31. Tsuji D, Ishida N, Miyamoto T, Inouye S, Akagi R
Acquisition mechanism of heme oxygenase-1 induction by heat shock in human monocytic cell line THP-1 after differentiation to macrophage-like cells.
J Biochem 178 135-143 (2025)
30. Tsuji D, Akagi R
Species-specific differences in acetaminophen hepatotoxicity depend on HSP70 expression level.
J Biochem 177 133-139 (2025)
29. Takizawa R, Nakagawa Y, Kim SY, Tsuji D, Kojoma M, Akagi R, Tanaka N
Triadenosides A–F, benzophenone rhamnosides from Triadenum japonicum and their anti-ferroptosis.
Fitoterapia 180 106348 (2025)
28. Takizawa R, Minamizono T, Tsuji D, Yan XJ, Lu FL, Yang XR, Li DP, Akagi R, Kashiwada Y, Tanaka N
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity.
J Nat Med 79 196–203 (2025)
27. Takizawa R, Nagata C, Kim SY, Tsuji D, Kojoma M, Akagi R, Kashiwada Y, Tanaka N
Meroterpenes and prenylated acylphloroglucinol from the aerial parts of Hypericum erectum.
J Nat Med 79 639–646 (2025)
26. Tsuji D, Hirayama T, Kawai K, Nagasawa H, Akagi R
Application of fluorescent probe for labile heme quantification in physiological dynamics.
Biochim Biophys Acta Gen Subj 1868 130707 (2024)
25. Sun C, Inokuma T, Tsuji D, Yamaoka Y, Akagi R, Yamada K
Total Synthesis of 1,4a-di-epi-ent-Pancratistatin, Exemplifying a Stereodivergent Approach to Pancratistatin Isomers.
Chem Commun 60, 6757–6760 (2024)
24. Kondo Y, Nakamura T, Tsuji D, Sato R, Karanjit S, Akagi R, Namba K
Development of 1,3a,6a-triazapentalene derivatives as practical erasable fluorescent cell staining reagents.
Tetrahedron Lett 138, 154986 (2024)
23. Tanaka N, Takizawa R, Shimomoto Y, Tsuji D, Yonekura K, Itoh K, Akagi R, Kashiwada Y
Meroterpenes and prenylated benzoylphloroglucinol from the flowers of Hypericum formosanum.
Phytochemistry 220, 114016 (2024)
22. Yoshino Y, Imanishi M, Miyamoto L, Tsuji D, Akagi R, Tsuchiya K, Kashiwada Y, Tanaka N
Dauferulins A–L, daucane-type sesquiterpenes from the roots of Ferula communis: Their structures and biological activities.
Fitoterapia 174, 105877 (2024)
21. Takizawa R, Shimomoto Y, Tsuji D, Imabayashi K, Itoh K, Akagi R, Kashiwada Y, Tanaka N
Formohyperins G-L, polycyclic prenylated benzoylphloroglucinols from the flowers of Hypericum formosanum.
J Nat Med 78, 970-977 (2024)
20. Tanaka N, Shibata I, Tasaki Y, Yoshino Y, Tsuji D, Lu FL, Yan XJ, Yang XR, Itoh K, Akagi R, Li DP, Kashiwada Y
Acylated iridoid glucoside and xanthones from Canscora lucidissima: Their structures and ferroptosis inhibitory activity.
Fitoterapia 168, 105539 (2023)
19. Watanabe R, Tsuji D, Tanaka H, Uno MS, Ohnishi Y, Kitaguchi S, Matsugu T, Nakae R, Teramoto H, Yamamoto K, Hirokawa T, Okino N, Ito M, Itoh K
Lysoglycosphingolipids have the ability to induce cell death through direct PI3K inhibition.
J Neurochem 167, 753-765 (2023)
18. Yoshino Y, Tanaka N, Tsuji D, Itoh K, Kashiwada Y
Communiferulins, farnesylated coumarins from the roots of Ferula communis and their anti-neuroinflammatory activity.
J Nat Meds 77, 173-179 (2023)
17. Tsuji D, Nakayama A, Yamamoto R, Nagano S, Taniguchi T, Sato R, Karanjit S, Muguruma N, Takayama T, Itoh K, Namba K
1,3a,6a-Triazapentalene derivatives as photo-induced cytotoxic small fluorescent dyes.
