Marburg virus is an enveloped, negative-sense, single-stranded RNA virus with a non-segmented genome approximately 19 kilobases in length. Its genome encodes several structural and nonstructural proteins that are essential for viral replication and immune evasion. Structurally, the virus has a distinctive filamentous and pleomorphic shape, with a nucleocapsid that exhibits helical symmetry. These unique structural features contribute to the virus’s stability and ability to infect host cells. Marburg virus belongs to the family Filoviridae, which also includes Ebola virus and other highly pathogenic hemorrhagic fever viruses. Understanding the genome structure of Marburg virus is critical for the development of diagnostics, vaccines, and antiviral therapies (Britannica, 2024; Brauburger et al., 2012; Kortepeter et al., 2011).