🏅   2025 諾貝爾生醫獎揭曉：免疫學的關鍵里程碑！

2025 年諾貝爾生醫獎頒給了 Brunkow、Ramsdell、Sakaguchi，表揚他們對周邊免疫耐受機制、調節性T細胞與 Foxp3 基因的突破性發現與貢獻。

本期簡訊帶你快速瀏覽：

🔸 得獎者電話訪談的第一反應與幽默瞬間

🔸 三位得獎者的學術影響力數據快覽、重要著作

🔸 也想知道自己的學術力？圖書館「學術研究影響力報告」服務簡介

🔸 輕鬆的延伸閱讀推薦：免疫學電子書、紀錄片等

(！請往下捲動頁面觀看全部！)  ※上期簡訊回顧【開始使用圖書館，必做設定】【請點此】

[全文] Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, Kelly TE, Saulsbury FT, Chance PF, Ochs HD. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001:27:20-21. 

[全文] Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003:299:1057-1061. 

[實體館藏] Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995:155:1151-1164. 

[全文] Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001:27:68-73. 

[全文] Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, Levy-Lahad E, Mazzella M, Goulet O, Perroni L, Bricarelli FD, Byrne G, McEuen M, Proll S, Appleby M, Brunkow M. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet. 2001:27:18-20.