Commun Chem 6, 37 (2023)
16. Inouye S, Kubo T, Miyamoto T, Iyoda T, Okita N, Akagi R
Heat shock-induced heme oxygenase-1 expression in a mouse hepatoma cell line is dependent on HSF1 and modified by NRF2 and BACH1.
Genes to Cells 27, 719-730 (2022)
15. Ohnishi Y, Tsuji D, Itoh K
Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8.
Biol Pharm Bull 45, 1609-1015, (2022)
14. Tanaka H, Tsuji D, Watanabe R, Ohnishi Y, Kitaguchi S, Nakae R, Teramoto H, Tsukimoto J, Horii Y, Itoh K
Aberrant autophagy in lysosomal storage disorders marked by a lysosomal SNARE protein shortage due to suppression of endocytosis.
J Inherit Metab Dis 45, 1191-1202 (2022)
13. Horii Y, Iniwa T, Onitsuka M, Tsukimoto J, Tanaka Y, Ike H, Fukushi Y, Andoh H, Takeuchi Y, Nishioka SI, Tsuji D, Ikuo M, Yamazaki N, Takiguchi Y, Ishim N, Itoh K
Reversal of neuroinflammation in novel galactosialidosis model mice by single intracerebroventricular administration of CHO-derived human recombinant cathepsin A precursor protein.
Mol Ther – Methods & Clin Dev 25, 297-310 (2022)
12. Tanaka N, Yoshino Y, Nakano F, Kurimoto S, Kawazoe K, Tsuji D, Itoh K, Li SL, Sun HD, Takaishi Y, Kashiwada Y
Lanicepines A and B, sesquiterpenes with amino acid-derived substituents from the flowering aerial parts of Saussurea laniceps.
J Nat Prod 85, 1180-1185 (2022)
11. Akagi R
Role of Heme Oxygenase in Gastrointestinal Epithelial Cells.
Antioxidants (Basel) 11, 1323 (2022)
10. Akagi R, Kubo T, Hatori Y, Miyamoto T, Inouye S
Heme oxygenase-1 induction by heat shock in rat hepatoma cell line is regulated by the coordinated function of HSF1, NRF2 and BACH1.
J Biochem 170, 501-510 (2021)
9. Inoue R, Irie Y, Akagi R
Role of heme oxygenase-1 in human placenta on iron supply to fetus.
Placenta 103, 53-58 (2021)
8. Hatori Y, Kubo T, Sato Y, Inouye S, Akagi R, Seyama T
Visualization of the Redox Status of Cytosolic Glutathione Using the Organelle- and Cytoskeleton-Targeted Redox Sensors.
Antioxidants (Basel) 9, 129 (2020)
7. Kubo T, Nishimura Y, Hatori Y, Akagi R, Mihara K, Yanagihara K, Seyama T
Antitumor effect of palmitic acid-conjugated DsiRNA for colon cancer in a mouse subcutaneous tumor model.
Chem Biol Drug Des 93, 570-581 (2019)
6. Inouye S, Hatori Y, Kubo T, Saito S, Kitamura H, Akagi R
NRF2 and HSF1 coordinately regulate heme oxygenase-1 expression.
Biochem Biophys Res Commun 506, 7-11 (2018)
5. Hatori Y, Inouye S, Akagi R, Seyama T
Local redox environment beneath biological membranes probed by palmitoylated-roGFP.
Redox Biol 14, 679-685 (2018)
4. Hatori Y, Inouye S, Akagi R
Thiol-based copper handling by the copper chaperone Atox1.
IUBMB Life 69, 246-254 (2017)
3. Akagi R, Akagi M, Hatori Y, Inouye S
Prevention of Barrier Disruption by Heme Oxygenase-1 in Intestinal Bleeding Model.
Biol Pharm Bull 39, 1007-12 (2016)
2. Akagi M, Matsui N, Akae H, Hirashima N, Fukuishi N, Fukuyama Y, Akagi R
Nonpeptide neurotrophic agents useful in the treatment of neurodegenerative diseases such as Alzheimer's disease.
J Pharmacol Sci 127, 155-63 (2015)
1. Akagi R, Ohno M, Matsubara K, Fujimoto M, Nakai A, Inouye S
Glutamine protects intestinal barrier function of colon epithelial cells from ethanol by modulating Hsp70 expression.
Pharmacology 91, 104-11 (2013)