Epigenetics
Why Epigenetics Matters
Stress. Diet. Sleep. Poor Air Quality. Environmental Exposures.
All are known to produce epigenetic effects, leaving chemical marks on and around the DNA, which changes how the DNA is 'read' by the body. This changes all sorts of things -- like which genes are transcribed and how much protein is made.
It's not just external environmental exposures. Two people can be sitting in the exact same room -- yet have very different experiences -- due to bullying and other factors. This new field is called social epigenetics.
Read:
Dobbs, D. (2013). The Social Life of Genes. PSMag. Published Sept 3, 2013; Updated June 14, 2017 https://psmag.com/social-justice/the-social-life-of-genes-64616
Shields, A. E. (2017). Epigenetic signals of how social disadvantage “gets under the skin”: a challenge to the public health community. Epigenomics, 9,(3), Published Online:22 Feb 2017 https://doi.org/10.2217/epi-2017-0013
Get PDF via Future Medicine.
Watch:
Epigenetics and public health (https://www.youtube.com/watch?v=gxKl0sOinYk). Note: Sorry for the audio quality -- my computer set-up had some trouble during the recording; I will re-record in time.
Help! I need a refresher!
Genetics Primer
Genetic Science Learning Center is amazing. Everything you need.
National Geographic video on genetics (3 min, see left)
Epigenetics Primer
The Genetic Science Learning Center also has a great section on epigenetics.
https://learn.genetics.utah.edu/content/epigenetics/Also, see Hank Green's 9 min overview video (see left).
Epigenetics Resources
Nurture your Nature
Interactive digital media for learning more about epigenetics and its mechanisms
2014 International Serious Play Award,
Silver Medal
Epigenetic Resources
Lesson plans, briefing sheets, manipulatives, and ideas for helping you teach epigenetics
Other Reading
Frumkin, H. (Ed.). (2016). Environmental health: from global to local. John Wiley & Sons. 3rd Edition.
See Ch 7: Genes, Genomics, and Environmental Health in Frumkin. (Goal: Reinforce general understanding of DNA, gene transcription, and gene expression so that gene-environment interactions make sense – you don’t need to know all terms and mechanisms – instead, focus on the big picture so you can make predictions in this class.)
New Science
DNA copy errors & cancer
New science about cell cycle, epigenetics, stress, and cancer risk. https://youtu.be/tMKhxJh9N54
Environmental Epigenetics
Keep an eye out for environmental epigenetics!
Optional Reading:
Eirin-Lopez, J. M., & Putnam, H. M. (2019). Marine environmental epigenetics. Annual Review of Marine Science, 11, 335-368. Link via Annual Reviews.org
Müller, R., Hanson, C., Hanson, M., Penkler, M., Samaras, G., Chiapperino, L., ... & Lloyd, S. (2017). The biosocial genome? Interdisciplinary perspectives on environmental epigenetics, health and society. EMBO Reports, 18(10), 1677-1682. Link via EMBO
Tiffon, C. (2018). The impact of nutrition and environmental epigenetics on human health and disease. International Journal of Molecular Sciences, 19(11), 3425. Link via MDPI