Positions

Actively seeking students (all levels) and postdoctoral fellows (see specific positions advertised below)!

For Einstein graduate students: Please email Sridhar Mani if you are interested in joining the lab.

Prospective graduate students: Please apply through one of the Einstein graduate programs: Genetics, Pharmacology or Medicine.

Postdoctoral candidates: Please see advertised positions below and if eligible email a cover letter, C.V., and contact information for three professional references to Dr. Mani.

Sridhar Mani MD

Professor

Department of Medicine & Genetics

Albert Einstein College of Medicine

1300 Morris Park Ave

Chanin Building #302D

Bronx, NY 10461

Email: sridhar.mani@einstein.yu.edu

PLEASE SEND A CC TO: smani855@gmail.com

Phone#: (718) 430-2871

POSTDOCTORAL POSITIONS AVAILABLE:

Postdoctoral Position Available in Microbiome Research: Host-Microbe Interactions, Microbial Genetics, Metagenomics and Metabolomics

The Mani Laboratory, housed in the Chanin Building (Inset), at the Departments of Medicine, Genetics and Pharmacology and The Cancer Institute and Einstein-Mount Sinai Diabetes Research Center of The Albert Einstein College of Medicine, INC has an open position for a highly motivated postdoctoral fellow to be part of an expanding research program on novel aspects of the mammalian microbiome.

Laboratory Research Focus and Expertise: The laboratory is focused on the study of orphan nuclear receptors, specifically the Pregnane X Receptor (PXR), that recognize xenobiotics (and endobiotics) as ligands and their effects on mammalian physiology and pathophysiology. Recently, we have shown that microbial metabolites can serve as ligands for such receptors (Immunity, 2014). In more recent work, in the study of these microbial ligands, we devised a biofilm assay that allowed for identification of new and novel bacterial species/strains from the enteric microbiota. The goal now is to study all aspects of the importance of these species to host physiology and pathophysiology (inflammation, cancer). These studies will include delving into the mechanisms of host-microbe (and microbe-host) interactions. Related research can expand to study of the mechanisms of bacterial biofilms using both genetic, biochemical and biophysical approaches.

SEE: http://www.einstein.yu.edu/faculty/5615/sridhar-mani/

Postdoctoral Expertise Required:

1. Recent doctoral degree or equivalent (e.g., M.D or M.D./Ph.D or Ph.D) and/or early postdoctoral training exposure.

2. First author publication record from Ph.D

3. Emphasis placed on record of new methods development and analytical/reasoning skills & curiosity driven investigations.

4. Prior experience in microbiome research and mouse work and/or metagenomics is preferred but not absolutely essential.

5. Strong reasoning, communication, visualization and written skills (English) are preferred

Postdoctoral Position Available in Cancer Research: Cancer Biology

Laboratory Research Focus and Expertise: The laboratory is currently investigating changes in oncogenic signaling by nuclear and other kinase receptor systems using gastrointestinal cell lines and organoid cultures.

SEE: http://www.einstein.yu.edu/faculty/5615/sridhar-mani/

Postdoctoral Expertise Required:

1. Recent doctoral degree or equivalent (e.g., M.D or M.D./Ph.D or Ph.D) and/or early postdoctoral training exposure.

2. First author publication record from Ph.D

3. CRISPR-Cas9 or similar gene deletion technology(ies) and fundamental molecular/cell biology skills

4. Prior experience in cancer biology is preferred