MIRTO Collaboration
MIRTO or “MicrodosImetric study and RBE measuremenT with 62 MeV clinical prOton beam” is a scientific collaboration established to evaluate the RBE in a clinical condition.
A collaboration, between INFN-LNS (Catania, Italy), the University of Wollongong (Australia), the IBFM-CNR Unit of Cefalù (Palermo, Italy), the INFN-LNL (Legnaro, Italy), the INFN-TIFPA (Trento, Italy), the INFN-MI (Milan, Italy), the INFN-RM (Rome, Italy) and Vinca Institute (Belgrade, Serbia) is currently ongoing to perform an experimental measure of the Relative Biological Effectivenes value along a typical SOBP for eye protontherapy.
RBE will be evaluated from by a twofold approach, i.e. using four different micorodosimetric detectors (silicon detector and mini-TEPC) and the MKM model [4] and by radiobiology measurements performed at seven positions along the CATANA 60-MeV SOBP.
Papers
V. Conte et al.,“Microdosimetry at the catana 62 mev proton beam with a sealed miniaturized tepc.”,Physica Medica, Vol.64, 114-122, (2019)
A. Selva et al., “Towards the use of nanodosimetry to predict cell survival”, Radiation protection and dosimetry, 183-1-2 (2019)
D. Mazzucconi et al., “Micorodosimetry at nanometric scale with an avalanche-confinement TEPC: Responce against a helium ion beam”, Radiation Protection Dosimetry 183-1-2 (2019)
D. Mazzucconi et al. “Nano-microdosimetric investigation at the proton irradiation line of CATANA”, Radiation Measurements 123, 26-33 (2019)
G. Petringa et al. “Radiobiological quantities in proton-therapy: estimation and validation using Geant4-based Monte Carlo simulations”, Physica Medica 58, P72-80, 2019
P.Colautti et al. “Therapeutic proton beams: LET, RBE and microdosimetric spectra with gas and silicon detectors”, Radiation Measurements, DOI: 10.1016/j.radmeas.2020.106386 (2020)
A. Bianchi et al. “Microdosimetry with a sealed mini-TEPC and a silicon telescope at a clinical proton SOBP of CATANA”, Radiation Physics and Chemistry, Volume 171 (2020)
G. Petringa et al. “Study and validation of Monte Carlo methods for linear energy transfer calculation in voxelized geometries with clinical proton beams”, Physics in Medicine and Biology, DOI: 10.1088/1361-6560/abaeb9 (2020)
C. Verona et al., “Microdosimteric measurements of a monoenergetic and modulated Bragg Peak of 62 MeV therapeutic proton beam with a synthetic single crystal diamond microdosimeter”, Medical Physics, (2020) Paper Accepted
B. James et al., "In-Field and Out-of-Field Microdosimetric Characterisation of a 62 MeV Proton Beam at CATANA", Medical Physics, (2020) Paper Accepted
V. Conte et al., "Microdosimetry of a therapeutic proton beam with a mini-TEPC and a MicroPlus-Bridge detector", Physics in Medicine and Biology, (2020) Paper Accepted
Talks
▪ 3rd Geant4 international user conference, (Bordeaux, Francia), Ottobre 2018
▫ Titolo del talk: “Relative Biological Effectiveness (RBE) of a clinical eye proton therapy beam: experiments and Monte Carlo approach"
▪ 1st International Biophysics Collaboration Meeting, (GSI), Maggio 2019
▫ “Relative Biological Effectiveness (RBE) of a clinical eye proton therapy beam: experiments and Monte Carlo approach”
▪ MCMA 2019 conference (Montreal, Canada), Giugno 2019 http://iccr-mcma.org/
▫ “MIRTO: A microdosimetric study and RBE measurement with 62 MeV clinical proton beam”