Bilasure M Tablet for Allergies, Sneezing & Itching – Uses & Side Effects

Key Composition & Ingredients

• Active Ingredients:

  • Bilastine 20mg: A second-generation H1-antihistamine

  • Montelukast 10mg: A selective leukotriene receptor antagonist

• Inactive Ingredients: May include:

  • Microcrystalline cellulose

  • Sodium starch glycolate

  • Magnesium stearate

  • Colloidal silicon dioxide

  • Hypromellose

  • Titanium dioxide

  • Polyethylene glycol

  • Pharmaceutical colorants

Uses of Bilasure M 20mg/10mg Tablet

• Treatment of moderate to severe allergic rhinitis (seasonal and perennial)

• Management of allergic rhinitis with concomitant asthmatic symptoms

• Relief from nasal congestion, sneezing, itchy/runny nose, and eye symptoms

• Control of urticaria (hives) and allergic skin conditions

• Management of allergic manifestations resistant to monotherapy

• Treatment of allergic rhinitis in patients with exercise-induced bronchoconstriction

• Symptomatic relief in patients with allergic rhinitis and bronchial hyperreactivity

• Management of allergies triggered by multiple allergens

• Long-term control of chronic allergic conditions requiring dual pathway inhibition

• Prevention of allergic symptoms in known seasonal triggers (prophylactic use)

Benefits of Bilasure M 20mg/10mg Tablet

• Dual-action approach targeting multiple allergic pathways

• Comprehensive control of both histamine and leukotriene-mediated symptoms

• Reduced nasal congestion, sneezing, and rhinorrhea

• Alleviation of allergic eye symptoms like itching, redness, and tearing

• Improvement in bronchial symptoms in patients with allergic asthma

• Once-daily dosing improving patient adherence

• Minimal sedation compared to older antihistamines

• Rapid onset of action for acute symptom relief

• 24-hour duration of action providing round-the-clock protection

• Better quality of life with improved sleep and daytime functioning

• May reduce the need for rescue medications like decongestants

• Potential reduction in allergic progression (allergic march)

• Improved control of mixed allergic conditions unresponsive to single agents

How Bilasure M 20mg/10mg Tablet Works

Bilasure M 20mg/10mg Tablet works through two complementary mechanisms to control allergic symptoms:

1. Bilastine (20mg):

   • Selectively blocks peripheral H1 histamine receptors, preventing histamine from binding to these receptors

   • Inhibits the early phase of allergic reaction characterized by itching, sneezing, rhinorrhea, and urticaria

   • Has minimal penetration across the blood-brain barrier, reducing central nervous system effects like sedation

   • Prevents histamine-mediated vasodilation and increased vascular permeability that cause tissue swelling

   • Has rapid onset of action (within 1 hour) and long duration (24 hours)

   • Does not undergo significant metabolism, being excreted largely unchanged

2. Montelukast (10mg):

   • Selectively antagonizes cysteinyl leukotriene receptor type 1 (CysLT1)

   • Blocks the action of leukotrienes (LTD4, LTC4, LTE4), which are important mediators in allergic inflammation

   • Inhibits the late phase allergic response characterized by nasal congestion and bronchial constriction

   • Reduces eosinophil recruitment and activation in allergic tissues

   • Decreases mucus production and inflammatory cell infiltration

   • Provides bronchodilation in patients with allergic asthma

   • Has anti-inflammatory effects in both upper and lower airways

The combination addresses both immediate allergic symptoms through antihistamine action and underlying inflammatory processes through leukotriene antagonism, providing comprehensive relief from allergic manifestations.

