2025
・ Uzu M, Takezawa T. Potential of connexin 32 as a predictive marker for drug-induced cholestatic liver injury in a collagen vitrigel-culture model of HepG2-NIAS cells, a new subline of HepG2 cells, with bile canaliculus-like structures. The Journal of Toxicological Sciences 50(3): 135-145, 2025.
・ Miyagawa-Hayashino A, Imura T, Takezawa T, Hirai M, Shibata S, Ogi H, Tsujikawa T, Konishi E. Activation of S1PR2 on macrophages and the hepatocyte S1PR2/RhoA/ROCK1/MLC2 pathway in vanishing bile duct syndrome. PLoS One 20(1): e0317568, 2025.
2024
・Tokito F, Kiyofuji M, Choi H, Nishikawa M, Takezawa T, Sakai Y. Modulation of hepatic cellular tight junctions via coculture with cholangiocytes enables non-destructive bile recovery. Journal of Bioscience and Bioengineering 137(5):403-411, 2024.
・Hayashi Y, Ohnishi H, Kitano M, Kishimoto Y, Takezawa T, Okuyama H, Yoshimatsu M, Kuwata F, Tada T, Mizuno K, Omori K. Comparative study of immunodeficient Urat strains in engraftment of human-induced pluripotent stem cell-derived airway epithelia. Tissue Engineering Part A 30 (3-4): 144-153, 2024.
・ Yamaguchi H, Kojima H, Takezawa T. Vitrigel-Eye Irritancy Test (EIT) Method Revised for Including Not Only Liquid But Also Solid Test Chemicals. Nano Biomedicine 16 (2): 89–101, 2024.
2023
・Uzu M, Takezawa T. Novel cell culture technology to harvest hepatic metabolites accumulated in the bile canaliculus-like structures between HepG2-NIAS cells utilizing crosstalk with TFK-1 cells. Nano Biomedicine 15 (2): 75-87, 2023.
2022
・Uzu M, Takezawa T. A hybrid human microvascular endothelial cell line created by utilizing a cell fusion technique and its advantage for expressing high endothelial barrier function. Nano Biomedicine 14 (1): 9-17, 2022.
・Kuwata F, Ohnishi H, Yamamoto N, Takezawa T, Yamashita M, Okuyama H, Hayashi Y, Yoshimatsu M, Kitada Y, Tada T, Kobayashi M, Omori K. Transplantation of human iPS cell-derived airway cells on vitrigel membrane into rat nasal cavity. Tissue Engineering Part A 28 (13-14): 586-594, 2022.
・Wang Y, Kanie K, Takezawa T, Horikawa M, Kaneko K, Sugimoto A, Yamawaki-Ogata A, Narita Y, Kato R. Bi-layered carboxymethyl cellulose-collagen vitrigel dual-surface adhesion- prevention membrane, Carbohydrate Polymers 285: 119223, 2022.
・Takezawa T, Uzu M. HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via a collagen vitrigel membrane. The Journal of Toxicological Sciences 47 (1): 39-50, 2022.
2021
・Hashiguchi M, Takezawa T, Nagase K, Tayama-Abe M, Matsuhisa F, Kitajima S, Morito S, Yamaji K, Futamata M, Sakata Y, Akutagawa T, Yokoyama M, Toda S, Aoki S. Collagen vitrigel membrane-coated nylon line prevents stenosis after conization of the cervix uteri. Tissue Engineering Part A 27 (23-24): 1480-1489, 2021.
・ Takezawa T. Revolution in cell culture technology based on a novel concept for enclosing cells using collagen vitrigel membranes. Nano Biomedicine 13 (1): 1-7, 2021.
2020
・Uzu M, Takezawa T. Novel microvascular endothelial model utilizing a collagen vitrigel membrane and its advantages for predicting histamine-induced microvascular hyperpermeability. Journal of Pharmacological and Toxicological Methods 106: 106916, 2020.
2019
・Kojima H, Yamaguchi H, Sozu T, Kleinstreuer N, Chae-Hyung L, Chen W, Watanabe M, Fukuda T, Yamashita K, Takezawa T. Multi-laboratory validation study of the vitrigel-eye irritancy test method as an alternative to in vivo eye irritation testing. Alternatives to Laboratory Animals 47 (3-4): 140-157, 2019.
・Okuyama H, Ohnishi H, Nakamura R, Yamashita M, Kishimoto Y, Tateya I, Suehiro A, Gotoh S, Takezawa T, Nakamura T, Omori K. Transplantation of multiciliated airway cells derived from human iPS cells using an artificial tracheal patch into rat trachea. Journal of Tissue Engineering and Regenerative Medicine 13: 1019-1030, 2019.
