MIRTO Collaboration

MIRTO or “MicrodosImetric study and RBE measuremenT with 62 MeV clinical prOton beam” is a scientific collaboration established to evaluate the RBE in a clinical condition.

A collaboration, between INFN-LNS (Catania, Italy), the University of Wollongong (Australia), the IBFM-CNR Unit of Cefalù (Palermo, Italy), the INFN-LNL (Legnaro, Italy), the INFN-TIFPA (Trento, Italy), the INFN-MI (Milan, Italy), the INFN-RM (Rome, Italy) and Vinca Institute (Belgrade, Serbia) is currently ongoing to perform an experimental measure of the Relative Biological Effectivenes value along a typical SOBP for eye protontherapy.

RBE will be evaluated from by a twofold approach, i.e. using four different micorodosimetric detectors (silicon detector and mini-TEPC) and the MKM model [4] and by radiobiology measurements performed at seven positions along the CATANA 60-MeV SOBP.

Papers

• V. Conte et al.,“Microdosimetry at the catana 62 mev proton beam with a sealed miniaturized tepc.”,Physica Medica, Vol.64, 114-122, (2019)

• A. Selva et al., “Towards the use of nanodosimetry to predict cell survival”, Radiation protection and dosimetry, 183-1-2 (2019)

• D. Mazzucconi et al., “Micorodosimetry at nanometric scale with an avalanche-confinement TEPC: Responce against a helium ion beam”, Radiation Protection Dosimetry 183-1-2 (2019)

• D. Mazzucconi et al. “Nano-microdosimetric investigation at the proton irradiation line of CATANA”, Radiation Measurements 123, 26-33 (2019)

• G. Petringa et al. “Radiobiological quantities in proton-therapy: estimation and validation using Geant4-based Monte Carlo simulations”, Physica Medica 58, P72-80, 2019

• P.Colautti et al. “Therapeutic proton beams: LET, RBE and microdosimetric spectra with gas and silicon detectors”, Radiation Measurements, DOI: 10.1016/j.radmeas.2020.106386 (2020)

• A. Bianchi et al. “Microdosimetry with a sealed mini-TEPC and a silicon telescope at a clinical proton SOBP of CATANA”, Radiation Physics and Chemistry, Volume 171 (2020)

• G. Petringa et al. “Study and validation of Monte Carlo methods for linear energy transfer calculation in voxelized geometries with clinical proton beams”, Physics in Medicine and Biology, DOI: 10.1088/1361-6560/abaeb9 (2020)

• C. Verona et al., “Microdosimteric measurements of a monoenergetic and modulated Bragg Peak of 62 MeV therapeutic proton beam with a synthetic single crystal diamond microdosimeter”, Medical Physics, (2020) Paper Accepted

• B. James et al., "In-Field and Out-of-Field Microdosimetric Characterisation of a 62 MeV Proton Beam at CATANA", Medical Physics, (2020) Paper Accepted

• V. Conte et al., "Microdosimetry of a therapeutic proton beam with a mini-TEPC and a MicroPlus-Bridge detector", Physics in Medicine and Biology, (2020) Paper Accepted

Talks

▪ 3^rd Geant4 international user conference, (Bordeaux, Francia), Ottobre 2018

▫ Titolo del talk: “Relative Biological Effectiveness (RBE) of a clinical eye proton therapy beam: experiments and Monte Carlo approach"

▪ 1st International Biophysics Collaboration Meeting, (GSI), Maggio 2019

▫ “Relative Biological Effectiveness (RBE) of a clinical eye proton therapy beam: experiments and Monte Carlo approach”

▪ MCMA 2019 conference (Montreal, Canada), Giugno 2019 http://iccr-mcma.org/

▫ “MIRTO: A microdosimetric study and RBE measurement with 62 MeV clinical proton beam”

Online Repository