PUBLICATIONS
PUBLICATIONS
click on the numbers for a link to the paper*indicates equal author contribution, underline indicates undergraduate co-author.
Embedded Files
click on the numbers for a link to the paper*indicates equal author contribution, underline indicates undergraduate co-author.
28. H.E. Kang*, A. Venkatesh*, S.C. Liu, and A.M. Leconte (2025). Enzymatic synthesis of mixed XNA polymers containing 2’-fluoro and 2’-azide modifications, ACS Omega (accepted).
27. M.K.C. Seto, T. Wu and A.M. Leconte. Practical Tips for Intentional and Inclusive Recruiting and Hiring for Academic Research Laboratories, ChemBioChem (in revision).
Pre-print on ChemRXiv: https://doi.org/10.26434/chemrxiv-2023-rxb7p
26. C.M. Colee and A.M. Leconte (2024). Directed Evolution: A Primer. ACS In Focus, 3.
25. C.M. Colee*, N.M. Oberlag*, M. Simon,* O.S. Chapman, L.C. Flanagan, E.S. Reid-McLaughlin, J.A. Gewing-Mullins, S. Maiche, D.F. Patel, A.R.O. Cavalcanti, and A.M. Leconte (2024). Discovery of red-shifting mutations in firefly luciferase using a high-throughput biochemical approach. Biochemistry, 63, 733.
24. S. J. Williams, J. A. Gewing-Mullins, W. K. Lieberman, B. Kolbaba-Kartchner, R. Iqbal, H. M. Burgess, C. M. Colee, M.Y. Ornelas, E. S. Reid-McLaughlin, J. H. Mills, J. A. Prescher*, and A. M. Leconte* (2023). Biochemical analysis leads to improved orthogonal bioluminescent tools, ChemBioChem, 24, e20220072.
23. T. A. Christensen, K. Y. Lee, S. Z. P. Gottlieb, M.B. Carrier, and A. M. Leconte (2022). Mutant polymerases capable of 2’ fluoro-modified nucleic acid synthesis and amplification with improved accuracy, RSC Chemical Biology, 3, 1044.
22. A. S. Thompson, S.E. Barrett, A.G. Weiden, A. Venkatesh, M.K.C. Seto, S.Z.P. Gottlieb and A. M. Leconte (2020). Accurate and efficient one-pot reverse transcription and amplification of 2’ fluoro-modified nucleic acids by commercial DNA polymerases, Biochemistry, 59, 2833.
21. M. D. Liu*, E. A. Warner*, C. A. Morrissey, C. W. Fick, T. S. Wu, M. Y. Ornelas, G. V. Ochoa, B. Zhang, C. M. Rathbun, W. B. Porterfield, J. A. Prescher, and A. M. Leconte (2018). Statistical Coupling Analysis-guided library design for discovery of mutant luciferases, Biochemistry, 57, 663.
20. E. L. Lewis and A. M. Leconte (2017). DNA polymerase activity assay using near-infrared fluorescent labeled DNA visualized by acrylamide gel electrophoresis, Journal of Visualized Experiments, 128, e56228.
19. J. M. Heemstra*, R. Waterman*, J. M. Antos, P. J. Beuning, S. K. Bur, L. Columbus, A. L. Feig, A. A. Fuller, J. G. Gilmore, A.M. Leconte, C. H. Londergan, W. C. K. Pomerantz, J. A. Prescher, and L. M. Stanley. Throwing away the cookbook: implementing course-based undergraduate research experiences (CUREs) in Chemistry. ACS Symposium Series, 1248.
18. S. L. Rosenblum, A. G. Weiden, E. L. Lewis, A. L. Ogonowsky, H. E. Chia, S. E. Barrett, M. D. Liu, and A. M. Leconte (2017) Design and discovery of new combinations of mutant DNA polymerases and modified DNA substrates, Chembiochem, 18, 816.
17. H. J. Schultz, A. M. Gochi, H. E. Chia, A. L. Ogonowsky, S. Chiang, N. Filipovic, A. G. Weiden, E. E. Hadley, S. E. Gabriel, and A. M. Leconte (2015) Taq DNA polymerase and 2' modified sugar recognition, Biochemistry, 54, 5999.