・Aoki S, Takezawa T, Nagase K, Oshikata-Miyazaki A, Morito S, Sakumoto T, Masuda M, Akutagawa T, Yamamoto-Rikitake M, Toda S. A high-density collagen xerogel thread prevents progression of peritoneal fibrosis. Biomaterials Science 7: 125-138, 2019.
2018
・Yamaguchi H, Takezawa T. Fabrication of a Corneal Model Composed of Corneal Epithelial and Endothelial Cells via a Collagen VitrigelMembrane Functioned as an Acellular Stroma and Its Application to the Corneal Permeability Test of Chemicals. Drug Metabolism and Disposition 46: 1684–1691, 2018.
・Watari R, Kakiki M, Oshikata A, Takezawa T, Yamasaki C, Ishida Y, Tateno C, Kuroda Y, Ishida S, Kusano K. A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers. The Journal of Toxicological Sciences 43 (8): 521-529, 2018.
2017
・Nakaegawa Y, Nakamura R, Tada Y, Suzuki R, Takezawa T, Nakamura T, Omori K. Effects of artificial tracheal fixation on tracheal epithelial regeneration and prevention of tracheal stenosis. Acta Oto-Laryngologica 137 (6): 627-634, 2017.
・Miyazaki H, Yamashita K, Uchino T, Takezawa T, Kojima H. Development of a novel in vitro skin sensitization test method using a collagen vitrigel membrane chamber. Alternatives to Animal Testing and EXperimentation 22 (2): 141-154, 2017.
・Yoshida J, Yokoo S, Oshikata-Miyazaki A, Amano S, Takezawa T, Yamagami S. Transplantation of Human Corneal Endothelial Cells Cultured on Bio-Engineered Collagen Vitrigel in a Rabbit Model of Corneal Endothelial Dysfunction. Current Eye Research 42 (11): 1420-1425, 2017.
・Aoki S, Sakata Y, Shimoda R, Takezawa T, Oshikata-Miyazaki A, Kimura H, Yamamoto M, Iwakiri R, Fujimoto K, Toda S. High-density collagen patch prevents stricture after endoscopic circumferential submucosal dissection of the esophagus: a porcine model. Gastrointestinal Endoscopy 85 (5): 1076-1085, 2017.
・Maruki H, Sato M, Takezawa T, Tani Y, Yokoyama M, Takahashi T, Toyoda E, Okada E, Aoki S, Mochida J, Kato Y. Effects of a cell-free method using collagen vitrigel incorporating TGF-β1 on articular cartilage repair in a rabbit osteochondral defect model. Journal of Biomedical Materials Research Part B: Applied Biomaterials 105 (8): 2592-2602, 2017.
・竹澤俊明.コラーゲンビトリゲル膜チャンバーを用いた組織構築とその化学物質の動態・毒性評価への応用.生物工学 95 (8): 468-471, 2017.
2016
・Uchino T, Kuroda Y, Ishida S, Yamashita K, Miyazaki H, Oshikata A, Shimizu K, Kojima H, Takezawa T, Akiyama T, Ikarashi Y. Increase of β2-integrin on adhesion of THP-1 cells to collagen vitrigel membrane. Bioscience, Biotechnology, and Biochemistry 80 (11): 2271-2276, 2016.
・Oshikata-Miyazaki A, Takezawa T. Development of an oxygenation culture method for activating the liver-specific functions of HepG2 cells utilizing a collagen vitrigel membrane chamber. Cytotechnology 68: 1801-1811, 2016.
・Yamaguchi H, Kojima H, Takezawa T. Predictive performance of the vitrigel-eye irritancy test method using 118 chemicals. Journal of Applied Toxicology 36 (8): 1025-1037, 2016.
・Aoki S, Noguchi M, Takezawa T, Ikeda S, Uchihashi K, Kuroyama H, Chimuro T, Toda S. Fluid dwell impact induces peritoneal fibrosis in the peritoneal cavity reconstructed in vitro. Journal of Artificial Organs 19 (1): 87-96, 2016.
・Aoki S, Takezawa T, Sugihara H, Toda S. Progress in cell culture systems for pathological research. Pathology International 66: 554-562, 2016.
・竹澤俊明.組織再生に有用なコラーゲンビトリゲル研究の最前線.日本白内障学会誌28: 43-45, 2016.
2015
・Aoki S, Takezawa T, Ikeda S, Narisawa Y, Oshikata-Miyazaki A, Miyauchi S, Hirayama H, Sawaguchi T, Chimuro T, Toda S. A new cell-free bandagetype artificial skin for cutaneous wounds. Wound Repair and Regeneration 23 (6): 819-829, 2015.
