Publications

✦ 原著論文

1. Yang, Y., Kubota, M., Hasegawa, K., Zeng, C., Nishikura, K., Hamada, M., Sakurai, M.*
   "Mitotic phosphorylation of ADAR1 regulates its centromeric localization and is required for faithful mitotic progression"
   bioRxiv [DOI: 10.1101/2025.05.28.656747] (2025)
    

2. Yang, Y., Sakurai, M.*
   "Advances in Detection Methods for A-to-I RNA Editing"
   WIREs RNA 16:e70014. [DOI: 10.1002/wrna.70014, PMID: 40223708] (2025)

3. Ichihashi, E., Kubota, M., Shiromoto, Y., Sakurai, M.*
   "ADAR1 RNA editing enzyme regulates telomeric R-loop formation"
   Methods Mol. Biol. (2025 in press).

4. Yang, Y., Nakayama, K., Okada, S., Sato, K., Wada, T., Sakaguchi, Y., Murayama, A., Suzuki, T., Sakurai, M.*
   "ICLAMP: A Novel Technique to Explore Adenosine Deamination via Inosine Chemical Labeling and Affinity Molecular Purification"
   FEBS Lett. 598:1080-1093. [DOI: 10.1002/1873-3468.14854, PMID: 38523059] (2024)

5. Hao, X., Shiromoto, Y., Sakurai, M., Havas, A., Wang, L., Berger, S., Adams, P.D., Nishikura K., Kossenkov, A.V., Liu, P., Zhang, R.*
   "ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels"
   Nat. Cell Biol. 24:1202-1210. [DOI: 10.1038/s41556-022-00959-z, PMID: 35851616] (2022).

6. Shiromoto, Y., Sakurai, M. (Equal contribution as 1st authors), Minakuchi, M., Ariyoshi, K., and Nishikura, K.*
   "ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells"
   Nat. Commun. 12:1654. [DOI: 10.1038/s41467-021-21921-x, PMID: 33712600] (2021).
   **This work is introduced by Nature Communications Editor’s Highlight-Focus "From molecules and cells to organisms" [https://www.nature.com/collections/bbcaeejggj] (2021 Mar).
   
   

7. Yang, Y., Okada, S., and Sakurai, M.*
   "Adenosine-to-inosine RNA editing in neurological development and disease"
   RNA Biol. 6:1-15. [DOI: 10.1080/15476286.2020.1867797, PMID: 33393416] (2021).
   
   

8. Sakurai, M.*, Okada, S., Ueda, H., and Yang, Y.
   "Discovering A-to-I RNA Editing Through Chemical Methodology 'ICE-seq'"
   Methods Mol. Biol. 2181:113-148. [DOI: 10.1007/978-1-0716-0787-9_8, PMID: 32729078] (2021).
   
   

9. Shiromoto, Y.*, Sakurai, M., Qu, H., Kossenkov, A.V., and Nishikura, K.*
   "Processing of Alu small RNAs by DICER/ADAR1 complexes and their RNAi targets"
   RNA. 26:1801-1814. [DOI: 10.1261/rna.076745.120, PMID: 32817447] (2020).

10. Sakurai, M., Shiromoto, Y., Ota, H., Song, C., Kossenkov, A.V., Wickramasinghe, J., Showe, L.C., Skordalakes, E., Tao, H.Y., Speicher, D.W., and Nishikura, K.*
    "ADAR1 controls apoptosis of stressed cells by inhibiting Staufen-mediated mRNA decay"
    Nat. Struct. Mol. Biol. 24:534-543. [DOI: 10.1038/nsmb.3403, PMID: 28436945] (2017).
    **This work is reviewed as Research Highlight in Nature Reviews Molecular Cell Biology. Zlotorynski, E “RNA decay: The anti-apoptotic function of ADAR1” Nat. Rev. Mol. Cell Biol. 18: 343. [DOI: 10.1038/nrm.2017.51, PMID: 28488701] (2017).

11. Gumireddy, K., Li, A., Kossenkov, A.V., Sakurai, M., Yan, J., Li, Y., Xu, H., Wang, J., Zhang, PJ., Zhang, L., Showe, L., Nishikura, K., and Huang, Q.*
    "The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis"
    Nat. Commun. 7:10715. [DOI: 10.1038/ncomms10715, PMID: 26869349] (2016).

12. Song, C., Sakurai, M., Shiromoto, Y., Ota, H., Nishikura, K.*
    "Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human Diseases"
    Genes 7(12):129. [DOI:10.3390/genes7120129, PMID: 27999332] (2016).

