Publication

2024

Tanida R, Goto H, Takayama H, Nakano Y, Oo HK, Galicia-Medina CM, Takahashi K, Ishii KA, Goli AS, Matsuzaka T, Harada K, Takamura T. LECT2 deletion exacerbates liver steatosis and macrophage infiltration in a male mouse model of LPS-mediated NASH. Endocrinology. 2024 May 23:bqae059. doi: 10.1210/endocr/bqae059. Epub ahead of print.

Yoshida K, Morishima Y, Ishii Y, Mastuzaka T, Shimano H, Hizawa N. Abnormal saturated fatty acids and sphingolipids metabolism in asthma. Respir Investig. 2024 Apr 18;62(4):526-530. doi: 10.1016/j.resinv.2024.04.006. 

Furuta Y, Osaki Y, Nakagawa Y, Han SI, Araki M, Shikama A, Ohuchi N, Yamazaki D, Matsuda E, Nohara S, Mizunoe Y, Kainoh K, Suehara Y, Ohno H, Takeuchi Y, Miyamoto T, Murayama Y, Sugano Y, Iwasaki H, Hirano KI, Koseki M, Nakano S, Tokiwa H, Sekiya M, Yahagi N, Matsuzaka T, Nakamagoe K, Tomidokoro Y, Mitsui J, Tsuji S, Suzuki H, Shimano H. Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia. J Atheroscler Thromb. 2024 Mar 28. doi: 10.5551/jat.64579. Epub ahead of print. 

Ishizawa M, Fujihara K, Yachida J, Ikeda I, Sato T, Yamada T, Kobayashi A, Tanaka S, Nakagawa Y, Matsuzaka T, Shimano H, Tashiro M, Kodama S, Kato K, Sone H. Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women. J Bone Metab. 2024 Feb;31(1):21-30. doi: 10.11005/jbm.2024.31.1.21.  

Oishi Y, Koike H, Kumagami N, Nakagawa Y, Araki M, Taketomi Y, Miki Y, Matsuda S, Matsuzaka T, Ozawa H, Shimano H, Murakami M, Manabe I. Macrophage SREBP1 regulates skeletal muscle regeneration. Front Immunol. 2024 Jan 8;14:1251784. doi: 10.3389/fimmu.2023.1251784.

2023

Han SI, Nakakuki M, Nakagawa Y, Wang Y, Araki M, Yamamoto Y, Tokiwa H, Takeda H, Mizunoe Y, Motomura K, Ohno H, Kainoh K, Murayama Y, Aita Y, Takeuchi Y, Osaki Y, Miyamoto T, Sekiya M, Matsuzaka T, Yahagi N, Sone H, Daitoku H, Sato R, Kawano H, Shimano H. Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids. PNAS Nexus. 2023 Nov 8;2(11):pgad351. doi: 10.1093/pnasnexus/pgad351. PMID: 37954160 

Motomura K, Matsuzaka T, Shichino S, Ogawa T, Pan H, Nakajima T, Asano Y, Okayama T, Takeuchi T, Ohno H, Han SI, Miyamoto T, Takeuchi Y, Sekiya M, Sone H, Yahagi N, Nakagawa Y, Oda T, Ueha S, Ikeo K, Ogura A, Matsushima K, Shimano H. Single-cell transcriptome profiling of pancreatic islets from early diabetic mice identifies Anxa10 for Ca2+ allostasis toward β-cell failure. Diabetes. 2024 Jan 1;73(1):75-92. doi: 10.2337/db23-0212. PMID: 37871012.  Press release (JP)  Press release (EN)

Chihara K, Okada K, Uchida F, Miura I, Komine S, Warabi E, Takayama T, Suzuki H, Matsuzaka T, Ishibashi-Kanno N, Yamagata K, Yanagawa T, Bukawa H, Shoda J. Macrophage specific restoration of the Nrf2 gene in whole-body knockout mice ameliorates steatohepatitis induced by lipopolysaccharide from Porphyromonas gingivalis through enhanced hepatic clearance. PLoS One. 2023 Oct 20;18(10):e0291880. doi: 10.1371/journal.pone.0291880. PMID: 37862331.

