Epigenetics

Why Epigenetics Matters

Stress. Diet. Sleep. Poor Air Quality. Environmental Exposures.

All are known to produce epigenetic effects, leaving chemical marks on and around the DNA, which changes how the DNA is 'read' by the body. This changes all sorts of things -- like which genes are transcribed and how much protein is made.

It's not just external environmental exposures. Two people can be sitting in the exact same room -- yet have very different experiences -- due to bullying and other factors. This new field is called social epigenetics.

Read:

Watch:

Help! I need a refresher!

Genetics Primer

Genetic Science Learning Center is amazing. Everything you need.

Epigenetics Primer

The Genetic Science Learning Center also has a great section on epigenetics.

https://learn.genetics.utah.edu/content/epigenetics/

Also, see Hank Green's 9 min overview video (see left).

Epigenetics Resources


Epigenetics for the Classroom

Lay summary on why epigenetics matters.

Marriott, L., Charbonneau, A., Moss, B., Shannon, J., Thornburg, K., & Turker, M. (2016). Epigenetics: A new science for middle school-and why you should teach it. Science Scope, 39(6), 6. Link via ProQuest

Nurture your Nature

Interactive digital media for learning more about epigenetics and its mechanisms

2014 International Serious Play Award,
Silver Medal

http://www.letsgethealthy.org/students/games/epigenetics-game/

Epigenetic Resources

Lesson plans, briefing sheets, manipulatives, and ideas for helping you teach epigenetics


http://www.letsgethealthy.org/about-the-research/station-descriptions/epigenetics/

Other Reading

  • Frumkin, H. (Ed.). (2016). Environmental health: from global to local. John Wiley & Sons. 3rd Edition.
    See Ch 7: Genes, Genomics, and Environmental Health in Frumkin. (Goal: Reinforce general understanding of DNA, gene transcription, and gene expression so that gene-environment interactions make sense – you don’t need to know all terms and mechanisms – instead, focus on the big picture so you can make predictions in this class.)

New Science

DNA copy errors & cancer

New science about cell cycle, epigenetics, stress, and cancer risk. https://youtu.be/tMKhxJh9N54

Environmental Epigenetics

Keep an eye out for environmental epigenetics!


Optional Reading:

  • Eirin-Lopez, J. M., & Putnam, H. M. (2019). Marine environmental epigenetics. Annual Review of Marine Science, 11, 335-368. Link via Annual Reviews.org

  • Müller, R., Hanson, C., Hanson, M., Penkler, M., Samaras, G., Chiapperino, L., ... & Lloyd, S. (2017). The biosocial genome? Interdisciplinary perspectives on environmental epigenetics, health and society. EMBO Reports, 18(10), 1677-1682. Link via EMBO

  • Tiffon, C. (2018). The impact of nutrition and environmental epigenetics on human health and disease. International Journal of Molecular Sciences, 19(11), 3425. Link via MDPI