Publications

1. Huang H, Wang H, Ganjam K, Staudinger J, Redinbo M, Mani S. Inhibiting the transcriptional control of drug metabolism. Oncogene. 26(2):258-68 (2007)

2. Das B, Madhukumar AV, Anguiano J, Kim S, Sinz M, Zvyaga TA, Power EC, Ganellin CR, Mani S. Synthesis of novel ketoconazole derivatives as antagonists of the human Pregnane X Receptor (PXR; NR1I2l alsotermed SXR, PAR). Bioorg Med Chem Lett. 18(14):3974-7 (2008)

3. Ekins S, Ni A, Sinz M, Gal J, Gera L, Welsh WJ, Mani S. Computational discovery of novel low micromolar human pregnane x receptor antagonists. Mol Pharmacol. 74(3):662-72 (2008)

4. Das B, Madhukumar AV, Anguiano J, Mani S. Synthesis and Biological Evaluation of 2H-benzo[b][1,4] Oxazine Derivatives as Hypoxia Targeted Compounds for Cancer Therapeutics. Bioorg Med Chem Lett. 19(15):4204-6 (2009)

5. Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ,Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, Cho SY, Roboz J, Redinbo M, Moore JT, Mani S. Thephytoestrogen coumestrol is a naturally occurring antagonist of pregnane x receptor (PXR). Mol Endo. 22(4):838-57(2008)

6. Ekins S*, Chang C*, Mani S*, Krasowski MD, Reschly EJ, Iyer M, Kholodovch V, Ai Ni, Welsh WJ, Sinz M, Swaan PW, Patel R, Bachman K. Human pregnane x receptor antagonists and agonists define molecular requirements for different binding sites. Mol Pharmacol. 72(3):592-603 (2007)

7. Gupta D, Venkatesh M, Wang H, Kim S, Sinz M, Goldberg GL, Whitney K, Longley C, Mani S. Expanding the roles for PXR in Cancer: Proliferation and Drug Resistance in Ovarian Cancer, Clin Cancer Res. 14(17):5332-40(2008) (F1000)

8. Wallace BD, Wang H, Lane KT, Scott JE, Orans J, Koo JS, Venkatesh M, Jobin C, Yeh LA, Mani S, Redinbo MR. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science. 330(6005):831-5 (2010)

9. Smith NF, Mani S, Schuetz EG, Yasuda K, Sissung TM, Bates SE, Figg WD, Sparreboom A. Induction of CYP3A4 by Vinblastine: Role of the nuclear receptor NR1I2. Ann Pharmacother. 44(11):1709-17 (2010)

10. Kortagere S, Krasowski MD, Reschly EJ, Venkatesh M, Mani S, Ekins S. Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database. Environ Health Perspect. 118(10):1412-7 (2010)

11. Krausova L, Stejskalova L, Wang H, Vrzal R, Dvorak Z, Mani S, Pavek P. Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene. Biochem Pharmacol. 82(11):1771-80 (2011)

12. Wang H, Venkatesh M, Li H, Goetz R, Mukherjee S, Biswas A, Zhu L, Kaubisch A, Wang L, Pullman J, Whitney K, Kuro-o M, Roig AI, Shay JW, Mohammadi M, Mani S. Pregnane X receptor activation induces FGF19- dependent tumor aggressiveness in humans and mice. J Clin Invest. 121(8):3220-32 (2011)

13. Venkatesh M, Wang H, Cayer J, Leroux M, Salvail D, Das B, Wrobel JE, Mani S. In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation. Mol Pharmacol. 80(1):124-35 (2011)

14. Biswas A, Pasquel D, Tyagi RK, Mani S. Acetylation of pregnane X receptor protein determines selective function independent of ligand activation. Biochem Biophys Res Commun. 406(3):371-6 (2011)

15. Dou V, Mukherjee S, Li H, Venkatesh M, Wang H, Kortagere S, Peleg A, Chillimuri SS, Wang ZT, Feng Y, Fearon E, Mani S. Baicalein Abrogates Inflammation through cdx2/Pregnane X Receptor (pxr) Pathway in a Mouse Model of Chemical Colitis. PLoS One 7(7):e36075 (2012)

16. Li H, Redinbo MR, Venkatesh M, Ekins S, Chaudhry A, Bloch N, Negassa A, Mukherjee P, Kalpana G, Mani S. Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR. J Biol Chem. 288(19):13655-68 (2013)

17. Dou W, Zhang J, Zhang E, Sun A, Ding L, Chou G, Wang Z, Mani S. Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway. J Pharmacol Exp Ther. 345(3):472-82 (2013)

