Space Biomedical Science
Research Group
  Pharmacological Research Center, Showa Medical University

Welcome

Humanity is once again advancing toward the Moon. International lunar exploration programs, including NASA’s Artemis program, are paving the way for sustained human activities on the lunar surface and future missions to Mars.

At the same time, the space environment exerts a wide range of effects on living organisms. Microgravity is known to cause bone loss and muscle atrophy, as well as alterations in immune function and the cardiovascular system. To enable long-term human activities in space, it is essential to understand the underlying biological mechanisms and to develop effective countermeasures.

My research has focused on bone metabolism and tissue remodeling, while also participating in spaceflight experiments using medaka (Oryzias latipes) to investigate the effects of microgravity on living organisms. Building on these experiences, I am working to elucidate the biological responses to altered gravity environments and to translate these findings into applications for terrestrial medicine.

The Space Medicine Research Group is a newly established research unit within the Pharmacology Research Center at Showa Medical University. Using model organisms such as medaka and mice, we investigate the molecular mechanisms underlying biological processes involving bone, teeth, blood vessels, and the immune system. In particular, we focus on bone loss and tissue remodeling under spaceflight conditions, integrating developmental biology, pharmacology, and space biomedicine.

Knowledge gained through space research contributes not only to maintaining the health of astronauts but also to understanding and addressing medical challenges on Earth, including osteoporosis and age-related diseases. By utilizing the unique environment of space, we seek to uncover fundamental principles of life and translate these discoveries into benefits for human health and medicine.

Our research is currently supported by several programs, including the JAXA Institute of Space and Astronautical Science (ISAS) Front Loading Program. Through collaborations with researchers both within and outside the university, we are committed to advancing the field of space medicine and biomedical science.

On this website, you will find information about our research projects, publications, members, and collaborative activities. We hope that you will find our work of interest and invite you to explore our research further.

Masahiro Chatani, Ph.D.