・Chae J.J, McIntosh Ambrose W, Espinoza F.A, Mulreany D.G, Ng S, Takezawa T, Trexler M.M, Schein O.D, Chuck R.S, Elisseeff J.H*. Regeneration of corneal epithelium utilizing a collagen vitrigel membrane in rabbit models for corneal stromal wound and limbal stem cell deficiency. Acta Ophthalmologica 93 (1): e57-e66, 2015.
・竹澤俊明.細胞の足場となる新素材「コラーゲンビトリゲル膜」の開発とその医薬学分野での実用化構想.薬剤学 75: 344-353, 2015.
2014
・Yoshida J, Oshikata A, Yokoo S, Yamagami S, Takezawa T, Amano S. Development and evaluation of porcine atelocollagen vitrigelmembrane with a spherical curve and transplantable artificial corneal endothelial grafts. Investigative Ophthalmology & Visual Science 55 (8): 4975-4981, 2014.
・Aoki S, Takezawa T, Oshikata-Miyazaki A, Ikeda S, Kuroyama H, Chimuro T, Oguchi Y, Noguchi M, Narisawa Y, Toda S. Epithelial-to-mesenchymal transition and slit function of mesothelial cells are regulated by the cross talk between mesothelial cells and endothelial cells. American Journal of Physiology - Renal Physiology 306 (1): F116-122, 2014.
・Aoki S, Takezawa T, Miyazaki-Oshikata A, Ikeda S, Nagase K, Koba S, Inoue T, Uchihashi K, Nishijima-Matsunobu A, Kakihara N, Hirayama H, Narisawa Y, Toda S. Collagen vitrigel membrane: a powerful tool for skin regeneration. Inflammation and Regeneration 34: 117-123, 2014.
・竹澤俊明.ものづくり細胞エンジニア10銃士リレー連載第7回:「組織再生工学」×「細胞工学」.日経バイオテク 788: 38-41, 2014.
2013
・Yamaguchi H, Kojima H, Takezawa T. Vitrigel-Eye Irritancy Test Method Using HCE-T Cells. Toxicological Sciences 135 (2): 347-355, 2013.
・河村 友里,岡本 愛,宮﨑(押方) 歩,森内 四郎,竹澤 俊明.新しい香粧品基材:マグロ原皮由来ゼラチンビトリゲル膜.日本香粧品学会誌 37 (2): 90-94, 2013.
・Aoki S, Udo K, Morimoto H, Ikeda S, Takezawa T, Uchihashi K, Nishijima-Matsunobu A, Noguchi M, Sugihara H, Toda S. Adipose tissue behavior is distinctly regulated by neighboring cells and fluid flow stress: a possible role of adipose tissue in peritoneal fibrosis. Journal of Artificial Organs 16 (3): 322-331, 2013.
・Tani A, Tada Y, Takezawa T, Wada I, Imaizumi M, Nomoto Y, Nomoto M, Omori K. Regenerative process of tracheal epithelium using a collagen vitrigel sponge scaffold. Laryngoscope 123 (6): 1469-1473, 2013.
・竹澤俊明.ビトリゲルの開発とその再生医療、創薬、動物実験代替法、化粧品および食品の分野での実用化構想.生物工学 91: 214-217, 2013.
・竹澤俊明.組織や器官を作り出す“職人肌”の科学者.Nature ダイジェスト 10 (11): 22-23, 2013.
2012
・Tani A, Tada Y, Takezawa T, Imaizumi M, Nomoto Y, Nakamura T, Omori K. Regeneration of tracheal epithelium using a collagen vitrigel-sponge scaffold containing basic fibroblast growth factor. Annals of Otology, Rhinology & Laryngology 121 (4): 261-268, 2012.
・Tada Y, Takezawa T, Tani A, Nakamura T, Omori K. Collagen vitrigel scaffold for regenerative medicine of the trachea: experimental study and quantitative evaluation. Acta Oto- Laryngologica 132 (4): 447-452, 2012.
・Takano T, Yamaguchi S, Matsunuma E, Komiya S, Shinkai M, Takezawa T, Nagamune T. Cell transfer printing from patterned poly(ethylene glycol)-oleyl surfaces to biological hydrogels for rapid and efficient cell micropatterning. Biotechnology and Bioengineering 109 (1): 244-251, 2012.
2011
・Aoki S, Ikeda S, Takezawa T, Kishi T, Makino J, Uchihashi K, Matsunobu A, Noguchi M, Sugihara H, Toda S. Prolonged effect of fluid flow stress on the proliferative activity of mesothelial cells after abrupt discontinuation of fluid streaming. Biochemical and Biophysical Research Communications 416 (3-4): 391-396, 2011.