13. Okada, S., Sakurai, M., Ueda, H., and Suzuki, T.*
    "Biochemical and Transcriptome-Wide Identification of A-to-I RNA Editing Sites by ICE-Seq"
    Methods Enzymol. 560:331-335. [DOI: 10.1016/bs.mie.2015.03.014, PMID: 26253977] (2015).

14. Suzuki, T.*, Ueda, H., Okada, S., and Sakurai, M. (2nd authorship)
    "Transcriptome-wide identification of adenosine-to-inosine editing using the ICE-seq method"
    Nat. Protoc. 10:715-732. [DOI: 10.1038/nprot.2015.037, PMID: 25855956] (2015).

15.  Sakurai, M., Ueda, H., Yano, T., Okada, S., Terajima, H., Mitsuyama T., Toyoda, A., Fujiyama, A., Kawabata, H., and Suzuki, T.*
    "A biochemical landscape of A-to-I RNA editing in the human transcriptome"
    Genome Res. 24:522-534. [DOI: 10.1101/gr.162537.113, PMID: 24407955] (2014).
    **This work was selected as Nature Methods "Method of the Year 2016": Li X., Xiong, X., and Yu C. “Epitranscriptome sequencing technologies: decoding RNA modifications.” Nature Methods 14: 23-31. [DOI: 10.1038/nmeth.4110, PMID: 28032622] (2017).

16. Nishikura, K.*, Sakurai, M., Ariyoshi, K., and Ohta, H.
    "Antagonistic and stimulative roles of ADAR in RNA silencing"
    RNA Biol. 10:1240-1247. [DOI: 10.4161/rna.25947, PMID: 23949595] (2013).

17. Ota, H., Sakurai, M. (Equal contribution as 1st authors), and Gupta, R., Valente, L., Wulff, B.E., Ariyoshi, K., Iizasa, H., Davuluri, R.V., and Nishikura, K.*
    "ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing"
    Cell 153:575-589. [DOI: 10.1016/j.cell.2013.03.024, PMID: 23622242] (2013).
    **This work is reviewed in Nature Reviews Molecular Cell Biology. Nishikura K. "A-to-I editing of coding and non-coding RNAs by ADARs." Nat. Rev. Mol. Cell Biol. 17:83-96. [DOI: 10.1038/nrm.2015.4, PMID: 26648264] (2016).

18. Wulff, B.E., Sakurai, M. and Nishikura, K.*
    "Elucidating the inosinome: Global approaches to adenosine-to-inosine RNA editing"
    Nat. Rev. Genet. 12:81-85. [DOI: 10.1038/nrg2915, PMID: 21173775] (2011).

19. Sakurai, M., Yano, T., and Suzuki, T.*
    "Biochemical identification of A-to-I RNA editing sites by the Inosine Chemical Erasing (ICE) method"
    Methods Mol. Biol. 718:89-99. [DOI: 10.1007/978-1-61779-018-8_5, PMID: 21370043] (2011).

20. Sakurai, M., Yano, T., Kawabata, H., Ueda, H., and Suzuki, T.*
    "Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome"
    Nat. Chem. Biol. 6:733-740. [DOI: 10.1038/nchembio.434, PMID: 20835228] (2010).
    **This work is reviewed as “pioneering work” in Nature Reviews Genetics. Helm, M., and Motorin, Y. "Detecting RNA modifications in the epitranscriptome: predict and validate" Nat. Rev. Genet. 18:275-291. [DOI: 10.1038/nrg.2016.169, PMID: 28216634] (2017).

21. Sakurai, M., Watanabe, Y., Watanabe, K., and Ohtsuki, T.*
    "A protein extension to shorten RNA: Elongated elongation factor Tu recognizes the D-arm of T-armless tRNAs in nematode mitochondria"
    Biochem. J. 399:249-256. [DOI: 10.1042/BJ20060781, PMID: 16859488] (2006).

22.  Sakurai, M., Ohtsuki, T., and Watanabe, K.*
    "Modification at position 9 with 1-methyladenosine is crucial for structure and function of nematode mitochondrial tRNAs lacking the entire T arm"
    Nucleic Acids Res. 33:1653-1661. [DOI: 10.1093/nar/gki309, PMID: 15781491] (2005).
     

