Pre-prints and Publications

2022

• He S, Lim GE. (2022). The Application of High-Throughput Approaches in Identifying Novel Therapeutic Targets and Agents to Treat Diabetes. Adv Biol (Weinh); e2200151. DOI: https://doi.org/10.1002/adbi.202200151

• Mugabo Y, Zhao C, Tan, JJ, Ghosh A, Campbell SA, Fadzeyeva E, Paré F, Pan SS, Galipeau M, Ast J, Broichhagen J, Hodson DJ, Mulvihill EE, Petropoulos S, Lim GE. (2022). 14-3-3ζ constrains insulin secretion by regulating mitochondrial function in pancreatic β-cells. JCI Insight.Apr 22;7(8):e156378 DOI: https://doi.org/10.1172/jci.insight.156378

• Abou Azar F, Mugabo Y,Yuen S, Allali S, Del Veliz S, G Lavoie, PP Roux, Lim GE. (2022). Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signalling pathway, bioRxiv, DOI: https://doi.org/10.1101/2022.02.03.478896

2021

• Abou Azar F, Lim GE. (2021). Metabolic Contributions of Wnt Signaling: More Than Controlling Flight. Front. Cell Dev. Biol, 9:709823. DOI: https://doi.org/10.3389/fcell.2021.709823

2020

• Botezelli JD, Overby P, Lindo L, Wang S, Haïda O, Lim GE, Templeman N, Pauli JR, Johnson JD. (2020). Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice. Am J Physiol Endo Metab. 319: E117-E132. DOI: https://doi.org/10.1152/ajpendo.00128.2020

• Diallo K, Dussault S, Noll C, Lopez AF, Rivard A, Carpentier A, and Lim GE. (2020). 14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance. Mol Metab. 101052.DOI: https://doi.org/10.1016/j.molmet.2020.101052

• Oppong AK, Diallo K, Frayne IR, Des Rosiers C, Lim GE. (2020). Reducing 14-3-3ζ expression influences adipocyte maturity and impairs function. Am J Physiol Endo Metab. 319: E117-E132. DOI: https://doi.org/10.1152/ajpendo.00093.2020

2019

• Diallo K, Oppong AK, and Lim GE. (2019). Can 14-3-3 proteins serve as therapeutic targets for the treatment of metabolic diseases? Pharmacol Res. 139:199-206 . DOI: 10.1016/j.phrs.2018.11.021

2018

• Mugabo Y and Lim GE. (2018). Scaffold proteins: From Coordinating Signaling Pathways to Metabolic Regulation. Endocrinology. 159 (11): 3615-3630. DOI: 10.1210/en.2018-00705

• Mugabo Y, Sadeghi M, Fang NN, Mayor T, Lim GE. (2018). Elucidation o the 14-3-3z interactome reveals critical roles of RNA splicing factors during adipogenesis. J Biol Chem. 293: 6736-6750. DOI: 10.1074/jbc.M117.816272

• Page MM, Skovsø S, Cen H, Chiu AP, Dionne DA, Hutchinson DF, Lim GE, Szabat M, Filbotte S, Sinha S, Nislow C, Rodrigues B, Johnson JD. (2018) Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain. FASEB J. 32(3): 1196-1206. DOI: 10.1096/fj.201700518R

2017

• Templeman NM, Filbotte S, Chik JHL, Sinha S, Lim GE, Foster LJ, Nislow C, Johnson JD. (2017). Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan. Cell Rep. 20(2): 451-63. DOI: 10.1016/j.celrep.2017.06.048

2016

• Templeman NM, Skovsø S, Page MM, Lim GE, Johnson JD (2016). A causal role for hyperinsulinemia in obesity. J Endocrinol. 232(3): R173-R183. DOI: 10.1530/JOE-16-0449

• Lim GE, Piske M, Lulo JE, Ramshaw HS, Lopez AF, Johnson JD. (2016). Ywhaz/ 14-3-3ζ deletion improves glucose tolerance through a GLP-1-dependent mechanism. Endocrinology. 157(7): 2649-59. DOI: 10.1210/en.2016-1016

• Boothe T, Lim GE, Cen H, Skovsø S, Piske M, Li SN, Nabi IR, Gilon P, Johnson JD. (2016). Inter-domain tagged insulin receptors implicate caveolin-1 in receptor trafficking and Erk signalling bias. Mol Metab. 5(5): 366-78. DOI: 10.1016/j.molmet.2016.01.009

  • • • • **Selected for a commentary: Hausmann S, Ussar S. (2016) Insulin receptor trafficking steers insulin action. Mol Metab. http://dx.doi.org/10.1016/j.molmet.2016.02.004

2015

• Lim GE, Johnson JD. (2015). 14-3-3ζ: A numbers game in adipocyte function? Adipocyte. 5(2): 232-7. DOI: 10.1080/21623945.2015.1120913