・Kotani N, Maeda K, Watanabe T, Hiramatsu M, Gong LK, Bi YA, Takezawa T, Kusuhara H, Sugiyama Y. Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes. Drug Metabolism and Disposition 39 (9): 1503-1510, 2011.
・Tanemoto T, Enosawa S, Takezawa T, Kitagawa M, Chiba T, Tanaka T. Non-suture skin closure using collagen vitrigel membrane for future repair of endoscopic fetal myelomeningocele. Organ Biology 18 (3): 292-296, 2011.
・Uchino T, Takezawa T, Ikarashi Y, Nishimura T. Development of an alternative test for skin sensitization using a three-dimensional human skin model consisting of dendritic cells, keratinocytes and fibroblasts. Alternatives to Animal Testing and EXperimentation 16 (1): 1-8, 2011.
・Takezawa T, Nishikawa K, Wang PC. Development of a human corneal epithelium model utilizing a collagen vitrigel membrane and the changes of its barrier function induced by exposing eye irritant chemicals. Toxicology in Vitro 25 (6): 1237-1241, 2011.
・竹澤俊明.ヒト試料の研究利用を促進する新しい培養技術の開発.HAB News Letter 17: 9-12, 2011.
2010
・Aoki S, Makino J, Nagashima A, Takezawa T, Nomoto N, Uchihashi K, Matsunobu A, Sanai T, Sugihara H, Toda S. Fluid flow stress affects peritoneal cell kinetics: possible pathogenesis of peritoneal fibrosis. Peritoneal Dialysis International 31 (4): 466-476, 2011. Tanaka A, Itoh F*, Nishiyama K, Takezawa T, Kurihara H, Itoh S, Kato M. Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis. Blood 115 (20): 4138-4147, 2010.
・Tanaka A, Itoh F, Nishiyama K, Takezawa T, Kurihara H, Itoh S, Kato M. Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis. Blood 115 (20): 4138-4147, 2010.
・Aoki S, Kitajima Y, Takezawa T, Uchihashi K, Matsunobu A, Sugihara H, Toda S. Epidermal regeneration by keratinocyte-alien mesenchymal cell interactions. Inflammation and Regeneration 30: 428-433, 2010.
・宮本義孝,絵野沢伸,竹内朋代,竹澤俊明.コラーゲンビトリゲル薄膜担体上で培養した初代肝細胞およびES細胞の凍結保存.低温生物工学会誌 56: 47-50, 2010.
・谷口彰良,竹澤俊明.新しい細胞培養システムの開発とその創薬支援研究への応用.薬学雑誌 130: 527-528, 2010.
・竹澤俊明,福田真野,McIntosh-Ambrose W,高知愛,Elisseeff J,芳賀早苗,尾崎倫孝,加藤聖子,王碧昭,内野正,西田輝夫.コラーゲンビトリゲル薄膜の特徴を活用した新しい細胞培養システムの開発.薬学雑誌 130: 565-574, 2010.
2009
・Hiragami F, Motoda H, Takezawa T, Takabayashi C, Inoue S, Wakatake Y, Kano Y. Heat shock-induced three-dimensional-like proliferation of normal human fibroblasts mediated by pressed silk. International Journal of Molecular Sciences 10 (11): 4963-4976, 2009.
・Puleo CM, McIntosh Ambrose W, Takezawa T, Elisseeff J, Wang TH. Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture. Lab on a Chip 9 (22): 3221-3227, 2009.
・Miyamoto Y, Enosawa S, Takeuchi T, Takezawa T. Cryopreservation in situ of cell monolayers on collagen vitrigel membrane culture substrata: ready-to-use preparation of primary hepatocytes and ES cells. Cell Transplantation 18 (5): 619-626, 2009.
・Aoki S, Takezawa T, Uchihashi K, Sugihara H, Toda S. Non-skin mesenchymal cell types support epidermal regeneration in a mesenchymal stem cell or myofibroblast phenotype- independent manner. Pathology International 59 (6): 368-375, 2009.
・McIntosh Ambrose W, Salahuddin A, So S, Ng S, Ponce Márquez S, Takezawa T, Schein O, Elisseeff J. Collagen Vitrigel membranes for the in vitro reconstruction of separate corneal epithelial, stromal, and endothelial cell layers. Journal of Biomedical Materials Research Part B: Applied Biomaterials 90 (2): 818-831, 2009.
・Zhao J, Shinkai M, Takezawa T, Ohba S, Chung UI, Nagamune T. Bone regeneration using collagen type I vitrigel with bone morphogenetic protein-2. Journal of Bioscience and Bioengineering 107 (3): 318-323, 2009.