23.  Sakurai, M., Ohtsuki, T.*, Suzuki, T., and Watanabe, K.
    "Unusual usage of wobble modifications in mitochondrial tRNAs of the nematode Ascaris suum"
    FEBS Lett. 579:2767-2772. [DOI: 10.1016/j.febslet.2005.04.009, PMID: 15907479] (2005).

24. Suematsu, T., Sato, A., Sakurai, M., Watanabe, K., and Ohtsuki, T.*
    "A unique tRNA recognition mechanism of Caenorhabditis elegans mitochondrial EF-Tu2"
    Nucleic Acids Res. 33:4683-4691. [DOI: 10.1093/nar/gki784, PMID: 16113240] (2005).
     

25. Ohtsuki, T., Sakurai, M., Sato, A., and Watanabe, K.*
    "Characterization of the interaction between the nucleotide exchange factor EF-Ts from nematode mitochondria and elongation factor Tu"
    Nucleic Acids Res. 30:5444-5451. [DOI: 10.1093/nar/gkf679, PMID: 12490713] (2002).

26.   Sakurai, M., Ohtsuki, T., Watanabe, Y., and Watanabe, K.*
    "Requirement of modified residue m1A9 for EF-Tu binding to nematode mitochondrial tRNA lacking the T arm"
    Nucleic Acids Res. Suppl. 1:237-238. [DOI: 10.1093/nass/1.1.237, PMID: 12836352] (2001).
     

✦ 和文総説

1. 櫻井雅之、岡田俊平 「A-to-I RNA 塩基編集による疾患と対策技術」MSD メディカル・サイエンス・ダイジェスト (ニューサイエンス社) 46(9): 592-595 (2020)

2. 櫻井雅之 「もう一つの遺伝子 ”編集” - 哺乳動物が備える核酸塩基の編集機構」MSD メディカル・サイエンス・ダイジェスト (ニューサイエンス社) 45: 576-577 (2019)

3. 櫻井雅之, 長谷川拓巳, 中山宏紀「【RNA修飾の解析法】簡易検出法から網羅的解析まで」特集号:遺伝子発現制御の隠されたシステム RNA修飾〜明かされ始めた多様な生命現象への関与から応用まで   実験医学 (羊土社) 36(19): 3212-3216 (2018)

4. 櫻井雅之, 城本悠助, 西倉和子「ストレス応答時におけるADAR1によるmRNA分解保護機構によるアポトーシスの制御」ライフサイエンス新着論文レビュー [DOI: 10.7875/first.author.2017.038] (2017).

5. 櫻井雅之, 太田博允, 西倉和子「RNA編集酵素ADAR1のRNAi促進機能」実験医学 31: 2615-2618 (2013).

6. 太田博允, 櫻井雅之, 西倉和子「ADAR1はDicerと複合体を形成しmiRNAのプロセシングおよびmiRNAに依存するRNAサイレンシングを促進する」ライフサイエンス新着論文レビュー [DOI: 10.7875/first.author.2013.062] (2013).

7. 櫻井雅之, 西倉和子「A-to-I RNA編集と疾患」日本薬学会機関紙ファルマシア 47: 135-140 (2011). 櫻井雅之, 矢野孝紀, 岡田俊平, 竹内裕樹, 鈴木勉.「mRNAの塩基修飾･編集と遺伝子発現制御機構」蛋白質核酸酵素 54: 2086-2091 [PMID: 21089622] (2009).

8. Hüttenhofer, A., 櫻井雅之, 鈴木勉.「機能性非コードRNAの同定とmRNA修飾の可能性」細胞工学 22: 965-968 (2003).

✦ その他 (書籍、出版物等)

1. 櫻井雅之、岡田俊平「分子生物学と遺伝子の研究」東京理科大学 科学フォーラム サイエンスへの招待 414, 40-41(2019)

✦ その他 (活動，学生受賞等)

• YouTubeにインタビュー動画がアップロードされました。YouTube YouTube (in English) 

• 2022/7/22 当研究室所属の久保田真依さんが第23回日本RNA学会年会でEMBO Reports AWARDを受賞しました。 日本RNA学会年会HP 生命研HP

• 2021/3 櫻井雅之講師が筆頭著者の論文がNature Communications Editors' Highlights:Focus "From molecules and cells to organisms" に特集されました。 リンクはこちら 論文はこちら 

• 2020/12/14 当研究室所属の楊 雨溪さんが上原記念生命科学財団 2020年度来日研究生助成金に採択されました。（協力教員 後飯塚 僚 教授）→上原記念生命科学財団様のHP