Takeuchi Y, Murayama Y, Aita Y, Mehrazad Saber Z, Karkoutly S, Tao D, Katabami K, Ye C, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Kawakami Y, Shimano H, Yahagi N. GR-KLF15 pathway controls hepatic lipogenesis during fasting. FEBS J. 2023 Sep 13. doi: 10.1111/febs.16957. Epub ahead of print. 

Garcia Corrales AV, Verberk SGS, Haidar M, Grajchen E, Dehairs J, Vanherle S, Loix M, Weytjens T, Gervois P, Matsuzaka T, Lambrichts I, Swinnen JV, Bogie JFJ, Hendriks JJA. Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination. Proc Natl Acad Sci U S A. 2023 Sep 12;120(37):e2301030120. doi: 10.1073/pnas.2301030120.

Sekiya M, Ma Y, Kainoh K, Saito K, Yamazaki D, Tsuyuzaki T, Chen W, Adi Putri PIP, Ohno H, Miyamoto T, Takeuchi Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Motomura K, Matsuzaka T, Murata K, Mizuno S, Takahashi S, Shimano H. Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function. Cell Rep. 2023 Aug 1:112914. doi: 10.1016/j.celrep.2023.112914.

Saito K, Sekiya M, Kainoh K, Yoshino R, Hayashi A, Han SI, Araki M, Ohno H, Takeuchi Y, Tsuyuzaki T, Yamazaki D, Wanpei C, Hada L, Watanabe S, Paramita Adi Putri PI, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Miyamoto T, Matsuzaka T, Shimano H. Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity. J Biol Chem. 2023 Jul;299(7):104890. doi: 10.1016/j.jbc.2023.104890.

Kiyoki Y, Kato T, Kito S, Matsuzaka T, Morioka S, Sasaki J, Makishima K, Sakamoto T, Nishikii H, Obara N, Sakata-Yanagimoto M, Sasaki T, Shimano H, Chiba S. The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation. Leukemia. 2023 Apr;37(4):910-913. doi: 10.1038/s41375-023-01842-y. Press release (JP)  Press release (EN) 

Istiqamah N, Matsuzaka T, Shimizu M, Motomura K, Ohno H, Hasebe S, Sharma R, Okajima Y, Matsuda E, Han SI, Mizunoe Y, Osaki Y, Aita Y, Suzuki H, Sone H, Takeuchi Y, Sekiya M, Yahagi N, Nakagawa Y, Shimano H. Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis. BBA Adv. 2023 Jan 22;3:100078. doi: 10.1016/j.bbadva.2023.100078. 

Yoshida K, Morishima Y, Ano S, Sakurai H, Kuramoto K, Tsunoda Y, Yazaki K, Nakajima M, Sherpa MT, Matsuyama M, Kiwamoto T, Matsuno Y, Ishii Y, Hayashi A, Matsuzaka T, Shimano H, Hizawa N. ELOVL6 deficiency aggravates allergic airway inflammation through the ceramide-S1P pathway in mice. J Allergy Clin Immunol. 2023 Apr;151(4):1067-1080.e9. doi: 10.1016/j.jaci.2022.12.808. Press release (JP)  Press release (EN)

2022

Araki M, Nakagawa Y, Saito H, Yamada Y, Han SI, Mizunoe Y, Ohno H, Miyamoto T, Sekiya M, Matsuzaka T, Sone H, Shimano H. Hepatocyte or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced NAFLD. Am J Physiol Gastrointest Liver Physiol. 2022 Oct 25. doi: 10.1152/ajpgi.00090.2022. Epub ahead of print. 

Yamada Y, Saito H, Araki M, Tsuchimoto Y, Muroi SI, Suzuki K, Toume K, Kim JD, Matsuzaka T, Sone H, Shimano H, Nakagawa Y. Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4-FGF21 Signaling in Mouse Hepatocyte AML12 Cells. Nutrients. 2022 Sep 21;14(19):3920. doi: 10.3390/nu14193920.

Nitta S, Kandori S, Tanaka K, Sakka S, Siga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H. ELOVL5-mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma. Cancer Sci. 2022 2022 Aug;113(8):2738-2752. doi: 10.1111/cas.15454.