• Lim GE, Albrecht T, Piske M, Sarai K, Lee JT, Ramshaw HS, Sinha S, Guthridge MA, Acker-Palmer A, Lopez AF, Clee SM, Nislow C, Johnson JD. (2015) 14-3-3ζ coordinates adipogenesis of visceral fat. Nat Commun. 6: 7671. DOI: 10.1038/ncomms8671

  • • • • Related news reports: National Post Global News CTV News

2014

• Chan MT, Lim GE, Yang YH, Alejandro EU, Hoesli C, Piret JM, Warnock GL, Johnson JD. (2014). Effects of insulin on human pancreatic cancer progression modeled in vitro. BMC Cancer.14: 814. DOI: 10.1186/1471-2407-14-814

2013

• Wang M, Li J, Lim GE, Luciani DS, Johnson JD. (2013). Is dynamic autocrine insulin signaling possible? A mathematical model predicts picomolar concentrations of extracellular monomeric insulin within human pancreatic islets. PLOS One. 8(6): e64860. DOI: 10.1371/journal.pone.0064860

• Lim GE, Piske M, Johnson JD. (2013). 14-3-3 proteins are essential signaling hubs for beta cell survival. Diabetologia. 56(4): 825-37. DOI: 10.1007/s00125-012-2820-x

2012

• Mehran AE, Templeman NM, Brigidi GS, Lim GE, Chu KY, Botezelli JD, Hu X, Asadi A, Hoffman BG, Kieffer BG, Bamji SX, Clee SM, Johnson JD. (2012). Hyperinsulinemia drives diet-induced obesity independently of brain insulin. Cell Metab. 16(6): 723-37. DOI: 10.1016/j.cmet.2012.10.019

2011

• Alejandro EU*, Lim GE* Mehran AE, Hu X, Taghizadeh F, Pelipeychenko D, Baccarini M, Johnson JD. (2011). Pancreatic beta-cell Raf-1 is required for glucose tolerance, insulin secretion and insulin 2 transcription. FASEB J., 25 (11): 3884-95. DOI: 10.1096/fj.10-180349

• Szabat M, Kalynyak TB, Lim GE, Yang YH, Asadi A, Gage BK, Chu KY, Ao Z, Warnock GL, Piret JM, Kieffer TJ, Johnson JD. (2011). Beta-cell musashi expression links ER-stress and diabetes to insulin expression and proliferation. Cell Death Dis, 2 : e232. DOI: 10.1038/cddis.2011.119

2009

• Lim GE, Xu M, Sun J, Jin T, Brubaker PL. (2009). The Rho GTPase, Cdc42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal L cell. Endocrinology, 150 (12): 5249-61. DOI: 10.1210/en.2009-0508

  • • • • • Highlighted in a “News and Views” Article:Thurmond DC. (2009). Insulin-regulated glucagon-like peptide-1 release from L cells: Actin’ out. Endocrinology, 150: 5202-04.

• Lim GE, Huang GJ, Flora N, LeRoith D, Rhodes CJ, Brubaker PL. (2009). Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell. Endocrinology, 150 (2): 580-91. DOI: 10.1210/en.2008-0726

2008

• Yi F, Sun J, Lim GE, Fantus IG, Brubaker PL, Jin T. (2008). Crosstalk between the insulin and Wnt signaling pathways : evidence from intestinal endocrine L cells. Endocrine pathways: evidence from intestinal endocrine L cells. Endocrinology, 149 (5): 2341-51. DOI: 10.1210/en.2007-1142

2006

• Lim GE, Brubaker PL. (2006). Glucagon-like peptide-1 secretion by the L cell: the view from within. Diabetes, 55 (suppl 2): S70-77. DOI: 10.2337/db06-S020

2005

• Holloway AC, Lim GE, Petrik JJ, Foster WG, Morrison KM, Gerstein HC. (2005). Fetal and neonatal exposure to nicotine results in endocrine and metabolic changes associated with type 2 diabetes in the offspring. Diabetologia, 48 (12): 2661-6. DOI: 10.1007/s00125-005-0022-5

• Gao Y, Holloway AC, Zeng Z, Lim GE, Petrik JJ, Foster WG, Lee RMKW. (2005). Prenatal exposure to nicotine causes postnatal obesity and an alteration in perivascular adipose tissue function. Obesity Res, 13 (4): 687-692. DOI: 10.1038/oby.2005.77

2004

• Lim GE, Stals SI, Petrik JJ, Foster WG, Holloway AC. (2004). The effects of in utero plus lactational exposure to chloroform on postnatal health in male Wistar rats. Endocrine, 25 (3): 223-228.

• Younglai EV, Holloway AC, Lim GE, Neal MS, Foster WG. (2004). Synergistic effects of follicle stimulating hormone and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p’-DDE) on human granulosa cell aromatase activity. Human Reprod, 19 (5): 1089-1093. DOI: 10.1093/humrep/deh252

2003

Lim GE, Li T, Buttar HS. (2003). Interactions of grapefruit juice and cardiovascular medications: a potential risk of toxicity. Exp Clin Cardiol, 8 (2): 99-107. PMC: PMC2716207