Dr. Mani: Principal Investigator

Sridhar Mani, M.D.

Sridhar Mani completed his M.D (Alpha Omega Alpha) at the Icahn School of Medicine at Mount Sinai, New York in 1990. After a residency in Internal Medicine and Oncology at the Yale-New Haven Hospital, he completed a postdoctoral fellowship investigating tumor suppressor genes in the laboratory of Eric Fearon at Yale University. In 1995, he completed a short stint as a faculty member of the Department of Oncology at the University of Chicago and returned to his native New York to establish a program in drug studies. In 2002, he became a Damon Runyon Clinical Scholar and focused his laboratory work in cooperation with Dr. Susan Horwitz at the Albert Einstein College of Medicine, Bronx, NY. Subsequently, he has been continuously funded by the National Institutes of Health and more recently by the US Department of Defense. His work focuses on the study (molecular and translational biology) of orphan nuclear receptors as it relates to drug metabolism and immunity. More recently, with the discovery of bacterial metabolites that may serve as ligands for the Pregnane X receptor (PXR), the laboratory has focused its efforts on the role of microbial metabolites in dictating host physiology and immunity.

Selected Awards and Honors

2002 Damon Runyon – Lilly Clinical Investigator Award, New York, NY

2003 Fellow, American College of Physicians, USA

2011 Scientific Award, Society of Asian American Scientists in Cancer Research (SAASCR)