Matsuzaka T, Shimano H. [Role of Fatty Acid Elongase Elovl6 in the Regulation of Fatty Acid Quality and Lifestyle-related Diseases]. Yakugaku Zasshi. 2022;142(5):473-476. Japanese. doi: 10.1248/yakushi.21-00176-4. (Review)

Nakagawa Y, Matsuzaka T, Shimano H. CREBH regulation of lipid metabolism through multifaceted functions that improve arteriosclerosis. J Diabetes Investig. 2022  Jul;13(7):1129-1131. doi: 10.1111/jdi.13766. (Commentary)

Okajima Y, Matsuzaka T, Miyazaki S, Motomura K, Ohno H, Sharma R, Shimura T, Istiqamah N, Han SI, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Miyamoto T, Aita Y, Takeuchi Y, Sekiya M, Yahagi N, Nakagawa Y, Tomita T, Shimano H. Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice. Biochim Biophys Acta Mol Basis Dis. 2022 Jan 8:166339. doi: 10.1016/j.bbadis.2022.

Nagatake T, Kishino S, Urano E, Murakami H, Kitamura N, Konishi K, Ohno H, Tiwari P, Morimoto S, Node E, Adachi J, Abe Y, Isoyama J, Sawane K, Honda T, Inoue A, Uwamizu A, Matsuzaka T, Miyamoto Y, Hirata SI, Saika A, Shibata Y, Hosomi K, Matsunaga A, Shimano H, Arita M, Aoki J, Oka M, Matsutani A, Tomonaga T, Kabashima K, Miyachi M, Yasutomi Y, Ogawa J, Kunisawa J. Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques. Mucosal Immunol. 2022 Jan 10. doi: 10.1038/s41385-021-00477-5.

2021

Takeuchi Y, Yahagi N, Aita Y, Mehrazad-Saber Z, Ho MH, Huyan Y, Murayama Y, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Kawakami Y, Shimano H. FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin. iScience. 2021 Nov 15;24(12):103446. doi: 10.1016/j.isci.2021.

Kodama S, Fujihara K, Horikawa C, Kitazawa M, Iwanaga M, Kato K, Watanabe K, Nakagawa Y, Matsuzaka T, Shimano H, Sones H. Predictive ability of current machine learning algorithms for type 2 diabetes mellitus - A meta-analysis. J Diabetes Investig. 2021 Dec 23. doi: 10.1111/jdi.13736.

Tanaka K, Kandori S, Sakka S, Nitta S, Tanuma K, Shiga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Watanabe M, Sato TA, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H. ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma. Oncol Rep. 2022 Feb;47(2):23. doi: 10.3892/or.2021.8234. Epub 2021 Nov 29.

Sekiya M, Kainoh K, Sugasawa T, Yoshino R, Hirokawa T, Tokiwa H, Nakano S, Nagatoishi S, Tsumoto K, Takeuchi Y, Miyamoto T, Matsuzaka T, Shimano H. The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis. Nat Commun. 2021 Nov 2;12(1):6315. doi: 10.1038/s41467-021-26638-5.

Mehrazad Saber Z, Takeuchi Y, Sawada Y, Aita Y, Ho MH, Karkoutly S, Tao D, Katabami K, Ye C, Murayama Y, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Sugasawa T, Takekoshi K, Kawakami Y, Shimano H, Yahagi N. High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways. Biochem Biophys Res Commun. 2021 Dec 10;582:35-42. doi: 10.1016/j.bbrc.2021.10.027.

Fujihara K, Nogawa S, Saito K, Horikawa C, Takeda Y, Cho K, Ishiguro H, Kodama S, Nakagawa Y, Matsuzaka T, Shimano H, Sone H. Carrot Consumption Frequency Associated with Reduced BMI and Obesity through the SNP Intermediary rs4445711. Nutrients. 2021 Sep 30;13(10):3478. doi: 10.3390/nu13103478. 

Koguchi-Yoshioka H, Watanabe R, Matsumura Y, Ishitsuka Y, Inoue S, Furuta J, Nakamura Y, Okiyama N, Matsuzaka T, Shimano H, Fujisawa Y, Fujimoto M. Serum lactate dehydrogenase level as a possible predictor of treatment preference in psoriasis. J Dermatol Sci. 2021 Jul 22:S0923-1811(21)00173-0. doi: 10.1016/j.jdermsci.2021.07.007. 