・Uchino T, Takezawa T, Ikarashi Y. Reconstruction of three-dimensional human skin model composed of dendritic cells, keratinocytes and fibroblasts utilizing a handy scaffold of collagen vitrigel membrane. Toxicology in Vitro 23 (2): 333-337, 2009.
・Ko JA, Yanai R, Morishige N, Takezawa T, Nishida T. Upregulation of connexin43 expression in corneal fibroblasts by corneal epithelial cells. Investigative Ophthalmology & Visual Science 50 (5): 2054-2060, 2009.
2008
・Zhu Z, Ohgo K, Watanabe R, Takezawa T, Asakura, T. Preparation and characterization of regenerated Bombyx mori silk fibroin fiber containing recombinant cell-adhesive proteins; Nonwoven fiber and monofilament. Journal of Applied Polymer Science 109 (5): 2956–2963, 2008.
・Tada Y, Suzuki T, Takezawa T, Nomoto Y, Kobayashi K, Nakamura T, Omori K. Regeneration of tracheal epithelium utilizing a novel bipotential collagen scaffold. Annals of Otology, Rhinology & Laryngology 117 (5): 359-365, 2008.
・Takeuchi T, Ochiya T, Takezawa T. Tissue array substratum composed of histological sections: a new platform for orienting differentiation of embryonic stem cells towards hepatic lineage. Tissue Engineering Part A 14 (2): 267-274, 2008.
・Ko JA, Liu Y, Yanai R, Chikama T, Takezawa T, Nishida T. Upregulation of tight-junctional proteins in corneal epithelial cells by corneal fibroblasts in collagen vitrigel cultures. Investigative Ophthalmology & Visual Science 49 (1): 113-119, 2008.
・竹澤俊明.新しい細胞培養技術の創出と応用:時代の潮流に沿ったアイデアの変遷.バイオインダストリー 25: 5–7, 2008.
・竹澤俊明.生体内環境を反映した細胞培養担体の開発とその再生医療あるいは創薬研究への応用構想.バイオインダストリー 25: 8–16, 2008.
・竹澤俊明,竹内朋代,柳原佳奈,中沢有紀子,二谷綾,寺田聡,落谷孝広,上野光一.動物組織を薄切した切片担体およびコラーゲンビトリゲル薄膜担体を利用した培養モデルの特徴と創薬研究への応用構想.薬学雑誌 128: 51–60, 2008.
・内野正,竹澤俊明,五十嵐良明,徳永裕司.樹状細胞を含む三次元培養ヒト皮膚モデルの構築とその皮膚感作性試験への応用.薬学雑誌 128:45–50, 2008.
・竹澤俊明,竹内朋代,落谷孝広,柳原佳奈,寺田聡,鈴木尚真,渡邉昌俊.組織病理学用の切片を動物細胞の培養担体に利用した先端研究.Organ Biology 15:107–114, 2008.
2007
・ Takezawa T, Takeuchi T, Nitani A, Takayama Y, Kino-Oka M, Taya M, Enosawa S. Collagen vitrigel membrane useful for paracrine assays in vitro and drug delivery systems in vivo. Journal of Biotechnology 131 (1): 76-83, 2007.
・ Takezawa T, Nitani A, Shimo-Oka T, Takayama Y. Protein-permeable scaffold of a collagen vitrigel membrane useful for reconstructing crosstalk models between two different cells. Cells Tissues Organs 185 (1-3): 237-241, 2007.
・Takezawa T, Ozaki K, Takabayashi C. Reconstruction of a hard connective tissue utilizing a pressed silk sheet and type-I collagen as the scaffold of fibroblasts. Tissue Engineering 13 (6): 1357-1366, 2007.
2006
・Takagishi Y, Kawakami T, Hara Y, Shinkai M, Takezawa T, Nagamune T. Bone-like tissue formation by three-dimensional culture of MG63 osteosarcoma cells in gelatin hydrogels using calcium-enriched medium. Tissue Engineering 12 (4): 927-937, 2006.
・Takayama Y, Takezawa T. Lactoferrin promotes collagen gel contractile activity of fibroblasts mediated by lipoprotein receptors. Biochemistry and Cell Biology 84: 268–274, 2006.
2005
・Kino-Oka M, Yashiki S, Ota Y, Mushiaki Y, Sugawara K, Yamamoto T, Takezawa T, Taya M. Subculture of chondrocytes on a collagen type I-coated substrate with suppressed cellular dedifferentiation. Tissue Engineering 11 (3-4): 597-608, 2005.
