As always the goal is always prevention of contracting the disease and protecting the body from damage. The strongest preventative measure is education of the public and infection control practices. Isolation of infected individuals, tracing contacts, and use of personal protective equipment are key to prevention. In some cultures, it is important to educate on safe burial practices to limit contact with bodily fluids that could spread disease. For intimate relationships, partners can use condoms or refrain from physical relations until the virus has been cleared from the patient (WHO, 2024; CDC, 2024; Cross et al., 2020).
Currently there are no approved antiviral treatments specifically for Marburg virus disease, and patient care relies on patient supportive therapies. Treatment focuses on electrolyte balance and fluid maintenance for dehydration and shock prevention. Blood transfusions can be used to manage coagulation abnormalities and severe bleeding. Supportive care can also include maintaining adequate oxygenation and blood pressure regulation to suppose organ function. adequate oxygenation and monitoring is also beneficial supportive care. Studies show early and aggressive supportive care has shown to significantly improve survival outcomes in patients (WHO, 2024; CDC, 2024; Cross et al., 2020).
Future research could explore the potential treatment of monoclonal antibodies, broad-spectrum antivirals and immunomodulators. Monoclonal therapies could use antibodies designated to neutralize the virus and prevent or limit spread of the virus. Broad spectrum antiviral drugs are also being explored for their ability to inhibit viral replication. Immunomodulators may help regulate uncontrolled immune responses, excessive cytokine production and accumulation that progress to severe disease. By advancing therapeutic strategies, patient outcomes could be improved. Continued research and clinical trials are necessary for potential translation of real world applications (Singh et al., 2024; Cross et al., 2020; Brauburger et al., 2012).