Kainoh K, Takano R, Sekiya M, Saito K, Sugasawa T, Ma Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Takeuchi Y, Yahagi N, Suzuki H, Miyamoto T, Nakagawa Y, Matsuzaka T, Shimano H. CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2. Biochem Biophys Res Commun. 2021 Jul 12;562:146-153. doi: 10.1016/j.bbrc.2021.05.069. 

Kurita K, Ohta H, Shirakawa I, Tanaka M, Kitaura Y, Iwasaki Y, Matsuzaka T, Shimano H, Aoe S, Arima H, Ogawa Y, Ito A, Suganami T. Macrophages rely on extracellular serine to suppress aberrant cytokine production. Sci Rep. 2021 May 27;11(1):11137. doi: 10.1038/s41598-021-90086-w.

Nakagawa Y, Kumagai K, Han SI, Mizunoe Y, Araki M, Mizuno S, Ohno H, Matsuo K, Yamada Y, Kim JD, Miyamoto T, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Takahashi S, Sone H, Shimano H. Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling. FASEB J. 2021 Jun;35(6):e21663. doi: 10.1096/fj.202002784RR.

Nakagawa Y, Wang Y, Han SI, Okuda K, Oishi A, Yagishita Y, Kumagai K, Ohno H, Osaki Y, Mizunoe Y, Araki M, Murayama Y, Iwasaki H, Konishi M, Itoh N, Matsuzaka T, Sone H, Yamada N, Shimano H. Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition. Cell Mol Gastroenterol Hepatol. 2021;11(4):949-971. doi: 10.1016/j.jcmgh.2020.11.004.

Shimizu Y, Tamura T, Kemmochi A, Owada Y, Ozawa Y, Hisakura K, Matsuzaka T, Shimano H, Nakano N, Sakashita S, Oda T, Ohkohchi N. Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model. J Gastroenterol Hepatol. 2021 Mar;36(3):800-810. doi: 10.1111/jgh.15239.

2020

Matsuzaka T. Role of fatty acid elongase Elovl6 in the regulation of energy metabolism and pathophysiological significance in diabetes. Diabetol Int. 2020 Dec 15;12(1):68-73. doi: 10.1007/s13340-020-00481-3. PMID: 33479581; PMCID: PMC7790921. 

Tadashi Imafuku, Hiroshi Watanabe, Takao Satoh, Takashi Matsuzaka, Tomoaki Inazumi, Hiromasa Kato, Shoma Tanaka, Yuka Nakamura, Takehiro Nakano, Kai Tokumaru, Hitoshi Maeda, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Motoko Tanaka, Kazutaka Matsushita, Soken Tsuchiya, Yukihiko Sugimoto, Hitoshi Shimano, Masafumi Fukagawa and Toru Maruyama. Advanced Oxidation Protein Products Contribute to Renal Tubulopathy via Perturbation of Renal Fatty Acids. Kidney360 August 2020, 1 (8) 781-796; DOI: https://doi.org/10.34067/KID.0000772019

Matsuzaka T, Shimano H. New perspective on type 2 diabetes, dyslipidemia and non-alcoholic fatty liver disease. J Diabetes Investig. 2020 May;11(3):532-534. doi: 10.1111/jdi.13258. Epub 2020 May 12. PMID: 32232972; PMCID: PMC7232277. 

Satoh A, Han SI, Araki M, Nakagawa Y, Ohno H, Mizunoe Y, Kumagai K, Murayama Y, Osaki Y, Iwasaki H, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Sone H, Shimano H. CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms. iScience. 2020 Mar 27;23(3):100930. doi: 10.1016/j.isci.2020.100930. Epub 2020 Feb 21. PMID: 32151974; PMCID: PMC7063134. 

Ma Y, Sekiya M, Kainoh K, Matsuda T, Iwasaki H, Osaki Y, Sugano Y, Suzuki H, Takeuchi Y, Miyamoto T, Yahagi N, Nakagawa Y, Matsuzaka T, Shimano H. Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1. Biochem Biophys Res Commun. 2020 Mar 5;523(2):354-360. doi: 10.1016/j.bbrc.2019.12.070. Epub 2019 Dec 19. PMID: 31866012. 