・Wang PC, Takezawa T. Reconstruction of renal glomerular tissue using collagen vitrigel scaffold. Journal of Bioscience and Bioengineering 99: 529-540, 2005.
・竹澤俊明.動物組織の切片を培養担体に活用した細胞挙動の制御新技術.再生医療 4: 39-44, 2005.
・竹澤俊明.動物細胞の培養新技術:組織切片を培養担体に活用したセロミクス研究と新しい診断システムの開発構想.バイオテクノロジージャーナル 5: 197-200, 2005.
2004
・Wang PC, Okada N, Takezawa T. Co-culture of glomerular epithelial cells and mesangial cells on collagen-gauze-fiber gel. Biochemical Engineering Journal 20 (2-3): 149-154, 2004.
・Takenouchi T, Takayama Y, Takezawa T. Co-treatment with dexamethasone and octanoate induces adipogenesis in 3T3-L1 cells. Cell Biology International 28 (3): 209-216, 2004.
・ Takezawa T, Ozaki K, Nitani A, Takabayashi C, Shimo-Oka T. Collagen vitrigel: a novel scaffold that can facilitate a three-dimensional culture for reconstructing organoids. Cell Transplantation 13 (4): 463-473, 2004.
・Patel OV, Yamada O, Kizaki K, Takahashi T, Imai K, Takahashi S, Izaike Y, Schuler LA, Takezawa T, Hashizume K. Expression of trophoblast cell-specific pregnancy-related genes in somatic cell-cloned bovine pregnancies. Biology of Reproduction 70 (4): 1114-1120, 2004.
・竹澤俊明.生体を反映した三次元培養基材の開発.バイオサイエンスとインダストリー 62: 375-380, 2004.
・竹澤俊明,二谷綾.新しい三次元培養担体−コラーゲンゲル薄膜.化学と生物 42: 713-716, 2004.
2003
・Yamauchi N, Takezawa T, Kizaki K, Herath CB, Hashizume K. Proliferative potential of endometrial stromal cells, and endometrial and placental expression of cyclin in the bovine. Journal of Reproduction and Development 49 (6): 553-560, 2003.
・Takayama Y, Takahashi H, Mizumachi K, Takezawa T. Low density lipoprotein receptor-related protein (LRP) is required for lactoferrin-enhanced collagen gel contractile activity of human fibroblasts. Journal of Biological Chemistry 278 (24): 22112-22118, 2003.
・Takezawa T. A strategy for the development of tissue engineering scaffolds that regulate cell behavior. Biomaterials 24: 2267-2275, 2003.
2002
・Takayama Y, Mizumachi K, Takezawa T. The bovine lactoferrin region responsible for promoting the collagen gel contractile activity of human fibroblasts. Biochemical and Biophysical Research Communications 299 (5): 813-817, 2002.
・ Takezawa T, Takenouchi T, Imai K, Takahashi T, Hashizume K. Cell culture on thin tissue sections commonly prepared for histopathology. FASEB Journal 16 (13): 1847-1849, 2002.
・Nakano H, Shimada A, Imai K, Takezawa T, Takahashi T, Hashizume K. Bovine trophoblastic cell differentiation on collagen substrata: formation of binucleate cells expressing placental lactogen. Cell and Tissue Research 307 (2): 225-235, 2002.
・竹澤俊明.器官工学の新しいアプローチ.生物工学会誌 80: 194-196, 2002.
2000
・ Takezawa T, Inoue M, Aoki S, Sekiguchi M, Wada K, Anazawa H, Hanai N. Concept for organ engineering: a reconstruction method of rat liver for in vitro culture. Tissue Engineering 6 (6): 641-650, 2000.
1999
・Nakamura K, Hanibuchi M, Yano S, Tanaka Y, Fujino I, Inoue M, Takezawa T, Shitara K, Sone S, Hanai N. Apoptosis induction of human lung cancer cell line in multicellular heterospheroids with humanized antiganglioside GM2 monoclonal antibody. Cancer Research 59 (20): 5323-5330, 1999.
1997
・ Takezawa T, Yoshizato K. Mass transport via naturally branched scaffolds maintains viability of a reconstituted model of connective tissue. Tissue Engineering 3 (4): 329-343, 1997.
1996
・Sato H, Suzuki A, Funahashi M, Takezawa T, Ogawa Y, Yoshizato K. Characteristics of growth, morphology, contractility, and protein expression of fibroblasts derived from keloid. Wound Repair and Regeneration 4 (1): 103-114, 1996.
1995
・Yamazaki M, Tsuchida M, Kobayashi K, Takezawa T, Mori Y. A novel method to prepare multicellular spheroids from varied cell types. Biotechnology and Bioengineering 48 (1): 17-24, 1995.