Dosage of Bilasure M 20mg/10mg Tablet

Daily Dose

• Adults and adolescents (12 years and older):

  • The typical dosage is one tablet (Bilastine 20mg + Montelukast 10mg) once daily

  • Best taken at the same time each day for consistent relief

  • Can be taken for seasonal allergies throughout the allergy season or daily for perennial allergies

  • Duration of therapy as advised by healthcare provider based on individual response and condition

Missed Dose

• Take as soon as remembered if within the same day

• Skip the missed dose if it's almost time for the next scheduled dose

• Do not double dose to make up for a missed tablet

• Return to regular dosing schedule

Overdose

• Symptoms may include headache, drowsiness, dizziness, dry mouth, increased heart rate, or abdominal pain

• Seek immediate medical attention if overdose is suspected

• Treatment is primarily supportive and symptomatic

How to Use Bilasure M 20mg/10mg Tablet

• Take one tablet once daily as prescribed by your healthcare provider

• Swallow the tablet whole with a full glass of water

• Can be taken with or without food, but taking it consistently with respect to meals helps maintain steady drug levels

• For optimal absorption of Bilastine component, take at least 1 hour before or 2 hours after a meal

• Take at approximately the same time each day to maintain consistent blood levels

• Do not crush, chew, or break the tablet unless specifically instructed by your healthcare provider

• Continue taking even if you feel well, as this medication may be prescribed for long-term control of chronic allergic conditions

• For seasonal allergies, start taking before exposure to allergens when possible

Side Effects of Bilasure M 20mg/10mg Tablet

Common Side Effects

• Headache

• Fatigue or drowsiness (though less common than with older antihistamines)

• Dry mouth

• Mild gastrointestinal disturbances (nausea, abdominal discomfort)

• Dizziness

• Increased appetite

• Mild elevation in liver enzymes

Uncommon Side Effects

• Sleep disturbances or insomnia

• Anxiety or irritability

• Prolonged QT interval (rare, primarily in susceptible individuals)

• Altered taste perception

• Palpitations

• Increased thirst

• Flatulence

• Skin rashes

Rare Side Effects

• Hypersensitivity reactions (skin rash, itching, swelling)

• Severe allergic reactions (anaphylaxis)

• Neuropsychiatric events (mood changes, depression, suicidal ideation)

• Significant elevation in liver enzymes

• Eosinophilic conditions including Churg-Strauss syndrome (extremely rare with Montelukast)

How to Manage Side Effects

• Dry mouth: Drink plenty of water, chew sugarless gum, use saliva substitutes

• Headache: Over-the-counter pain relievers may help (consult doctor first)

• Drowsiness: Take the medication in the evening if drowsiness occurs

• GI discomfort: Taking with food may help reduce stomach upset

• Report any mood changes, unusual behavior, or allergic reactions to your healthcare provider immediately

• Regular follow-up with healthcare provider to monitor for any adverse effects

Safety Advice for Bilasure M 20mg/10mg Tablet

Alcohol

CAUTION: Alcohol may enhance the sedative effects of this medication. Limit alcohol consumption while taking Bilasure M.

Pregnancy

CONSULT DOCTOR: Limited data available. Use only if potential benefits outweigh risks. Discuss with your healthcare provider if you are pregnant or planning pregnancy.

Breastfeeding

CONSULT DOCTOR: Both active ingredients may pass into breast milk. Caution is advised. Discuss with your healthcare provider before use during breastfeeding.

Driving

CAUTION: While Bilastine causes less sedation than older antihistamines, monitor your response to the medication before driving or operating machinery, especially during initial treatment.

Kidney

CAUTION: Dose adjustment may be necessary in patients with severe renal impairment. Consult your doctor if you have kidney problems.

Liver

CAUTION: Both active ingredients are metabolized by the liver. Regular monitoring of liver function may be advisable for long-term use, especially in patients with pre-existing liver conditions.

Children

NOT RECOMMENDED: Safety and efficacy not established in children under 12 years of age. Alternative age-appropriate formulations should be considered for younger patients.

Older Adults

CAUTION: Elderly patients may be more sensitive to side effects. Start with lower doses if necessary and monitor for adverse effects.

Allergy

CONTRAINDICATED: Do not use if allergic to Bilastine, Montelukast, or any component of the formulation.

