For a Full List: NCBI
2026
Smuder, A.J.; Doerr, V.; Jacintho Moritz, C.E.; Li, J.; Nguyen, B.L. Mitochondrial transporter ABCB10 protects against doxorubicin-induced respiratory muscle dysfunction independent of changes to diaphragm accumulation. J Cachexia Sarcopenia Muscle. 2026 Feb;17(1)e70171. https://doi.org/10.1002/jcsm.70171.
Deb, A.; Gomez, V.; Cheng, Y.; Li, Z.; Yang, J.; Dowllah, I.; Nguyen, N.; Adekanye, O.; Smuder, A.J.; Cheng, Z.; Liu, B. Ablation of mitochondrial calcium uniporter alleviates cardiac dysfunction in type 1 diabetes. Cell Calcium. 2026 Jan;133:103106. https://doi.org/10.1016/j.ceca.2025.103106.
Halle, J.L.; Zhang, Q.; Baumfalk, D.R.; Puppa, M.J.; Mohamed, J.S.; Glazer, E.S.; Smuder, A.J.; Alway, S.E.; Carson, J.A. Sex impacts inflammatory signaling, body composition, and physical function in tumor-bearing mice receiving chemotherapy. Am J Physiol Cell Physiol. 2026, Jan 1;330(1):C166-C183. https://doi.org/10.1152/ajpcell.00643.2025.
Montalvo, R.N.; Nguyen, B.L.; Doerr, V.; Dowllah, I.M.; Wendler, C.C.; Baumfalk, D.R.; Babuschak, J.C.; Krueger, R.W.; Smuder, A.J. Sex differences in response to acute doxorubicin cardiorespiratory muscle dysfunction and preconditioning exercise. Med Sci Sports Exerc. 2026 Jan 1;58(1):47-59. https://doi.org/10.1249/MSS.0000000000003837.
2025
Cheung, C.V.; Searcy, R.A.; Atube, K.J.; Colonna, N.A.; Krusen, K.E.; Coppage, K.J.; Holly, K.M.; Ward Pratz, R.P.; Fournier, J.H.; Sikirzhytski, V.; Smuder, A.J.; Gower, R.M. Local injection of particles for retinoic acid drug delivery improves muscle structure and modulates inflammation in mice recovering from cast immobiization. Am J Physiol Cell Physiol. 2025, Nov 1;329(5):C1343-C1359. https://doi.org/10.1152/ajpcell.00097.2025
Alzahrani, J.M.; Smuder, A.J.; Gambino, B.J.; Delgado, C.; Rua, M.T.; Montalvo, R.N.; Fitton, F.P.; Morse, D.A.; Clanton, T.L. Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke. Commun. Biol. 2025, 8, 65. https://doi.org/10.1038/s42003-025-07484-3
2024
Deb, A.; Tow, B.D.; Hao, J.; Nguyen, B.L.; Gomez, V.; Stewart, J.A.; Smuder, A.J.; Knollmann, B.C.; Wang, Y.; Liu, B. Conditional ablation of MCU exacerbated cardiac pathology in a genetic arrhythmic model of CPVT. J. Mol. Cell. Cardiol. Plus 2024, 4, 100093. https://doi.org/10.1016/j.jmccpl.2024.100093
Nguyen, B.L.; Baumfalk, D.R.; Lapierre-Nguyen, S.S.; Zhong, R.; Doerr, V.; Montalvo, R.N.; Wei-LaPierre, L.; Smuder, A.J. Effects of exercise and doxorubicin on acute diaphragm neuromuscular transmission failure. Exp. Neurol. 2024, 378, 114818. https://doi.org/10.1016/j.expneurol.2024.114818
Smuder, A.J. Doxorubicin-related effects on cardiorespiratory function and body composition. Am Heart J Plus 2024, 38, 100360. https://doi.org/10.1016/j.ahjo.2024.100360
2023
Sunshine, M.D.; Bindi, V.E.; Nguyen, B.L.; Doerr, V.; Boeno, F.P.; Chandran, V.; Smuder, A.J.; Fuller, D.D. Oxygen Therapy Attenuates Neuroinflammation after Spinal Cord Injury. J. Neuroinflammation 2023, 20, 303. https://doi.org/10.1186/s12974-023-02985-6
Halle, J.L.; Counts, B.R.; Paez, H.G.; Baumfalk, D.R.; Zhang, Q.; Mohamed, J.S.; Glazer, E.S.; Puppa, M.J.; Smuder, A.J.; Alway, S.E.; Carson, J.A. Recovery from FOLFOX Chemotherapy-Induced Systemic and Skeletal Muscle Metabolic Dysfunction in Mice. American Journal of Physiology-Endocrinology and Metabolism 2023, 325, E132–E151. https://doi.org/10.1152/ajpendo.00096.2023
