Publications

2022

Doerr, V.; Montalvo, R.N.; Nguyen, B.L.; Boeno, F.P.; Sunshine, M.D.; Bindi, V.E.; Fuller, D.D.; Smuder, A.J. Effects of Hyperbaric Oxygen Preconditioning on Doxorubicin Cardiorespiratory Toxicity. Antioxidants 2022, 11, 2073. https://doi.org/10.3390/antiox11102073

2021

Montalvo RN, Doerr V, Nguyen BL, Kelley RC, Smuder AJ. Consideration of Sex as a Biological Variable in the Development of Doxorubicin Myotoxicity and the Efficacy of Exercise as a Therapeutic Intervention. Antioxidants (Basel). 2021 Feb 25;10(3):343. doi: 10.3390/antiox10030343. PMID: 33669040.

2020

Montalvo RN, Doerr V, Kwon OS, Talbert EE, Yoo JK, Hwang MH, Nguyen BL, Christou DD, Kavazis AN, Smuder AJ. Protection against Doxorubicin-Induced Cardiac Dysfunction Is Not Maintained Following Prolonged Autophagy Inhibition. Int J Mol Sci. 2020 Oct 30;21(21):8105. doi: 10.3390/ijms21218105. PMID: 33143122; PMCID: PMC7662380.

Smuder AJ, Turner SM, Schuster CM, Morton AB, Hinkley JM, Fuller DD. Hyperbaric Oxygen Treatment Following Mid-Cervical Spinal Cord Injury Preserves Diaphragm Muscle Function. Int J Mol Sci. 2020 Sep 30;21(19):7219. doi: 10.3390/ijms21197219. PMID: 33007822.

Smuder AJ, Roberts BM, Wiggs MP, Kwon OS, Yoo JK, Christou DD, Fuller DD, Szeto HH, Judge AR. Pharmacological targeting of mitochondrial function and reactive oxygen species production prevents colon 26 cancer-induced cardiorespiratory muscle weakness. Oncotarget. 2020 Sep 22;11(38):3502-3514. doi: 10.18632/oncotarget.27748. PMID: 33014286.

Doerr V, Montalvo RN, Kwon OS, Talbert EE, Hain BA, Houston FE and Smuder AJ. Prevention of Doxorubicin-Induced Autophagy Attenuates Oxidative Stress and Skeletal Muscle Dysfunction. Antioxidants (Basel). 2020 Mar 23;9(3):263. PMID: 32210013.

Montalvo RN, Doerr V, Min K, Szeto HH and Smuder AJ. Doxorubicin-induced oxidative stress differentially regulates proteolytic signaling in cardiac and skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2020 Feb 1;318(2):R227-R233. PMID: 31774307.

2019

Smuder AJ. Exercise stimulates beneficial adaptations to diminish doxorubicin-induced cellular toxicity. Am J Physiol Regul Integr Comp Physiol. 2019 Nov 1 1;317(5):R662-R672. PMID: 31461307.

Hall SE, Smuder AJ and Hayward R. Effects of calorie restriction and voluntary exercise on doxorubicin-induced cardiotoxicity. Integr Cancer Ther. 2019 Jan-Dec;18:1534735419843999. PMID: 30999765.

Hinkley JM, Morton AB, Ichinoseki-Sekine N, Huertas AM and Smuder AJ. Exercise training prevents doxorubicin-induced mitochondrial dysfunction of the liver. Med Sci Sports Exerc. 2019 Jun;51(6):1106-1115. PMID: 30629044.

VanderVeen BN, Fix DK, Montalvo RN, Counts BR, Smuder AJ, Murphy EA, Koh HJ and Carson JA. The regulation of skeletal muscle fatigability and mitochondrial function by chronically elevated interleukin-6. Exp Physiol. 2019 Mar;104(3):385-397. PMID: 30576589.

Morton AB, Huertas AM, Hinkley JM, Ichinoseki-Sekine N, Christou DD and Smuder AJ. Mitochondrial accumulation of doxorubicin in cardiac and diaphragm muscle following exercise preconditioning. Mitochondrion. 2019 Mar;45:52-62. PMID: 29474837.

Kavazis AN, Morton AB, Hall SE and Smuder AJ. Effects of doxorubicin on cardiac muscle subsarcolemmal and intermyofibrillar mitochondria. Mitochondrion. 2017 May;34:9-19. PMID: 27832997.

Powers SK, Morton AB, Ahn B and Smuder AJ. Redox control of skeletal muscle atrophy. Free Radic Biol Med. 2016 Sep;98:208-17. PMID: 26912035.

Min K, Kwon OS, Smuder AJ, Wiggs MP, Sollanek KJ, Christou DD, Yoo JK, Hwang MH, Szeto HH, Kavazis AN, and Powers SK. Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin-induced cardiac and skeletal muscle myopathy. J Physiol. 2015 Apr 15;593(8):2017-36. Epub 2015 Feb 23. PMID: 25643692; PMCID: PMC4405757.

Kavazis AN*, Smuder AJ* and Powers SK. Effects of short-term exercise training on acute doxorubicin-induced FOXO transcription in cardiac and skeletal muscle. J Appl Physiol. 2014 Aug 1;117(3):223-30. PMID: 24947024. *Co-first authors

Powers SK, Smuder AJ, Kavazis AN and Quindry JC. Mechanisms of exercise-induced cardioprotection. Physiology. 2014 Jan;29(1):27-38. PMID: 24382869.

Powers SK, Sollanek KJ, Wiggs MP, Demirel H and Smuder AJ. Exercise- induced improvements in myocardial antioxidant capacity: the antioxidant players and cardioprotection. Free Radic Res. 2013 Jan;48(1):43-51. PMID: 23915097.

Smuder AJ, Kavazis AN, Min K, and Powers SK. Doxorubicin-induced markers of myocardial autophagic signaling in sedentary and exercise trained animals. J Appl Physiol. 2013 Jul;115(2):176-85. PMID: 23703114.

Smuder AJ, Kavazis AN, Min K, and Powers SK. Exercise attenuates doxorubicin-induced skeletal muscle damage. J Appl Physiol. 2011 Apr;110(4):935-42. PMID: 21310889.

Smuder AJ, Kavazis AN, Min K, and Powers SK. Exercise attenuates doxorubicin-induced autophagy in skeletal muscle. J Appl Physiol. 2012 Feb;112(3):501-10. PMID: 21778418.

Smuder AJ, Kavazis AN, Min K and Powers SK. Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle. J Appl Physiol (1985). 2011 Apr;110(4):935-42. PMID: 21310889; PMCID: PMC3075128.

Smuder AJ, Kavazis AN, Min K and Powers SK. Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle. J Appl Physiol (1985). 2011 Oct;111(4):1190-8. PMID: 21778418.

Kavazis AN, Smuder AJ, Min K, Tumer N, and Powers SK. Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1515-24. PMID: 20833957