Key Articles

Guidelines

Canadian Guidelines

• 2023 Osteoporosis Canada Guideline (CMAJ)

  • Appendix 1: Tables

  • Appendix 2: Supplementary material

• 2010 Osteoporosis Canada guidelines

• 2015 Osteoporosis Canada - Preventing fractures in LTC

Other guidelines

• 2019 Endocrine Society guidelines

• 2017 KDIGO - Chronic Kidney Disease–Mineral and Bone Disorder

• 2017 American College of Rheumatology - Prevention of glucocorticoid induced osteoporosis

• 2017 American College of Physicians

Treatments

Network Meta-analysis:

• 2019 JCEM - Efficacy of Pharmacological Therapies for the Prevention of Fractures in Postmenopausal Women

Bisphosphonates

• Alendronate

  • Fracture Intervention Trial (FIT) - Lancet 1996

  • Fracture Intervention Trial Long-term Extension (FLEX) - JAMA 2006

• Risedronate

• Zoledronic acid

  • Fracture Prevention with Zoledronate in Older Women with Osteopenia - NEJM 2018

Denosumab

• FREEDOM - Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis - NEJM 2009

• FREEDOM extension (8 years) - The effect of 8 or 5 years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM Extension study - Osteoporosis International 2015

• FREEDOM extension (10 years) - 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension - Lancet Endocrinology 2017

• Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS - Bone 2017

Teriparatide

Romosozumab

• FRAME - Romosozumab Treatment in Postmenopausal Women with Osteoporosis - NEJM 2016

• ARCH - Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis - NEJM 2017

Drug Holiday

• Commentary from Osteoporosis Canada - 2014

• ASBMR task force on Long Term Bisphosphonate therapy - JBMR 2016

Medication Side effects

Atypical femur fractures

• 2014 ASBMR AFF task force

Osteonecrosis of the Jaw

• Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and International Consensus - JBMR 2015

• 2007 ASBMR ONJ task force

Bone Mineral Density Interpretation

• 2019 ISCD Official Positions