業績

PUBLICATIONS （2020～）

Change in the ability of bovine granulosa cells to elongate transzonal projections and their transcriptome changes during follicle development.

Mihoko Fushii, Hirohisa Kyogoku, Jibak Lee, Takashi Miyano

The Journal of reproduction and development (2024)

DOI, PubMed

Embryonic genome instability upon DNA replication timing program emergence.

Saori Takahashi*, Hirohisa Kyogoku*⁺, Takuya Hayakawa, Hisashi Miura, Asami Oji, Yoshiko Kondo, Shin-ichiro Takebayashi, Tomoya S. Kitajima⁺ & Ichiro Hiratani⁺ (*These authors contributed equally to this work, ⁺Co-corresponding authors.)

Nature (2024)

DOI, PubMed, Nature

朝日新聞，日本経済新聞，日本経済新聞，科学新聞、神戸大プレスリリース，Science Japan

Bioenginner.org，ScienMag，Phys.org，Alert Breaking News-US，The Medical News，AZO Life Sciences，news-medical.net，It Ain't Magic

Birth of mice from meiotically arrested spermatocytes following biparental meiosis in halved oocytes.

Narumi Ogonuki, Hirohisa Kyogoku, Toshiaki Hino, Yuki Osawa, Yasuhiro Fujiwara, Kimiko Inoue, Tetsuo Kunieda, Seiya Mizuno, Hiroyuki Tateno, Fumihiro Sugiyama, Tomoya S Kitajima, Atsuo Ogura

EMBO reports (2022)

DOI, PubMed

Oocyte-derived growth factors promote development of antrum-like structures by porcine cumulus granulosa cells in vitro.

Riho Morikawa, Hirohisa Kyogoku, Jibak Lee, Takashi Miyano

The Journal of reproduction and development (2022)

DOI, PubMed

Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes

Shuhei Yoshida, Sui Nishiyama, Lisa Lister, Shu Hashimoto, Tappei Mishina, Aurélien Courtois, Hirohisa Kyogoku, Takaya Abe, Aki Shiraishi, Meenakshi Choudhary, Yoshiharu Nakaoka, Mary Herbert, Tomoya S. Kitajima

Nature Communications (2020)

DOI, PubMed

Reconstitution of the oocyte transcriptional network with transcription factors

Nobuhiko Hamazaki, Hirohisa Kyogoku, Hiromitsu Araki, Fumihito Miura, Chisako Horikawa, Norio Hamada, So Shimamoto, Orie Hikabe, Kinichi Nakashima, Tomoya S. Kitajima, Takashi Ito, Harry G. Leitch, Katsuhiko Hayashi

Nature (2020)

DOI, PubMed

Review and Books

初期胚の染色体分配異常

京極博久

Journal of Mammalian Ova Research

42(1) 3-8, (2025)

Chromosome segregation errors during early embryonic development

Hirohisa Kyogoku

Reproductive Medicine and Biology (2025)

DOI, PubMed

The large cytoplasmic volume of oocyte.

Hirohisa Kyogoku, Tomoya S Kitajima

The Journal of reproduction and development（2022）

DOI, PubMed

初期胚の染色体分配異常

京極博久

細胞 54(11) 657-659 2022年10月

PUBLICATIONS （～2019）

Single nucleolus precursor body formation in the pronucleus of mouse zygotes and SCNT embryos

Hirohisa Kyogoku, Teruhiko Wakayama, Tomoya S. Kitajima, Takashi Miyano

PLoS ONE (2018)

DOI, PubMed

Cytoplasmic removal, enucleation, and cell fusion of mouse oocytes

Hirohisa Kyogoku, Shuhei Yoshida, Tomoya S. Kitajima

Methods in Cell Biology (2018)

DOI, PubMed

Mouse oocytes nucleoli rescue embryonic development of porcine enucleolated oocytes

Martin Morovic, Frantisek Strejcek, Shoma Nakagawa, Rahul S. Deshmukh, Matej Murin, Michal Benc, Helena Fulka, Hirohisa Kyogoku, Lazo Pendovski, Josef Fulka, Jozef Laurincik

Zygote (2017)

DOI, PubMed

Large Cytoplasm Is Linked to the Error-Prone Nature of Oocytes

Hirohisa Kyogoku, Tomoya S. Kitajima

Developmental Cell (2017)

DOI, PubMed

Can Nucleoli Be Markers of Developmental Potential in Human Zygotes?

Helena Fulka, Hirohisa Kyogoku, Olga Zatsepina, Alena Langerova, Josef Fulka

Trends in Molecular Medicine (2015)

DOI, PubMed

De novo formation of nucleoli in developing mouse embryos originating from enucleolated zygotes

Hirohisa Kyogoku, Josef Fulka, Teruhiko Wakayama, Takashi Miyano