18. Dou W, Zhang J, Sun A, Zhang E, Ding L, Mukherjee S, Wei X, Chou G, Wang ZT, Mani S. Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling. Br J Nutr. Mar 110:599-608 (2013)

19. Roberts AB, Wallace BD, Venkatesh MK, Mani S, Redinbo MR. Molecular Insights into Microbial β- Glucuronidase Inhibition to Abrogate CPT-11 Toxicity. Mol Pharmacol. 84(2):208-17 (2013)

20. Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani S. Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4. Immunity 41(2):296-310 (2014)

21. Zhang J, Ding L, Wang B, Ren G, Sun A, Deng C, Wei X, Mani S, Wang Z, and Dou W. Notoginsenoside R1 Attenuates Experimental Inflammatory Bowel Disease via Pregnane X Receptor Activation. JPET 352(2):315-24 (2015)

22. Pondugula SR, Flannery PC, Abbott KL, Coleman ES, Mani S, Samuel T, Xie W. Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR. Toxicol Lett.232(3):580-9 (2015)

23. Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C, Rusakiewicz S, Routy B, Roberti MP, Duong CP, Poirier-Colame V, Roux A, Becharef S, Formenti S, Golden E, Cording S, Eberl G, Schlitzer A, Ginhoux

F, Mani S, Yamazaki T, Jacquelot N, Enot DP, Bérard M, Nigou J, Opolon P, Eggermont A, Woerther PL, Chachaty E, Chaput N, Robert C, Mateus C, Kroemer G, Raoult D, Boneca IG, Carbonnel F, Chamaillard M, Zitvogel L. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 350(6264):1079-84 (2015)

24. Wallace BD, Roberts AB, Pollet RM, Ingle JD, Biernat KA, Pellock SJ, Venkatesh MK, Guthrie L, O'Neal SK, Robinson SJ, Dollinger M, Figueroa E, McShane SR, Cohen RD, Jin J, Frye SV, Zamboni WC, Pepe-Ranney C, Mani S, Kelly L, Redinbo MR. Structure and Inhibition of the Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chem Biol. 22(9):1238-49 (2015)

25. Pasquel D, Doricakova A, Li H, Kortagere S, Krasowski MD, Biswas A, Walton WG, Redinbo MM, Dvorak Z, Mani S. Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity. Biochim Biophys Acta. (GRM) Feb 9. pii: S1874-9399(16)30003-7 (2016)

26. Qiu Z, Cervantes JL, Cicek BB, Mukherjee S, Venkatesh M, Maher LA, Salazar JC, Mani S, Khanna KM. Pregnane X Receptor Regulates Pathogen-Induced Inflammation and Host Defense against an Intracellular Bacterial Infection through Toll-like Receptor 4. Sci Rep. 6:31936 (2016)

Conference Report:

Liu JM, Lipton JM, Mani S. Sixth International Congress on Shwachman-Diamond syndrome: from patients to genes and back. Ann N Y Acad Sci. 1242(1):26-39 (2011)

Book Chapters:

1. Mani S, Buzaid A, Cadman E. Pharmacology of antineoplastic agents, multidrug resistance and the future. In: Hoffman R Benz EJ, Sanford JS, Furie B, Cohen HJ (eds), Hematology: Basic Principles and Practice 2nd edition, 1919 pp. New York, Churchill Livingstone, 1994.

2. Mani S. Hepatobiliary Cancer, Pancreatic Cancer, and Neuroendocrine Cancers of the GI Tract, In: E. E. Vokes, H. M. Golomb (Eds), Oncologic Therapies 2nd Edition, 500 pp Springer Verlag, NY 2002

3. Mani S, Stein C. Antisense Oligonucleotides as Cancer Therapy. Semin Oncol., Semin Oncol. 2005 Dec;32(6):563-72.

4. S, Stein C. Antisense Inhibition of Gene Expression. In Cancer: Principles of Oncology 7th Edition (DeVita et al), 2005

5. Mani S, Stein C. Antisense Oligonucleotides as Cancer Therapy: Past, Present and its Future. In: G.F. Schwartz (Ed), Combination Drug Therapies 1st Edition (Humana Press)(in press)

6. Mani S. Orphan Nuclear Receptors and Cancer, Encyclopedia on Cancer, 2nd Edition, 2007


Pubmed URL(s):

https://www.ncbi.nlm.nih.gov/pubmed/?term=Mani+and+PXR

https://www.ncbi.nlm.nih.gov/pubmed/?term=Mani+Sridhar+and+cancer

https://www.ncbi.nlm.nih.gov/pubmed/?term=Sridhar+Mani

https://www.ncbi.nlm.nih.gov/pubmed/?term=Mani+S+and+Pestell