Boeno, F.P.; Patel, J.; Montalvo, R.N.; Lapierre-Nguyen, S.S.; Schreiber, C.M.; Smuder, A.J. Effects of Exercise Preconditioning on Doxorubicin-Induced Liver and Kidney Toxicity in Male and Female Rats. Int. J. Mol. Sci. 2023, 24, 10222. https://doi.org/10.3390/ijms241210222
Mankowski, R.T.; Wohlgemuth, S.E.; Bresciani, G.; Martin, A.D.; Arnaoutakis, G.; Beaver, T.; Leeuwenburgh, C.; Smith, B.K.; Ferreira, L.F.; et al. Intraoperative Hemi-Diaphragm Electrical Stimulation Demonstrates Attenuated Mitochondrial Function without Change in Oxidative Stress in Cardiothoracic Surgery Patients. Antioxidants 2023, 12, 1009. https://doi.org/10.3390/antiox12051009
Montalvo, R.N.; Boeno, F.P.; Dowllah, I.M.; Jacintho Moritz, C.E.; Nguyen, B.L.; Doerr, V.; Bomkamp, M.P.; Smuder, A.J. Exercise and Doxorubicin Modify Markers of Iron Overload and Cardiolipin Deficiency in Cardiac Mitochondria. Int. J. Mol. Sci. 2023, 24, 7689. https://doi.org/10.3390/ijms24097689
Smuder, A. J., Levine, S., & Powers, S. K. (2023). Critical illness myopathy alters diaphragm neuromuscular junction protein and gene expression. American Journal of Respiratory and Critical Care Medicine, 207(3), 358–361. https://doi.org/10.1164/rccm.202204-0683LE
Huot, J.R.; Baumfalk, D.; Resendiz, A.; Bonetto, A.; Smuder, A.J.; Penna, F. Targeting Mitochondria and Oxidative Stress in Cancer- and Chemotherapy-Induced Muscle Wasting. Antioxid Redox Signal 2023, 38, 352–370. https://doi.org/10.1089/ars.2022.0149
2022
Ozdemir, M.; Bomkamp, M.P.; Hyatt, H.W.; Smuder, A.J.; Powers, S.K. Intensive Care Unit-Acquired Weakness Is Associated with Rapid Changes to Skeletal Muscle Proteostasis. Cells 2022, 11, 4005. https://doi.org/10.3390/cells11244005
Doerr, V.; Montalvo, R.N.; Nguyen, B.L.; Boeno, F.P.; Sunshine, M.D.; Bindi, V.E.; Fuller, D.D.; Smuder, A.J. Effects of Hyperbaric Oxygen Preconditioning on Doxorubicin Cardiorespiratory Toxicity. Antioxidants 2022, 11, 2073. https://doi.org/10.3390/antiox11102073
Fuller, D.D.; Rana, S.; Smuder, A.J.; Dale, E.A. The Phrenic Neuromuscular System. Handbook of Clinical Neurology 2022, 188, 393–408. https://doi.org/10.1016/B978-0-323-91534-2.00012-6
Turner, S.M.F.; Sunshine, M.D.; Chandran, V.; Smuder, A.J.; Fuller, D.D. Hyperbaric Oxygen Therapy after Mid-Cervical Spinal Contusion Injury. J Neurotrauma 2022, 39, 715–723. https://doi.org/10.1089/neu.2021.0412
2021
Montalvo RN, Doerr V, Nguyen BL, Kelley RC, Smuder AJ. Consideration of Sex as a Biological Variable in the Development of Doxorubicin Myotoxicity and the Efficacy of Exercise as a Therapeutic Intervention. Antioxidants (Basel). 2021 Feb 25;10(3):343. doi: 10.3390/antiox10030343. PMID: 33669040.
2020
Montalvo RN, Doerr V, Kwon OS, Talbert EE, Yoo JK, Hwang MH, Nguyen BL, Christou DD, Kavazis AN, Smuder AJ. Protection against Doxorubicin-Induced Cardiac Dysfunction Is Not Maintained Following Prolonged Autophagy Inhibition. Int J Mol Sci. 2020 Oct 30;21(21):8105. doi: 10.3390/ijms21218105. PMID: 33143122; PMCID: PMC7662380.
Smuder AJ, Turner SM, Schuster CM, Morton AB, Hinkley JM, Fuller DD. Hyperbaric Oxygen Treatment Following Mid-Cervical Spinal Cord Injury Preserves Diaphragm Muscle Function. Int J Mol Sci. 2020 Sep 30;21(19):7219. doi: 10.3390/ijms21197219. PMID: 33007822.
Smuder AJ, Roberts BM, Wiggs MP, Kwon OS, Yoo JK, Christou DD, Fuller DD, Szeto HH, Judge AR. Pharmacological targeting of mitochondrial function and reactive oxygen species production prevents colon 26 cancer-induced cardiorespiratory muscle weakness. Oncotarget. 2020 Sep 22;11(38):3502-3514. doi: 10.18632/oncotarget.27748. PMID: 33014286.