Matsuzaka T, Kuba M, Koyasu S, Yamamoto Y, Motomura K, Arulmozhiraja S, Ohno H, Sharma R, Shimura T, Okajima Y, Han SI, Aita Y, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H. Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice. Hepatology. 2020 May;71(5):1609-1625. doi: 10.1002/hep.30953. Epub 2020 Feb 7. PMID: 31529722.  Press release

2019

Miyamoto T, Matsuzaka T, Shimano H. Rho-associated, coiled-coil-containing protein kinase 1 as a new player in the regulation of hepatic lipogenesis. J Diabetes Investig. 2019 Sep;10(5):1165-1167. doi: 10.1111/jdi.13051. Epub 2019 Apr 19. PMID: 30919598; PMCID: PMC6717821. 

Sharma R, Matsuzaka T, Kaushik MK, Sugasawa T, Ohno H, Wang Y, Motomura K, Shimura T, Okajima Y, Mizunoe Y, Ma Y, Saber ZM, Iwasaki H, Yatoh S, Suzuki H, Aita Y, Han SI, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Shimano H. Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism. Sci Rep. 2019 Mar 26;9(1):5169. doi: 10.1038/s41598-019-41631-1. PMID: 30914769; PMCID: PMC6435753. 

Murayama Y, Yahagi N, Takeuchi Y, Aita Y, Mehrazad Saber Z, Wada N, Li E, Piao X, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Miyamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H. Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex. FEBS Lett. 2019 Feb;593(4):423-432. doi: 10.1002/1873-3468.13328. Epub 2019 Feb 1. PMID: 30659595. 

2018

Nakamura Y, Matsuzaka T, Tahara-Hanaoka S, Shibuya K, Shimano H, Nakahashi-Oda C, Shibuya A. Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation. Cell Death Dis. 2018 Dec 5;9(12):1181. doi: 10.1038/s41419-018-1226-1. PMID: 30518914; PMCID: PMC6281680. 

Araki M, Nakagawa Y, Oishi A, Han SI, Wang Y, Kumagai K, Ohno H, Mizunoe Y, Iwasaki H, Sekiya M, Matsuzaka T, Shimano H. The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice. Int J Mol Sci. 2018 Jul 23;19(7):2148. doi: 10.3390/ijms19072148. PMID: 30041488; PMCID: PMC6073532. 

Ozawa Y, Tamura T, Owada Y, Shimizu Y, Kemmochi A, Hisakura K, Matsuzaka T, Shimano H, Isoda H, Ohkohchi N. Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis. World J Gastroenterol. 2018 Apr 21;24(15):1622-1631. doi: 10.3748/wjg.v24.i15.1622. PMID: 29686469; PMCID: PMC5910545. 

Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H. Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance. Endocrinology. 2018 Jun 1;159(6):2308-2323. doi: 10.1210/en.2017-03179. PMID: 29668871. 

Yamamoto Y, Takei K, Arulmozhiraja S, Sladek V, Matsuo N, Han SI, Matsuzaka T, Sekiya M, Tokiwa T, Shoji M, Shigeta Y, Nakagawa Y, Tokiwa H, Shimano H. Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα. Biochem Biophys Res Commun. 2018 May 5;499(2):239-245. doi: 10.1016/j.bbrc.2018.03.135. Epub 2018 Mar 22. PMID: 29567478. 

Karasawa T, Kawashima A, Usui-Kawanishi F, Watanabe S, Kimura H, Kamata R, Shirasuna K, Koyama Y, Sato-Tomita A, Matsuzaka T, Tomoda H, Park SY, Shibayama N, Shimano H, Kasahara T, Takahashi M. Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages. Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):744-756. doi: 10.1161/ATVBAHA.117.310581. Epub 2018 Feb 8. PMID: 29437575. 

Piao X, Yahagi N, Takeuchi Y, Aita Y, Murayama Y, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H. A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes. FEBS Lett. 2018 Feb;592(3):422-433. doi: 10.1002/1873-3468.12975. Epub 2018 Jan 23. PMID: 29331016. 

