose more frequently when starting therapy

Drug-Food Interactions

1. Food in General:
   
   

   • Taking with food may reduce gastrointestinal side effects

   • High-fat meals might slightly delay absorption but not significantly affect overall bioavailability

   • Consistent timing with respect to meals is recommended

2. Caffeine:
   
   

   • Found in coffee, tea, energy drinks, some sodas, and chocolate

   • Additive effects with the xanthine component

   • May increase risk of side effects like nervousness, insomnia, and palpitations

   • Moderate caffeine consumption advised during treatment

3. Dairy Products:
   
   

   • May slightly reduce absorption of Acetylcysteine component

   • Not usually clinically significant

   • If concerned, can separate dairy consumption by 1-2 hours

Contraindications of Broclear Tablet

Broclear Tablet is absolutely contraindicated in patients with:

1. Hypersensitivity to Acebrophylline, Acetylcysteine, or any component of the formulation

2. Active peptic ulcer disease

3. Severe liver impairment

4. History of seizure disorders

5. Severe uncontrolled cardiac arrhythmias

6. Recent myocardial infarction

7. Pregnancy (first trimester)

8. Children under 12 years of age (unless specifically prescribed by a specialist)

9. Severe renal impairment (eGFR <30 ml/min)

10. Severe bronchial asthma with history of bronchospasm with mucolytics

Safety Measures & FDA Pregnancy Category

• FDA Pregnancy Category: C (Risk cannot be ruled out)

• Risk-Benefit Assessment: Use only when potential benefits justify potential risks

• Monitoring Requirements:

  • Regular assessment of respiratory function

  • Periodic liver function tests with long-term use

  • Monitoring of cardiac parameters in those with heart conditions

  • Assessment of mucus production and clearance

Diet & Lifestyle Advice

1. Hydration Recommendations:
   
   

   • Drink 2-3 liters of water daily unless contraindicated

   • Adequate hydration enhances mucolytic effects

   • Warm liquids may further help loosen secretions

   • Avoid excessive dairy products which may thicken mucus in some individuals

2. Dietary Considerations:
   
   

   • Limit caffeine intake (coffee, tea, energy drinks)

   • Consider reducing dairy consumption if it seems to increase mucus production

   • Include fruits and vegetables rich in antioxidants

   • Avoid known respiratory irritants in food (if identified)

3. Lifestyle Modifications:
   
   

   • Stop smoking and avoid second-hand smoke

   • Use air purifiers in the home if possible

   • Maintain optimal humidity levels (40-50%)

   • Regular moderate exercise as tolerated to improve lung function

   • Avoid exposure to air pollution when possible

   • Practice good sleep hygiene for adequate rest

4. Airway Clearance Techniques:
   
   

   • Learn and practice effective coughing techniques

   • Consider postural drainage positions if recommended

   • Deep breathing exercises can help mobilize secretions

   • Physical activity helps promote natural clearance mechanisms

5. Environmental Considerations:
   
   

   • Minimize exposure to allergens if allergic

   • Wear a mask in very cold weather or polluted environments

   • Keep indoor air clean and well-ventilated

   • Avoid strong fumes from cleaning products, paints, etc.

Why Doctors Recommend This Medicine

Physicians prescribe Broclear Tablet for several key reasons:

1. Dual Mechanism Advantage:
   
   

   • Combines bronchodilation and mucolytic effects

   • Addresses both airway constriction and mucus hypersecretion

   • More comprehensive than single-agent therapy

2. Improved Expectoration:
   
   

   • Facilitates clearance of obstructing secretions

   • Reduces the effort required to cough up phlegm

   • Helps break the cycle of mucus retention and infection

3. Enhanced Respiratory Function:
   
   

   • Improves lung function parameters

   • Reduces feelings of breathlessness

   • Enhances oxygen exchange

4. Exacerbation Prevention:
   
   

   • May reduce frequency of acute flare-ups

   • Decreases need for additional medications

   • Potentially reduces hospitalization rates

5. Convenience of Combination:
   
   

   • Single tablet rather than multiple medications

   • Improves adherence to treatment regimen

   • Simplified dosing schedule

6. Additional Benefits:
   
   

   • Anti-inflammatory and antioxidant properties

   • Potential protective effects on lung tissue

   • May improve quality of life measurements

Substitutes & Alternative Medicines

Other Combination Products

1. Similar Combinations:
   
   

   • Ambrodil-S (Ambroxol + Salbutamol)

   • Mucolite-LS (Levosalbutamol + Ambroxol)

   • Ascoril (Salbutamol + Bromhexine + Guaiphenesin)

   • Mucobrom (Terbutaline + Bromhexine)

2. Alternative Combinations:
   
   