Doerr V, Montalvo RN, Kwon OS, Talbert EE, Hain BA, Houston FE and Smuder AJ. Prevention of Doxorubicin-Induced Autophagy Attenuates Oxidative Stress and Skeletal Muscle Dysfunction. Antioxidants (Basel). 2020 Mar 23;9(3):263. PMID: 32210013.
Montalvo RN, Doerr V, Min K, Szeto HH and Smuder AJ. Doxorubicin-induced oxidative stress differentially regulates proteolytic signaling in cardiac and skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2020 Feb 1;318(2):R227-R233. PMID: 31774307.
2019
Smuder AJ. Exercise stimulates beneficial adaptations to diminish doxorubicin-induced cellular toxicity. Am J Physiol Regul Integr Comp Physiol. 2019 Nov 1 1;317(5):R662-R672. PMID: 31461307.
Hall SE, Smuder AJ and Hayward R. Effects of calorie restriction and voluntary exercise on doxorubicin-induced cardiotoxicity. Integr Cancer Ther. 2019 Jan-Dec;18:1534735419843999. PMID: 30999765.
Hinkley JM, Morton AB, Ichinoseki-Sekine N, Huertas AM and Smuder AJ. Exercise training prevents doxorubicin-induced mitochondrial dysfunction of the liver. Med Sci Sports Exerc. 2019 Jun;51(6):1106-1115. PMID: 30629044.
VanderVeen BN, Fix DK, Montalvo RN, Counts BR, Smuder AJ, Murphy EA, Koh HJ and Carson JA. The regulation of skeletal muscle fatigability and mitochondrial function by chronically elevated interleukin-6. Exp Physiol. 2019 Mar;104(3):385-397. PMID: 30576589.
Morton AB, Huertas AM, Hinkley JM, Ichinoseki-Sekine N, Christou DD and Smuder AJ. Mitochondrial accumulation of doxorubicin in cardiac and diaphragm muscle following exercise preconditioning. Mitochondrion. 2019 Mar;45:52-62. PMID: 29474837.
Kavazis AN, Morton AB, Hall SE and Smuder AJ. Effects of doxorubicin on cardiac muscle subsarcolemmal and intermyofibrillar mitochondria. Mitochondrion. 2017 May;34:9-19. PMID: 27832997.
Powers SK, Morton AB, Ahn B and Smuder AJ. Redox control of skeletal muscle atrophy. Free Radic Biol Med. 2016 Sep;98:208-17. PMID: 26912035.
Min K, Kwon OS, Smuder AJ, Wiggs MP, Sollanek KJ, Christou DD, Yoo JK, Hwang MH, Szeto HH, Kavazis AN, and Powers SK. Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin-induced cardiac and skeletal muscle myopathy. J Physiol. 2015 Apr 15;593(8):2017-36. Epub 2015 Feb 23. PMID: 25643692; PMCID: PMC4405757.
Kavazis AN*, Smuder AJ* and Powers SK. Effects of short-term exercise training on acute doxorubicin-induced FOXO transcription in cardiac and skeletal muscle. J Appl Physiol. 2014 Aug 1;117(3):223-30. PMID: 24947024. *Co-first authors
Powers SK, Smuder AJ, Kavazis AN and Quindry JC. Mechanisms of exercise-induced cardioprotection. Physiology. 2014 Jan;29(1):27-38. PMID: 24382869.
Powers SK, Sollanek KJ, Wiggs MP, Demirel H and Smuder AJ. Exercise- induced improvements in myocardial antioxidant capacity: the antioxidant players and cardioprotection. Free Radic Res. 2013 Jan;48(1):43-51. PMID: 23915097.
Smuder AJ, Kavazis AN, Min K, and Powers SK. Doxorubicin-induced markers of myocardial autophagic signaling in sedentary and exercise trained animals. J Appl Physiol. 2013 Jul;115(2):176-85. PMID: 23703114.
Smuder AJ, Kavazis AN, Min K, and Powers SK. Exercise attenuates doxorubicin-induced skeletal muscle damage. J Appl Physiol. 2011 Apr;110(4):935-42. PMID: 21310889.
Smuder AJ, Kavazis AN, Min K, and Powers SK. Exercise attenuates doxorubicin-induced autophagy in skeletal muscle. J Appl Physiol. 2012 Feb;112(3):501-10. PMID: 21778418.
Smuder AJ, Kavazis AN, Min K and Powers SK. Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle. J Appl Physiol (1985). 2011 Apr;110(4):935-42. PMID: 21310889; PMCID: PMC3075128.
Smuder AJ, Kavazis AN, Min K and Powers SK. Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle. J Appl Physiol (1985). 2011 Oct;111(4):1190-8. PMID: 21778418.
Kavazis AN, Smuder AJ, Min K, Tumer N, and Powers SK. Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1515-24. PMID: 20833957