Owada Y, Tamura T, Tanoi T, Ozawa Y, Shimizu Y, Hisakura K, Matsuzaka T, Shimano H, Nakano N, Sakashita S, Matsukawa T, Isoda H, Ohkohchi N. Novel non-alcoholic steatohepatitis model with histopathological and insulin-resistant features. Pathol Int. 2018 Jan;68(1):12-22. doi: 10.1111/pin.12612. Epub 2017 Nov 20. PMID: 29154469. 

2017

Muranaka H, Hayashi A, Minami K, Kitajima S, Kohno S, Nishimoto Y, Nagatani N, Suzuki M, Kulathunga LAN, Sasaki N, Okada N, Matsuzaka T, Shimano H, Tada H, Takahashi C. A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling. Oncogenesis. 2017 Jun 26;6(6):e350. doi: 10.1038/oncsis.2017.51. PMID: 28650445; PMCID: PMC5519198. 

Sawada Y, Izumida Y, Takeuchi Y, Aita Y, Wada N, Li E, Murayama Y, Piao X, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Kadowaki T, Shimano H, Yahagi N. Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry. Biochem Biophys Res Commun. 2017 Nov 4;493(1):40-45. doi: 10.1016/j.bbrc.2017.09.081. Epub 2017 Sep 18. PMID: 28928093. 

Zhao H, Matsuzaka T, Nakano Y, Motomura K, Tang N, Yokoo T, Okajima Y, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H. Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity. Diabetes. 2017 Jul;66(7):1833-1846. doi: 10.2337/db16-1277. Epub 2017 May 1. PMID: 28461456. Press release 

Takei K, Nakagawa Y, Wang Y, Han SI, Satoh A, Sekiya M, Matsuzaka T, Shimano H. Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice. J Pharmacol Sci. 2017 Apr;133(4):214-222. doi: 10.1016/j.jphs.2017.02.003. Epub 2017 Feb 11. PMID: 28366492. 

Nishi-Tatsumi M, Yahagi N, Takeuchi Y, Toya N, Takarada A, Murayama Y, Aita Y, Sawada Y, Piao X, Oya Y, Shikama A, Masuda Y, Kubota M, Izumida Y, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y, Kawakami Y, Kadowaki T, Yamada N, Shimano H. A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes. FEBS Lett. 2017 Apr;591(7):965-978. doi: 10.1002/1873-3468.12620. Epub 2017 Mar 27. PMID: 28281280. 

Takei K, Han SI, Murayama Y, Satoh A, Oikawa F, Ohno H, Osaki Y, Matsuzaka T, Sekiya M, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Yamada N, Nakagawa Y, Shimano H. Selective peroxisome proliferator-activated receptor-α modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-α pathway and improves lipid metabolism in mice. J Diabetes Investig. 2017 Jul;8(4):446-452. doi: 10.1111/jdi.12621. Epub 2017 Apr 25. PMID: 28084058; PMCID: PMC5497046. 

Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK. SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab. 2017 Feb 7;25(2):412-427. doi: 10.1016/j.cmet.2016.11.009. Epub 2016 Dec 29. PMID: 28041958; PMCID: PMC5568699. Press release 

2016

Nakagawa Y, Satoh A, Tezuka H, Han SI, Takei K, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Iwasaki Y, Sone H, Matsuzaka T, Yamada N, Shimano H. CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα. Sci Rep. 2016 Dec 16;6:39182. doi: 10.1038/srep39182. PMID: 27982131; PMCID: PMC5159891. 

Sunaga H, Matsui H, Anjo S, Syamsunarno MR, Koitabashi N, Iso T, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M. Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Krüppel-Like Factor 4 (AMPK/KLF4) Signaling. J Am Heart Assoc. 2016 Nov 23;5(12):e004014. doi: 10.1161/JAHA.116.004014. PMID: 27881420; PMCID: PMC5210431. 

Kikuchi T, Orihara K, Oikawa F, Han SI, Kuba M, Okuda K, Satoh A, Osaki Y, Takeuchi Y, Aita Y, Matsuzaka T, Iwasaki H, Yatoh S, Sekiya M, Yahagi N, Suzuki H, Sone H, Nakagawa Y, Yamada N, Shimano H. Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression. Mol Metab. 2016 Sep 17;5(11):1092-1102. doi: 10.1016/j.molmet.2016.09.004. PMID: 27818935; PMCID: PMC5081412. 

