He is also known as a revolutionary for insisting upon using observations of nature, rather than looking to ancient texts, in open and radical defiance of medical practice of his day. He is also credited for giving zinc its name, calling it zincum. Modern psychology often also credits him for being the first to note that some diseases are rooted in psychological conditions.

Paracelsus pioneered the use of chemicals and minerals in medicine. His hermetical views were that sickness and health in the body relied on the harmony of man (microcosm) and Nature (macrocosm). He took an approach different from those before him, using this analogy not in the manner of soul-purification but in the manner that humans must have certain balances of minerals in their bodies, and that certain illnesses of the body had chemical remedies that could cure them.

Paracelsus viewed the universe as one coherent organism pervaded by a uniting lifegiving spirit, and this in its entirety, Man included, was 'God'. His views put him at odds with the Church, for which there necessarily had to be a difference between the Creator and the created.

"Many have said of Alchemy, that it is for the making of gold and silver. For me such is not the aim, but to consider only what virtue and power may lie in medicines."