Warnings & Precautions of Bilasure M 20mg/10mg Tablet

• Neuropsychiatric Events: Monitor for behavioral changes, depression, or suicidal thoughts, particularly in patients with a history of mental health disorders

• QT Prolongation: Use with caution in patients with cardiac conditions or those taking other medications that may prolong the QT interval

• Drug Interactions: Potential interactions with certain medications that affect liver enzymes

• Phenylketonuria: Some formulations may contain aspartame; check ingredients if you have phenylketonuria

• Eosinophilic Conditions: Rare reports of eosinophilic conditions including Churg-Strauss syndrome with Montelukast

• Not for Acute Attacks: Not effective for treatment of acute asthma attacks or status asthmaticus

• Renal Impairment: Use with caution in severe renal impairment

• Hepatic Impairment: Caution advised in patients with liver dysfunction

• Elderly Patients: May be more susceptible to adverse effects

• Concomitant Medications: Inform doctor about all current medications due to potential interactions

• Abrupt Discontinuation: Avoid stopping suddenly, especially if used for asthma control

Interactions with Bilasure M 20mg/10mg Tablet

Drug-Drug Interactions

• P-glycoprotein inhibitors (e.g., ketoconazole, erythromycin, cyclosporine): May increase Bilastine levels

• CYP3A4 inducers (e.g., rifampin, phenytoin): May decrease Montelukast effectiveness

• CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): May increase Montelukast levels

• QT-prolonging medications (certain antiarrhythmics, antibiotics, antipsychotics): Potential additive effect on QT prolongation

• Sedatives and CNS depressants: May enhance sedative effects

• Other antihistamines: Potential additive effects and increased risk of side effects

• Phenobarbital: May decrease effectiveness of Montelukast

• Warfarin: Montelukast may enhance anticoagulant effect in some patients

Drug-Food Interactions

• Grapefruit juice: May interfere with the metabolism of both active ingredients

• High-fat meals: May reduce the absorption rate of Bilastine

• Food generally: Bilastine absorption is reduced when taken with food; take at least 1 hour before or 2 hours after meals for optimal effect

Contraindications of Bilasure M 20mg/10mg Tablet

• Known hypersensitivity to Bilastine, Montelukast, or any component of the formulation

• Severe renal impairment (creatinine clearance <30 ml/min) without appropriate dose adjustment

• Patients with history of angioedema with previous antihistamine use

• Congenital prolongation of the QT interval or use with other medications known to prolong the QT interval

• Patients with galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption (if the formulation contains lactose)

• Pregnancy and breastfeeding (unless potential benefits outweigh risks)

• Children under 12 years of age

Diet & Lifestyle Advice

• Allergen Avoidance:

  • Identify and avoid known allergic triggers

  • Use air purifiers and allergen-proof bedding if appropriate

  • Keep windows closed during high pollen seasons

  • Shower and change clothes after outdoor activities during pollen season

• Environmental Control:

  • Reduce house dust mite exposure through regular cleaning

  • Control indoor humidity to prevent mold growth

  • Consider removing carpets in favor of hard flooring if dust allergies are severe

  • Avoid pet dander if known to trigger symptoms

• Dietary Considerations:

  • Take Bilastine component on an empty stomach for optimal absorption

  • Avoid grapefruit juice which may interfere with medication metabolism

  • Be aware of potential food allergies that may contribute to symptoms

  • Stay well hydrated to help thin mucus secretions

• Lifestyle Modifications:

  • Monitor air quality reports and limit outdoor activities when pollen or pollution levels are high

  • Saline nasal rinses may help remove allergens and support medication effectiveness

  • Practice stress reduction techniques, as stress can worsen allergic responses

  • Maintain good sleep hygiene, as allergies can disrupt sleep quality

Why Doctors Recommend This Medicine

Healthcare providers prescribe Bilasure M 20mg/10mg Tablet for several specific reasons:

• It provides dual-pathway inhibition targeting both histamine and leukotriene-mediated allergic responses

• Effective for patients with mixed allergic conditions affecting multiple body systems

• Particularly beneficial for allergic rhinitis patients with asthmatic components

• The once-daily dosing improves patient adherence to treatment

• Minimal sedation compared to older antihistamines enhances quality of life

• Both components have established safety and efficacy profiles

• Offers comprehensive symptom control for patients who have not responded adequately to monotherapy

