生物機能制御化学研究室

研究業績

2025年度

Nishida, M., Pecorilla, C., Masuya, T.*, Hirano, K., Abe, M, Zdorevskyi, O., Sharma V., Miyoshi, H., and Murai, M.* (2025) Dynamic binding of acetogenin-type inhibitors to mitochondrial complex I revealed by photoaffinity labeling, Biochim. Biophys. Acta (Bioenergetics), 1866, 149566.
Ishikawa-Fukuda, M., Kishikawa, J., Masuya, T., Ito, T., Butler, N. L., McFee, D., Kato, T., Barquera, B., Miyoshi, H., and Murai, M.* (2025) Structural elucidation of the mechanism for inhibitor resistance in the Na+-translocating NADH-ubiquinone oxidoreductase from Vibrio cholerae, Biochemistry 64, 1963-1972.
高岡洋輔

「天然変性領域リデザインによる植物転写因子の選択的制御」

化学と生物, in press (2025)

2025年以前の論文ー植物ホルモンのケミカルバイオロジー関係ー

その他、過去の主要論文

Takaoka, Y., Uchinomiya, S., Kobayashi, D., Engo, M., Hayashi, T., Fukuyama, Y., Hayasaka, H., Miyasaka, M., Ueda, T., Shimada, I., Hamachi, I.* (2018) Endogenous Membrane Receptor Labeling by Reactive Cytokines and Growth Factors to Chase Their Dynamics in Live Cells, Chem (Cell press), 4, 1451-1464.
Takaoka, Y., Nishikawa, Y., Hashimoto, Y., Sasaki, K., Hamachi, I.* (2015) Ligand-directed Dibromophenyl Benzoate Chemistry for Rapid and Selective Acylation of Intracellular Natural Proteins, Chem. Sci., 6, 3217-3224.
Yoshii, T., Mizusawa, K., Takaoka, Y.,* Hamachi, I.* (2014) Intracellular Protein-responsive Supramolecules; Protein Sensing and In-cell Construction of Inhibitor Assay System, J. Am. Chem. Soc., 136, 16635-16642 (2014).
Asanuma, D.** Takaoka, Y.,** Namiki, S., Takikawa, K., Nagano, T., Urano, Y., Hirose, K.* (2014) Acidic-pH-Activatable Fluorescence Probes for Visualizing Exocytosis Dynamics, Angew. Chem. Int. Ed., 53, 6085-6089. (** Co-first author)
Takaoka, Y., Kioi, Y., Morito, A., Otani, J., Arita, K., Ashihara, E., Ariyoshi, M., Tochio, H., Shirakawa, M., Hamachi, I.* (2013) Quantitative comparison of protein dynamics in live cells and in vitro by in-cell 19F-NMR, Chem. Commun., 49, 2801-2803.
Mizusawa, K., Takaoka, Y., Hamachi, I.* (2012) Specific Cell Surface Protein Imaging by Extended Self-Assembling Fluorescent Turn-on Nanoprobes, J. Am. Chem. Soc., 134, 13386-13395.
Takaoka, Y., Kiminami, K., Mizusawa, K., Matsuo, K., Narazaki, M., Matsuda, T., Hamachi, I.* (2011) Systematic Study of Protein Detection Mechanism of Self-assembling 19F NMR/MRI Nanoprobes toward Rational Design and Improved Sensitivity, J. Am. Chem. Soc., 133, 11725-11731.
Takaoka, Y., Sakamoto, T., Tsukiji, S., Narazaki, M., Matsuda, T., Tochio, H., Shirakawa, M., Hamachi, I.* (2009) Self-assembling nano-probes displaying off/on 19F NMR signals for protein detection and imaging, Nat. Chem., 1, 557-561.
Tsukiji, S., Miyagawa, M., Takaoka, Y., Tamura, T., Hamachi, I.* (2009) Ligand-directed tosyl chemistry for protein labeling in vivo, Nat. Chem. Biol., 5, 341-343.
Takaoka, Y., Tsutsumi, H., Kasagi, N., Nakata, E., Hamachi, I.* (2006) One-pot and sequential organic chemistry on an enzymatic surface to tether a fluorescent probe at the proximity of the active site with restoring enzyme activity, J. Am. Chem. Soc. 128, 3273-3280.

2025年以前の論文　ー呼吸鎖電子伝達酵素のケミカルバイオロジー関連ー