Takeuchi Y, Yahagi N, Aita Y, Murayama Y, Sawada Y, Piao X, Toya N, Oya Y, Shikama A, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Yamamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Urayama O, Kawakami Y, Iizuka Y, Gotoda T, Itaka K, Kataoka K, Nagai R, Kadowaki T, Yamada N, Lu Y, Jain MK, Shimano H. KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting. Cell Rep. 2016 Aug 30;16(9):2373-86. doi: 10.1016/j.celrep.2016.07.069. Epub 2016 Aug 18. PMID: 27545894; PMCID: PMC5031553. 

Kikuchi M, Shimada M, Matsuzaka T, Ishii K, Nakagawa Y, Takayanagi M, Yamada N, Shimano H. Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice. PLoS One. 2016 Jul 28;11(7):e0159375. doi: 10.1371/journal.pone.0159375. PMID: 27467521; PMCID: PMC4965081. 

Suzuki-Kemuriyama N, Matsuzaka T, Kuba M, Ohno H, Han SI, Takeuchi Y, Isaka M, Kobayashi K, Iwasaki H, Yatoh S, Suzuki H, Miyajima K, Nakae D, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H. Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. PLoS One. 2016 Jun 22;11(6):e0157580. doi: 10.1371/journal.pone.0157580. PMID: 27333187; PMCID: PMC4917109. 

Nakagawa Y, Oikawa F, Mizuno S, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, Han SI, Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Isaka M, Suzuki H, Sone H, Takahashi S, Yamada N, Shimano H. Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system. Sci Rep. 2016 Jun 13;6:27857. doi: 10.1038/srep27857. PMID: 27291420; PMCID: PMC4904192. 

Matsuzaka T, Shimano H. Novel role for the CRTC2 in lipid homeostasis. J Diabetes Investig. 2016 Sep;7(5):677-9. doi: 10.1111/jdi.12497. Epub 2016 Mar 24. PMID: 27181382; PMCID: PMC5009128. 

2015

Kuba M, Matsuzaka T, Matsumori R, Saito R, Kaga N, Taka H, Ikehata K, Okada N, Kikuchi T, Ohno H, Han SI, Takeuchi Y, Kobayashi K, Iwasaki H, Yatoh S, Suzuki H, Sone H, Yahagi N, Arakawa Y, Fujimura T, Nakagawa Y, Yamada N, Shimano H. Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model. Sci Rep. 2015 Dec 1;5:17604. doi: 10.1038/srep17604. PMID: 26619823; PMCID: PMC4664962. 

Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Sone H, Ohashi K, Ishibashi S, Yamada N, Shimano H. Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy. Biochem Biophys Res Commun. 2015 Oct 23;466(3):536-40. doi: 10.1016/j.bbrc.2015.09.065. Epub 2015 Sep 14. PMID: 26381177. 

Shikama A, Shinozaki H, Takeuchi Y, Matsuzaka T, Aita Y, Murayama T, Sawada Y, Piao X, Toya N, Oya Y, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Yamada N, Shimano H, Yahagi N. Identification of human ELOVL5 enhancer regions controlled by SREBP. Biochem Biophys Res Commun. 2015 Oct 2;465(4):857-63. doi: 10.1016/j.bbrc.2015.08.101. Epub 2015 Aug 28. PMID: 26321664. 

Murata S, Ogawa K, Matsuzaka T, Chiba M, Nakayama K, Iwasaki K, Kurokawa T, Sano N, Tanoi T, Ohkohchi N. 1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation. Int J Mol Sci. 2015 May 27;16(6):12051-63. doi: 10.3390/ijms160612051. PMID: 26023714; PMCID: PMC4490428. 

2014

Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H. Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. Endocrinology. 2014 Dec;155(12):4706-19. doi: 10.1210/en.2014-1113. Epub 2014 Sep 18. PMID: 25233440. 

Tang N, Matsuzaka T, Suzuki M, Nakano Y, Zao H, Yokoo T, Suzuki-Kemuriyama N, Kuba M, Okajima Y, Takeuchi Y, Kobayashi K, Iwasaki H, Yatoh S, Takahashi A, Suzuki H, Sone H, Shimada M, Nakagawa Y, Yahagi N, Yamada N, Shimano H. Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion. Biochem Biophys Res Commun. 2014 Jul 18;450(1):318-23. doi: 10.1016/j.bbrc.2014.05.113. Epub 2014 Jun 2. PMID: 24938128. 