• Reduces the need for multiple medications, simplifying treatment regimens

• Provides both immediate relief and addresses underlying inflammation

• May help prevent progression of allergic conditions when used consistently

Substitutes of Bilasure M 20mg/10mg Tablet & Alternative Medicines

Similar Combination Products:

• Other brands containing Bilastine + Montelukast in same or different strengths

• Combinations of different second-generation antihistamines with Montelukast

Monotherapy Alternatives:

• Antihistamines alone: Bilastine, Fexofenadine, Desloratadine, Levocetirizine, Cetirizine

• Leukotriene modifiers alone: Montelukast, Zafirlukast

• Intranasal corticosteroids: Fluticasone, Mometasone, Budesonide sprays

• Intranasal antihistamines: Azelastine, Olopatadine nasal sprays

Other Therapeutic Approaches:

• Combined use of separate antihistamine and leukotriene modifier tablets

• Intranasal corticosteroid + oral antihistamine combinations

• Allergen-specific immunotherapy (for long-term modification of allergic response)

• Nasal saline irrigation as adjunctive therapy

• In severe cases: Short courses of oral corticosteroids

• For urticaria: H2 antihistamines as add-on therapy

Storage Guidelines

• Store at room temperature between 20-25°C (68-77°F)

• Protect from light and moisture

• Keep away from direct sunlight

• Store in the original package or container

• Keep out of reach of children

• Do not use after the expiration date

• Do not store in bathroom medicine cabinets due to heat and humidity

• Do not freeze

User Feedback & Patient Concerns

Common feedback from patients includes:

• Most report significant improvement in both nasal and eye symptoms

• Many appreciate the non-sedating nature compared to older antihistamines

• Patients with asthma symptoms often note improvement in breathing alongside allergic symptom relief

• Some report initial adjustment period with mild headaches that typically resolve

• Generally good tolerability with few discontinuations due to side effects

• Occasional reports of mild drowsiness, especially during initial therapy

• Some patients mention increased effectiveness compared to single-agent therapy

• Questions about long-term safety are common, especially regarding Montelukast

• Some patients report delayed onset of full effect (may take several days)

• Concerns about cost compared to individual components purchased separately

Quick Tips

• Take consistently at the same time each day for optimal effect

• For best absorption of Bilastine component, take on an empty stomach

• Allow at least 2 weeks of regular use to evaluate full effectiveness

• Continue using even when symptoms improve to maintain control

• Be aware of mood changes and report them promptly to your doctor

• During severe allergy seasons, starting treatment before exposure to allergens is beneficial

• Carry medication information with you when traveling

• Inform all healthcare providers about this medication before any procedures

• Keep a symptom diary during initial use to track effectiveness

• For seasonal allergies, don't discontinue abruptly when season ends; follow doctor's guidance

Fact Box

• Chemical Class: H1-antihistamine (Bilastine) + Leukotriene receptor antagonist (Montelukast)

• Habit Forming: No

• Therapeutic Class: Antiallergic combination

• Action Class: Histamine H1-receptor antagonist + Cysteinyl leukotriene CysLT1 receptor antagonist

Useful Diagnostic Tests

Before or during treatment, your doctor may recommend:

• Allergy skin testing to identify specific triggers

• Blood tests for specific IgE antibodies

• Complete blood count to evaluate eosinophil levels

• Pulmonary function tests if asthmatic symptoms are present

• ECG in patients with cardiac risk factors or before long-term therapy

• Liver function tests for baseline and monitoring during long-term use

• Renal function tests in patients with kidney problems

References

1. Clinical guidelines for the management of allergic rhinitis

2. Pharmacology references for antihistamines and leukotriene modifiers

3. Clinical studies on combination therapy for allergic disorders

4. Safety profiles of Bilastine and Montelukast

5. Therapeutic guidelines for allergic conditions

Link to credible health sources:

• Drugs.com

• WHO

• NCBI

Disclaimer

This information is provided for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment. Never disregard professional medical advice or delay in seeking it because of information you have read here. This medication should only be used under the supervision of a qualified healthcare provider.