   • Bronchodilator + Inhaled Corticosteroid combinations

   • Bronchodilator + Anticholinergic combinations

   • Expectorant + Antihistamine combinations (for certain conditions)

Single-Agent Alternatives

1. For Bronchodilator Effect:
   
   

   • Theophylline

   • Doxofylline

   • Beta-2 agonists (Salbutamol, Formoterol)

   • Anticholinergics (Tiotropium, Ipratropium)

2. For Mucolytic Effect:
   
   

   • Ambroxol

   • Bromhexine

   • Erdosteine

   • Carbocisteine

   • Guaifenesin

3. Other Respiratory Medications:
   
   

   • Inhaled corticosteroids (for inflammatory component)

   • Leukotriene modifiers (for certain asthmatic conditions)

   • Phosphodiesterase-4 inhibitors (for COPD)

Note: Substitution should only be done under medical supervision as different medications have different properties, side effects, and contraindications.

Storage Guidelines

• Store at room temperature (15-30°C or 59-86°F)

• Keep away from direct sunlight and moisture

• Store in the original container with the lid tightly closed

• Keep out of reach of children

• Do not store in the bathroom or near the kitchen sink

• Do not refrigerate or freeze

• Check the expiration date regularly and discard expired medication properly

• Avoid storing near heat sources or in very humid environments

• Do not remove the desiccant (if present) from the bottle

User Feedback & Patient Concerns

Common Patient Questions

1. "How quickly will I notice improvement?"
   
   

   • Most patients notice easier expectoration within 2-3 days

   • Full benefits for chronic conditions may take 1-2 weeks of regular use

   • Bronchodilator effects may be noticeable within hours of first dose

2. "Will this medication cure my condition?"
   
   

   • For chronic conditions like COPD, it manages symptoms but is not curative

   • In acute bronchitis, it helps speed recovery but doesn't replace antibiotics if needed

   • Regular use can help prevent complications and exacerbations

3. "Is this medication addictive?"
   
   

   • No, neither component has addictive properties

   • No evidence of physical or psychological dependence

   • Can be safely discontinued when no longer needed (though gradual reduction sometimes recommended)

4. "Can I take this with my other medications?"
   
   

   • Many medications can be taken with Broclear, but always inform your doctor

   • Specific timing may be important with certain antibiotics

   • Review all your medications with your healthcare provider or pharmacist

Typical Patient Experiences

Most patients report improvement in cough productivity and ease of breathing, with manageable side effects. Gastrointestinal symptoms are the most commonly reported issues but tend to improve with continued use or taking the medication with food.

Quick Tips for Broclear Tablet

1. Take with food to minimize stomach upset

2. Drink plenty of fluids to enhance the mucolytic effect

3. Continue taking as prescribed even after feeling better

4. Be patient—mucolytic effects may take several days to become noticeable

5. Practice deep breathing and effective coughing techniques

6. Monitor for changes in color or consistency of expectorated mucus

7. Inform all healthcare providers about this medication

8. Keep a log of symptoms to discuss with your doctor

9. Never abruptly stop taking without medical advice

10. Store away from heat, moisture, and direct sunlight

Fact Box

• Chemical Class

• Acebrophylline: Xanthine derivative<br>Acetylcysteine: N-acetyl derivative of amino acid cysteine

• Habit Forming

• No

• Therapeutic Class

• Bronchodilator + Mucolytic

• Action Class

• Phosphodiesterase inhibitor + Mucolytic/Antioxidant agent

Useful Diagnostic Tests

1. Before Starting Treatment:
   
   

   • Pulmonary function tests (spirometry)

   • Chest X-ray if not recently done

   • Complete blood count

   • Liver function tests

   • Kidney function tests

   • Sputum culture if infection suspected

   • ECG for patients with cardiac history

2. During Treatment:
   
   

   • Periodic spirometry to assess response

   • Liver function tests with extended use

   • Monitoring of sputum characteristics

   • Oxygen saturation measurements

   • Repeat chest imaging as clinically indicated

More Information & References

For more detailed information about Acebrophylline, Acetylcysteine, and Broclear Tablet, consult reliable medical sources such as:

1. British National Formulary (BNF)

2. Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines

3. Global Initiative for Asthma (GINA) guidelines

4. American Thoracic Society recommendations

5. European Respiratory Society publications

6. Your healthcare provider or pharmacist

Link to credible health sources:

• Drugs.com

• WHO

• NCBI

Disclaimer

This information is intended for educational purposes only and should not replace professional medical advice. Always consult your healthcare provider regarding any questions or concerns about your medical condition or treatment. Individual responses to medication can vary. Report any unusual or severe side effects to your healthcare provider immediately.