Matsuzaka T, Shimano H. New liver-β-cell axis that controls insulin secretory capacity. J Diabetes Investig. 2014 May 4;5(3):276-7. doi: 10.1111/jdi.12199. Epub 2014 Mar 17. PMID: 24843772; PMCID: PMC4020328. 

2013

Matsuzaka T, Shimano H. Insulin-dependent and -independent regulation of sterol regulatory element-binding protein-1c. J Diabetes Investig. 2013 Sep 13;4(5):411-2. doi: 10.1111/jdi.12098. PMID: 24843688; PMCID: PMC4025107. 

Izumida Y, Yahagi N, Takeuchi Y, Nishi M, Shikama A, Takarada A, Masuda Y, Kubota M, Matsuzaka T, Nakagawa Y, Iizuka Y, Itaka K, Kataoka K, Shioda S, Niijima A, Yamada T, Katagiri H, Nagai R, Yamada N, Kadowaki T, Shimano H. Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization. Nat Commun. 2013;4:2316. doi: 10.1038/ncomms3316. Erratum in: Nat Commun. 2013;4:2930. PMID: 23939267; PMCID: PMC3753545. 

Fujimoto Y, Nakagawa Y, Satoh A, Okuda K, Shingyouchi A, Naka A, Matsuzaka T, Iwasaki H, Kobayashi K, Yahagi N, Shimada M, Yatoh S, Suzuki H, Yogosawa S, Izumi T, Sone H, Urayama O, Yamada N, Shimano H. TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis. Endocrinology. 2013 Oct;154(10):3577-88. doi: 10.1210/en.2013-1203. Epub 2013 Jul 24. PMID: 23885019. 

Naka A, Iida KT, Nakagawa Y, Iwasaki H, Takeuchi Y, Satoh A, Matsuzaka T, Ishii KA, Kobayashi K, Yatoh S, Shimada M, Yahagi N, Suzuki H, Sone H, Yamada N, Shimano H. TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin. Biochem Biophys Res Commun. 2013 Jan 11;430(2):664-9. doi: 10.1016/j.bbrc.2012.11.094. Epub 2012 Dec 2. PMID: 23211595. 

2012

Matsuzaka T, Atsumi A, Matsumori R, Nie T, Shinozaki H, Suzuki-Kemuriyama N, Kuba M, Nakagawa Y, Ishii K, Shimada M, Kobayashi K, Yatoh S, Takahashi A, Takekoshi K, Sone H, Yahagi N, Suzuki H, Murata S, Nakamuta M, Yamada N, Shimano H. Elovl6 promotes nonalcoholic steatohepatitis. Hepatology. 2012 Dec;56(6):2199-208. doi: 10.1002/hep.25932. PMID: 22753171. 

Fujimoto Y, Nakagawa Y, Shingyouchi A, Tokushige N, Nakanishi N, Satoh A, Matsuzaka T, Ishii KA, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yahagi N, Urayama O, Yamada N, Shimano H. Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells. Biochem Biophys Res Commun. 2012 Apr 20;420(4):931-6. doi: 10.1016/j.bbrc.2012.03.110. Epub 2012 Mar 26. PMID: 22475483. 

Matsuzaka T, Shimano H. GLUT12: a second insulin-responsive glucose transporters as an emerging target for type 2 diabetes. J Diabetes Investig. 2012 Mar 28;3(2):130-1. doi: 10.1111/j.2040-1124.2011.00177.x. PMID: 24843555; PMCID: PMC4020729. 

Iwasaki H, Naka A, Iida KT, Nakagawa Y, Matsuzaka T, Ishii KA, Kobayashi K, Takahashi A, Yatoh S, Yahagi N, Sone H, Suzuki H, Yamada N, Shimano H. TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice. Am J Physiol Endocrinol Metab. 2012 Apr 1;302(7):E896-902. doi: 10.1152/ajpendo.00204.2011. Epub 2012 Jan 31. PMID: 22297304.