1994
・Yamazaki M, Tuchida M, Kobayashi K, Takezawa T, Mori Y. A novel method to prepare size-regulated spheroids composed of human dermal fibroblasts. Biotechnology and Bioengineering 44 (1): 38-44, 1994.
・ Takezawa T, Ito A, Mori Y. Histological observations on hetero-spheroid consisting of human dermal fibroblasts and human epidermal keratinocytes. Connective Tissue 26 (2): 111-115, 1994.
・Ueno K, Endoh K, Miyashita A, Takezawa T, Mori Y, Satoh T. An alternative to hepatotoxicity testing using muliticellular spheroids composed of rat liver cells. In Vitro Toxicology 7 (4): 351- 356, 1994.
1993
・ Takezawa T, Mori Y, Yonaha T, Yoshizato K. Characterization of morphology and cellular metabolism during the spheroid formation by fibroblasts. Experimental Cell Research 208 (2): 430-441, 1993.
・竹澤俊明.人工細胞外マトリックスによる器官形成の誘導.実験医学 11: 156-162, 1993.
・吉里勝利,竹澤俊明.人工皮膚.バイオサイエンスとインダストリー 51: 296-297, 1993.
・竹澤俊明,森有一,上野光一,佐藤哲男,吉里勝利.温度感受性三次元培養基質とその応用.組織培養 19: 328-331, 1993.
1992
・窪田 倭,竹澤 俊明,森 有一,高桑 俊文.癌細胞と正常細胞との三次元共培養法の確立とその個人別抗癌剤感受性試験への応用.日本外科学会誌 93: 960-963, 1992.
・Ueno K, Miyashita A, Endoh E, Takezawa T, Yamazaki M, Mori Y, Satoh T. Formation of multicellular spheroids composed of rat hepatocytes. Research Communications in Chemical Pathology and Pharmacology 77 (1): 107-120, 1992.
・ Takezawa T, Yamazaki M, Mori Y, Yonaha T, Yoshizato K. Morphological and immuno- cytochemical characterization of a hetero-spheroid composed of fibroblasts and hepatocytes. Journal of Cell Science 101 (3): 495-501, 1992.
・窪田倭,竹澤俊明,森有一,富沢弘美,高桑俊文.温度感応性高分子化合物を用いた株化癌細胞と正常細胞の球状凝集塊(スフェロイド)の作製法と形態学的検討.医学のあゆみ 161: 539-540, 1992.
1991
・ 竹澤 俊明,森 有一,吉里 勝利.温度感受性ポリマーを用いたヒト真皮由来線維芽細胞のスフェロイド形成法.応用細胞生物学研究 9 (1): 1-11, 1991.
・ 竹澤 俊明,森 有一,吉里 勝利.温度感受性ポリマーを用いた新規細胞培養法による正常細胞のスフェロイド形成.組織培養研究 9 (2): 81-86, 1991.
1990
・ Takezawa T, Mori Y, Yoshizato K. Cell culture on a thermo-responsive polymer surface. Nature Biotechnology 8 (9): 854-856, 1990.
2023
・竹澤俊明.細胞挙動を制御する培養担体.日本組織培養学会(編)細胞培養・組織培養の技術 第4版.朝倉書店(東京) pp.140-144, 2023.
・竹澤俊明.ゲル培養法2:コラーゲンビトリゲル膜培養法.日本組織培養学会(編)細胞培養・組織培養の技術 第4版.朝倉書店(東京) pp.148-152, 2023.
2019
・竹澤俊明.コラーゲンビトリゲルを用いた再生医療用足場材料開発.株式会社技術情報協会(編集)再生医療の開発戦略と最新研究事例集.株式会社技術情報協会(東京)pp.176-178, 2019.
2018
・竹澤俊明,山口宏之.コラーゲンビトリゲル膜チャンバーを用いた眼刺激性試験法.株式会社技術情報協会(編集)皮膚の安全性・有用性評価法.株式会社技術情報協会(東京)pp.73-77, 2018.
・竹澤俊明.人工皮膚.日経BP総研 日経xTECH(編集)スマートマテリアル総覧自己修復材料編.日経BP社(東京)pp.277-279, 2018.
2016
・竹澤俊明.コラーゲンビトリゲル.シーエムシー出版(企画編集)再生医療用足場材料の開発と市場.シーエムシー出版(東京)pp.95-102, 2016.
2014
・竹澤俊明.コラーゲンビトリゲル膜チャンバーを用いた細胞培養システム.株式会社技術情報協会(監修)動物細胞培養の手法と細胞死・増殖不良・細胞変異を防止する技術.株式会社技術情報協会(東京)pp.101-106, 2014.