Before Keck Science:
(click on number for link to paper)
16. B. C. Dickinson, A. M. Leconte, B. Allen, K. M. Esvelt, and D. R. Liu (2013) Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution, Proc. Natl. Acad. Sci. USA, 110, 9007.
15. A. M. Leconte, B. C. Dickinson, D. D. Yang, I. A. Chen, B. Allen, and D. R. Liu (2013) A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes, Biochemistry, 52, 1490.
14. C. E. Dumelin, Y. Chen, A. M. Leconte, Y. G. Chen, and D. R. Liu, (2012) Discovery and biological characterization of geranylated RNA in bacteria, Nature Chemical Biology, 8, 913.
highlighted in Nature Reviews Microbiology, Chemistry and Engineering News.
13. M. H. Duyzend, C. T. Clark, S. L. Simmons, W. B. Johnson, A. M. Larson, A. M. Leconte, A. W. Willis, M. Ginder-Vogel, A. K. Wilhelm, J. A. Czechowicz, and D. G. Alberg, (2012) Synthesis and evaluation of substrate analogue inhibitors of trypanothione reductase, J. Enzyme Inhib. Med. Chem., 27, 784.
12. A. M. Leconte, M. P. Patel, L. E. Sass, P. McInerney, M. Jarosz, L. Kung, J. L. Bowers, P. R. Buzby, J. W. Efcavitch, and F. E. Romesberg, (2010) Directed evolution of DNA polymerases for next generation sequencing, Angew. Chem. Int. Ed., 34, 5921.
11. A. M. Leconte and F. E. Romesberg. Invited book chapter, (2009) Development of Unnatural DNA Base Pair Systems, in Protein Engineering (Springer).
10. Y. Hari, G. T. Hwang, A. M. Leconte, N. Joubert, M. Hocek and F. E. Romesberg, (2008), Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication, Chembiochem, 9, 2796.
9. A. M. Leconte, G. T. Hwang, S. Matsuda, P. Capek, Y. Hari, and F. E. Romesberg, (2008) Discovery, Characterization, and Optimization of an Unnatural Base Pair for Expansion of the Genetic Alphabet, J. Am. Chem. Soc. 130, 2336.
highlighted in Popular Science, New Scientist, Journal of the American Medical Association.
8. G. T. Hwang, A. M. Leconte, and F. E. Romesberg, (2007) Polymerase Recognition and Stability of Fluoro-Substituted Pyridone Nucleobase Analogues. Chembiochem., 8, 1606.
7. S. Matsuda, A. M. Leconte, and F. E. Romesberg, (2007) Minor Groove Hydrogen Bonds and the Replication of Unnatural Base Pairs. J. Am. Chem. Soc., 129, 5551.
6. A. M. Leconte and F. E. Romesberg. Invited commentary, (2006) Chemical biology: a broader take on DNA. Nature, 444, 553.
5. A. M. Leconte, S. Matsuda, and F. E. Romesberg. (2006) An Efficiently Extended Class of Unnatural Base Pairs. J. Am. Chem. Soc., 128, 6780.
4. Y. Kim, A. M. Leconte, Y. Hari, and F. E. Romesberg. (2006) Stability and Polymerase Recognition of Pyridine Nucleobase Analogs. Angew. Chem. Int. Ed., 45, 7809.
3. A. M. Leconte, S. Matsuda, G. Hwang, and F. E. Romesberg. (2006) Efforts toward Expansion of the Genetic Alphabet: Methyl Pyridone and Pyridone Nucleobases. Angew. Chem. Int. Ed., 45, 4326.
2. A. M. Leconte and F. E. Romesberg. Invited commentary, (2006) Amplify this! DNA and RNA get a third base pair. Nature Methods, 3, 667.
1. A. M. Leconte, L. Chen, and F. E. Romesberg. (2005) Polymerase Evolution: Efforts toward Expansion of the Genetic Code. J. Am. Chem. Soc., 127, 12470.
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