2013
・竹澤俊明.コラーゲンビトリゲル膜チャンバーを用いたADMET解析に有用な培養システム.小島肇夫(監修)In vitro毒性・動態評価の最前線.株式会社シーエムシー出版(東京)pp.110-118, 2013.
・竹澤俊明.コラーゲンビトリゲルの開発と再生医療への応用.株式会社技術情報協会(監修)再生医療における臨床研究と製品開発.株式会社技術情報協会(東京)pp.271-274, 2013.
・竹澤俊明.ビトリゲルの開発と再生医療分野での実用化構想.株式会社技術情報協会(監修)ゲルの安定化と機能性付与・次世代への応用開発.株式会社技術情報協会(東京)pp.428-432, 2013.
2012
・竹澤俊明.組織再生に有用なコラーゲンビトリゲルの開発.秋吉一成・石原一彦・山岡哲二(監修)先端バイオマテリアルハンドブック.株式会社エヌ・ティー・エス(東京)pp. 277-282, 2012.
・Haga S, Takezawa T, Ozawa T, Remington S.J, Morita N, Ozaki M. ‘Collagen vitrigel sheet’ as a novel drug delivery bio-material. Magjarevic R. (ed.): IFMBE Proceedings Vol. 37. Springer (Netherlands) pp. 1354-1357, 2012.
・Takezawa T, Aoki S, Oshikata A, Okamoto C, Yamaguchi H, Narisawa Y, Toda S. A novel material of high density collagen fibrils: a collagen xerogel membrane and its application to transplantation in vivo and a culture chamber in vitro. International Proceedings Division (ed.): 24th European Conference on Biomaterials. Medimond (Bologna) pp. 181-185, 2012.
2011
・Takezawa T. A Novel Strategy for Drug Discovery and Development by Analyzing the Behavior of ES Cells Cultured on TOSHI (Tissue/Organ Sections for Histopathology)–Substrata. Atwood C. (ed.): Methodological Advances in the Culture: Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications. InTech (Croatia) Chapter 26 (pp. 473-488), 2011.
2008
・長棟輝行,高野等覚,竹澤俊明,新海政重.細胞転写技術を用いた細胞アレイ作製技術.田畑泰彦(編集)遺伝子医学MOOK別冊「進みつづける細胞移植治療の実際」上巻.株式会社メディカルドゥ(東京)pp. 230-234, 2008.
2007
・竹澤俊明.三次元培養技術とオルガノイド.関口清俊(編著)再生医療のための細胞生物学.コロナ社(東京)pp. 183-208, 2007.
・竹澤俊明.組織培養.岡野光夫・大和雅之(監修)再生医療技術の最前線.シーエムシー出版(東京)pp. 33-38, 2007.
・高山喜晴,竹澤俊明.コラーゲンビトリゲル薄膜を用いたラクトフェリンの徐放化と骨組織再生への応用.第2回ラクトフェリンフォーラム実行委員会(編集)ラクトフェリン2007.日本医学館(東京)pp. 84-87, 2007.
・竹澤俊明.生体内環境モデルとなる培養担体の開発.酒井康行・民谷栄一(監修)動物実験代替のためのバイオマテリアル開発.シーエムシー出版(東京)pp. 174-181, 2007.
2006
・Saito T, Terada S, Takezawa T. Culture of insulinoma cells on pancreas sections. Iijima S, Nishijima K. (eds.): Animal cell technology “Basic & applied aspects Vol. 14”. Springer (Netherlands) pp. 271-276, 2006.
2004
・Takezawa T. A novel technology for conversion of in vivo tissue architecture into a three-dimensional in vitro culture mode. Yagasaki K, Miura Y, et al. (eds.): Animal cell technology “Basic & applied aspects Vol. 13”. Kluwer Academic Publishers (Netherlands) pp. 19-24, 2004.
・Takenouchi T, Takezawa T. Isolation and characterization of fetal bovine cells derived from liver and bone marrow. Yagasaki K, Miura Y, et al. (eds.): Animal cell technology “Basic & applied aspects Vol. 13”. Kluwer Academic Publishers (Netherlands) pp. 219-223, 2004.
1999
・Takezawa T, Yoshizato K. Organoid formation with branched capillary-like networks. Kitagawa Y, Matsuda T, et al. (eds.): Animal cell technology “Basic & applied aspects Vol. 10”. Kluwer Academic Publishers (Netherlands) pp. 43-47, 1999.
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17.許第第7112736号「半透膜及びその使用」
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26.特許第6906805号、特許第6993740号「糸及びその製造方法」
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32.特許第7251867号「容器、及び細胞輸送装置」
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